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health services (Abe-Kim et al. 2007; Bebbington et al. 2000; Cheung and snowden 1990; Harris et al. 2005; Kirmayer et al. 1996; Klimidis et al. 2000; Lai et al. 2003; Leong 1994; matsuoka et al. 1997; Roberts ...pmid:21037825 pmcid:PMC2805139 fatcat:w5suwdjynve6zj5q7nzhynklza
curvilinear nature of the surface features discussed here have similarities to the "flow lineations" discussed by Walker [ 1987a] from the Koolau dike complex in Hawaii, to surface lineations described by Roberts ...doi:10.1029/97jb02717 fatcat:igzhzpfxwvfqvhjoia7os6ohay
Am J Physiol Endocrinol Metab 284: E213-E218, 2003. First published September 3, 2002 10.1152/ajpendo.00248.2002. ... Farese, Jr.) and the J. David Gladstone Institutes. ...doi:10.1152/ajpendo.00248.2002 pmid:12388146 fatcat:qmtq3vtyh5aazec2zrcgrqhzla
SHUTE, PELLEGRINO, HUBERT,AND REYNOLDS more precisely the form and level of the relationship between androgen levels and spatial performance in a sample of normal males and females. ...doi:10.3758/bf03330010 fatcat:53kjgpxmvzfm5palg7m7ii25di
A novel electrochemical method for driving fluids in micro-channels is presented. The principle is based upon the onset of Marangoni flow along the interface between an aqueous solution (mobile phase) and an organic electrolyte polymer gel coated on the inner walls of the microchannel. The gradient of surface tension responsible for the fluid motion arises from local changes in the surface charge. The excess charge is determined by the ionisation of surfactant species at the gel coatingNaqueousdoi:10.1016/s1388-2481(99)00038-7 fatcat:5l7m7rgqqza5hpt6qml2g54scm
more »... gel coatingNaqueous electrolyte interface which is effectively dependent on the Galvani potential difference. Potential differences of less than a volt between two closely spaced silver band electrodes along the microchannel can generate zones of high and low surface tension, promoting the motion of the aqueous electrolyte. q 1999 Elsevier Science S.A. All rights reserved.
(J Clin Endocrinol Metab 86: 3948 -3957, 2001) ...doi:10.1210/jcem.86.8.7739 pmid:11502837 fatcat:usr663keb5gmtiatkvd7sp5nx4
This study aims to evaluate the safety and feasibility of obtaining wedged pulmonary artery (PA) samples and investigate the differential vascular beds' distribution of select inflammatory and cellular adhesion molecules that are implicated in pulmonary arterial hypertension (PAH) pathogenesis. This is a cross-sectional study of adult patients. Serum samples were simultaneously drawn from three different vascular sites during right heart catheterization as part of PAH evaluation: The superiordoi:10.4103/2045-8932.105036 pmid:23372932 pmcid:PMC3555418 fatcat:5src66sa4ngtni6zabwkoyh7nq
more »... ion: The superior vena cava, distal pulmonary artery prior to wedging, and distal pulmonary artery after (and distal to) wedging. The study group was comprised of patients with either PAH or chronic thromboembolic pulmonary hypertension (i.e., WHO/Dana Point Group 1 or 4). The internal control group included patients whose hemodynamics were not consistent with pulmonary hypertension. The external control group consisted of healthy volunteers who had a peripheral venous sample drawn. The mean age of the 25 study patients was 55 ± 14 years and mean BMI was 31 ± 10, and those of the 25 internal control patients were 49 ± 14 years and 26 ± 5, respectively. There were no complications resulting from obtaining wedged PA samples. Obtaining adequate wedged samples was successful in 80% of patients. More severe pulmonary hypertension was associated with lower success rates. There were no significant differences in the concentrations of the different biomarkers studied amongst the different vascular sites (n = 25 study patients). There was a nonsignificant trend of decreasing biomarkers concentrations from peripheral to wedged to un-wedged PA samples. Compared to the healthy external controls, sVCAM-1 levels were higher in the study group. Obtaining wedged PA blood samples is safe and feasible in adult patients with pulmonary hypertension. There were no differences in the distribution of markers between the vascular beds within patients.
During the in vitro differentiation of human villous cytotrophoblast (CTB) cells to a syncytiotrophoblast (STB) phenotype, mRNA levels for the nuclear hormone receptor NR2F2 (ARP-1, COUP-TFII) increase rapidly, reaching a peak at day 1 of differentiation that is 8.8-fold greater than that in undifferentiated CTB cells. To examine whether NR2F2 is involved in the regulation of villous CTB cell differentiation, studies were performed to determine whether NR2F2 regulates the expression of TFAP2Adoi:10.1371/journal.pone.0009417 pmid:20195529 pmcid:PMC2828470 fatcat:qtvtxinee5eulkjvoqjuwzxkju
more »... ression of TFAP2A (AP-2a), a transcription factor that is critical for the terminal differentiation of these cells to a STB phenotype. Methodology/Primary Findings: Overexpression of NR2F2 in primary cultures of human CTB cells and JEG-3 human choriocarcinoma cells induced dose-dependent increases in TFAP2A promoter activity. Conversely, siRNA mediated silencing of the NR2F2 gene in villous CTB undergoing spontaneous differentiation blocked the induction of the mRNAs for TFAP2A and several STB cell specific marker genes, including human placental lactogen (hPL), pregnancy specific glycoprotein 1 (PSG1) and corticotropin releasing hormone (CRH) by 51-59%. The induction of TFAP2A promoter activity by NR2F2 was potentiated by the nuclear hormone receptors retinoic acid receptor alpha (RARA) and retinoid X receptor alpha (RXRA). Conclusions/Significance: Taken together, these results strongly suggest that NR2F2 is involved in villous CTB cell differentiation and that NR2F2 acts, at least in part, by directly activating TFAP2A gene expression and by potentiating the transactivation of TFAP2A by RARA and RXRA.
The p53 tumor suppressor protein is a key regulator of cell cycle and death that is involved in many cell signaling pathways and is tightly regulated in mammalian cells. Post-translational modifications of p53 have been investigated previously mainly using antibodies. In this study, utilizing LC-MS/MS analysis, we have characterized p53 protein from COS-1 cells. Several already known posttranslational modifications were observed, such as phosphorylation on serines 15, 33, 315, and 392 as welldoi:10.1074/mcp.m800487-mcp200 pmid:19155208 pmcid:PMC2690490 fatcat:jzrn4hgy35cxnkcq7jskyhorge
more »... , and 392 as well as acetylation on lysines 305, 370, 372, 373, 381, 382, and 386. Interestingly novel acetylation sites were identified at lysines 319 and 357. This study confirmed that p53 is a highly acetylated protein and revealed new acetylation sites that might aid the further understanding of p53 regulation.
Malnutrition affects 5-10% of elderly people living in the community. A few studies suggest that nutritional intervention may reduce health care costs. The present study included malnourished elderly patients living at home. It aimed to compare health care costs between patients that were prescribed ONS by their general practitioner and those who were not, and to assess the effect of ONS prescription on the risk of hospitalisation. This prospective multicentre observational study includeddoi:10.1016/j.clnu.2019.08.005 pmid:31471163 fatcat:peedanjtr5fvfiy66yzq4v3tqa
more »... tudy included malnourished patients ≥70 years old who lived at home. Patients were defined as malnourished if they presented with one or more of the following criteria: weight loss ≥5% in 1 month, weight loss ≥10% in 6 months, BMI <21 kg/m2, albuminemia <35 g/L or Short-Form MNA ≤ 7. Their general practitioners prescribed an ONS, or not, according to their usual practice. Health care costs were recorded during a 6-month period. Other collected data were diseases, disability, self-perception of current health status, quality of life (QoL), nutritional status, appetite and compliance to ONS. A propensity score method was used to compare costs and risk of hospitalisation to adjust for potential confounding factors and control for selection bias. We analysed 191 patients. At baseline, the 133 patients (70%) who were prescribed ONS were more disabled (p < 0.001) and had poorer perception of their health (p = 0.02), lower QoL (p = 0.04) and lower appetite (p < 0.001) than the 58 patients (30%) who were not prescribed ONS. At 6 months, appetite had improved more in the ONS prescription group (p = 0.001). Weight change was not different between groups. Patients prescribed ONS were more frequently hospitalised (OR 2.518, 95% CI: [1.088; 5.829] hosp; p = 0.03). Analyses of adjusted populations revealed no differences in health care costs between groups. In the ONS prescription group, we identified that health care costs were lower (p = 0.042) in patients with an energy intake from ONS ≥ 500 kcal/d (1389 ± 264 €) vs. < 500 kcal/d (3502 ± 839 €). The risk of hospitalisation was reduced 3 and 5 times when the intake from ONS was ≥30 g of protein/day or ≥500 kcal/d, respectively. ONS prescription in malnourished elderly patients generated no extra heath care cost. High energy and protein intake from ONS was associated with a reduced risk of hospitalisation and health care costs.
(Am J Pathol 2000, 156:311-319) ...doi:10.1016/s0002-9440(10)64732-3 pmid:10623680 pmcid:PMC1868630 fatcat:hbaw5xztbffejpxbj5sawg7pny
This work was supported by the NIH (R01 DK56084), the CardioFellows Foundation, the Endocrine Fellows Foundation, and the J. David Gladstone Institutes. ... These histological changes reverted to pretreatment states 2 weeks after the cessation of leptin administration ( Figure 5, i and j) . Abnormal fur lipids in Dgat -/mice. ...doi:10.1172/jci0213880 pmid:11805129 pmcid:PMC150839 fatcat:upsu6jlr5jglbj7p4z75y3f7ye
Pundavela, J., Roselli, S., Faulkner, S., Attia, J., Scott, R. J., Forbes', J. F., Bradshaw, R. A., Walker, M. M., Jobling, P. and Hondermarck, H., submitted for publication. ...doi:10.1016/j.jbior.2014.11.003 pmid:25491371 pmcid:PMC4426037 fatcat:q6tun2hn4ndrhc7zngolnaww4m
This work was supported by the NIH (R01 DK56084), the CardioFellows Foundation, the Endocrine Fellows Foundation, and the J. David Gladstone Institutes. ... These histological changes reverted to pretreatment states 2 weeks after the cessation of leptin administration ( Figure 5, i and j) . Abnormal fur lipids in Dgat -/mice. ...doi:10.1172/jci13880 pmid:11805129 pmcid:PMC150839 fatcat:xpf6xdog5vhgdf45dibznz6kvm
Aliquots (0.5 j) of the 5 gl bead suspension, containing < 4 pmol for each duplex, were loaded with 0.5 gl of matrix (0.7 M 3-HPA, 0.07 M ammonium citrate). ...doi:10.1093/nar/23.16.3126 pmid:7667088 pmcid:PMC307169 fatcat:ysmsted2mreyhooyeyh2odeuf4
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