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Quality of Life and Sleep Study Findings After Adenotonsillectomy in Children With Obstructive Sleep Apnea

Michael G. Stewart, Daniel G. Glaze, Ellen M. Friedman, E. O'Brian Smith, Marilyn Bautista
2005 Archives of Otolaryngology - Head and Neck Surgery  
Objectives: To assess polysomnogram (PSG) results and global and disease-specific quality of life (QOL) in children with obstructive sleep apnea (OSA), before and after adenotonsillectomy, and to assess the association between PSG findings and QOL. Design: Prospective observational study. We performed overnight PSG using standardized techniques and assessed disease-specific and global QOL using validated instruments. Follow-up was assessed at 1 year. We compared QOL outcomes between children
more » ... between children who underwent adenotonsillectomy and children who did not. Setting: A large tertiary care children's hospital. Patients: Children with sleep-disordered breathing who were suspected of having OSA. Intervention: Adenotonsillectomy. Main Outcome Measures: We evaluated PSG parameters, disease-specific QOL, and global QOL. Results: We enrolled 47 children, 31 of whom met PSG criteria for OSA. Disease-specific and global QOL
doi:10.1001/archotol.131.4.308 pmid:15837898 fatcat:xijskzqeqja47jb6h43fpj2b3u

Hypoxia Moderates γ134.5-Deleted Herpes Simplex Virus Oncolytic Activity in Human Glioma Xenoline Primary Cultures

Gregory K. Friedman, Marilyn C. Haas, Virginia M. Kelly, James M. Markert, George Yancey Gillespie, Kevin A. Cassady
2012 Translational Oncology  
Translational Oncology Vol. 5, No. 3, 2012 Hypoxia Moderates Mutant HSV Oncolytic Activity Friedman et al. can evade the mechanism(s) or limit the effects.  ...  Cells were filtered through a 40-μm pore Cell Strainer (BD Biosciences, San Jose, CA) to remove any clumps, washed in medium, and counted by hemacytometer with trypan blue viability determination.  ... 
doi:10.1593/tlo.12115 pmid:22741039 pmcid:PMC3384274 fatcat:ofos5rqqnfggraomeynrcb4dme

Validation of an Outcomes Instrument for Tonsil and Adenoid Disease

Michael G. Stewart, Ellen M. Friedman, Marcelle Sulek, Andrew deJong, Gregory F. Hulka, Marilyn H. Bautista, Susan E. Anderson
2001 Archives of Otolaryngology - Head and Neck Surgery  
Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Tex (Drs Stewart, Friedman, Sulek, and deJong and Ms Bautista), and the Division of Otolaryngology-Head  ... 
doi:10.1001/archotol.127.1.29 pmid:11177011 fatcat:i6qdky2sibfwpdrwznfr3goedi

Quality of Life and Health Status in Pediatric Tonsil and Adenoid Disease

Michael G. Stewart, Ellen M. Friedman, Marcelle Sulek, Gregory F. Hulka, Ronald B. Kuppersmith, Willard C. Harrill, Marilyn H. Bautista
2000 Archives of Otolaryngology - Head and Neck Surgery  
Objective: To assess the baseline global health status and quality of life (QOL) in children with tonsil and adenoid disease.
doi:10.1001/archotol.126.1.45 pmid:10628710 fatcat:xkfczyutwbfgplbly2fdaajhyy

CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV

Joseph G. Pressey, Marilyn C. Haas, Christine S. Pressey, Virginia M. Kelly, Jacqueline N. Parker, G. Yancey Gillespie, Gregory K. Friedman
2012 Pediatric Blood & Cancer  
M-Cadherin (M-CAD) expression was equivalent (0.817x ±0.137, p=0.161).  ...  A) Relative expression of satellite cell markers PAX7, c-MET, and M-CAD. B) Relative expression of various stem cell markers in CD133+ cells.  ... 
doi:10.1002/pbc.24117 pmid:22408058 pmcid:PMC3374896 fatcat:56xwnlavpngq7jr5fxqt3f4wc4

Unemployment Among Adult Survivors of Childhood Cancer

Anne C. Kirchhoff, Wendy Leisenring, Kevin R. Krull, Kirsten K. Ness, Debra L. Friedman, Gregory T. Armstrong, Marilyn Stovall, Elyse R. Park, Kevin C. Oeffinger, Melissa M. Hudson, Leslie L. Robison, Thomas Wickizer
2010 Medical Care  
Background-Adult childhood cancer survivors report high levels of unemployment although it is unknown whether this is due to health or employability limitations. Objectives-We examined two employment outcomes from 2002-2005 in the Childhood Cancer Survivor Study (CCSS): 1. health-related unemployment and 2. unemployed but seeking work. We compared survivors to a nearest-age CCSS sibling cohort and examined demographic and treatment-related risk groups for each outcome. Methods-We studied 6339
more » ... s-We studied 6339 survivors and 2280 siblings aged ≥25 years excluding those unemployed by choice. Multivariable generalized linear models evaluated whether survivors were more likely to be unemployed than siblings and whether certain survivors were at a higher risk for unemployment. Results-Survivors (10.4%) reported health-related unemployment more often than siblings (1.8%; Relative Risk [RR] 6.07, 95% Confidence Interval [CI] 4.32-8.53). Survivors (5.0%) were more likely to report being unemployed but seeking work than siblings (2.7%; RR 1.90, 95% CI 1.43-2.54). Health-related unemployment was more common in female survivors than males (Odds Ratio [OR] 1.73, 95% CI 1.43-2.08). Cranial radiotherapy doses ≥25 Gy were associated with higher odds of unemployment (health-related: OR 3.47, 95% CI 2.54-4.74; seeking work: OR 1.77, 95% CI 1.15-2.71). Unemployed survivors reported higher levels of poor physical functioning than employed survivors, and had lower education and income and were more likely to be publicly insured than unemployed siblings. Conclusions-Childhood cancer survivors have higher levels of unemployment due to health or being between jobs. High-risk survivors may need vocational assistance.
doi:10.1097/mlr.0b013e3181eaf880 pmid:20940653 pmcid:PMC3428202 fatcat:c456nsvpm5ebbp2dp7dmeknyuu

Risk of Second Primary Thyroid Cancer after Radiotherapy for a Childhood Cancer in a Large Cohort Study: An Update from the Childhood Cancer Survivor Study

Parveen Bhatti, Lene H. S. Veiga, Cécile M. Ronckers, Alice J. Sigurdson, Marilyn Stovall, Susan A. Smith, Rita Weathers, Wendy Leisenring, Ann C. Mertens, Sue Hammond, Debra L. Friedman, Joseph P. Neglia (+5 others)
2010 Radiation Research  
treatment, plus any additional treatment that occurred during the ensuing 10 years, were obtained from the treating institution and forwarded to the CCSS Radiation Physics Center at the University of Texas M.  ... 
doi:10.1667/rr2240.1 pmid:21128798 pmcid:PMC3080023 fatcat:6mnbuho24vdvrargfmx5lhlhua

Breast Cancer After Chest Radiation Therapy for Childhood Cancer

Chaya S. Moskowitz, Joanne F. Chou, Suzanne L. Wolden, Jonine L. Bernstein, Jyoti Malhotra, Danielle Novetsky Friedman, Nidha Z. Mubdi, Wendy M. Leisenring, Marilyn Stovall, Sue Hammond, Susan A. Smith, Tara O. Henderson (+9 others)
2014 Journal of Clinical Oncology  
Bernstein, Jyoti Malhotra, Danielle Novetsky Friedman, Nidha Z.  ...  Bernstein, Wendy M. Leisenring, Sue Hammond, John D. Boice, Melissa M. Hudson, Lisa R. Diller, Joseph P. Neglia, Colin B. Begg, Leslie L. Robison, Kevin C. Oeffinger Financial support: Chaya S.  ... 
doi:10.1200/jco.2013.54.4601 pmid:24752044 pmcid:PMC4100937 fatcat:ls2fpfype5dvjbf3ugvkhh3t4a

Breast Cancer Risk in Childhood Cancer Survivors Without a History of Chest Radiotherapy: A Report From the Childhood Cancer Survivor Study

Tara O. Henderson, Chaya S. Moskowitz, Joanne F. Chou, Angela R. Bradbury, Joseph Phillip Neglia, Chau T. Dang, Kenan Onel, Danielle Novetsky Friedman, Smita Bhatia, Louise C. Strong, Marilyn Stovall, Lisa B. Kenney (+8 others)
2016 Journal of Clinical Oncology  
(Table 3) revealed that exposure to high doses of alkylator (CED . 18,000 mg/m 2 ; rSIR = 3.0; 95% CI, 1.2 to 7.7) or anthracycline chemotherapy (. 250 mg/m 2 ; rSIR = 3.8; 95% CI, 1.7 to 8.3) was significantly  ...  (59.0) 17 (38.6) 2,099 (59.3) 1-5,999 624 (17.4) 4 (9.1) 620 (17.5) 6,000-17,999 675 (18.8) 16 (36.4) 659 (18.6) $ 18,000 169 (4.7) 7 (15.9) 162 (4.6) Anthracycline cumulative dose, mg/m  ... 
doi:10.1200/jco.2015.62.3314 pmid:26700127 pmcid:PMC4871997 fatcat:gtpnlzqkbzevjckiiao7j43gum

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, Samuela Pollack, Anne Barton, Heike Bickeböller, Donald W. Bowden, Steve Eyre, Barry I. Freedman, David J. Friedman (+37 others)
2012 PLoS Genetics  
{c(t{ t t){m e 1 ffiffiffiffiffi ffi 2p p exp {e 2 2 de , ð ? {c(t{ t t){m 1 ffiffiffiffiffi ffi 2p p exp {e 2 2 de if z~1, ð1Þ E(ejz,t)~ð {c(t{ t t){m {?  ...  de 2 6 4 3 7 5, where L i~{ c(t i { t t){m,U i~? for cases and L i~{ ?,U i~{ c(t i { t t){m for controls.  ... 
doi:10.1371/journal.pgen.1003032 pmid:23144628 pmcid:PMC3493452 fatcat:p2s3bcfxibhvjfmoj4ulyophae

Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants

Tarah T. Colaizy, Melissa C. Bartick, Briana J. Jegier, Brittany D. Green, Arnold G. Reinhold, Andrew J. Schaefer, Debra L. Bogen, Eleanor Bimla Schwarz, Alison M. Stuebe, Alan H. Jobe, William Oh, Betty R. Vohr (+119 others)
2016 Journal of Pediatrics  
Objective-To estimate risk of NEC for ELBW infants as a function of preterm formula and maternal milk (MM) intake and calculate the impact of suboptimal feeding on NEC incidence and costs. Design-We used adjusted odds ratios (aORs) derived from the Glutamine Trial to perform Monte Carlo simulation of a cohort of ELBW infants under current suboptimal feeding practices, compared to a theoretical cohort in which 90% of infants received at least 98% MM. Results-NEC incidence among infants receiving
more » ... g infants receiving ≥98% MM was 1.3%; 11.1% among infants fed only preterm formula; and 8.2% among infants fed a mixed diet (p=0.002). In adjusted models, compared with infants fed predominantly MM, we found an increased risk of NEC associated with exclusive preterm formula (aOR=12.1, 95% CI 1.5, 94.2), or a mixed diet (aOR 8.7, 95% CI 1.2-65.2). In Monte Carlo simulation, current feeding of ELBW infants was associated with 928 excess NEC cases and 121 excess deaths annually, compared with a model in which 90% of contributed conceptually to the framing of the study and its overall design and presentation and critical review of the manuscript. Dr. Alison Stuebe contributed substantially to designing the model and decision tree for the outcomes for breastfed versus non-breastfed infants and to identification of race-specific birth and mortality to use for the model and also to critical review of the manuscript. The authors recognize the role of John Langer, PhD, RTI International, in the secondary analysis of the Glutamine Trial dataset that formed the estimates of NEC with various intakes of human milk used in this cost analysis. Dr.
doi:10.1016/j.jpeds.2016.03.040 pmid:27131403 pmcid:PMC5274635 fatcat:iphubwufojf7reill7o5ayai5m

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

Jeong H. Yun, Andrew Lamb, Robert Chase, Dave Singh, Margaret M. Parker, Aabida Saferali, Jørgen Vestbo, Ruth Tal-Singer, Peter J. Castaldi, Edwin K. Silverman, Craig P. Hersh, James D. Crapo (+230 others)
2018 Journal of Allergy and Clinical Immunology  
Slovenia: M. Kosnik, Golnik. Spain: A. Agusti, J. Sauleda, P. de Mallorca. Ukraine: Y. Feschenko, V. Gavrisyuk, L. Yashina, Kiev; N. Monogarova, Donetsk. United Kingdom: P. Calverley, Liverpool; D.  ...  Giessel, Richmond, VA; M. Gotfried, Phoenix, AZ; G. Greenwald, Rancho Mirage, CA; N. Hanania, Houston; D. Mahler, Lebanon, NH; B. Make, Denver; S. Rennard, Omaha, NE; C. Rochester, New Haven, CT; P.  ... 
doi:10.1016/j.jaci.2018.04.010 pmid:29709670 pmcid:PMC5994197 fatcat:sppvssw6hjbj7krzskpkht7ujy

Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects

Robert Busch, Brian D. Hobbs, Jin Zhou, Peter J. Castaldi, Michael J. McGeachie, Megan E. Hardin, Iwona Hawrylkiewicz, Pawel Sliwinski, Jae-Joon Yim, Woo Jin Kim, Deog K. Kim, Alvar Agusti (+270 others)
2017 American Journal of Respiratory Cell and Molecular Biology  
Acknowledgments: The authors acknowledge and thank Augustine M. K. Choi, M.D. (Weill Cornell Medicine, New York, NY), for his support of this project.  ... 
doi:10.1165/rcmb.2016-0331oc pmid:28170284 pmcid:PMC5516277 fatcat:ftsj2bpwyjdtjoju2u6bgejmre

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression

Adel Boueiz, Yale Chang, Michael H. Cho, George R. Washko, Raul San José Estépar, Russell P. Bowler, James D. Crapo, Dawn L. DeMeo, Jennifer G. Dy, Edwin K. Silverman, Peter J. Castaldi, James Crapo (+159 others)
2018 Chest  
BACKGROUND: Emphysema has considerable variability in its regional distribution. Craniocaudal emphysema distribution is an important predictor of the response to lung volume reduction. However, there is little consensus regarding how to define upper lobepredominant and lower lobe-predominant emphysema subtypes. Consequently, the clinical and genetic associations with these subtypes are poorly characterized. METHODS: We sought to identify subgroups characterized by upper-lobe or lower-lobe
more » ... or lower-lobe emphysema predominance and comparable amounts of total emphysema by analyzing data from 9,210 smokers without alpha-1-antitrypsin deficiency in the Genetic Epidemiology of COPD (COPDGene) cohort. CT densitometric emphysema was measured in each lung lobe. Random forest clustering was applied to lobar emphysema variables after regressing out the effects of total emphysema. Clusters were tested for association with clinical and imaging outcomes at baseline and at 5-year follow-up. Their associations with genetic variants were also compared. RESULTS: Three clusters were identified: minimal emphysema (n ¼ 1,312), upper lobepredominant emphysema (n ¼ 905), and lower lobe-predominant emphysema (n ¼ 796). Despite a similar amount of total emphysema, the lower-lobe group had more severe airflow obstruction at baseline and higher rates of metabolic syndrome compared with subjects with upper-lobe predominance. The group with upper-lobe predominance had greater 5-year progression of emphysema, gas trapping, and dyspnea. Differential associations with known COPD genetic risk variants were noted. CONCLUSIONS: Subgroups of smokers defined by upper-lobe or lower-lobe emphysema predominance exhibit different functional and radiological disease progression rates, and the upper-lobe predominant subtype shows evidence of association with known COPD genetic risk variants. These subgroups may be useful in the development of personalized treatments for COPD. CHEST 2018; 153(1):65-76 KEY WORDS: clustering; COPD; COPD disease progression; emphysema distribution; machine learning ABBREVIATIONS: COPDGene = Genetic Epidemiology of COPD; GOLD = Global Initiative for Chronic Obstructive Lung Disease; GWAS = genome-wide association studies; HU = Hounsfield units; MMRC = Modified Medical Research Council; PCA = principal components analysis; % LAA-950 = percent of CT low attenuation area < -950 HU at end-inspiration; Pi10 = square root of the wall area of a hypothetical airway of 10-mm internal perimeter; PRM = Parametric Response Mapping; PRM-fSAD = functional small airways disease; SGRQ = St. George's Respiratory Questionnaire
doi:10.1016/j.chest.2017.09.022 pmid:28943279 pmcid:PMC6026264 fatcat:ncholkydmrgyvbc62euhmdqbuy

WAO International Scientific Conference (WISC 2016) Abstracts

Jun Bao, Yi-Hui Wang, Quan-Hua Liu, Yi-Xiao Bao, Nurit Azouz, Julie Caldwell, Leanne Ray, Mark Rochman, Melissa Mingler, Matthew Eilerman, Ting Wen, Jocelyn Biagini Myers (+495 others)
2017 The World Allergy Organization Journal  
Results Stimulation with bradykinin, hIL-15 and hIL-18 did not increase NO production above baseline (base: 0.61±0.76 μM: bradykinin+hIL-15 +hIL-18: 0.63±0.76 μM, p=0.62).  ...  Addition of melatonin did not alter NO production (0.59±0.76μM) (p=ns).  ... 
doi:10.1186/s40413-017-0155-2 fatcat:kbfudpsuu5bgdn5cucyfdjnq4q
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