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h Guidance level for total intake. i SUL. j Reference does not consider Pb. ... After 1 h a 5.0 mL aliquot, representing the stomach phase of extraction, was removed and filtered through a Gelman 0.45 lm cellulose filter. ...doi:10.1016/j.apgeochem.2005.09.015 fatcat:45bt3q2dk5cozns33rxmro3dhy
For the submerged porous dock, this was first achieved by Evans & Peter  . ... The problem of a submerged semi-infinite porous rigid dock was solved by the Wiener-Hopf method in Evans & Peter  . ...arXiv:2009.13464v1 fatcat:wq3ekkpj3bhbrlro72bb7xnjsy
., & Juri, H. O. (2010). ... Archives of Pathology & Laboratory Medic P ine, 135, 215-P bert, H. W. (2006). 219. atel, S. G., Rosenbaum, B. P., Chark, D. ...doi:10.4236/ce.2013.410a002 fatcat:yo6bh5sknrgwzhf5wl5trdw5re
T h e ne w e ngl a nd jou r na l o f m e dic i ne n engl j med 359;22 www.nejm. ...doi:10.1056/nejmoa0802828 pmid:18987363 pmcid:PMC2756409 fatcat:f2gz5yh4njaqppvelk5nbueoz4
Sequential spread of TDP43 load in the brain may be a pathological characteristic of amyotrophic lateral sclerosis (ALS). Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) based marker of this pathological feature. Cognitive deficits known to be present in a subset of ALS patients might act as an additional in vivo clinical marker of disease spread. N=139 patients with ALS were tested with the Edinburgh Cognitive and Behavioural ALS screen (ECAS) in addition to DTI braindoi:10.1016/j.cortex.2018.01.004 pmid:29477906 fatcat:2hdsia5qlvdt3fiypzdg3fcjca
more »... n to DTI brain measures of pathological spread. Executive function, memory and disinhibited behaviour were selected for Cognitive-Staging criteria, as these cognitive functions are attributed to cerebral areas analogous to the pattern of MRI markers of TDP43 pathology. ROC curve analyses were performed to define cut-off scores for cognitive stages 2 (executive function), stage 3 (disinhibited behaviour) and stage 4 (memory), and staging was performed according to the cognitive profile subsequently. Associations of Cognitive-Staging (stage 2-4) and MRI-Staging measures were determined. In total, 77 patients (55%) performed below ROC cut-off scores in either executive function or memory or both and / or were reported to have disinhibited behaviour which permitted Cognitive-Staging. The cognitive profile of patients with discrete MRI stages 2 to 4 correlated significantly with DTI parameters. For those patients with cognitive impairment, there was a high congruency between MRI and Cognitive-Staging with high specificity and sensitivity of executive functions for MRI stage 2, disinhibited behaviour for MRI stage 3 and moderate of memory for MRI stage 4. Cognitive impairment follows specific patterns in ALS and these patterns can be used for Cognitive-Staging with a high specificity compared to MRI-Staging. For the individual, cognitive screening is a fast and easy to apply measurement of cerebral function giving valuable information in a clinical context. Abbreviations: ALS = amyotrophic lateral sclerosis, ALS-FRS-R = ALS functional rating scale-revised, DTI = diffusion tensor imaging, FA = fractional anisotropy, FTD = fronto-temporal dementia
Little is known about the functional course after initiating dialysis in elderly patients with ESKD. The aim of this study was to assess the association of the initiation of dialysis in an elderly population with functional status and caregiver burden.doi:10.2215/cjn.13131118 pmid:31248948 pmcid:PMC6625621 fatcat:kwnbqxt5bjcc3j7srm6rui62we
Millimeter and Submillimeter Detectors for Astronomy II
We are developing a new type of detector for observational cosmology and astrophysical research. Incoming radiation from the sky is coupled to a superconducting microstrip transmission line that terminates in a thin film absorber. At sub-Kelvin temperature, the thermal isolation between the electrons and the lattice makes it possible for the electrons in the small absorber (100's of µm 3 ) and superconducting bilayer (Transition Edge Sensor) to heat up by the radiation absorbed by the electronsdoi:10.1117/12.552836 fatcat:fbo5wc37l5fvfmrsstganpmp64
more »... ed by the electrons of the normal absorbing layer. We call this detector a Transition-edge Hot-electron Micro-bolometer (THM). THMs can be fabricated by photo lithography, so it is relatively easy to make matched detectors for a large focal plane array telescope. We report on the thermal properties of Mo/Au THMs with Bi/Au absorbers. TRANSITION-EDGE HOT-ELECTRON MICROBOLOMETER TES devices have proved to be a lot faster than the conventional Neutron-Transmutation-Doped (NTD) or doped Si bolometers. TES bolometers are a close match for the NTD bolometers in sensitivity. In addition TES bolometers can be fabricated lithographically and multiplexed making them highly suitable for large array formats. We are building a type of TES bolometer we call Transition-edge Hot-Electron Microbolometer (THM). A small TES is in thermal contact with a normal metal absorber. The electrons in the normal metal absorber are heated by incident radiation. The weak electron-phonon thermal coupling in metals at low temperature allows the the temperature of the electrons in the adjacent TES to rise for a small change in absorbed power. The thermally active area for the antenna coupled bolometer can be much smaller than the wavelength of
De-N-glycosylation was performed using 1-2 U PNGase F per 20 μg protein in 10 μl water/well, 16 h, 37°C. ... The released Nglycans were transferred into fresh tubes and hydroxylated by the addition of 100 mM aqueous ammonium acetate, pH 5, 1 h, 20°C. ...doi:10.1002/pmic.201900010 pmid:31419058 fatcat:llp3skrtlfgs5gtikocgdnq4zq
T cell kinetics in subjects (A) CH256, (B) CH470, (C) CAP239, (D) CH185, (E) CH162, (F) CH042, (G) CAP210, and (H) CH164, with VL set points from 18,621-575,440 copies per ml (red dotted lines). ...doi:10.1172/jci65330 pmid:23221345 pmcid:PMC3533301 fatcat:x5qiwehk45ghvfbpae45uifxoi
applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.doi:10.1007/s00439-011-1094-6 pmid:21996756 pmcid:PMC3303079 fatcat:cwdg5q75avhf3decjkpyvahfe4
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk of infection with Mycobacterium tuberculosis and progression to disease. Objectives: We investigated biosignatures with predictive ability for incident TB. Methods: In a case-control study nested within the Grand Challenges 6-74 longitudinal HIV-negative African cohort of exposed household contacts, we employed RNA sequencing, PCR, and the pairdoi:10.1164/rccm.201711-2340oc pmid:29624071 fatcat:d5pcuojts5awbkddd5flr7nmdu
more »... PCR, and the pair ratio algorithm in a training/test set approach. Overall, 79 progressors who developed TB between 3 and 24 months after diagnosis of index case and 328 matched nonprogressors who remained healthy during 24 months of follow-up were investigated. Measurements and Main Results: A four-transcript signature derived from samples in a South African and Gambian training set predicted progression up to two years before onset of disease in blinded test set samples from South Africa, the Gambia, and Ethiopia with little population-associated variability, and it was also validated in an external cohort of South African adolescents with latent M. tuberculosis infection. By contrast, published diagnostic or prognostic TB signatures were predicted in samples from some but not all three countries, indicating site-specific variability. Post hoc meta-analysis identified a single gene pair, C1QC/TRAV27 (complement C1q C-chain / T-cell receptor-a variable gene 27) that would consistently predict TB progression in household contacts from multiple African sites but not in infected adolescents without known recent exposure events. Conclusions: Collectively, we developed a simple whole blood-based PCR test to predict TB in recently exposed household contacts from diverse African populations. This test has potential for implementation in national TB contact investigation programs.
doi:10.1038/ejhg.2011.75 pmid:21522181 pmcid:PMC3190264 fatcat:faw5ujwgm5gsxmqaxtxmkc3424
Background COVID-19-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients three months after their COVID-19 diagnosis. Methods We analyzed data on dialysis patients diagnosed with COVID-19 from February 1st, 2020-March 31st, 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residency, and functional- anddoi:10.1093/ndt/gfac008 pmid:35030246 fatcat:eqej3fufeja3li7px3iiskq2lu
more »... nd functional- and mental health status (estimated by their treating physician) three months after COVID-19 diagnosis. Complete follow-up data was available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results In 2449 hemodialysis patients (mean ± SD age: 67.5 ± 14.4 years, 62% male) survival probabilities at three months after COVID-19 diagnosis were 90% for non-hospitalized patients (N = 1087), 73% for patients admitted to the hospital but not to an ICU (N = 1165) and 40% for those admitted to an ICU (N = 197). Patient survival hardly decreased between 28 days and three months after COVID-19 diagnosis. At three months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (between 0.8 and 6.3%) or a nursing home (approximately 5%). Higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions Mortality between 28 days and 3 months after COVID-19 diagnosis was low, and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at three months after diagnosis.
A public-private partnership created the Program. Forming the Program captured all the elements of team science. The Program used best practices of collaborative scientific. Research training for future investigators was a high priority. and Engelgaudoi:10.1016/j.gheart.2015.12.016 pmid:27102018 pmcid:PMC4843818 fatcat:3qdlgks5uffibmccl6xezkwxxy