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as -PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity

Hui Wang, Caroline Magnain, Ruopeng Wang, Jay Dubb, Ani Varjabedian, Lee S. Tirrell, Allison Stevens, Jean C. Augustinack, Ender Konukoglu, Iman Aganj, Matthew P. Frosch, Jeremy D. Schmahmann (+2 others)
2018 NeuroImage  
regions, all based on volumetric reconstructions. as-PSOCT provides a viable tool for studying quantitative cytoarchitecture and myeloarchitecture and mapping connectivity with microscopic resolution  ...  In this study, we developed a fully automatic serial sectioning polarization sensitive optical coherence tomography (as-PSOCT) system to enable volumetric reconstruction of human brain samples with unprecedented  ...  In addition, BF has a financial interest in CorticoMetrics, a company whose medical pursuits focus on brain imaging and measurement technologies.  ... 
doi:10.1016/j.neuroimage.2017.10.012 pmid:29017866 pmcid:PMC5732037 fatcat:tr6imkudzfbbrdkn5pfn2ugdtu

Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue [article]

Chao J. Liu, William Ammon, Robert Jones, Jackson Nolan, Ruopeng Wang, Shuaibin Chang, Matthew P Frosh, Anastasia Yendiki, David A. Boas, Caroline Magnain, Bruce Fischl, Hui Wang
2021 bioRxiv   pre-print
Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to  ...  The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging.  ...  The increased imaging depth and SNR could pave the road to a comprehensive mapping of fiber architecture in the human brain using as-PSOCT. Funding.  ... 
doi:10.1101/2021.09.12.459943 fatcat:5uod5dichvawldkplkqe66kx2y

Optical Coherence Tomography: Basic Concepts and Applications in Neuroscience Research

Mobin Ibne Mokbul
2017 Journal of Medical Engineering  
Despite some limitations, OCT proves to be a useful imaging tool in both basic and clinical neuroscience research.  ...  Optical coherence tomography is a micrometer-scale imaging modality that permits label-free, cross-sectional imaging of biological tissue microstructure using tissue backscattering properties.  ...  Chudler for his selfless help, comments, and revision.  ... 
doi:10.1155/2017/3409327 pmid:29214158 pmcid:PMC5682075 fatcat:dtshjhpdvfel5moafcm2mqq6yy