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In vitro antimicrobial assay of nano-iron sulfide (nFeS)
2018
Protocol Exchange
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Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections by Zhuobin Xu, Zhiyue Qiu, Qi Liu, +15 Figure 1 1 Figure 1
Figure1 anti-bacterial (S.mutans UA159) activity ...
doi:10.1038/protex.2018.136
fatcat:fh6tcnymvrd4voz4hldmalbbe4
Progress in Transparent Nano-Ceramics and Their Potential Applications
2022
Nanomaterials
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Transparent nano-ceramics have an important high-transmittance, material-integrating structure and function and a variety of potential applications, such as use in infrared windows, optical isolators, composite armors, intelligent terminal screens, and key materials of solid-state lasers. Transparent ceramics were originally developed to replace single crystals because of their low fabricating cost, controllable shape, and variable composition. Therefore, this study reviews and summarizes the
doi:10.3390/nano12091491
pmid:35564200
pmcid:PMC9099613
fatcat:tfdrif3nc5gjficpkgbi5wbn3u
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... velopment trends in transparent nano-ceramics and their potential applications. First, we review the research progress and application of laser nano-ceramic materials, focusing on the influence of controllable doping of rare earth ions on thermal conductivity and the realization of large-scale fabrication technology. Second, the latest research progress on magneto-optical transparent nano-ceramics, mainly including terbium gallium garnet (Tb3Ga5O12, TGG) ceramics and terbium aluminum garnet (Tb3Al5O12, TAG) ceramics, are summarized, and their performance is compared. Third, the research progress of transparent armor nano-ceramic materials, represented by MgAl2O3 and Aluminum oxynitride (AlON), are reviewed. Lastly, the progress in electro-optical transparent nano-ceramics and scintillation transparent nano-ceramics is reported, and the influence of the material-fabrication process on electro-optic effect or luminous intensity is compared. Moreover, the effect of particle diameter on fabrication, the relationship between nano powder and performance, and different sintering methods are discussed. In summary, this study provides a meaningful reference for low-cost and sustainable production in the future.
Molecular Dynamics Study of Laser Interaction with Nanoparticles in Liquids and Its Potential Application
2022
Nanomaterials
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Laser interaction with nanoparticles in liquid is the fundamental theoretical basis for many applications but it is still challenging to observe this nanoscale phenomenon within a few nanoseconds in liquid by experiment. The successful implementation of the two-temperature method integrated with molecular dynamics (TTM-MD) in laser interaction with bulk material has shown great potential in providing a panoramic view of the laser interaction with the nanoparticles. However, the current TTM-MD
doi:10.3390/nano12091524
pmid:35564233
pmcid:PMC9105410
fatcat:i6ofyyhu6nde5cuc25d44buvcq
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... del has to divide the system into cubic cells, which leads to mistakes near the nanoparticle's surface. We introduce the latest model, which performs the TTM-MD on each individual cluster instead of the cubic cells, and its high-performance parallel cluster analysis algorithm to update the cluster size. The cluster-based TTM-MD revealed the nanoparticle formation mechanism of laser fragmentation in liquid (LFL) and facilitated the study of laser fluence's effect on the size distribution. In addition to LFL, this model is promising to be implemented in the laser thermal therapy of tumors, laser melting in liquid (LML), etc. Although cluster-based TTM-MD has proven to be a powerful tool for studying laser interaction with nanoparticles, a few challenges and future developments for the cluster-based TTM-MD, especially the ionization induced by femtosecond, are also discussed.
A humanized anti-DLL4 antibody promotes dysfunctional angiogenesis and inhibits breast tumor growth
2016
Scientific Reports
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Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine antihuman DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ01 variable fragment (Fv) was established and framework region (FR) residues which supported complementarily determining region (CDR) loop conformation were identified. Important
doi:10.1038/srep27985
pmid:27301650
pmcid:PMC4908374
fatcat:j2asnw63rfc7hclkaojv3zi6yi
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... dues interactions were also identified through docking MMGZ01 Fv with antigen epitope in DLL4. To humanize the murine antibody, we modified MMGZ01 Fv through CDR grafting and the reconstructed antibody (H 3 L 2 ) maintained similar structure and binding affinity to parental MMGZ01 after back mutation of 12 canonical murine residues in the FRs. Meanwhile, H 3 L 2 promoted human umbilical vein endothelial cell (HUVEC) proliferation through inhibiting DLL4-directed Notch pathway. Moreover, in MDA-MB-231-bearing nude mice, H 3 L 2 induced dysfunctional angiogenesis and tumor cell apoptosis and showed superior anti-tumor activity. In conclusion, H 3 L 2 is an ideal humanized antibody that inhibits tumor growth through targeting DLL4-Notch pathway and has attracting potentials for clinical applications.
Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections
2018
Nature Communications
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The use of natural substance to ward off microbial infections has a long history. However, the large-scale production of natural extracts often reduces antibacterial potency, thus limiting practical applications. Here we present a strategy for converting natural organosulfur compounds into nano-iron sulfides that exhibit enhanced antibacterial activity. We show that compared to garlic-derived organosulfur compounds nano-iron sulfides exhibit an over 500fold increase in antibacterial efficacy to
doi:10.1038/s41467-018-06164-7
pmid:30213949
pmcid:PMC6137151
fatcat:espcsl72zvdind5iux7cg3cwyi
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... kill several pathogenic and drug-resistant bacteria. Furthermore, our analysis reveals that hydrogen polysulfanes released from nano-iron sulfides possess potent bactericidal activity and the release of polysulfanes can be accelerated by the enzyme-like activity of nano-iron sulfides. Finally, we demonstrate that topical applications of nano-iron sulfides can effectively disrupt pathogenic biofilms on human teeth and accelerate infected-wound healing. Together, our approach to convert organosulfur compounds into inorganic polysulfides potentially provides an antibacterial alternative to combat bacterial infections.
Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds
2021
Journal of Nanobiotechnology
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Xu (School of Medicine, Yangzhou University).
Synthesis and characterization of PDA/Cur NFs In brief, 50 mg of Cur was dissolved in 50 mL ethanol, and then 200 mL of water was added. ...
doi:10.1186/s12951-021-01152-4
pmid:34865643
pmcid:PMC8647563
fatcat:ffwqg2sp2rhcvmsxrkgatvrfmy
Formation and properties of chalcogenide glasses based on GeS2–Sb2S3–AgI system
2014
Materials letters (General ed.)
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Novel glasses in GeS 2 -Sb 2 S 3 -AgI system have been prepared by melt-quenching method. A large glass-forming region was found in the novel system, in which almost 60mol% AgI has been incorporated. The basic physiochemical properties of glass samples were investigated. With the addition of AgI, red shift of short-wavelength absorption edge indicates and distinct drop of the glass transition temperature (T g ) were observed. In addition, a high Ag + ion conductivity of 6.37 10 -4 S/cm at room
doi:10.1016/j.matlet.2014.06.083
fatcat:5a2ma7423vgfzh2iuqhe32qwga
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... emperature can be obtained in 55(0.6GeS 2 -0.4Sb 2 S 3 )-45AgI sample, indicating that these glasses have potential application as amorphous solid electrolytes.
ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
2018
Nature Communications
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Actively transcribed regions of the genome are protected by transcription-coupled DNA repair mechanisms, including transcription-coupled homologous recombination (TC-HR). Here we used reactive oxygen species (ROS) to induce and characterize TC-HR at a transcribed locus in human cells. As canonical HR, TC-HR requires RAD51. However, the localization of RAD51 to damage sites during TC-HR does not require BRCA1 and BRCA2, but relies on RAD52 and Cockayne Syndrome Protein B (CSB). During TC-HR,
doi:10.1038/s41467-018-06586-3
fatcat:7o4qyzgeznbdhjniboygzxjk2i
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... 2 is recruited by CSB through an acidic domain. CSB in turn is recruited by R loops, which are strongly induced by ROS in transcribed regions. Notably, CSB displays a strong affinity for DNA:RNA hybrids in vitro, suggesting that it is a sensor of ROS-induced R loops. Thus, TC-HR is triggered by R loops, initiated by CSB, and carried out by the CSB-RAD52-RAD51 axis, establishing a BRCA1/2-independent alternative HR pathway protecting the transcribed genome.
Apatite U-Pb Dating and Composition Constraints for Magmatic–Hydrothermal Evolution in the Giant Renli Nb-Ta Deposit, South China
2022
Minerals
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Apatite is a nearly ubiquitous accessory phase in igneous rocks that crystallizes during the entire magma evolution process and has great implications for geochronology and petrogenesis. Previous studies suggested that Nb-Ta mineralization in the giant Renli deposit was genetically related to Late Jurassic two-mica monzogranite or Early Cretaceous muscovite monzogranite. Moreover, the magmatic–hydrothermal evolution of these two stages is poorly understood. In our study, we confirm that the
doi:10.3390/min12030344
fatcat:infwg4d22jd63ll62l5zq7huvi
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... ovite monzogranite, biotite monzogranite, and two-mica monzogranite are all spatially associated with Nb-Ta pegmatites. We present new apatite U-Pb ages to constrain the timing of Nb-Ta mineralization and related magmatism. The results show that apatite from the two-mica pegmatite yield a lower intercept age of 130 ± 2 Ma (2σ), and apatite grains from two two-mica pegmatite samples yield a lower intercept age of 135 ± 8 Ma (2σ) and 134 ± 3 Ma (2σ), respectively. Apatite and whole-rock geochemistry suggest the oxidation degree of the Nb-Ta mineralization increases from north (RL-6) to south (RL-16) in the giant Renli deposit. This study demonstrates that a combination of apatite composition and U-Pb ages can be used to constrain the magmatic–hydrothermal evolution of granite and pegmatite-type Nb-Ta deposits.
Protocol for the synthesis of Cys-nFeS
2018
Protocol Exchange
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Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections by Zhuobin Xu, Zhiyue Qiu, Qi Liu, +15 Figure 1 SEM 1 image of Cys-nFeS SEM image of Cys~0.5~-nFeS(the ...
doi:10.1038/protex.2018.137
fatcat:k3dceptnjbcq3k2cm7srxu57lu
Protocol for synthesis of DADS-nFeS
2018
Protocol Exchange
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Xu, Zhiyue Qiu, Qi Liu, +15
ethylene glycol, FeCl3•6H2O, sodium acetate(NaOAc), diallyl sulfide(DADS) Equipment
magnetic stirring bar, oven, Teflon-lined stainless steel autoclave
Procedure
1. ...
DADS-nFeS SEM image of DADS~1.0~-nFeS(the amount of inputDADS in solvothermal synthesis is 1.0 g Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections by Zhuobin ...
doi:10.1038/protex.2018.138
fatcat:ctaoxuz4xzbs5ptfiglw6vye4q
Contents
2011
Procedia Engineering
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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 506 Independent Component Analysis in Frequency Domain and its Application in Structural Vibration Signal Separation Cao Junhong and Wei Zhuobin ...
130nm 1Mb Embedded Phase Change Memory with 500kb/s Single Channel Write Throughput DING Sheng, SONG Zhitang, CHEN Houpeng, CAI Daolin, WANG Qian, CHEN Yifeng, CHEN Xiaogang, WU Guanpin, FENG Gaoming, XU ...
doi:10.1016/s1877-7058(11)02795-0
fatcat:lj5rvqupp5eyhd4giswgbl6goy
Self-Attention ConvLSTM for Spatiotemporal Prediction
2020
PROCEEDINGS OF THE THIRTIETH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE AND THE TWENTY-EIGHTH INNOVATIVE APPLICATIONS OF ARTIFICIAL INTELLIGENCE CONFERENCE
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vision and artificial intelligence and received growing interests in the research communities (Shi et al. 2015; Zhang et al. 2017; Shi et al. 2017a; Kalchbrenner et al. 2017; Wang et al. 2017a; 2018b; Xu ...
It deserves to be studied in depth to serve the practical applications, such as traffic flows prediction Xu et al. 2018) , precipitation fore-Copyright c 2020, Association for the Advancement of Artificial ...
doi:10.1609/aaai.v34i07.6819
fatcat:gf6lmryzybh23aqrqqe5n4mpby
Analysis of environmental policy's impact on remanufacturing decision under the effect of green network using differential game model
2020
IEEE Access
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ZHUOBIN HE is currently pursuing the B.S. degree with the School of Humanity, Jinan University of Cultural Industrial Management. ...
In the same year, Xu and Han [26] used differential game model to provide theoretical reference for supply chain cooperative emission reduction and government subsidy strategies. Wang et al. ...
doi:10.1109/access.2020.3002864
fatcat:eoltp5qpp5dybaz4ooxdmbnq7m
TLeague: A Framework for Competitive Self-Play based Distributed Multi-Agent Reinforcement Learning
[article]
2020
arXiv
pre-print
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Shuxing Li (meowli) and Jiawei Xu (ztjiaweixu) are funded by Tencent AI Lab RhinoBird Focused Research Program JR201986. ...
Thanks Zhuobin Zheng (jackzbzheng) and Jiaming Lu (loyavejmlu) for initiating the ViZDoom experiments during the internship with Tencent AI Lab. ...
arXiv:2011.12895v2
fatcat:ntgchwkkt5b3nhjfveiuihd7tu
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