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Time-resolved femtosecond coherent anti-Stokes Raman spectroscopy (fs-CARS) is utilized to measure the methane/oxygen/nitrogen flame temperature at atmospheric-pressure. The measurements are performed using the CARS signal of N2 with 40-fs laser pulses in the first few picoseconds after the initial in-phase excitation. Flame temperatures at 300 and 1 325 K are measured, the experimental results show good agreements with theoretical ones and present a good repeatability.doi:10.3788/col201210.s13002 fatcat:c7frks3v5zcdfci65zht6ahw6y
We model the Knudsen layer in Kramers' problem by linearized high order hyperbolic moment system. Due to the hyperbolicity, the boundary conditions of the moment system is properly reduced from the kinetic boundary condition. For Kramers' problem, we give the analytical solutions of moment systems. With the order increasing of the moment model, the solutions are approaching to the solution of the linearized BGK kinetic equation. The velocity profile in the Knudsen layer is captured witharXiv:1704.05451v1 fatcat:myrc5v2i5ngkdfxin2ax55vejm
more »... accuracy for a wide range of accommodation coefficients.
Lipofibromatous hamartoma, a rarely occurring nerve hamartoma, can present as an acrochordon, cutaneous cyst or other soft tissue tumor and is usually seen within the first three decades of life. The lesion presents as a slowly growing mass that is largely composed of fat and fibrous tissue with epineural and perineural proliferation. Although such tumors are rare, it is important for physicians to be aware of this disorder and recognize its signs because patients may present with what appearsdoi:10.1016/j.dsi.2011.09.007 fatcat:ma7av2iikfezrbfkjierxdxjtm
more »... o be a benign skin tumor. If left untreated, the lesion may result in nerve compression and eventually lead to the development of peripheral neuropathy. Here, we present two cases of lipofibromatous hamartomas that presented over the ankle and dorsal foot, respectively, that appeared as simple and benign tumors upon initial inspection. Patients were without symptoms or neurological deficits, and diagnosis was not made until histopathological examination of the biopsied specimens. We also discuss the clinical manifestations, histopathological findings, and the management of lipofibromatous hamartomas.
Keywords: condyloma genitofemoral area human papillomavirus Ki-67 p21 seborrheic keratosis a b s t r a c t Background: Making a clinical and histological distinction between condyloma and seborrheic keratosis in the genitofemoral area can be difficult. This study aimed to find reliable histological and immunohistological criteria to diagnose these entities. Methods: We retrospectively studied genitofemoral skin biopsy specimens obtained between January 2004 and December 2007 that had beendoi:10.1016/j.dsi.2012.09.008 fatcat:dhmaltysgzh5rgzjj6vceegihm
more »... sed as showing condyloma or seborrheic keratosis. The histological findings were assessed and immunohistochemical stains were performed for human papillomavirus, Ki-67, and p21. DNA was extracted from paraffin sections and amplified by polymerase chain reaction to detect the presence and type of human papillomavirus. Results: DNA extraction was successfully performed for 58 lesions. The final diagnoses were condyloma in 41 and seborrheic keratosis in 17. The diagnosis of condyloma rather than seborrheic keratosis was likely in the presence of broad, evenly distributed reticulated acanthosis (p < 0.0001), koilocytosis (p < 0.001), a fascicular arrangement of keratinocytes (p < 0.01), and an absence of horn cysts (p < 0.01). Immunohistochemical staining supported the diagnosis of condyloma when positive for human papillomavirus (p < 0.0001), Ki-67 (p < 0.0001), and p21 (p < 0.0001). Conclusion: A combination of histological and immunohistochemical findings is useful to distinguish condyloma from seborrheic keratosis in the genitofemoral area.
Purpuric pigmented dermatoses represent a form of chronic, recurrent capillaritis characterized by petechiae and purpuric macules over the lower limbs. We report three female cases who presented with clinical features of purpuric pigmented dermatosis with unusual histopathologic features. The first patient had golden-brown pigmented purpura over bilateral knees, shins and dorsal feet. The second patient showed purpuric papules on the medial aspects of the ankles. The third patient presenteddoi:10.1016/s1027-8117(10)60016-x fatcat:mbzw4hhlwvb57hhcp7zaptocai
more »... numerous petechiae on her lower legs. All three patients demonstrated granulomatous inflammation in addition to the histologic features of pigmented purpuric dermatosis. A total of 11 patients have currently been reported in the literature. A review of the clinical details of the cases revealed a high incidence of hyperlipidemia (7/11) and hypertension (4/11) among these patients.
Not including the phase II study by Fan  which studied a relatively small sample size, OS benefits were not gained with first-line PBCT in our study and the TNT trial. ...doi:10.18632/oncotarget.5654 pmid:26447756 pmcid:PMC4767497 fatcat:75c2cx36avfpjfow4lnptvm6ee
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in excitable neurons and other cells and are targeted by commonly used local anesthetics, antiarrhythmics, and anticonvulsants. They are also common targets of neurotoxins including shellfish toxins. Shellfish toxins are a variety of toxic secondary metabolites produced by prokaryotic cyanobacteria and eukaryotic dinoflagellates in both marine and fresh water systems, which candoi:10.3390/md11124698 pmid:24287955 pmcid:PMC3877881 fatcat:sbu7utv525d3rimpzbyncbq7tm
more »... late in marine animals via the food chain. Consumption of shellfish toxin-contaminated seafood may result in potentially fatal human shellfish poisoning. This article provides an overview of the structure, bioactivity, and pharmacology of shellfish toxins that act on VGSCs, along with a brief discussion on their pharmaceutical potential for pain management.
Then, a typical fan converter is taken as an example, and the electromagnetic disturbance of the converter is tested in four key positions and two working frequencies, respectively. ... In the past, coal mines mostly adopted press in ventilation with fans, and the constant speed operation of fans often caused the phenomenon of "one wind blowing" CH 4 discharge, which was easy to create ... is tested. e output frequency range of the fan variable frequency speed regulating device used in this test is 0.5-60 Hz. ...doi:10.1155/2021/5509562 fatcat:3hdoe4xferggfdwfpc3zujdlcy
Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the physiological significance of stenotic lesions. A noninvasive "one-stop-shop" diagnostic test that can provide both anatomical significance and functional significance of stenotic lesions would be beneficial in the diagnosis and management of CAD.doi:10.1155/2015/435737 pmid:25685790 pmcid:PMC4320886 fatcat:yfnvn37z7jbvjf7yu2tz2zhxoy
more »... tly, with the introduction of novel techniques, such as myocardial CT perfusion, CT-derived fractional flow reserve (FFRCT), and transluminal attenuation gradient (TAG), CCTA has emerged as a noninvasive method for the assessment of both anatomy of coronary lesions and its physiological consequences during a single study. This review provides an overview of the current status of new CT techniques for the physiologic assessments of CAD.
Copyright © 2020 Ji, Fan, Zhu, Gao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fonc.2020.01342 pmid:33014776 pmcid:PMC7493788 fatcat:yh7w25fcezhxdadvbedb7uo3cy
Animal genes of different lineages, such as vertebrates and arthropods, are well-organized and blended into dynamic chromosomal structures that represent a primary regulatory mechanism for body development and cellular differentiation. The majority of genes in a genome are actually clustered, which are evolutionarily stable to different extents and biologically meaningful when evaluated among genomes within and across lineages. Until now, many questions concerning gene organization, such asdoi:10.4137/ebo.s8540 pmid:22267903 pmcid:PMC3256993 fatcat:qu5dqkwawjemzo3nzt5djf6fni
more »... is the minimal number of genes in a cluster and what is the driving force leading to gene co-regulation, remain to be addressed. Here, we provide a user-friendly database-LCGbase (a comprehensive database for lineage-based co-regulated genes)-hosting information on evolutionary dynamics of gene clustering and ordering within animal kingdoms in two different lineages: vertebrates and arthropods. The database is constructed on a web-based Linux-Apache-MySQL-PHP framework and effective interactive user-inquiry service. Compared to other gene annotation databases with similar purposes, our database has three comprehensible advantages. First, our database is inclusive, including all high-quality genome assemblies of vertebrates and representative arthropod species. Second, it is human-centric since we map all gene clusters from other genomes in an order of lineage-ranks (such as primates, mammals, warmblooded, and reptiles) onto human genome and start the database from well-defined gene pairs (a minimal cluster where the two adjacent genes are oriented as co-directional, convergent, and divergent pairs) to large gene clusters. Furthermore, users can search for any adjacent genes and their detailed annotations. Third, the database provides flexible parameter definitions, such as the distance of transcription start sites between two adjacent genes, which is extendable to genes that flanking the cluster across species. We also provide useful tools for sequence alignment, gene ontology (GO) annotation, promoter identification, gene expression (co-expression), and evolutionary analysis. This database not only provides a way to define lineage-specific and species-specific gene clusters but also facilitates future studies on gene co-regulation, epigenetic control of gene expression (DNA methylation and histone marks), and chromosomal structures in a context of gene clusters and species evolution. LCGbase is freely available at http://lcgbase.big.ac.cn/ LCGbase.
This study established a numerical model to investigate the degradation mechanism and behavior of bioabsorbable cardiovascular stents. In order to generate the constitutive degradation material model, the degradation characteristics were characterized with user-defined field variables. The radial strength bench test and analysis were used to verify the material model. In order to validate the numerical degradation model, in vitro bench test and in vivo implantation studies were conducted underdoi:10.1371/journal.pone.0110278 pmid:25365310 pmcid:PMC4217724 fatcat:tno6wzxbcngyrhsxy6nvendijm
more »... hysiological and normal conditions. The results showed that six months of degradation had not influenced the thermodynamic properties and mechanical integrity of the stent while the molecular weight of the stents implanted in the in vivo and in vitro models had decreased to 61.8% and 68.5% respectively after six month's implantation. It was also found that the degradation rate, critical locations and changes in diameter of the stents in the numerical model were in good consistency in both in vivo and in vitro studies. It implies that the numerical degradation model could provide useful physical insights and prediction of the stent degradation behavior and evaluate, to some extent, the in-vivo performance of the stent. This model could eventually be used for design and optimization of bioabsorbable stent.
Acknowledgements We acknowledge Xiuzhi Zhu and Yu Gao for collecting data, Zhangru yang and Jianjiao Ni for critically reviewing the manuscript, and Lei Fan and ZhongHua Wang for their leadership and guidance ...doi:10.1186/s12885-021-07968-5 pmid:33676449 fatcat:cefgppoj4jekjepkcxyziyugpa
In order to meet the needs of social development and explore the teaching strategies that meet the needs of sports translators, this paper focuses on the sports translation teaching strategies, the research objective of this paper, using literature research methods, case studies, and questionnaire, based on the analysis of the status quo of sports translator talents and combined with brain science and its research results in the field of education. The present research puts forward the wholedoi:10.12738/estp.2018.5.128 fatcat:qmbxqenlgffl5nu46wtz6ozoby
more »... in teaching strategies of sports translation, expounds the concrete contents of the teaching strategies, and conducts the investigation and analysis of the implementation effects of sports translation teaching strategies based on neurocognitive science taking the basketball item in the course of Sports English as an example. The results show that the strategies of sports translation teaching based on neurocognitive science has a certain guiding role in improving the effectiveness of sports translation teaching.
The prediction of protein-protein binding site can provide structural annotation to the protein interaction data from proteomics studies. This is very important for the biological application of the protein interaction data that is increasing rapidly. Moreover, methods for predicting protein interaction sites can also provide crucial information for improving the speed and accuracy of protein docking methods. Results: In this work, we describe a binding site prediction method by designing a newdoi:10.1186/1471-2105-9-553 pmid:19102736 pmcid:PMC2627892 fatcat:hohpo2ugkvgvjin5pj5vvoofuq
more »... residue neighbour profile and by selecting only the core-interface residues for SVM training. The residue neighbour profile includes both the sequential and the spatial neighbour residues of an interface residue, which is a more complete description of the physical and chemical characteristics surrounding the interface residue. The concept of core interface is applied in selecting the interface residues for training the SVM models, which is shown to result in better discrimination between the core interface and other residues. The best SVM model trained was tested on a test set of 50 randomly selected proteins. The sensitivity, specificity, and MCC for the prediction of the core interface residues were 60.6%, 53.4%, and 0.243, respectively. Our prediction results on this test set were compared with other three binding site prediction methods and found to perform better. Furthermore, our method was tested on the 101 unbound proteins from the protein-protein interaction benchmark v2.0. The sensitivity, specificity, and MCC of this test were 57.5%, 32.5%, and 0.168, respectively. Conclusion: By improving both the descriptions of the interface residues and their surrounding environment and the training strategy, better SVM models were obtained and shown to outperform previous methods. Our tests on the unbound protein structures suggest further improvement is possible.
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