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HVDC Intelligent Controller

Hua Lan, Tian-gang Yuan, Mu-Zi Zhang, Zhi-min Liao
2012 Energy Procedia  
The Purposes of this paper describes Gezhouba to Nanqiao rectifier direct current transmission project PI controller, through the intelligent control theory and the combination of the traditional PI controller are intelligent controller-HVDC fuzzy-PI controller, using the improved genetic algorithm domain Fuzzy-PI controller's language of control theory. The result of improved intelligent controller has a simple structure, fast response characteristics. Using MATLAB / SIULIKMN the fuzzy toolbox
more » ... and genetic algorithm toolbox for system simulation, simulation results show that the Conclusions of the intelligent controller has better adaptability and dynamic features to improve the robustness of the system and transient stability for the intelligent control of high voltage DC reference.
doi:10.1016/j.egypro.2012.02.267 fatcat:6zo2qrt5lffw5ljed3ogzab7zq

Calculation of PV Power Station Access

Hua Lan, Zhi-min Liao, Tian-gang Yuan, Feng Zhu
2012 Energy Procedia  
With the PV system capacity continues to expand, they identify a given network to bear the largest photovoltaic power generation into power, it is an urgent need to address the problem. This paper analyzes the PV of the distribution network voltage distribution and the impact of the trend line. From the perspective of network security, it creates access to computing power PV model. This is combined with two sub-enumeration method for solving the mathematical model and its analysis by the actual
more » ... distribution system, which verify the correctness and effectiveness. In addition, it analyzes the location of the PV power plant access to the power of access.
doi:10.1016/j.egypro.2012.02.266 fatcat:v3apvuoxsbbpvf555iib7qyyvq

Effectiveness and Safety of Warfarin in Dialysis Patients With Atrial Fibrillation

Gang Liu, Ming Long, Xun Hu, Cheng-Heng Hu, Xin-Xue Liao, Zhi-Min Du, Yu-Gang Dong
2015 Medicine  
In routine practice, warfarin is widely used in dialysis patients with atrial fibrillation (AF) for stroke prevention though the ratio of risks to benefits remains unclear. Recent cohort studies investigating the association between warfarin use and the risks of stroke and bleeding in dialysis patients with AF present conflicting results. The objective of this study was to assess the effectiveness and safety of warfarin use in patients with AF undergoing dialysis. Three databases PubMed,
more » ... and OVID were searched from their inception to August 2015. Observational studies which assessed the ischemic stroke or bleeding risk of warfarin use in dialysis patients with AF were included. Two reviewers independently extracted data and assessed methodological quality based on the Newcastle-Ottawa Scale score. Combined hazard ratios (HRs) and 95% condence intervals (CIs) were calculated using the random-effects model and heterogeneity was assessed based on the Cochrane Q-statistic test and the I 2 statistic. Metaregression analyses were performed to explore the source of heterogeneity. A total of 11 eligible studies with 25,407 patients were included in the analysis. Warfarin use, in comparison with no-warfarin use, was not associated with a lower risk for ischemic stroke (HR 0.95, 95% CI 0.66-1.35). Sensitivity analyses found results to be robust. Metaregression analysis showed that demographic feature, clinical characteristics, or study-level variable had no impact of warfarin use on stroke risk. In addition, warfarin use was associated with a 27% higher risk for bleeding (95% CI 1.04-1.54). Overall, warfarin use did not have a significant association with reduced mortality (95% CI 0.96-1.11). It appears that warfarin use is not beneficial in reducing stroke risk, but with a high risk for bleeding in dialysis patients with AF. Randomized trials are needed to determine the risk-benefit ratio of warfarin in dialysis patients with AF. (Medicine 94(50):e2233) Abbreviations: AF = atrial fibrillation, CIs = condence intervals, ESRD = end-stage renal disease, HR = hazard ratio, NOS = Newcastle-Ottawa Scale.
doi:10.1097/md.0000000000002233 pmid:26683937 pmcid:PMC5058909 fatcat:epvcobus4bbjhkop7qp5ixmubu

HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

Gang Ding, He-Dai Liu, Qian Huang, Hong-Xiang Liang, Zhao-Han Ding, Zhi-Jun Liao, Gang Huang
2013 FEBS Letters  
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HDAC6 is a transcriptional regulator of the histone deacetylase family, subfamily 2. Previous studies have shown that HDAC6 plays critical roles in transcription regulation, cell cycle progression and developmental events. However, its biological roles in the development of HCC remain largely unexplored. In the present study, we found that mRNA and protein levels of HDAC6 were up-regulated in HCC tissues and cell lines. The
more » ... proinflammatory cytokines, which were up-regulated in the human HCC microenvironment, increased HDAC6 expression through a proximal NF-kappaB binding site on the HDAC6 gene promoter. Furthermore, overexpression of HDAC6 could promote cell proliferation in HCC cell lines. In contrast, HDAC6 knockdown using small interfering RNA inhibited cell proliferation. At the molecular level, we demonstrated that HDAC6 could interact with p53 and attenuate its transcriptional activity through promotion of its degradation. Therefore, our results suggest a previously unknown HDAC6-p53 molecular network controlling HCC development.
doi:10.1016/j.febslet.2013.02.001 pmid:23402884 fatcat:76nggndwvzdazmbkd6oojacsga

Optimizing Synchronization Algorithm for Auto-parallelizing Compiler [article]

Gang Liao, Zhi-hui Qin, Long-fei Ma, Qi Sun
2013 arXiv   pre-print
In this paper, we focus on the need for two approaches to optimize producer and consumer synchronization for auto-parallelizing compiler. Emphasis is placed on the construction of a criterion model by which the compiler reduce the number of synchronization operations needed to synchronize the dependence in a loop and perform optimization reduces the overhead of enforcing all dependence. In accordance with our study, we transform to modify and eliminate dependence on iteration space diagram
more » ... , and carry out the problems of acyclic and cyclic dependence in detail. we eliminate partial dependence and optimize the synchronize instructions. Some didactic examples are included to illustrate the optimize procedure.
arXiv:1211.4101v3 fatcat:2ro36423fvflnfkbyew3tj52ru

Au impact on GaAs epitaxial growth on GaAs (111)B substrates in molecular beam epitaxy

Zhi-Ming Liao, Zhi-Gang Chen, Zhen-Yu Lu, Hong-Yi Xu, Ya-Nan Guo, Wen Sun, Zhi Zhang, Lei Yang, Ping-Ping Chen, Wei Lu, Jin Zou
2013 Applied Physics Letters  
doi:10.1063/1.4792053 fatcat:gdrdavxgubcpdex77gltznmezy

UPLC-QTOFMS-based metabolomic analysis of the serum of hypoxic preconditioning mice

Jie Liu, Gang Zhang, Dewei Chen, Jian Chen, Zhi-Bin Yuan, Er-Long Zhang, Yi-Xing Gao, Gang Xu, Bing-Da Sun, Wenting Liao, Yu-Qi Gao
2017 Molecular Medicine Reports  
Hypoxic preconditioning (HPC) is well-known to exert a protective effect against hypoxic injury; however, the underlying molecular mechanism remains unclear. The present study utilized a serum metabolomics approach to detect the alterations associated with HPC. In the present study, an animal model of HPC was established by exposing adult BALB/c mice to acute repetitive hypoxia four times. The serum samples were collected by orbital blood sampling. Metabolite profiling was performed using
more » ... performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS), in conjunction with univariate and multivariate statistical analyses. The results of the present study confirmed that the HPC mouse model was established and refined, suggesting significant differences between the control and HPC groups at the molecular levels. HPC caused significant metabolic alterations, as represented by the significant upregulation of valine, methionine, tyrosine, isoleucine, phenylalanine, lysophosphatidylcholine (LysoPC; 16:1), LysoPC (22:6), linoelaidylcarnitine, palmitoylcarnitine, octadecenoylcarnitine, taurine, arachidonic acid, linoleic acid, oleic acid and palmitic acid, and the downregulation of acetylcarnitine, malate, citrate and succinate. Using MetaboAnalyst 3.0, a number of key metabolic pathways were observed to be acutely perturbed, including valine, leucine and isoleucine biosynthesis, in addition to taurine, hypotaurine, phenylalanine, linoleic acid and arachidonic acid metabolism. The results of the present study provided novel insights into the mechanisms involved in the acclimatization of organisms to hypoxia, and demonstrated the protective mechanism of HPC.
doi:10.3892/mmr.2017.7493 pmid:28901489 pmcid:PMC5865841 fatcat:32n6ra3xjbfqnlss37bmyakj2i

Establishment of Water Quality Monitoring Database in Poyang Lake

Xiong Peng, Fang Chao-yang, Chen Hong-wen, Liu Zhi-gang, Liao Bin, Feng Ming-lei
2011 Procedia Environmental Sciences  
By selecting the data that can objectively reflect the water quality of Poyang Lake, using currently popular database management software and program language, a water quality database system is developed which can collect, manage, analyze and present water environment data. The result can provide information service for protecting precious lake data resources and for lake environmental protection and resources utilization.
doi:10.1016/j.proenv.2011.09.401 fatcat:ssjc5ph54vfxtecd2iqnc676au

Shape-Controlled Synthesis of Gold Nanoparticles in Deep Eutectic Solvents for Studies of Structure-Functionality Relationships in Electrocatalysis

Hong-Gang Liao, Yan-Xia Jiang, Zhi-You Zhou, Sheng-Pei Chen, Shi-Gang Sun
2008 Angewandte Chemie International Edition  
doi:10.1002/anie.200803202 pmid:18925592 fatcat:36avwlxjbvgk3izzmv6o3oqlla

Dynamic Analysis of Metro Train-Monolithic Bed Track System under Tunnel Differential Settlement

Jiqing Jiang, Beibei Dong, Zhi Ding, Gang Wei, He Zhang, Juan Liao
2020 Shock and Vibration  
The metro tunnel lines built in a soft soil area may suffer from tunnel differential settlement due to the high compressibility of soft soil, the engineering constructions nearby tunnel lines, and the cyclic load of metro trains. In this paper, a dynamic coupling model for a metro train-monolithic bed track system under tunnel differential settlement is established. A cosine function is introduced to simulate a real settlement curve measured from a metro tunnel in southern China, and the
more » ... on performance of the train-track system under tunnel settlements is investigated in both the time domain and frequency domain. Based on the standards for the train safety and passengers' comfort, the speed limit for the metro train traveling on a monolithic bed track with different settlement distributions are concluded. The present research could be useful for the operation and maintenance of metro tunnels in soft soil areas.
doi:10.1155/2020/5632180 fatcat:g353psnxvnb7xiua7nk4rqbamy

Morphological analysis of lymph vessels and capillaries in gastric carcinoma

Xin-Bo Liao, Wei-Ping Tang, Qin-Ming Zhang, Zhi-Gang Fu, Ying-Hai Zhao
2011 World Journal of Gastroenterology  
Xin-Bo Liao, Wei-Ping Tang, Qin-Ming Zhang, Zhi-Gang Fu, Ying-Hai Zhao Submit a Manuscript: Help Desk: DOI: 10.3748/wjg.v3.i2.90 Table  ... 
doi:10.3748/wjg.v3.i2.90 pmid:27041953 pmcid:PMC4801938 fatcat:larkcooptnhufmzlzuwdoai7iu

Metabolite Modulation in Human Plasma in the Early Phase of Acclimatization to Hypobaric Hypoxia

Wen-Ting Liao, Bao Liu, Jian Chen, Jian-Hua Cui, Yi-Xing Gao, Fu-Yu Liu, Gang Xu, Bing-Da Sun, Er-Long Zhang, Zhi-Bin Yuan, Gang Zhang, Yu-Qi Gao
2016 Scientific Reports  
The exposure of healthy subjects to high altitude represents a model to explore the pathophysiology of diseases related to tissue hypoxia. We explored a plasma metabolomics approach to detect alterations induced by the exposure of subjects to high altitude. Plasma samples were collected from 60 subjects both on plain and at high altitude (5300 m). Metabolite profiling was performed by gas chromatography-mass spectrometry (GC-MS) and ultra-performance liquid chromatographyquadrupole
more » ... t mass spectrometry (UPLC-QTOFMS) in conjunction with univariate and multivariate statistical analyses. ELISA assays were further employed to measure the levels of several relevant enzymes together with perturbed metabolic pathways. The results showed that hypobaric hypoxia caused significant and comprehensive metabolic changes, as represented by significant changes of 44 metabolites and 4 relevant enzymes. Using MetaboAnalyst 3.0, it was found that several key metabolic pathways were acutely perturbed. In addition, 5 differentially expressed metabolites in pre-exposure samples from the acute mountain sickness-susceptible (AMS-S) group compared with those from the AMS-resistant (AMS-R) group are identified, which warrant further validation as potential predictive biomarkers for AMS-S individuals. These results provide new insights for further understanding the pathophysiological mechanism of early acclimatization to hypobaric hypoxia and other diseases correlated to tissue hypoxia. at high altitude include pulmonary, cardiac and hemeatological changes. The processes of adaptation to hypoxia are likely to reflect the modulation of related metabolites as previously demonstrated 1 . Genomics and proteomics have merged as biochemical profiling tools to provide important insights into the biology of hypoxia-related conditions 1 . Although these profiling approaches focus on upstream genetic and protein variations, whereas the discipline of metabolomics captures the global metabolic changes that occur in response to pathological, environmental or lifestyle factors 2 . Consequently, metabolomics complements the information obtained by genomics and proteomics and has already shown promise in identifying metabolite-based biomarkers of acute and chronic hypoxia, including stroke 3 , cardiovascular diseases 4 and various cancers 5 . Recently, nuclear magnetic resonance (NMR)-based metabolomics have enabled study of the effects of acute hypobaric hypoxia on metabolic profiles 6-10 . Metabolic profiles of animal models have been used to reveal changes in energy metabolism with the use of an anti-anxiety herb formula 6 or with vitamin supplements 7 . Metabolic profiles of healthy human volunteers subjected to 8 h of 12% oxygen have shown changes in Hypoxia-Inducible Factor 1 HIF-1 levels and oxidative stress 8 . Our metabolomic study of high-altitude pulmonary edema using high resolution 1 H NMR spectroscopy identified a panel of 20 differential plasma metabolites, including valine, leucine, citrate and glucose, demonstrating that metabolic profiles can be used in the discovery of biomarkers of disease 9 . Recently, Lou et al. (2014) employed urinary liquid chromatography-mass spectrometry (LC-MS)-based metabolomic analysis to study systemic changes resulting from acute hypoxia and found that purine metabolic products (uric acid, xanthine and hypoxathine) and 1-methyladenosine were highly upregulated after rapid exposure to a hypoxic environment 10 . In this study, we conducted a comprehensive analysis of the plasma metabolites in 60 subjects both on plain and on the fourth day after arriving at high altitude (5300 m) using gas chromatography-mass spectrometry (GC-MS) and ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS). The metabolic variations were comprehensively investigated and were cross-checked by the two analytical methods. Our results show the perturbation of metabolically-relevant pathways during early acclimatization to high altitude, including inflammatory response-related metabolism, energy metabolism, bile acid metabolism and heme metabolism. Five metabolites showed significantly higher or lower levels in pre-exposure samples from acute mountain sickness susceptible (AMS-S) subjects compared with those from acute mountain sickness resistant (AMS-R) subjects, and may be potential predictive biomarkers for AMS-S individuals. This work provides new insights into the pathophysiological changes of hypobaric hypoxia and the prediction of AMS-S individuals. A flow chart illustrating the study design is shown in Fig. 1 . Results Clinical Characteristics of Subjects. The clinical characteristics of the subjects are in Table 1 . It is well established that rapid ascent of subjects to a high altitude causes a cascade of physiological responses. However, none of the 60 subjects in this study progressed to the more severe and potentially fatal forms of high-altitude pulmonary edema or high-altitude cerebral edema. In this study, oxygen saturation decreased significantly, whereas heart rate and blood pressure increased after entering the plateau. These altitude-induced changes of physiological indices have a common trend, and they show no significant differences between AMS-S (ten subjects with the
doi:10.1038/srep22589 pmid:26940428 pmcid:PMC4778071 fatcat:fq3k54o2jfc3jeadd7kxnadbhi

Thiel-embalming technique: investigation of possible modification in embalming tissue as evaluation model for radiofrequency ablation

Pei-Yu Liao, Zhi-Gang Wang
2019 Journal of Biomedical Research  
Contrary to freezing preservation and formalin embalming, Thiel embalmed cadaver presents soft texture and color very close to that of living organism, and many applications based on Thiel embalmed cadavers have been reported. However, Thiel embalmed cadavers cannot be used as reliable evaluation model for radiofrequency ablation (RFA) due to dramatic changes of electrical conductivity in the embalmed tissue. To address this issue, we investigated various modifications of the original Thiel
more » ... lming solution. By altering the chemicals' species and concentration we figured out a formula that can greatly reduce the embalming fluid's electrical conductivity without significantly compromising the 18-day embalmed kidney samples' suppleness and color. We also investigated a two-stage embalming technique by first submerging the kidney sample into original Thiel's tank fluid for 28 days, then the sample was withdrawn from the tank fluid and placed into modified dilution fluids for additional two weeks. Stiffening and discoloration occurred in these diluted samples implying the reversibility of Thiel-embalmed tissues' suppleness and color with the removal of the strong electrolytes. This study presents a modified embalming method which could be used for RFA evaluation and also helps our understanding of the mechanism of embalmment process.
doi:10.7555/jbr.32.20160148 pmid:30956232 pmcid:PMC6813523 fatcat:7v7jpdkpgzbrfpliu53dbhlpte

The High Precision Capacitance Array in 16-bit SAR ADC

Yong-Kai Li, Xu Qi, Ping Yang, Yuan-Jun Cen, Da-Gang Li, Zhi-Kai Liao
2019 Journal of Physics, Conference Series  
In SAR ADC, the capacitance array is a very important unit, it will determine the conversion performance of the whole ADC. In normal semiconductor foundry, the matching precision of the linear capacitor is always about 10 bit, so it is not impossible to realize the 16bit conversion precision in normal COMS foundry. This paper introduces a new design, for getting a smaller layout area, the main body frame of capacitor array uses the M+N+L bit sectional type; For getting the high matching
more » ... n performance, the lower bridging capacitor will be the normalized capacitor; For getting the high conversion precision, all the Upper-Bit in capacitance array will add a sub-calibrated capacitor array. So in this paper, it uses the circuit structure to realize the high precision capacitor array in 16-bit SAR ADC.
doi:10.1088/1742-6596/1213/4/042070 fatcat:y4szhtl24fcnvmu7nw4qy4q474

Propagation properties of vortex beams in a ring photonic crystal fiber

Zhang Ling-Xiang, Wei Wei, Zhang Zhi-Ming, Liao Wen-Ying, Yang Zhen-Guo, Fan Wan-De, Li Yi-Gang
2017 Wuli xuebao  
In the last decade, the vortex beams have received lots of attention for their orbital angular momentum.When they are applied to optical fiber communication field,the data channels will increase and information propagation speed will be effectively improved. Recently, researchers have shown the capabilities of long length stably propagation, nonlinear frequency conversion and mode division multiplexing of vortex modes in a ring fiber. Due to the photonic crystal fiber (PCF) having very flexible
more » ... design degrees of freedom, it will enable a wide range of propagation properties. In this paper, a SiO2 air-hole ring PCF is proposed for separation and propagation of optical vortex modes.By using COMSOL Multiphysics software,the vortex modes (TE01, HE ± 21 and TM01) are simulated and calculated. The differences in effective refractive index between them are 4.59 × 10 −4 and 3.62 × 10 −4 respectively. One can analyze the propagation properties of vortex beams in the ring PCF by changing the size of first layer air hole radius and air hole pitch. When the incident light wavelength of TE01 mode ranges from 1650 nm to 1950 nm, this ring PCF can achieve a total dispersion variation between 44.18 to 45.83 ps•nm −1 •km −1 , which is tend to be flat. When incident light wavelength is 1550 nm, the nonlinear coefficient of TE01 mode vortex light is 1.37 W −1 •km −1 . Due to the fact that long wavelength light is easier to leakage through the cladding than the short wavelength light, the confinement loss increases with the wavelength. When incident light wavelength is 2000 nm, there is still an eight-orders-of-magnitude of the low confinement loss. Theoretically, flat dispersion and low loss vortex beams in this fiber can be beneficial to propagating stably, and the vortex modes lay the foundation for long distance propagation in the optical fiber. In the future, this ring PCF will be used in optical fiber communication field and applications in aspects such as continuous spectrum research, which can make it have immense advantage over traditional fibers.
doi:10.7498/aps.66.014205 fatcat:6cu75lnjjbembblsqesmdsye4q
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