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Multi-wavelength quantum light sources, especially at telecom band, are extremely desired in quantum information technology. Despite recent impressive advances, such a quantum light source with high quality remains challenging. Here we demonstrate a multi-wavelength quantum light source using a silicon nitride micro-ring with a free spectral range of 200 GHz. The generation of eight pairs of correlated photons is ensured in a wavelength range of 25.6 nm. With device optimization andarXiv:2209.11417v1 fatcat:ueajsa2nbrff3c22e7vwq7rkhq
more »... ing filters, our source enables the generation of heralded single-photons - at a rate of 62 kHz with g^(2)_h(0)=0.014±0.001, and the generation of energy-time entangled photons - with a visibility of 99.39± 0.45% in the Franson interferometer. These results, at room temperature and telecom wavelength, in a CMOS compatible platform, represent an important step towards integrated quantum light devices for the quantum networks.
Polygala plants contain a large number of xanthones with good physiological activities. In our previous work, 18 xanthones were isolated from Polygala crotalarioides. Extented study of the chemical composition of the other species Polygala sibirica led to the separation of two new xanthones-3-hydroxy-1,2,6,7,8-pentamethoxy xanthone (A) and 6-O-β-D-glucopyranosyl-1,7dimethoxy xanthone (C)-together with 14 known xanthones. Among them, some xanthones have a certain xanthine oxidase (XO) inhibitorydoi:10.3390/molecules23020365 pmid:29425137 fatcat:z5jkjbnevzeofbfr27ggvtib6i
more »... activity. Furthemore, 14 xanthones as XO inhibitors were selected to develop three-dimensional quantitative structure-activity relationship (3D-QSAR) using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) models. The CoMFA model predicted a q 2 value of 0.613 and an r 2 value of 0.997. The best CoMSIA model predicted a q 2 value of 0.608 and an r 2 value of 0.997 based on a combination of steric, electrostatic, and hydrophobic effects. The analysis of the contour maps from each model provided insight into the structural requirements for the development of more active XO inhibitors. Molecules 2018, 23, 365 2 of 11 QSAR modeling. Especially, the alignment based on docking was normally more reasonable than on common structures as it takes the binding pose in the receptor into consideration. It also provides us convenience for docking as many crystal structures of XO have been released     . Herein, we studied the structure-activity relationship (SAR) of xanthones as inhibitors of XO through 3D-QSAR techniques based on molecular docking. We expect that our work could provide complementary and useful information to discover novel potent XO inhibitors. Molecules 2018, 23, x FOR PEER REVIEW 2 of 11 QSAR modeling. Especially, the alignment based on docking was normally more reasonable than on common structures as it takes the binding pose in the receptor into consideration. It also provides us convenience for docking as many crystal structures of XO have been released     . Herein, we studied the structure-activity relationship (SAR) of xanthones as inhibitors of XO through 3D-QSAR techniques based on molecular docking. We expect that our work could provide complementary and useful information to discover novel potent XO inhibitors.
Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC levels between patients with MS and healthy controls. In addition, we analyzed the impact of URIC on the risk of MS and symptom severity. Compared with normal subjects, URIC content was remarkably decreased indoi:10.3389/fnins.2021.755056 pmid:34658782 pmcid:PMC8517269 fatcat:tqpumrxoxnfplmud3j5dc5zz2q
more »... MS patients. In addition, URIC was regarded as a protective factor for MS, as verified by multivariate logistic regression models. We also found non-linear relationships between the levels of serum URIC and the incidence rate of MS and the Burke-Fahn-Marsden dystonia rating scale score. Our study is the first to show a connection between serum URIC levels and MS. Low serum URIC levels indicate an increased risk of MS incidence and more severe clinical symptoms. Our findings provide new insights into the prevention and treatment of MS.
The etiology and the underlying mechanism of CD4 1 T-cell polarization are unclear. This study sought to investigate the mechanism by which interleukin (IL)-13 prevents the activation-induced apoptosis of CD4 1 T cells. Here we report that CD4 1 T cells expressed IL-13 receptor a2 in the intestine of sensitized mice. IL-13 suppressed both the activation-induced apoptosis of CD4 1 T cells and the expression of p53 and FasL. Exposure to recombinant IL-13 inhibited activation-induced cell deathdoi:10.1038/cmi.2015.50 pmid:26189367 pmcid:PMC5037282 fatcat:ypjau3ukzzgctl23faq62j6mpa
more »... CD) along with the expression of p53, caspase 3, and tumor necrosis factor-a in CD4 1 T cells. Administration of an anti-IL-13 antibody enhanced the effect of specific immunotherapy on allergic inflammation in the mouse intestine, enforced the expression of p53 in intestinal CD4 1 T cells, and enhanced the frequency of CD4 1 T-cell apoptosis upon challenge with specific antigens. In summary, blocking IL-13 enhances the therapeutic effect of antigen-specific immunotherapy by regulating apoptosis and thereby enforcing AICD in CD4 1 T cells.
The authors appreciate the excellent technical assistance of Li-hui Wang, Fei-meng Zheng, Zheng-zhi Zou, Yan Zhang and Zi-jie Long. ...doi:10.1186/1471-2407-10-536 pmid:20929525 pmcid:PMC2958947 fatcat:sd3vtwto2bb3pfmizqpp4n6cpy
A new phase state, named the U phase, was observed in DPPC–diC8PC mixtures at low DPPC contents.doi:10.1039/c6ra24961b fatcat:bz3jpua3kngzflggtxivcr2wuu
and aims: Loss of the endotoxin tolerance of intestinal epithelium contributes to a number of intestinal diseases. The etiology is not clear. Psychological stress is proposed to compromise the intestinal barrier function. The present study aims to elucidate the role of the stress-derived corticotropin releasing factor (CRF) in breaching the established intestinal epithelial endotoxin tolerance. Methods: Epithelial cells of HT-29, T84 and MDCK were exposed to lipopolysaccharide to induce thedoi:10.1371/journal.pone.0065760 pmid:23840363 pmcid:PMC3686760 fatcat:3snsqstxojcyzma3yygsj2ziai
more »... toxin tolerance; the cells were then stimulated with CRF. The epithelial barrier function was determined using as indicators of the endotoxin tolerant status. A water-avoid stress mouse model was employed to test the role of CRF in breaching the established endotoxin tolerance in the intestine. Results: The established endotoxin tolerance in the epithelial cell monolayers was broken down by a sequent exposure to CRF and LPS manifesting a marked drop of the transepithelial resistance (TER) and an increase in the permeability to a macromolecular tracer, horseradish peroxidase (HRP). The exposure to CRF also increased the expression of Cldn2 in the epithelial cells, which could be mimicked by over expression of TLR4 in epithelial cells. Over expression of Cldn2 resulted in low TER in epithelial monolayers and high permeability to HRP. After treating mice with the 10-day chronic stress, the intestinal epithelial barrier function was markedly compromised, which could be prevented by blocking either CRF, or TLR4, or Cldn2. Conclusions: Psychological stress-derived CRF can breach the established endotoxin tolerance in the intestinal mucosa.
Keratin is an important protein used in wound healing and tissue recovery. In this study, keratin was modified chemically with iodoacetic acid (IAA) to enhance its solubility in organic solvent. Poly(hydroxybutylate-cohydroxyvalerate) (PHBV) and modified keratin were dissolved in hexafluoroisopropanol (HFIP) and electrospun to produce nanofibrous mats. The resulting mats were surface-characterized by ATR-FTIR, field-emission scanning electron microscopy (FE-SEM) and electron spectroscopy fordoi:10.1007/bf03218625 fatcat:rb75vojgxrg5nc7udnc76ysnv4
more »... mical analysis (ESCA). The pure m-keratin mat was cross-linked with glutaraldehyde vapor to make it insoluble in water. The biodegradation test in vitro showed that the mats could be biodegraded by PHB depolymerase and trypsin aqueous solution. The results of the cell adhesion experiment showed that the NIH 3T3 cells adhered more to the PHBV/m-keratin nanofibrous mats than the PHBV film. The BrdU assay showed that the keratin and PHBV/m-keratin nanofibrous mats could accelerate the proliferation of fibroblast cells compared to the PHBV nanofibrous mats.
E58, o929-o930 [https://doi.org/10.1107/S160053680201317X] 2,2′-Diamino-4,4′-bi-1,3-thiazolium dichloride Jia-Geng Liu, Duan-Jun Xu, Yuan-Zhi Xu, Jing-Yun Wu and Michael Y. source: fine-focus sealed tube ... The title compound was obtained from an aqueous solution as a by-product in the course of the synthesis of an Ni II complex with DABT, using NiCl 2 as a starting reagent. organic papers o930 Jia-Geng Liu ...doi:10.1107/s160053680201317x fatcat:myy4hzo7jrgqdl2dus2bdjxf6i
ZnO/TiO 2 nanolaminates were grown on Si (100) and quartz substrates by atomic layer deposition at 200°C using diethylzinc, titanium isopropoxide, and deionized water as precursors. All prepared multilayers are nominally 50 nm thick with a varying number of alternating TiO 2 and ZnO layers. Sample thickness and ellipsometric spectra were measured using a spectroscopic ellipsometer, and the parameters determined by computer simulation matched with the experimental results well. The effect ofdoi:10.1186/1556-276x-8-107 pmid:23442741 pmcid:PMC3599444 fatcat:vlxvnpmpvnbjhm7j4d4lko7bim
more »... laminate structure on the optical transmittance is investigated using an ultraviolet-visible-near-infrared spectrometer. The data from X-ray diffraction spectra suggest that layer growth appears to be substrate sensitive and film thickness also has an influence on the crystallization of films. High-resolution transmission electron microscopy images show clear lattice spacing of ZnO in nanolaminates, indicating that ZnO layers are polycrystalline with preferred (002) orientation while TiO 2 layers are amorphous.
Rationale: Mast cells play a crucial role in allergic diseases. Yet, the regulation of mast cell bioactivities is not fully understood. This study aims to elucidate the role of B cell lymphoma 2 like protein 12 (Bcl2L12), one of the anti-apoptosis proteins, in regulating mast cell apoptosis. Methods: A food allergy (FA) mouse model was developed to establish mast cell over population in the intestinal tissue. Either compound 48/80 (C48/80) or specific antigens were used to activate mast cellsdoi:10.7150/thno.34001 pmid:31410196 pmcid:PMC6691383 fatcat:uzlhzzktorfjlmq22dqjdcw34q
more »... the intestinal mucosa. Results: After treating with C48/80, apoptosis was induced in mast cells of the intestine of naive control mice, but not in FA mice. The expression of Fas ligand (FasL) was lower in the mast cells of FA mice. Interleukin (IL)-5 was responsible for the suppression of FasL by upregulating the expression of Bcl2L12 in mast cells. Bcl2L12 prevented c-Myc, the major transcription factor of FasL, from binding the FasL promoter to inhibit the expression of FasL in mast cells. Inhibition of Bcl2L12 restored the apoptosis machinery of mast cells in the FA mouse intestine. Conclusions: The apoptosis machinery in mast cells is impaired in an allergic environment. Inhibition of Bcl2L12 restores the apoptosis machinery in mast cells in the FA mouse intestine.
A B S T R A C T A Fe-N-C catalyst was prepared by pyrolyzing carbon black supported Fe-imidazole complexes. The effect of different pyrolysis temperatures on the catalysts' oxygen reduction reaction (ORR) activity was investigated by electrochemical rotating disk electrode tests in 0.5 M H 2 SO 4 . The Fe-N-C catalyst heat-treated at 700°C was found to display the best ORR activity with a highest half-wave potential of 0.656 V vs. normal hydrogen electrode (NHE), which was only 64 mV lower thandoi:10.1016/j.carbon.2013.02.017 fatcat:homr3vthnje6tatx7uozdvf6ei
more »... that of the commercial Pt-C (loading: 10 lg Pt cm À2 ), and a lowest H 2 O 2 yield (0.6% at 0.4 V vs. NHE). Furthermore, potential cycling tests showed that the catalyst had a better electrochemical stability than Pt-C catalyst. X-ray photoelectron spectroscopy characterization of these catalysts was also conducted to identify the active nitrogen species for ORR.
The purpose was to investigate the prevalence rate, characteristics and related factors of breast cancer among women in Eastern China. A total of 122,058 female subjects completed the study, with 320 confirmed cases of breast cancer (crude prevalence: 262.5/100,000; standardized prevalence: 207.7/100,000). Among all of the identified breast cancer cases, 91.6% were diagnosed after the age of 35 and 60.0% were diagnosed before menopause. The odds ratios (95% confidence interval) of those breastdoi:10.1371/journal.pone.0037784 pmid:22723840 pmcid:PMC3377727 fatcat:mpsdjnlxzrcndl3y76jdxxarxe
more »... ancer risk factors as selected through multivariate logistic regression were as follows: 5.438 (1.553-19.004) for family history of breast cancer, 3.556 (1.880-6.728) for high behavior intervention score, 3.556 (0.904-13.994) for history of diabetes, 3.357 (1.131-9.969) for history of benign breast tumors, 2.196 (1.355-3.556) for poor overall life satisfaction, 1.826 (0.995-3.350) for premenopause of breast cancer, 1.528 (1.083-2.155) for high BMI index, 1.500 (0.920-2.446) for poor financial status, 1.497 (1.014-2.211) for multiple miscarriages/abortions, and 1.231 (0.972-1.559) for infrequent consumption of garlic (frequent garlic consumption is a protective factor). There were significantly more cases of breast cancer diagnosed prior to menopause than after menopause, and most of the patients were diagnosed after the age of 35. These findings suggest that attention should be focused on the incidence of breast cancer among premenopausal women older than 35.
Synechococcus is one of the most important contributors to global primary productivity, and ocean warming is predicted to increase abundance and distribution of Synechococcus in the ocean. Here, we investigated molecular response of an oceanic Synechococcus strain WH8102 grown in two nitrogen sources (nitrate and urea) under present (25°C) and predicted future (28°C) temperature conditions using an isobaric tag (IBT)-based quantitative proteomic approach. Rising temperature decreased growthdoi:10.3389/fmicb.2019.01976 pmid:31507578 pmcid:PMC6716455 fatcat:fkdk3wn3mfarzhx34q5wrjlc3i
more »... , contents of chlorophyll a, protein and sugar in the nitrate-grown cells, but only decreased protein content and significantly increased zeaxanthin content of the urea-grown cells. Expressions of CsoS2 protein involved in carboxysome formation and ribosomal subunits in both nitrate- and urea-grown cells were significantly decreased in rising temperature, whereas carbohydrate selective porin and sucrose-phosphate synthase (SPS) were remarkably up-regulated, and carbohydrate degradation associated proteins, i.e., glycogen phosphorylase kinase, fructokinase and glucose-6-phosphate dehydrogenase, were down-regulated in the urea-grown cells. Rising temperature also increased expressions of three redox-sensitive enzymes (peroxiredoxin, thioredoxin, and CP12) in both nitrate- and urea-grown cells. Our results indicated that rising temperature did not enhance cell growth of Synechococcus; on the contrary, it impaired cell functions, and this might influence cell abundance and distribution of Synechococcus in a future ocean.
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