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In this paper, the IJ=00, 11, 20 partial wave ππ scattering phase shifts determined by the lattice QCD approach are analyzed by using a novel dispersive solution of the S-matrix, i.e. the PKU representation, in which the unitarity and analyticity of scattering amplitudes are automatically satisfied and the phase shifts are conveniently decomposed into the contributions of the cuts and various poles, including bound states, virtual states and resonances. The contribution of the left-hand cut isarXiv:2202.03124v1 fatcat:egrh7ardt5dv7m5d2byhdaumlq
more »... stimated by the SU(2) chiral perturbation theory to 𝒪(p^4). The Balanchandran-Nuyts-Roskies relations are considered as constraints to meet the requirements of the crossing symmetry. It is found that the IJ=00 ππ scattering phase shifts obtained at m_π=391 MeV by Hadron Spectrum Collaboration (HSC) reveal the presence of both a bound state pole and a virtual state pole below the ππ threshold rather than only one bound state pole for the σ. To reproduce the lattice phase shifts at m_π=391 MeV, a virtual-state pole in the IJ=20 channel is found to be necessary in order to balance the left-hand cut effects from the chiral amplitudes. Similar discussions are also carried out for the lattice results with m_π=236 MeV from HSC. The observed behaviors of the pole positions with respect to the variation of the pion masses can provide deep insights into our understanding of the dynamical origin of σ resonance.
Quantum entanglement, as the strictly non-classical phenomena, is the kernel of quantum computing and quantum simulation, and has been widely applied ranging from fundamental tests of quantum physics to quantum information processing. The decoherence of quantum states restricts the capability of building quantum simulators and quantum computers in a scalable fashion. Meanwhile, the topological phase is found inherently capable of protecting physical fields from unavoidable fabrication-inducedarXiv:1903.03015v1 fatcat:pqnefy553je75padhkag72mnhy
more »... sorder, which inspires the potential application of topological protection on quantum states. Here, we present the first experimental demonstration of topologically protected quantum polarization entangled states on a photonic chip. The process tomography shows that quantum entanglement can be well preserved by the boundary states even when the chip material substantially introduces relative polarization rotation in phase space. Our work links topology, material and quantum physics, opening the door to wide applications of topological enhancement in genuine quantum regime.
A Setosphaeria turcica gene encoding the catalytic subunit of calcineurin was cloned using degenerated primers corresponding to conserved domains of Ser/Thr protein phosphatases and its complete cDNA (GenBank accession No. EF 407562) was obtained with RACE method. It's validated single copied model by southern hybridization. Furthermore, the CNA inhibitor Cyclosporin A (CsA) exhibited potent antifungal activity against conidial germination and appressorium formation of S. turcica. Thedoi:10.3724/sp.j.1005.2009.01059 pmid:19840929 fatcat:hbcpq4ljpbdsbbwqdkgrfuzg4u
more »... ratio was positively correlated to CsA concentration. However, appressorium formation was more sensitive than conidium germination to the inhibitor at the same concentration. It was suggested that CNA might play an important role in the pathogenicity of S. turcica.
Go has long been considered as a testbed for artificial intelligence. By introducing certain quantum features, such as superposition and collapse of wavefunction, we experimentally demonstrate a quantum version of Go by using correlated photon pairs entangled in polarization degree of freedom. The total dimension of Hilbert space of the generated states grows exponentially as two players take turns to place the stones in time series. As nondeterministic and imperfect information games are morearXiv:2007.12186v1 fatcat:zx56pmznifcpvbogcyilaoy34m
more »... ifficult to solve using nowadays technology, we excitedly find that the inherent randomness in quantum physics can bring the game nondeterministic trait, which does not exist in the classical counterpart. Some quantum resources, like coherence or entanglement, can also be encoded to represent the state of quantum stones. Adjusting the quantum resource may vary the average imperfect information (as comparison classical Go is a perfect information game) of a single game. We further verify its non-deterministic feature by showing the unpredictability of the time series data obtained from different classes of quantum state. Finally, by comparing quantum Go with a few typical games that are widely studied in artificial intelligence, we find that quantum Go can cover a wide range of game difficulties rather than a single point. Our results establish a paradigm of inventing new games with quantum-enabled difficulties by harnessing inherent quantum features and resources, and provide a versatile platform for the test of new algorithms to both classical and quantum machine learning.
Four new triterpene glucosides (1–4) were isolated from the 90% ethanol extract of Salacia cochinchinensis, together with five known compounds (5–9). The structures of the new compounds were elucidated by comprehensive spectroscopic analysis including HRESIMS, IR, 1 D and 2 D NMR analysis. All isolates were assayed for their α-glucosidase inhibitory activity. Compound 9 showed remarkable α-glucosidase inhibitory activity with an IC50 value of 0.31 μM, and the triterpene glycosides (1–5) exhibited moderate α-glucosidase inhibitory activity.doi:10.6084/m9.figshare.13078842.v1 fatcat:ra5bj4ts4jaaxajz56rzr6hyom
Gao, W. ... points, cystic: 3 points), with the maximal score of 18. 21 Etiology of bronchiectasis was determined after meticulous testing recommended by British Thoracic Society guidelines 2 and group discussion (Yong-hua ... Z. recruited patients; Yong-hua Gao, W. G., and G. X. contributed to critical review of the manuscript; and Yong-hua Gao, W. G., G. X., Zhi-ya Lin, Y. T., Zhi-min Lin, Yang Gao, H. L., N. Z., G. ...doi:10.1378/chest.14-1961 pmid:25412225 pmcid:PMC7094490 fatcat:7lppvegqirhf3odyxraz2a4i3i
Topological phase, a novel and fundamental role in matter, displays an extraordinary robustness to smooth changes in material parameters or disorder. A crossover between topological physics and quantum information may lead to inherent fault-tolerant quantum simulations and quantum computing. Quantum features may be preserved by being encoded among topological structures of physical evolution systems. This requires us to stimulate, manipulate and observe topological phenomena at single quantumarXiv:1809.01661v1 fatcat:3r5g47obyngzfiumcutoqfphdq
more »... rticle level, which, however, hasn't been realized yet. Here, we address such a question whether the quantum features of single photons can be preserved in topological structures. We experimentally observe the boundary states of single photons and demonstrate the performance of topological phase on protecting the quantum features in quasi-periodic systems. Our work confirms the compatibility between macroscopic topological states and microscopic single photons on a photonic chip. We believe the emerging 'quantum topological photonics' will add entirely new and versatile capacities into quantum technologies.
Objective: To explore the positive inotropic effect of atractylodin which is major active component of Rhzoma Atractylodis Lanceae and its underlying mechanism. Methods: For in vivo study, six male SD rats were randomly selected for the heart pressure-volume loop (P-V loop) experiment. The effects of atractylodin (3 mg/kg, intraperitoneal injection) on hemodynamic parameters such as LVDP (left ventricular developed pressure), SW (stroke work), HR (heart rate), CO (cardiac output), SBP (systolicdoi:10.12047/j.cjap.5992.2020.087 pmid:33629552 fatcat:fjxhgxvu4vbk7na2ur752ambce
more »... blood pressure) and DBP (diastolic blood pressure) were analyzed. For in vitro study, left ventricular developed pressure (LVDP) from the Langendroff-perfused isolated rat heart was analyzed before as the control and after atractylodin perfusion. For in vitro study, the effects of atractylodin and atractylodin with H89 (PKA inhibitor) or KN-93 (CaMKII inhibitor or Calyculin A (PP1, PP2A inhibitor) on LVDP were analyzed. The experiments were separated into four parts with six isolated hearts for each as follows: (1) Control→0.1→1→10 μmol/L atractylodin; (2) Control→200 nmol/L H89 (PKA inhibitor)→200 nmol/L H89+10 μmol/L atractylodin; (3) Control→500 nmol/L KN-93 (CaMKII inhibitor)→500 nmol/L KN-93+10 μmol/L atractylodin; (4) Control→10 nmol/L Calyculin A (PP1, PP2A inhibitor)→10 nmol/L Calyculin A+10 μmol/L atractylodin. For the study of rat left ventricular myocyte Ca2+ transient induced by field stimulation, the experiment design was the same as in vitro study. The six cells from the different rats were used for each part experiment. Results: ① Atractylodin (3 mg/kg) significantly increased the heart rate, cardiac output and stroke work (P<0.05) and decreased the diastolic blood pressure (P<0.05). ② Atractylodin (0.1, 1, 10 μmol/L) significantly increased the LVDP in a concentration dependent manner (P<0.05). The positive inotropic effect of atractylodin could be blocked by PKA inhibitor H89. ③ Atractylodin (10 μmol/L) significantly increased the amplitude of SR Ca2+ transient amplitude mediated by facilitating sarcoplasmic reticulum SERCA2a. The enhanced amplitude of SR Ca2+ transient could be blocked by PKA inhibitor H89. Conclusion: Atractylodin had positive inotropic effect in rat heart both in vivo and in vitro with decreased diastolic blood pressure and its underlying mechanism was mediated by PKA. Based on the fact that the atractylodin exerted its positive inotropic effect was mediated by PKA, the PKA-SERCA2a signaling pathway might be the mechanism of the atractylodin's positive inotropy.
Two new biphenyls (1 and 2) and three known xanthones (3–5) were isolated from the ethanol extract of the stems of Garcinia tetralata. Structural elucidations of 1–2 were elucidated by spectroscopic methods including extensive 1D- and 2D-nuclear magnetic resonance spectroscopy techniques. Compounds 1–2 showed anti-rotavirus activities with SI above 10.doi:10.6084/m9.figshare.4621798.v1 fatcat:2jhplvrtgvbdpju77un2yfm2se
Studies have found tight and linear correlations between luminosities of HCN J=1→0 and IR emission (Gao & Solomon 2004a; Gao et al. 2007; Krips et al. 2008; Chen et al. 2015; Privon et al. 2015) . ... Wang et al. (2011) , for which the CO J=1→0 data are taken from Gao & Solomon (2004b) . DDO 70 is plotted as the filled magenta circle. ...arXiv:2005.03907v1 fatcat:72b44kovb5addcc2gndam2plma
SN Applied Sciences
The freestanding of reduced graphene oxides/carbon nanotubes (rGO/CNTs) hybrid films are synthesized via the simple vacuum filtration and thermal reduction methods. And the electrochemical behaviors of rGO/CNTs hybrid films are investigated in KOH and in Et 4 NBF 4 /AN electrolyte, respectively. In three-electrode systems, the rGO/CNTs hybrid films show a maximum specific capacitance of 221 F g −1 , a 71% capacitance retention, and an excellent cycle life in 1 M KOH electrolyte. And thedoi:10.1007/s42452-018-0059-y fatcat:lswcgw7dcresxovqewuwivse4q
more »... hemical behaviors of rGO/CNTs films in Et 4 NBF 4 /AN electrolyte under three-electrode systems show a maximum specific capacitance of 174 F g −1 and good rate capability. Moreover, a symmetric supercapacitor of rGO/ CNTs//rGO/CNTs demonstrates a maximum specific capacitance of 24 F g −1 at 1 A g −1 , a energy density of 20.8 Wh kg −1 at 1.27 kW kg −1 , and an excellent cycle life of 86.1% retention after 5000 cycles. It suggests that the symmetric supercapacitor could be regarded as an ideal energy storage system.
A systematic review and meta-analysis was conducted to evaluate the efficacy and safety of macrolide therapy in adults and children with bronchiectasis. Methods: We searched the PUBMED, EMBASE, CENTRAL databases to identify relevant studies. Two reviewers evaluated the studies and extracted data independently. The primary outcome was the number of bronchiectasis exacerbations. Secondary outcomes included exacerbation-related admissions, quality of life (QoL), spirometry, 6-minute walk testdoi:10.1371/journal.pone.0090047 pmid:24603554 pmcid:PMC3946068 fatcat:fnqizpeqa5cslkokv3dg6ubyv4
more »... ) and adverse events. Results: Nine eligible trials with 559 participants were included. Six were conducted on adults, and the remaining on children. Macrolide therapy significantly reduced the number of patients experiencing one or more exacerbation in adults [risk ratio (RR) = 0.59; 95% CI, 0.40 to 0.86; P = 0.006; I 2 = 65%] and children [RR = 0.86; 95% CI, 0.75-0.99; P = 0.04; I 2 = 0%], but not the number of patients with admissions for exacerbation. Macrolide therapy was also associated with reduced frequency of exacerbations in adults (RR = 0.42; 95% CI, 0.29 to 0.61; P,0.001; I 2 = 64%) and children (RR = 0.50; 95% CI, 0.35 to 0.71; P,0.001). Pooled analyses suggested that spirometry, including FEV 1 and FVC, were significantly improved in adults but not in children. Macrolide therapy improved the QoL (WMD, 26.56; 95% CI, 211.99 to 21.12; P = 0.02; I 2 = 86%) but no significant difference in 6MWT (WMD, 4.15; 95% CI, 211.83 to 20.13; P = 0.61; I 2 = 31%) and the overall adverse events (RR, 0.96; 95% CI, 0.82 to 1.13; P = 0.66; I 2 = 0%) in adults. However, reports of diarrhea and abdominal discomforts were higher with macrolide therapy. Conclusions: Macrolide maintenance therapy, both in adults and children, was effective and safe in reducing bronchiectasis exacerbations, but not the admissions for exacerbations. In addition, macrolide administration in adults was associated with improvement in QoL and spirometry, but not 6WMT. Future studies are warranted to verify the optimal populations and clarify its potential effects on antimicrobial resistance.
With the fast development of giant LEO constellations, the effective spectrum utilization has been regarded as one of the key orientations for satellite communications. This paper focuses on improving the spectrum utilization efficiency of satellite communications by proposing a non-continuous orthogonal frequency division multiplexing (NC-OFDM) method. Based on the models of NC-OFDM system, we first propose a sub-carrier allocation method by using spectrum sensing to efficiently perceive anddoi:10.3390/s22103800 fatcat:yelz6yzs4zh7fl4rvqnr2dfqpi
more »... ilize the spectrum holes in the satellite communication system. Then, a hybrid genetic particle swarm optimization method is adopted to allocate the channel resources effectively. Finally, simulation results verify that the proposed algorithm can significantly improve the spectrum efficiency of satellite communications.
AbstractFever is a systemic inflammatory response of the body to pyrogens. Nuclear factor κB (NF-κB) is a central signalling molecule that causes the excessive secretion of various proinflammatory factors induced by pyrogens. This study explored the feasibility of a novel reporter gene assay (RGA) for pyrogen detection using RAW 264.7 cells stably transfected with the NF-κB reporter gene as a pyrogenic marker. Pyrogen was incubated with the transgenic cells, and the intensity of thedoi:10.1101/613190 fatcat:ybuqfopxtzbflntumi4khosnx4
more »... signal generated by luciferase secreted by the reporter gene was used to reflect the degree of activation of NF-κB, so as to quantitatively detect the pyrogens. The RGA could detect different types of pyrogens, including the lipopolysaccharide (LPS) of gram-negative bacteria, the lipoteichoic acid (LTA) of gram-positive bacteria, and the zymosan of fungi, and a good dose-effect relationship was observed in terms of NF-κB activity. The limits of detection of the RGA to those pyrogens were 0.03 EU/ml, 0.001 μg/ml, and 1 μg/ml, respectively. The method had good precision and accuracy and could be applied to many biological products (e.g., nivolumab, rituximab, bevacizumab, etanercept, basiliximab, haemophilus influenzae type b conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine, and group A and group C meningococcal conjugate vaccine). The results of this study suggest that the novel RGA has a wide pyrogen detection spectrum and is sufficiently sensitive, stable, and accurate for various applications.ImportancePyrogen testing is mandatory and a critical method to ensure the safety of parenteral products including vaccines.Currently, only two pharmacological tests, including the rabbit pyrogen test and the bacterial endotoxins test (BET), are applied to evaluate pyrogenic contamination in parenteral pharmaceuticals by most of state pharmacopoeias. Although generally reliable, both of these assays have shortcomings. The rabbit test is not quantitative but is expensive and involves the use of animals. It can also produce varying responses depending on the strain, age and housing conditions of the rabbits. The BET, however, does not detect pyrogens other than gram-negative bacterial endotoxins and is often problematic when used to test solutions with a high protein content.To overcome these shortcomings and satisfy the growing need for new methods prompted by the constantly increasing production of biological compounds, it is necessary to develop the novel assay for pyrogen detection.HighlightsThis novel reporter gene assay can detect different types of pyrogens, including the lipopolysaccharide of gram-negative bacteria, the lipoteichoic acid of gram-positive bacteria, and the zymosan of fungi.The novel reporter gene assay is sufficiently sensitive, stable, and accurate for various applications.
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