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Journal of Traditional Chinese Medicine
Proficient in Moxibustion Therapy WANG Zhi-zhong made contribution to inheriting from the past and carrying on for the future in moxibustion therapy. ... WANG Zhi-zhong, an acupuncturist, said that acupuncture was not as good as herbs for some diseases in his book. This shows his broadmindedness and noble thought. ...doi:10.1016/s0254-6272(09)60055-8 fatcat:latfrclvvrhf7cekbl2bu4mdsq
Personal identity as the chooser of our desires and author of our actions can be thought of as the common denominator between Korsgaard and Wang Yangming (王陽明); for liang-zhi (良知) is none other than the ... Moreover, further engagement between the two sides reveals that Wang's characterizations of liang-zhi, particularly those of practical experience, law-embodying identity, and zhi-zhi (致知) can be seen as ... To achieve this goal, we must start by following through with instructions or commands from liang-zhi, which is called by Wang the endeavor of "zhi-zhi" (realizing liang-zhi; 致知). ...doi:10.31979/2151-6014(2015).060105 fatcat:4iyps3ta7vdtzas5wlyjj3hrrq
Auch Wang Ji, der eine "ontologische und zeitliche Einheit" von "stiller Substanz" (jiran zhi ti 寂然之體) und "erregten Funktionen" (suo gan zhi yong 所感之用) des ‚ursprünglichen Wissens' (S. 600; 605) annimmt ... Im Arbeitstitel hätten zudem lange Jahre die Begriffe ‚Gewissen' für liang zhi 良知 ("ursprüngliches Wissen") und ‚Gewissensbildung' für zhi liang zhi 致良知 ("Verwirklichung des ursprünglichen Wissens") figuriert ...doi:10.1515/asia-2016-0020 fatcat:ond4bq4q7fbyhmxqaxpacpo3cu
Liu Zhi. ... Beginning with a brief historical overview of the Sinicised Muslim community which created this tradition, the paper proceeds to examine the work of three key Han Kitab figures: Wang Daiyu, Ma Zhu and ... Our paper will then examine the Hān Kitāb's three key figures: Wang Daiyu, Ma Zhu and Liu Zhi. ...doi:10.52282/icr.v7i1.282 fatcat:dftebuwgwva5nh5zwulkxb25lm
Large amounts of fat deposition often lead to loss of reproductive efficiency in humans and animals. We used broiler chickens as a model species to conduct a two-directional selection for and against abdominal fat over 19 generations, which resulted in a lean and a fat line. Direct selection for abdominal fat content also indirectly resulted in significant differences (P < 0.05) in testis weight (TeW) and in TeW as a percentage of total body weight (TeP) between the lean and fat lines. Results:doi:10.1186/s12711-017-0299-0 pmid:28235410 pmcid:PMC5326497 fatcat:xms7j4ezwzcpjhbpga5bkpxxle
more »... fat lines. Results: A total of 475 individuals from the generation 11 (G 11 ) were genotyped. Genome-wide association studies revealed two regions on chicken chromosomes 3 and 10 that were associated with TeW and TeP. Forty G 16 individuals (20 from each line), were further profiled by focusing on these two chromosomal regions, to identify candidate genes with functions that may be potentially related to testis growth and development. Of the nine candidate genes identified with database mining, a significant association was confirmed for one gene, TCF21, based on mRNA expression analysis. Gene expression analysis of the TCF21 gene was conducted again across 30 G 19 individuals (15 individuals from each line) and the results confirmed the findings on the G 16 animals. Conclusions: This study revealed that the TCF21 gene is related to testis growth and development in male broilers. This finding will be useful to guide future studies to understand the genetic mechanisms that underlie reproductive efficiency.
Eight compounds were isolated from the water extract of Pu-erh tea and their structures were elucidated by NMR and MS as gallic acid (1), (+)-catechin (2), (−)-epicatechin (3), (−)-epicatechin-3-O-gallate (4), (−)-epigallocatechin-3-O-gallate (5), (−)-epiafzelechin- 3-O-gallate (6), kaempferol (7), and quercetin (8). Their in vitro antioxidant activities were assessed by the DPPH and ABTS scavenging methods with microplate assays. The relative order of DPPH scavenging capacity for thesedoi:10.3390/molecules171214037 pmid:23187287 pmcid:PMC6268774 fatcat:2jlow4o435d37blhwtbrwjsiae
more »... y for these compounds was compound 8 > compound 7 > compound 1 > compound 6 > compound 4 ≈ compound 5 > compound 2 > VC (reference) > compound 3, and that of ABTS scavenging capacity was compound 1 > compound 2 > compound 7 ≈ compound 8 > compound 6 > compound 5 > compound 4 > VC (reference) > compound 3. The results showed that these phenolic compounds contributed to the antioxidant activity of Pu-erh tea.
We report a non-iterative localization algorithm that utilizes the scaling of a three-dimensional (3D) image in the axial direction and focuses on evaluating the radial symmetry center of the scaled image to achieve the desired single-particle localization. Using this approach, we analyzed simulated 3D particle images by wide-field microscopy and confocal microscopy respectively, and the 3D trajectory of quantum dots (QDs)-labeled influenza virus in live cells. Both applications indicate thatdoi:10.1038/srep02462 pmid:23955270 pmcid:PMC3746204 fatcat:46f6gwmi5bggvobxq2c27c263i
more »... ons indicate that the method can achieve 3D single-particle localization with a sub-pixel precision and sub-millisecond computation time. The precision is almost the same as that of the iterative nonlinear least-squares 3D Gaussian fitting method, but with two orders of magnitude higher computation speed. This approach can reduce considerably the time and costs for processing the large volume data of 3D images for 3D single-particle tracking, which is especially suited for 3D high-precision single-particle tracking, 3D single-molecule imaging and even new microscopy techniques.
E62, o4238-o4239 [https://doi.org/10.1107/S1600536806034799]5-Bromo-2-iodopyrimidineZhi-TaoXing, Wei-Lin Ding, Hai-Bo Wang, Zhi-Qian Liu and Pinsource: fine-focus sealed tube Graphite monochromator ω/2θ ...doi:10.1107/s1600536806034799 fatcat:4fu57vt2yfg2rbvikzeu6c3jdy
Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF. Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, includingdoi:10.1186/1471-2164-13-704 pmid:23241142 pmcid:PMC3557156 fatcat:zwgvlocz4zbxvhijk67sy3kxo4
more »... egions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens. Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.
Alzheimer's disease (AD) is the most common neurodegenerative disorder and there is currently no efficient cure for this devastating disease. Cognitive stimulation can delay memory loss during aging and in patients with mild cognitive impairment. In 3 3 Tg-AD mice, training decreased the neuropathologies with transient amelioration of memory decline. However, the neurobiological mechanisms underlying the learning-improved memory capacity are poorly understood. Here, we found in Tg2576 micedoi:10.1038/srep09488 pmid:25820815 pmcid:PMC4377552 fatcat:256mcvk4v5dhflzppojrqvorha
more »... in Tg2576 mice spatial training in Morris water maze (MWM) remarkably improved the subsequent associative memory acquisition detected by contextual fear conditioning. We also found that spatial training enhanced long term potentiation, dendrite ramification and spine generation in hippocampal dentate gyrus (DG) and CA1 neurons at 24 h after the training. In the molecular level, the MWM training remarkably activated calcium/ calmodulin-dependent protein kinase II (CaMKII) with elevation of glutamate AMPA receptor GluA1 subunit (GluA1), postsynaptic density protein 93 (PSD93) and postsynaptic density protein 95 (PSD95) in the hippocampus. Finally, the training also significantly ameliorated AD-like tau and amyloid pathologies. We conclude that spatial training in MWM preserves associative memory capacity in Tg2576 mice, and the mechanisms involve augmentation of dendrite ramification and spine generation in hippocampus. A lzheimer's disease (AD) is the most common neurodegenerative disorder characterized clinically by spatial memory loss in early stage of the onset. Accumulation of b-amyloid and hyperphosphorylated microtubule-associated protein tau are the major pathological hallmarks in the AD brains. The mechanisms underlying neurodegeneration are not fully elucidated, and there is currently no proven, effective diseasemodifying therapy for this devastating disorder. Low education increases risk for AD, and cognitive stimulating therapy improves the memory functions with the same efficacy as galantamine or tacrine 1 . Studies also show that participation in cognitively stimulating activities, such as reading, is associated with a reduced risk of dementia 2-4 and a reduced risk of amnestic mild cognitive impairment (aMCI) 5,6 . Different types of cognitive training programs can also improve the cognitive function in elder population 6,7 . These studies strongly suggest that cognitive stimulation can preserve memory capacities in AD and aMCI patients. However, the neurobiological mechanisms underlying the training-induced memory improvement are largely unknown. Morris water maze training was reported to reduce the amyloid load and tau hyperphosphorylation with improvement of memory in 3 3 Tg-AD mice 8 . Although the amyloid plaques and tau hyperphosphorylation/ neurofibrillary tangle formation are the primary characteristics of pathology in AD, these pathological changes are not strongly correlated with the cognitive decline of the patients 9,10 . On the other hand, the synaptic strength, which is influenced by dendrite ramification and spine generation/plasticity, play a crucial role in learning and memory 11,12 . Loss of synapse and spine in various brain areas strongly correlates with the clinical scores of dementia of AD 13-15 . The dendrite ramification and spine generation are regulated by the expression of post-OPEN SUBJECT AREAS: SPATIAL MEMORY COGNITIVE NEUROSCIENCE
Dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides were rapidly identified from Ruditapes philippinarum hydrolysate. The hydrolysate was fractionated by ethanol precipitation and preparative reverse phase high-performance liquid chromatography (RP-HPLC). The fraction which showed the highest DPP-IV inhibitory activity was then analyzed by a high-throughput nano-liquid chromatography electrospray ionization tandem mass spectrometry (nano-LC ESI-MS/MS) method, and the sequences of peptides weredoi:10.3390/molecules22101714 pmid:29027968 fatcat:logbawwnqbfzxjrfsofvqr52xm
more »... es of peptides were identified based on the MS/MS spectra against the Mollusca protein data from the UniProt database. In total, 50 peptides were identified. Furthermore, molecular docking was used to identify potential DPP-IV inhibitors from the identified peptides. Docking results suggested that four peptides: FAGDDAPR, LAPSTM, FAGDDAPRA, and FLMESH, could bind pockets of DPP-IV through hydrogen bonds, π-π bonds, and charge interactions. The four peptides were chemically synthesized and tested for DPP-IV inhibitory activity. The results showed that they possessed DPP-IV inhibitory activity with IC 50 values of 168.72 µM, 140.82 µM, 393.30 µM, and >500 µM, respectively. These results indicate that R. philippinarum-derived peptides may have potential as functional food ingredients for the prevention of diabetes.
Background Babesiosis is an emerging tick-borne zoonotic infectious disease. Babesia microti is responsible for most cases of human babesiosis globally. It is important to investigate the prevalence of B. microti in the mammalian host population of a specific region in order to elucidate mechanisms of pathogen transmission and to define geographic areas where humans face the greatest risk of exposure. The aim of this study is to understand the prevalence and genotypes of B. microti in the smalldoi:10.1186/s40249-020-00775-3 pmid:33176879 fatcat:eeycnhrawnhtzkgt53tiqvyauu
more »... icroti in the small mammals that are found in Beijing, China. Methods We trapped small mammals from all of the 16 urban, suburban, and outer suburban districts of Beijing during the years 2014, 2017 and 2018. Genomic DNA was extracted from the heart tissues individually and the Babesia 18S rRNA gene was detected by PCR. The genotypes of B. microti were identified based on sequence alignments and phylogenetic analysis. The morphology of the parasites was observed under light microscopy. The risk factors were analyzed statistically based on both univariate analyses and multivariate logistic regression. Results A total of 1391 small mammals were collected. Positive infection of B. microti was detected in 12.1% (168/1391) of small mammals from 15 out of the 16 districts. Both Kobe-type and U.S.-type B. microti, accounting for 9.5% and 2.7%, respectively, were identified. Classic diverse morphologic forms of B. microti were observed. Specific types of ecological habitats including shrub areas, broad-leaved forest, and cropland were revealed to be risk factors associated with B. microti infection. Conclusions This study demonstrated the wide prevalence of B. microti infection in eight species of small mammals in Beijing, with Kobe-type more prevalent than U.S.-type. This study provides fundamental information for the development of informed prevention and control measures by public health authorities; the data gathered indicates a need for further monitoring of both clinical diseases in individuals presenting with babesiosis-like symptoms, as well as the infection status of ticks in high risk areas.
E63, o3969 [https://doi.org/10.1107/S1600536807042055] 2,3-Bis(3-nitrophenyl)quinoxaline Peng Lei, Zhi-Zhi Hu, Cui-Ping Wang, Xing Chen and Zhi-Qiang Zhang S1. ...doi:10.1107/s1600536807042055 fatcat:ipnrythkjvd2bmc3p6tq7sbzkq
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine Jian-Zhi Wang, et al. ... J Neurosci 2007, 27: 12211-12220.  Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, et al. ...doi:10.1007/s12264-013-1415-y pmid:24627329 pmcid:PMC5562660 fatcat:msb5svszebajpdyzpbczxcdyjq
We probe the inner structure of the meson D^*_s0(2317) through the decays of B_(s) to two charmed mesons within pQCD approach. Assuming D^*_s0(2317) as a scalar meson with c̅s structure, we find that the predictions for the branching ratios of the decays B^+→ D^*+_s0(2317)D̅^(*)0, B^0→ D^*+_s0(2317)D^(*)- can explain data within errors. The branching ratios for the decays B_s→ D^*+_s0(2317)D_s^(*)+ are estimated to reach up to 10^-3 order, which can be observed by the present LHCb and SuperKEKBarXiv:2105.02688v1 fatcat:df65gu6znreznnhvw7fffs53ee
more »... LHCb and SuperKEKB experiments. In this work, the decay constant of the meson D^*_s0(2317) is an input parameter. Unfortunately, its value has been studied by many references but with large uncertainties. Our calculation shows that a smaller decay constant of the meson D^*_s0(2317) is supported by compared with the present data, say 55∼70 MeV. We also calculate the ratios R_1=Br(B^+→ D^*+_s0(2317)D̅^0)/Br(B^+→ D^*+_s0(2317)D̅^*0)) and R_2=Br(B^0→ D^*+_s0(2317)D^-)/Br(B^0→ D^*+_s0(2317)D^*-), which are valuable to determine the inner structure of D^*_s0(2317) by compared with the experimental results. Our predictions for the ratios R_1,2 are consistent with the present data within errors.We expect that these two ratios can be well measured by the future experiments through improving the measurement accuracy for the decays B^+→ D^*+_s0(2317)D̅^*0 and B^0→ D^*+_s0(2317)D^*-.
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