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Adiponectin and insulin cross talk: The microvascular connection

Lina Zhao, Zhuo Fu, Zhenqi Liu
2014 Trends in cardiovascular medicine  
., 2011a; Zhao et al., 2013) . Not surprisingly, all these factors have been shown to possess insulin sensitizing property.  ...  muscle and facilitating its own trans-endothelial transport Chai et al., 2011; Chai et al., 2014; Fu et al., 2014; Fu et al., 2013; Premilovac et al., 2013; Vincent et al., 2004; Wang et al., 2008; Zhao  ... 
doi:10.1016/j.tcm.2014.08.001 pmid:25220977 pmcid:PMC4252703 fatcat:acqwhi3rxzekdl5iplbhifbwce

Open Versus Laparoscopic Inguinal Herniotomy in Children

Shaoguang Feng, Lingling Zhao, Zhenqi Liao, Xiaoming Chen
2015 Surgical laparoscopy, endoscopy & percutaneous techniques  
Purpose: There is an ongoing debate about whether laparoscopic or open herniorrhaphy (LH or OH) is the best choice for inguinal hernia in children. The aim of this study was to compare both of the surgical strategies as regards operative time, recurrence rate, postoperative complications by means of a systematic review, and meta-analysis of the available literatures. Methods: A systematic search for randomized clinical trials comparing OH and LH was conducted. Studies were reviewed for quality,
more » ... inclusion and exclusion criteria, operative time for bilateral and unilateral hernias, recurrence, and complications. Results: Five randomized clinical trials with a total of 553 children (OH 278, LH 275) fulfilled the inclusion criteria and were analyzed in this review. Compared with OH, shorter operative time for unilateral hernias was noted in extraperitoneal approaches' group [95% confidence interval (CI), À 6.71 to À3.71; I 2 = 0%] as well as for bilateral hernias (95% CI, À 12.18 to À 3.79; I 2 = 82%). Besides, less total postoperative complications was found in LH group, especially for major postoperative complications in male children (95% CI, 0.01-0.78; I 2 = 0%). However, no significant difference was observed between LH and OH in patients' recurrence. Conclusions: This meta-analysis favors LH in the repair of bilateral hernias and for unilateral hernias in extraperitoneal approaches' group. Total postoperative complications were significantly reduced in LH, especially for major postoperative complications in male children. A B FIGURE 2. A, Forest plot comparing operative time for children treated with unilateral laparoscopic versus open inguinal herniotomy. B, Forest plot comparing operative time for the subgroups of randomized clinical trials of which extraperitoneal approaches' group versus open inguinal herniotomy in unilateral hernias. CI indicates confidence interval.
doi:10.1097/sle.0000000000000161 pmid:26018053 fatcat:z5auz44ldjb45cuxpkmxuifzsa

Abandoned land reclamation planning in coastal area in North-East of China

Shan Zhao, Zhenqi Hu, Yinli Bi, Yanling Zhao
2002 Journal American Society of Mining and Reclamation  
The damaged environment is a global problem. It is more serious in China because of the cultivable land destroyed. So the agroecosystem reconstruction is the primary object in China. A case of reclamation planning in LiaoNing Province was studied in this paper. A large number of abandoned land sites have become an urgent task for the local government since farmland is so short in this area. The land suitability and usage should be determined before the land reclaimed. Based on land-use
more » ... cal models and software MATLAB 6.0, optimum land-use structure should fit for local ecological and economic requirement. The horizontal, vertical structure and food chains of the system should be considered. Ecological engineering was used to planning as the shelter-forest, farmland and livestock farms. Irrigation work was designed to remove the salt. The forestry, fishery, poultry breeding were set up after rehabilitation. Therefore, the regional environment can get a great progress and their economy will have a sustainable development.
doi:10.21000/jasmr02010361 fatcat:kixucaqfbjcmdj3wg2uqxi4c3u

Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis

Peng Wang, Huan Zhao, Zhenqi Wang, Xuan Zhang
2018 Journal of Inflammation  
Authors' contributions Wang P mainly carried out laboratory work and data analysis; Zhao H and Wang Z identified patients with atherosclerosis and collected clinical data; Zhang X conceived of this study  ... 
doi:10.1186/s12950-018-0199-2 pmid:30479572 pmcid:PMC6240255 fatcat:pidblrrrwnfl5orvho5icedqrq

Analysis of Cultural Meme Characteristics for Big Data of Cultural Relics

Haifeng Li, Zuoqin Shi, Li Chen, Zhenqi Cui, Sumin Li, Ling Zhao
2020 Information  
The cultural meme is the smallest unit constituting a dynasty′s culture, which has the same inheritance and variability as biological genes. Here, based on the name of cultural relics, we extract cultural memes through semantic word segmentation, word frequency statistics, and the synonym merging method, and construct dynasty cultural meme vectors. We analyzed color, auxiliary, texture, shape, and overall networks of five types of model to construct the culture network, using the social network
more » ... analysis method, and explored the clustering and degrees of centrality characteristics of cultural memes. We then analyzed the similarities and differences among cultures of the dynasties. The main conclusions are as follows: (1) Cultural memes represent different cultural characteristics of dynasties, and the inheritance and differences among dynasties' cultures are closely related to their historical background. (2) Prevalence memes construct the cultural label of dynasties, which can roughly restore the cultural appearance of dynasties through fewer prevalence memes. (3) The use of community detection with a cultural meme network can determine the clustering of dynasties′ cultures, and the degree of centrality further reflects the main cultural characteristics presented by successive dynasties.
doi:10.3390/info11120584 fatcat:sq6bftvs5nftjjmwqjebiuj4qe


Yujmg JIANG, Xiaodong ZHAO, Zhenqi SONG
2003 Macro Review  
The development harmonizing with environment is being paid more and more importance with the increase concerning the environmental problems in China. The current state of coal mining and its impacts on geo-environment is reviewed, especially for the subsidence due to underground mining and the corresponding countermeasures against them in a view of geo-environment. Also, the new technology of GIS used in the prediction and environmental assessment is discussed
doi:10.11286/jmr1988.16.489 fatcat:xpipx3d24zaxbotnbzb7vdqq5m

Contour Detection for Fibre of Preserved Szechuan Pickle Based on Dilated Convolution

Hongyang Li, Lizhuang Liu, Zhenqi Han, Dan Zhao
2019 Applied Sciences  
Peeling fibre is an indispensable process in the production of preserved Szechuan pickle, the accuracy of which can significantly influence the quality of the products, and thus the contour method of fibre detection, as a core algorithm of the automatic peeling device, is studied. The fibre contour is a kind of non-salient contour, characterized by big intra-class differences and small inter-class differences, meaning that the feature of the contour is not discriminative. The method called
more » ... ed-holistically-nested edge detection (Dilated-HED) is proposed to detect the fibre contour, which is built based on the HED network and dilated convolution. The experimental results for our dataset show that the Pixel Accuracy (PA) is 99.52% and the Mean Intersection over Union (MIoU) is 49.99%, achieving state-of-the-art performance.
doi:10.3390/app9132684 fatcat:btwc6hw2brandfav3w7m4efbue


Zhenqi Hu, Shili Chu, Shan Zhao, J.R. Zhang, Z.J. Zhao
2004 Journal American Society of Mining and Reclamation  
Reclaimed land usually has some problems such as poor soil structure and nutrients shortage. The man-made improvement treatments could accelerate soil development of reclaimed soil and increase soil productivity. This study was conducted to determine the effectiveness of soil improvement with fly ash and organic fertilizer for reclaimed subsided land. A 0.23 ha of experimental site was chosen in Jiawang coal mining area, Jiangsu province, and 6 treatments were used in the design with 3 types of
more » ... materials such as 1% fly ash, 5% fly ash and poultry litter. The results showed that the application of fly ash could improve the reclaimed soil, but the amount of the fly ash should be more than 1%. The treatment of 1% fly ash had the lowest yield of soybeans, even lower that of the reference plot. As fly ash has fewer nutrients, some organic fertilizers are needed for higher yield. The treatment with 5% fly ash with poultry litter had the highest yield of soybeans. All the treatments of soil amendments were lower or equal to the concentrations of metal elements found for the control plot. The addition of organic fertilizer (D, E, F treatments) resulted significant decreases in the concentrations of Zn and Cu in the soybeans while the addition of 5% fly ash had only a slight decrease of the concentration of Zn and Cu in the beans. The pH and available nutrient contents of soils after harvest of the soybean were not affected by the application of fly ash.
doi:10.21000/jasmr04010948 fatcat:uarko7cyfbb3rciphrbkwe2o3q

Molecular Mechanism of Thiazolidinedione-Mediated Inhibitory Effects on Osteoclastogenesis

Dongfeng Zhao, Zhenqi Shi, Amy H. Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng, Jean-Marc Vanacker
2014 PLoS ONE  
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor c agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the mechanism by which thiazolidinediones augment fracture risks is not fully understood. Several groups recently demonstrated that thiazolidinediones stimulate osteoclast formation, thus proposing that thiazolidinediones induce bone loss in part by
more » ... ting osteoclastogenesis. However, numerous other studies showed that thiazolidinediones inhibit osteoclast formation. Moreover, the molecular mechanism by which thiazolidinediones modulate osteoclastogenesis is not fully understood. Here we independently address the role of thiazolidinediones in osteoclastogenesis in vitro and furthermore investigate the molecular mechanism underlying the in vitro effects of thiazolidinediones on osteoclastogenesis. Our in vitro data indicate that thiazolidinediones dose-dependently inhibit osteoclastogenesis from bone marrow macrophages, but the inhibitory effect is considerably reduced when bone marrow macrophages are pretreated with RANKL. In vitro mechanistic studies reveal that thiazolidinediones inhibit osteoclastogenesis not by impairing RANKLinduced activation of the NF-kB, JNK, p38 and ERK pathways in bone marrow macrophages. Nonetheless, thiazolidinediones inhibit osteoclastogenesis by suppressing RANKL-induced expression of NFATc1 and c-Fos, two key transcriptional regulators of osteoclastogenesis, in bone marrow macrophages. In addition, thiazolidinediones inhibit the RANKL-induced expression of osteoclast genes encoding matrix metalloproteinase 9, cathepsin K, tartrate-resistant acid phosphatase and carbonic anhydrase II in bone marrow macrophages. However, the ability of thiazolidinediones to inhibit the expression of NFATc1, c-Fos and the four osteoclast genes is notably weakened in RANKL-pretreated bone marrow macrophages. These in vitro studies have not only independently demonstrated that thiazolidinediones exert inhibitory effects on osteoclastogenesis but have also revealed crucial new insights into the molecular mechanism by which thiazolidinediones inhibit osteoclastogenesis.
doi:10.1371/journal.pone.0102706 pmid:25032991 pmcid:PMC4102552 fatcat:5unp6rawzffmzhrlhfmt4amxea

Biochemical characterization of selenium-containing catalytic antibody as a cytosolic glutathione peroxidase mimic

Lan DING, Zi LIU, Zhenqi ZHU, Guimin LUO, Daqing ZHAO, Jiazuan NI
1998 Biochemical Journal  
A selenium-containing catalytic antibody (Se-4A4), prepared by converting reactive serine residues of a monoclonal antibody (4A4) raised against a GSH derivative into selenocysteines, acts as a mimic of cytosolic glutathione peroxidase (cGPX). To clarify the mechanism of action of this catalytic antibody, detailed studies on kinetic behaviour and biological activity were carried out. A rate of acceleration (k cat \K m \k uncat ) 10(-fold that of the uncatalytic reaction is observed. Under
more » ... r conditions, the turnover number (k cat ) of Se-4A4 is 42 % of that of the natural
doi:10.1042/bj3320251 pmid:9576875 pmcid:PMC1219475 fatcat:ibplm7zqove7hhu4pg4rystzma

Recent Advance in Biological Responsive Nanomaterials for Biosensing and Molecular Imaging Application

Zhenqi Jiang, Xiao Han, Chen Zhao, Shanshan Wang, Xiaoying Tang
2022 International Journal of Molecular Sciences  
In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many of the demands for physiologically responsive nanomaterials in applications involving the human body cannot be met by conventional technologies. Due to the field's importance, considerable effort has been expended, and biologically responsive nanomaterials have achieved remarkable success thus far. This review summarizes the recent advancements in
more » ... responsive nanomaterials and their applications in biosensing and molecular imaging. The nanomaterials change their structure or increase the chemical reaction ratio in response to specific bio-relevant stimuli (such as pH, redox potentials, enzyme kinds, and concentrations) in order to improve the signal for biologically responsive diagnosis. We use various case studies to illustrate the existing issues and provide a clear sense of direction in this area. Furthermore, the limitations and prospects of these nanomaterials for diagnosis are also discussed.
doi:10.3390/ijms23031923 pmid:35163845 pmcid:PMC8837089 fatcat:if3bczjx3bhnxeat2pthgdg2lq

A review of UAV monitoring in mining areas: current status and future perspectives

He Ren, Yanling Zhao, Wu Xiao, Zhenqi Hu
2019 International Journal of Coal Science & Technology  
With the emergence and development of unmanned aerial vehicles (UAVs), different sensors have become more miniaturized and intelligent. UAVs equipped with various sensors are now an important approach for acquiring spatial data. Many advantages, such as low cost, short revisiting cycle, flexibility and high precision, have made UAVs powerful tools in geological, agricultural, ecological and forestry growth monitoring, as well as evaluation. Now, UAVs are a hotspot in scientific research. Their
more » ... pplication in mining areas (MA), although still in its infancy, is developing rapidly in terms of speed, scale and service scope. This research examines aspects such as UAV platforms, different sensors and their application fields, as well as reviewing the advances of scientific research in MA at the present time. By combining current research and the functions of multiple sensors, an application framework for UAV monitoring in MA is constructed. Finally, the challenge and prospects for the development of UAVs and sensors are also considered. This research hopes to provide a technical reference, expanding the knowledge and recognition of UAV monitoring in MA, as well as an assessment of applications in mining, reclamation and environment.
doi:10.1007/s40789-019-00264-5 fatcat:kacstkahgrgotkgssdhtox3n3y

Genetic Ablation of CD68 Results in Mice with Increased Bone and Dysfunctional Osteoclasts

Jason W. Ashley, Zhenqi Shi, Haibo Zhao, Xingsheng Li, Robert A. Kesterson, Xu Feng, Paul McNeil
2011 PLoS ONE  
CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage. This lineage restriction includes osteoclasts, and, while previous studies of CD68 in macrophages and dendritic cells have proposed roles in lipid metabolism, phagocytosis, and antigen presentation, the expression and function of CD68 in osteoclasts have not been explored. In this study, we investigated the expression and localization of
more » ... 8 in macrophages and osteoclasts in response to the monocyte/macrophage-colony stimulating factor (M-CSF) and the receptor activator of NF-kB ligand (RANKL). We found that M-CSF stimulates CD68 expression and RANKL alters the apparent molecular weight of CD68 as measured by Western immunoblotting. In addition, we explored the significance of CD68 expression in osteoclasts by generating mice that lack expression of CD68. These mice have increased trabecular bone, and in vitro assessment of CD68 2/2 osteoclasts revealed that, in the absence of CD68, osteoclasts demonstrate an accumulation of intracellular vesicle-like structures, and do not efficiently resorb bone. These findings demonstrate a role for CD68 in the function of osteoclasts, and future studies will determine the mechanistic nature of the defects seen in CD68 2/2 osteoclasts.
doi:10.1371/journal.pone.0025838 pmid:21991369 pmcid:PMC3185056 fatcat:gr6meu3kbzahrjpzu2ct57thmm

The Compared Study of Competitiveness of Electron Industry Clusters: Case of Wuhan, Shanghai and Guangzhou

Chunyan Zhao, Xin Liu, Zhenqi Zhang
2016 DEStech Transactions on Computer Science and Engineering  
Chunyan Zhao, Xin Liu, Zhenqi Zhang 2 THE CURRENT SITUATION OF ELECTRON INDUSTRIAL CLUSTERS IN WUHAN, SHANGHAI, GUANGZHOU 2.1 The development overview of electron industrial clusters in Wuhan, Shanghai  ... 
doi:10.12783/dtcse/icte2016/4823 fatcat:piidzcaxpffnbehd7dzd6fhb7m

Up-regulation of LncRNA UCA1 by TGF-β promotes doxorubicin resistance in breast cancer cells

Like Wo, Bei Zhang, Xiongbin You, Yuanyuan Hu, Zhenqi Gu, Mengning Zhang, Qi Wang, Zhengyi Lv, Hong Zhao
Doxorubicin (DOX) resistance remains a major challenge for adriamycin-based treatment of breast cancer (BC). Transforming growth factor β (TGF-β) has been reported to contribute to drug resistance. Although the role of long noncoding RNAs (LncRNAs) in cancer progression has been widely studied, its effect on TGF-β-induced resistance remains limited. This study aimed to investigate the role of LncRNA on the regulation of TGF-β-induced drug resistance. Cell counting kit-8 (CCK-8) and an EdU assay
more » ... were used to evaluate cell viability and proliferation. The level of LncRNA mRNA expression in BC tissues and cells was examined by quantitative real-time PCR. Changes in epithelial-mesenchymal transition (EMT) and cell apoptosis were quantified by Western blot and immunofluorescence. TGF-β induced EMT and promoted DOX resistance. LncRNA urothelial carcinoma-associated 1(lncRNA UCA1) associated with TGF-β was upregulated in BC cells and tissues. LncRNA UCA1 silencing enhanced sensitivity to DOX decreased cellular proliferation and increased apoptosis in BC cells. The effect of TGF-β on EMT and DOX resistance disappeared following a lncRNA UCA1 knockdown. These findings suggest that lncRNA-UCA1, a mediator of TGF-β signaling, could predispose BC patients to EMT and DOX resistance.
doi:10.6084/m9.figshare.19419243.v1 fatcat:4e3sdy3bmrcv5khc4a6dlaliji
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