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Introduction In our previous work we have developed a linked polymer solution (LPS), which is used for in-depth profile control of oil-bearing reservoirs with water flooding Li et al, 2000; Lin et al, ...doi:10.1007/s12182-009-0047-3 fatcat:kfpayie545chdaythevagksqgu
The aim of this study was to retrospectively evaluate the effectiveness of intravesical electrical stimulation (IVES) on detrusor underactivity (DU). From 2009 to 2016, a total of 105 patients with symptoms of DU who were treated with IVES were included in this retrospective study. The medical records, physical examination findings, urine culture results, and video-urodynamic studies were reviewed. Changes in post-void residual urine (PVR) and voiding efficiency (VE) were included fordoi:10.1097/md.0000000000008020 pmid:28930838 pmcid:PMC5617705 fatcat:azy4oob7i5avjoki6aznucvnfq
more »... of efficacy. Patients achieving a >50% reduction in the PVR were regarded as responders. A >80% reduction in the PVR was considered obvious improvement. A questionnaire was administered to patients with bladder sensation. Of the 105 patients, the information of residual urine volume and voiding volume was obtained in 89 patients, and detailed pre-and post-IVES bladder sensation information was available on 96 patients. Of the 89 patients, 47.2% (42/89) were responders and achieved a >50% reduction in the PVR. Obvious improvement in the PVR, defined as a >80% reduction, occurred in 27% (24/89) of the patients. VE developed in 76.4% (68/89) of the patients, and 30.3% (27/89) of the patients increased >50%. Significant improvements in the PVR and VE were observed during IVES treatment (P < .05). Based on the questionnaire, bladder sensation developed and was sustained in 44.8% (43/96) of the patients. IVES provides a promising method for improving the PVR and VE in a majority of patients with DU. Thus, IVES is worth to further study and carry out. Abbreviations: AIS = American Impairment Scale, ASIA = American Spinal Injury Association, CIC = clean intermittent catheterization, DU = detrusor underactivity, IVES = intravesical electrical stimulation, PVR = post-void residual urine, SCI = spinal cord injury, UTI = urinary tract infection, VE = voiding efficiency.
Journal of Software
Metadata distribution is important in mass storage system. Sub-tree partition and hash are two traditional metadata distribution algorithms used in file system. But they both have a defect in system scalability. This paper presents a new metadata management method, Directory Path Code Hash ("DPCH"). This method is to store directory and file metadata separately, and effectively solving the unbalanced metadata distribution and access hot point problems in Sub-tree partition and the excessivedoi:10.4304/jsw.9.9.2443-2453 fatcat:lkzua2h3zjhc7ldpp6nzjdh55q
more »... ing times and large metadata migration amount after directory property modification in hash algorithm. The experiment indicates that this method proposed significantly outweighs other algorithms in terms of throughput rate, metadata distribution, reading times, etc. Index Terms-metadata distribution, binary code, file system, directory path code hash(DPCH) Hui Cai, born in 1983, Ph. D. His research orientations are cloud and P2P computing.
To investigate and compare the anterior segment biometrics in high myopia and control groups. Methods: Thirty-four eyes of 34 high myopia patients and 42 eyes of 42 control subjects were included. The Schlemm's canal (SC) area, trabecular meshwork (TM) thickness and length, scleral spur (SS) length and anterior scleral thickness (AST) were measured using swept-source optical coherence tomography. Associations between SC area, TM thickness, TM length, SS length and AST were also estimated.doi:10.1159/000526280 pmid:35926453 fatcat:fduwsgjzw5bjxffq65lox3zxhu
more »... s: SC area, TM thickness and SS length were significantly associated with AST0 (AST at 0mm from SS) in both high myopia and control groups. AST0 (702.61±78.05 vs. 729.12±95.87 μm, p=0.085) and SS length (206.25±52.25 vs. 212.09±51.86 μm, p=0.556) were not significantly different between high myopia and control groups, whereas SC area (6622.68±1130.06 vs. 6105.85±1297.84 μm2, p=0.015) was significantly greater and TM thickness (96.15±34.40 vs. 107.93±29.97 μm, p=0.048) was significantly thinner in high myopia group than in control group. Conclusion: SC area and TM thickness were significantly associated with AST0, while AST0 and SS length were not significantly different between high myopia and control groups. The changes in SC and TM dimensions in high myopia eyes might be caused by factors other than AST0 and SS length.
Recent evidence suggests that complex traits are likely determined by multiple loci, each of which contributes a weak to moderate individual effect. Although extensive literature exists on multilocus analysis of unrelated subjects, there are relatively fewer strategies for jointly analyzing multiple loci using family data. Here we address this issue by evaluating two pseudosibship methods: the 1:1 matching, which matches each affected offspring to the pseudosibling formed by the alleles notdoi:10.1002/sim.4397 pmid:21953439 pmcid:PMC3882162 fatcat:wx7afubsvrakdoouszhbobvn6q
more »... smitted to the affected offspring, and the exhaustive matching, which matches each affected offspring to the pseudosiblings formed by all the other possible combinations of parental alleles. We prove that the two matching strategies use exactly and approximately the same amount of information from data under additive and multiplicative genetic models, respectively. Using numerical calculations under a variety of models and testing assumptions, we show that compared with the exhaustive matching, the 1:1 matching has comparable asymptotic power in detecting multiplicative/additive effects in single-locus analysis and main effects in multilocus analysis, and it allows association testing of multiple linked loci. These results pave the way for many existing multilocus analysis methods developed for the case-control (or matched case-control) design to be applied to case-parents data with minor modifications. As an example, with the 1:1 matching, we applied an L 1 regularized regression to a Crohn's disease dataset. Using the multiple loci selected in our approach, we obtained an order-of-magnitude decrease in p-value and an 18.9% increase in prediction accuracy when compared with using the most significant individual locus. Figure 1. One (a) versus three (b) pseudosiblings for the affected offspring with AA genotype, Aa father, and Aa mother. The filled circles represent the genotypes of the affected offspring, and the dotted diamonds represent the genotypes of the pseudosiblings. Figure 4. The power of the HWE test for the 1:3 matching (solid line) and the 1:1 matching (dashed line) when the true genetic models are multiplicative, additive, dominant, and recessive, respectively.
Protein & Cell
One of the most widespread cellular organelles in nature is cilium, which is found in many unicellular and multicellular organisms. Formerly thought to be a mostly vestigial organelle, the cilium has been discovered in the past several decades to play critical motile and sensory roles involved in normal organogenesis during development. The role of cilia has also been implicated in an ever increasing array of seemingly unrelated human diseases, including blindness, kidney cysts, neural tubedoi:10.1007/s13238-010-0098-7 pmid:21203914 pmcid:PMC4875200 fatcat:zyvlizv7qfegnonf4ks6dzly3m
more »... cts and obesity. In this article we review some of the recent developments in research on cilia, and how defects in ciliogenesis and function can give rise to developmental disorders and disease.
Deep learning is getting more and more outstanding performance in many tasks such as autonomous driving and face recognition and also has been challenged by different kinds of attacks. Adding perturbations that are imperceptible to human vision in an image can mislead the neural network model to get wrong results with high confidence. Adversarial Examples are images that have been added with specific noise to mislead a deep neural network model However, adding noise to images destroys thearXiv:2110.02700v2 fatcat:d2qqczbydncznmckznxexkg2u4
more »... al data, making the examples useless in digital forensics and other fields. To prevent illegal or unauthorized access of image data such as human faces and ensure no affection to legal use reversible adversarial attack technique is rise. The original image can be recovered from its reversible adversarial example. However, the existing reversible adversarial examples generation strategies are all designed for the traditional imperceptible adversarial perturbation. How to get reversibility for locally visible adversarial perturbation? In this paper, we propose a new method for generating reversible adversarial examples based on local visual adversarial perturbation. The information needed for image recovery is embedded into the area beyond the adversarial patch by reversible data hiding technique. To reduce image distortion and improve visual quality, lossless compression and B-R-G embedding principle are adopted. Experiments on ImageNet dataset show that our method can restore the original images error-free while ensuring the attack performance.
Lecture Notes in Computer Science
In noise removal by the approach of regularization, the regularization parameter is global. Constructing the variational model min ,g is in some wavelets space. Through the wavelets pyramidal decompose and the different time-frequency properties between noise and signal, the regularization parameter is adaptively chosen, the different parameter is chosen in different level for adaptively noise removal.doi:10.1007/3-540-45333-4_52 fatcat:nq7j6oxpmfgtbayho42zpkqwgu
Acknowledgments: We thank Xuewen Li (Yangtze University) for her assistance in generating antibodies. Conflicts of Interest: The authors declare no conflict of interest in this work. ... After incubation with primary and secondary antibodies, the membranes were visualized by an Odyssey 2-color infrared fluorescence imaging system (LI-COR, Lincoln, NE, USA). ... antibodies used in Western blotting and IFA were for anti-mouse IgG (H+L) DyLight™ 800-Labeled (042-07-18-06) from Sera Care (Milford, MA, USA), IRDye ® 800CW goat anti-rabbit IgG (H+L) (925-32211) from LI-COR ...doi:10.3390/v13112240 pmid:34835046 pmcid:PMC8617669 fatcat:negs54neufcfrpxsjhqnqdv6xa
Maize kernels are the harvested portion of the plant and are related to the yield and quality of maize. The endosperm of maize is a large storage organ that constitutes 80–90% of the dry weight of mature kernels. Maize kernels have long been the study of cereal grain development to increase yield. In this study, a natural mutation that causes abnormal kernel development, and displays a shrunken kernel phenotype, was identified and named "shrunken 2008 (sh2008)". The starch grains in sh2008 aredoi:10.3390/ijms222212137 pmid:34830019 pmcid:PMC8624104 fatcat:ktnhx4i54vfcnasdznibwi5kem
more »... oose and have a less proteinaceous matrix surrounding them. The total storage protein and the major storage protein zeins are ~70% of that in the wild-type control (WT); in particular, the 19 kDa and 22 kDa α-zeins. Map-based cloning revealed that sh2008 encodes a GT-2 trihelix transcription factor, ZmThx20. Using CRISPR/Cas9, two other alleles with mutated ZmThx20 were found to have the same abnormal kernel. Shrunken kernels can be rescued by overexpressing normal ZmThx20. Comparative transcriptome analysis of the kernels from sh2008 and WT showed that the GO terms of translation, ribosome, and nutrient reservoir activity were enriched in the down-regulated genes (sh2008/WT). In short, these changes can lead to defects in endosperm development and storage reserve filling in seeds.
In addition, Li et al.  reported that circ_0002483 overexpression can enhance Taxol sensitivity in non-small cell lung cancer (NSCLC). ...doi:10.1186/s12943-020-01240-3 pmid:32799866 fatcat:75ddeio77jcuhjdbjottiurhmy
Engineered nanomaterials (ENMs) continue to attract significant attentions because they have novel physicochemical properties that can improve the functions of products that will benefit human lives. However, the physicochemical properties that make ENMs attractive could interact with biological systems and induce cascades of events that cause toxicological effects. Recently, there are more studies suggesting inflammasome activation may play an important role in ENMsinduced biologicaldoi:10.1002/smll.201201962 pmid:23180683 pmcid:PMC4056676 fatcat:uhc7byzzbzhojjaxfkkrg6e6de
more »... Inflammasomes are a family of multi-protein complexes and are increasingly recognized as major mediators of host immune system. Among these, NLRP3 inflammasome is the most studied one that could directly interact with ENMs to generate inflammatory responses. In this review, we aim to link the ENM physicochemical properties to NLRP3 inflammasome activation. The understanding of the mechanisms of ENMs-NLRP3 inflammasome interaction will provide us strategies for safer nanomaterial design and therapy.
Li  produced an adjustable pitch columnar array of silicon plates to study the impact of water droplets on silicon plates with regular roughness from an energetic perspective. e slurry droplet collision ...doi:10.1155/2018/7401358 fatcat:2b6tprwz3vh5lefr2pgxqphl6y
The surgical procedures have been described in previous studies (Li et al., 2015; Zhai et al., 2018) . ...doi:10.3389/fnins.2020.585604 pmid:33328856 pmcid:PMC7710898 fatcat:locc5iyizvc2fnvcot5evu4ega
Ma et al. MRI Atrophy Computing for AD the discrimination accuracy between AD and NC, MCI and NC, AD and MCI was 92.7, 91.7, and 78.4%, respectively. For three-way prediction, the accuracy was 74.6%. Furthermore, the proposed two indicators could also identify the atrophy rate differences among the three groups in longitudinal analysis. The proposed method could serve as an automatic and time-sparing approach for early diagnosis and tracking the progression of AD.doi:10.3389/fnagi.2016.00243 pmid:27803665 pmcid:PMC5067377 fatcat:7g3wz4sqozgtrimkdcfkdfwcny
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