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Integrating Semantic Knowledge to Tackle Zero-shot Text Classification [article]

Jingqing Zhang, Piyawat Lertvittayakumjorn, Yike Guo
2019 arXiv   pre-print
Jingqing and Piyawat would also like to thank the support from the LexisNexis R Risk Solutions HPCC Systems R academic program and Anandamahidol Foundation, respectively.  ...  ., 2017; Kobayashi, 2018) , and the algorithms were designed to preserve semantic meaning of an original document by using synonyms (Zhang and Le-Cun, 2015) or adding noises (Xie et al., 2017) , for  ... 
arXiv:1903.12626v1 fatcat:xkb222r4hrbn5csx7hsdpsgipa

Thinking about translational medicine and traditional Chinese medicine

Boli Zhang, Junhua Zhang, Jingqing Hu
2012 Journal of Translational Medicine  
Published: 17 October 2012 doi:10.1186/1479-5876-10-S2-A33 Cite this article as: Zhang et al.: Thinking about translational medicine and traditional Chinese medicine.  ...  publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit © 2012 Zhang  ... 
doi:10.1186/1479-5876-10-s2-a33 pmcid:PMC3479998 fatcat:fyfze7va5vbednvcaguye2e62m

Integrated Multi-omics Analysis Using Variational Autoencoders: Application to Pan-cancer Classification [article]

Xiaoyu Zhang, Jingqing Zhang, Kai Sun, Xian Yang, Chengliang Dai, Yike Guo
2019 arXiv   pre-print
Ma and Zhang [8] proposed an end-to-end multi-omics model using factorization autoencoder to predict disease progressionfree interval events with an average precision of 0.664 for bladder tumour dataset  ... 
arXiv:1908.06278v1 fatcat:pnpia4oppbdtnezq5bxfqe7gme

Unsupervised Annotation of Phenotypic Abnormalities via Semantic Latent Representations on Electronic Health Records [article]

Jingqing Zhang, Xiaoyu Zhang, Kai Sun, Xian Yang, Chengliang Dai, Yike Guo
2019 arXiv   pre-print
ACKNOWLEDGMENT Jingqing Zhang would like to thank the support from the LexisNexis ® Risk Solutions HPCC Systems ® academic program and Pangaea Data.  ... 
arXiv:1911.03862v1 fatcat:iodfacmsrrb2dljctxh3jbalju

Efficient intracellular delivery makes cancer cells sensitive to nanoemulsive chemodrugs

Shan Liu, Dilong Chen, Yuming Yuan, Xue Zhang, Yao Li, Shenglei Yan, Jingqing Zhang
2017 OncoTarget  
Evodiamine has been documented to possess activities in numerous cancer cells. Our preliminary study showed that A549 cells were insensitive to evodiamine. In this paper, A549 cells are sensitive to nanoemulsive evodiamine (EVONE) through an efficient intracellular and systematic delivery. EVONE entered tumor cells by energy-dependent and mainly through clathrin-mediated endocytosis. EVONE exerted a higher cytotoxicity in a dose-and time-dependent manner. The enhanced induction of cell cycle
more » ... est was ascribed to the down-regulation of cyclin B and cyclin dependent kinase 1, while the enhanced induction of apoptosis was due to the activation of caspase −3, −8 and −9 and the decreased B-cell lymphoma 2/ assaciated X protein ratio. Furthermore, the in vivo kinetic, bioavailability and in situ absorption characteristics of EVONE were much better than those of free evodiamine. The cancer cells insensitive to free chemodrugs became sensitive to nanoemulsive chemodrugs.
doi:10.18632/oncotarget.17536 pmid:29029410 pmcid:PMC5630310 fatcat:7e4xsxhkuza4nhn74lb5zofzvq

Acute psychological stress impairs attention disengagement toward threat-related stimuli

Yu LUO, Jingqing NIAN, Wei BAO, Jingjing ZHANG, Shouying ZHAO, Yun PAN, Shuang XU, Yu ZHANG
2020 Acta Psychologica Sinica  
doi:10.3724/sp.j.1041.2020.00026 fatcat:3x6qxkelljditnnzacejbcvzce

Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles

Liangke Zhang, Jie Lou, Wenjing Hu, Rui Tian, Hua Zhang, Yuntao Jia, Jingqing Zhang
2014 International Journal of Nanomedicine  
doi:10.2147/ijn.s60270 pmid:24904211 pmcid:PMC4039420 fatcat:gjcjnuiwsbf63lkfsxufapuyre

Reverse Circulation Drilling Method Based on a Supersonic Nozzle for Dust Control

Dongyu Wu, Kun Yin, Qilei Yin, Xinxin Zhang, Jingqing Cheng, Dong Ge, Pengfei Zhang
2016 Applied Sciences  
Dongyu Wu and Xinxin Zhang performed the numerical simulations. Dongyu Wu, Jingqing Cheng, Dong Ge and Pengfei Zhang conducted the experiments. Dongyu Wu wrote the paper.  ... 
doi:10.3390/app7010005 fatcat:5wq2glw7lzcehoxinhvggubllu

Unsupervised Numerical Reasoning to Extract Phenotypes from Clinical Text by Leveraging External Knowledge [article]

Ashwani Tanwar, Jingqing Zhang, Julia Ive, Vibhor Gupta, Yike Guo
2022 arXiv   pre-print
Extracting phenotypes from clinical text has been shown to be useful for a variety of clinical use cases such as identifying patients with rare diseases. However, reasoning with numerical values remains challenging for phenotyping in clinical text, for example, temperature 102F representing Fever. Current state-of-the-art phenotyping models are able to detect general phenotypes, but perform poorly when they detect phenotypes requiring numerical reasoning. We present a novel unsupervised
more » ... ogy leveraging external knowledge and contextualized word embeddings from ClinicalBERT for numerical reasoning in a variety of phenotypic contexts. Comparing against unsupervised benchmarks, it shows a substantial performance improvement with absolute gains on generalized Recall and F1 scores up to 79% and 71%, respectively. In the supervised setting, it also surpasses the performance of alternative approaches with absolute gains on generalized Recall and F1 scores up to 70% and 44%, respectively.
arXiv:2204.10202v1 fatcat:czpgpdhbmvdonksbqk7jygbary

The changing epidemiology of asthma in Shanghai, China

Fengying Zhang, Jingqing Hang, Buyong Zheng, Li Su, David C. Christiani
2014 Journal of Asthma  
Table 4 Mean age and asthma duration by FEV1 Figure 1 . 1 Zhang Table 1 1 Demographic characteristics of the population Variable Results Number 27042 Gender (%) Male 46.3 Female 53.7  ...  Asthma prevalence at different ages by gender Zhang  ... 
doi:10.3109/02770903.2014.982762 pmid:25387151 pmcid:PMC4667773 fatcat:fj3hr5s7fzg6tnp6llzelmb27a

GCS: Graph-based Coordination Strategy for Multi-Agent Reinforcement Learning [article]

Jingqing Ruan, Yali Du, Xuantang Xiong, Dengpeng Xing, Xiyun Li, Linghui Meng, Haifeng Zhang, Jun Wang, Bo Xu
2022 arXiv   pre-print
Many real-world scenarios involve a team of agents that have to coordinate their policies to achieve a shared goal. Previous studies mainly focus on decentralized control to maximize a common reward and barely consider the coordination among control policies, which is critical in dynamic and complicated environments. In this work, we propose factorizing the joint team policy into a graph generator and graph-based coordinated policy to enable coordinated behaviours among agents. The graph
more » ... or adopts an encoder-decoder framework that outputs directed acyclic graphs (DAGs) to capture the underlying dynamic decision structure. We also apply the DAGness-constrained and DAG depth-constrained optimization in the graph generator to balance efficiency and performance. The graph-based coordinated policy exploits the generated decision structure. The graph generator and coordinated policy are trained simultaneously to maximize the discounted return. Empirical evaluations on Collaborative Gaussian Squeeze, Cooperative Navigation, and Google Research Football demonstrate the superiority of the proposed method.
arXiv:2201.06257v1 fatcat:tbj2otiuxjdtldedpoj67a3g3a

Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes

Yunli Zhou, Mi Zhang, Dan He, Xueyuan Hu, Huarong Xiong, Jianyong Wu, Biyue Zhu, Jingqing Zhang
2016 Scientific Reports  
Enzyme therapy is an effective strategy to treat diseases. Three strategies were pursued to provide the favorable microenvironments for uricase (UCU) to eventually improve its features: using the right type of buffer to constitute the liquid media where catalyze reactions take place; entrapping UCU inside the selectively permeable lipid vesicle membranes; and entrapping catalase together with UCU inside the membranes. The nanosized alkaline enzymosomes containing UCU/(UCU and catalase)
more » ... ) in bicine buffer had better thermal, hypothermal, acid-base and proteolytic stabilities, in vitro and in vivo kinetic characteristics, and uric acid lowering effects. The favorable microenvironments were conducive to the establishment of the enzymosomes with superior properties. It was the first time that two therapeutic enzymes were simultaneously entrapped into one enzymosome having the right type of buffer to achieve added treatment efficacy. The development of ESU/ESUC in bicine buffer provides valuable tactics in hypouricemic therapy and enzymosomal application. An enzyme therapy 1-4 such as uricase (UCU) application represents an alternative strategy which is more effective than the traditional chemotherapy. The incidences of hyperuricaemia and its related diseases have been growing fast worldwide 5,6 . The commonly used allopurinol and febuxostat are ineffective dissolving existing uric acid crystals, and their long-term use may disturb the purine metabolism 7 . UCU is effective at dissolving existing uric acid by converting uric acid into more soluble allantoin. UCU has been used in the clinical detection of uric acid and treatment of hyperuricemia for over 40 years 8, 9 . It has also been used for the prevention and treatment of tumor lysis syndrome 10 . Recently, a Phase I study of UCU in the reduction of acute graft-versus-host disease after myeloablative allogeneic stem cell transplantation has been conducted 11 . However, more extensive use of UCU has been hampered by its disadvantages ascribed to the intrinsic properties of an enzyme, such as relatively low catalytic activity and therapeutic effect under physical conditions. Therefore, there is an urgent need to develop superior UCU delivery systems with enhanced stabilities and catalytic activities when administered in vivo. A few efforts have been made to make UCU better: developing new UCU or recombinant UCU with higher activity using the mutation method 12,13 ; immobilizing in polymer polypyrrole-polyvinyl sulphonate film to obtain new biosensors 14 ; conjugating with polymer polyethylene glycol to achieve sustained effects and improve enzymatic stabilities 15 ; and encapsulating in alkaline enzymosomes (i.e., nanosized liposomes containing enzyemes) to enhance biochemical and pharmacological characteristics 16,17 . Particularly, a recent report from our laboratory showed that the enzymosome containing UCU (ESU) has the potential to unexpectedly improve the stability and therapeutic efficacy of UCU 18 . Here, we design and develop the novel nanosized delivery systems, alkaline enzymosomes containing UCU and catalase (CAT) (ESUC), which have better stabilities and anti-hyperuricemia effects than above-mentioned
doi:10.1038/srep20136 pmid:26823332 pmcid:PMC4731772 fatcat:u45f33q465hq7gai65so5g6maa

Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report

Shuwen Zhong, Jingqing Zeng, Zhaohui Deng, Lirong Jiang, Bin Zhang, Kaihua Yang, Wenyu Wang, Tianao Zhang
2019 Italian Journal of Pediatrics  
Bin Zhang, Dr. Jingqing Zeng and Dr. Lirong Jiang: drafting the article. Dr. Shuwen Zhong, Dr. Kaihua Yang, Dr. Wenyu Wang and Dr. Tianao Zhang: revising the article.  ... 
doi:10.1186/s13052-019-0708-9 pmid:31462301 pmcid:PMC6714385 fatcat:snksyvm25vgknfisyhhsv3xfl4

Catan-ionic hybrid lipidic nano-carriers for enhanced bioavailability and anti-tumor efficacy of chemodrugs

Bilin Liu, Dan He, Jianyong Wu, Quan Sun, Mi Zhang, Qunyou Tan, Yao Li, Jingqing Zhang
2017 OncoTarget  
To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catanionic hybrid lipidic nano-carriers containing curcumin (CUR-C-HLN) inherit the merits of catan-ionic systems, hybrid lipidic systems and nano-structured carriers (the second-generation substitute of solid lipidic nano-systems). Catan-ionic surfactants increased microvesicle stabilization by producing unordered isometric clusters,
more » ... ced absorptive amount as an inhibitor of enzyme and protein, improved tumor accumulation by cellular endocytosis and membranous fusion; hybrid lipids helped to obtain high drug content and low leakage by forming a less-organized matrix arrangement. CUR-C-HLN favorably changed absorptive and pharmacokinetic properties after oral and/or intravenous administrations; improved cell growth inhibition, apoptotic inducing and anti-invasion effects; enhanced antitumor efficiency and reduced cancerous growth. Catan-ionic hybrid lipidic nano-carriers provide an alternative good choice for effective delivery of anticancerous chemodrugs.
doi:10.18632/oncotarget.15942 pmid:28427235 pmcid:PMC5458178 fatcat:tns4smzwg5hjppt22y3ouezfje

Nanosized sustained-release pyridostigmine bromide microcapsules: process optimization and evaluation of characteristics

Jingqing Zhang, Tan, Jiang, Xu, Li, Liu
2013 International Journal of Nanomedicine  
Pyridostigmine bromide (3-[[(dimethylamino)-carbonyl]oxy]-1-methylpyridinium bromide), a reversible inhibitor of cholinesterase, is given orally in tablet form, and a treatment schedule of multiple daily doses is recommended for adult patients. Nanotechnology was used in this study to develop an alternative sustained-release delivery system for pyridostigmine, a synthetic drug with high solubility and poor oral bioavailability, hence a Class III drug according to the Biopharmaceutics
more » ... ion System. Novel nanosized pyridostigmine-poly(lactic acid) microcapsules (PPNMCs) were expected to have a longer duration of action than free pyridostigmine and previously reported sustained-release formulations of pyridostigmine. Methods: The PPNMCs were prepared using a double emulsion-solvent evaporation method to achieve sustained-release characteristics for pyridostigmine. The preparation process for the PPNMCs was optimized by single-factor experiments. The size distribution, zeta potential, and sustained-release behavior were evaluated in different types of release medium. Results: The optimal volume ratio of inner phase to external phase, poly(lactic acid) concentration, polyvinyl alcohol concentration, and amount of pyridostigmine were 1:10, 6%, 3% and 40 mg, respectively. The negatively charged PPNMCs had an average particle size of 937.9 nm. Compared with free pyridostigmine, PPNMCs showed an initial burst release and a subsequent very slow release in vitro. The release profiles for the PPNMCs in four different types of dissolution medium were fitted to the Ritger-Peppas and Weibull models. The similarity between pairs of dissolution profiles for the PPNMCs in different types of medium was statistically significant, and the difference between the release curves for PPNMCs and free pyridostigmine was also statistically significant. Conclusion: PPNMCs prepared by the optimized protocol described here were in the nanometer range and had good uniformity, with significantly slower pyridostigmine release than from free pyridostigmine. This novel sustained-release delivery nanosystem for pyridostigmine might alleviate the need to identify new acetylcholinesterase inhibitors.
doi:10.2147/ijn.s40860 pmid:23459707 pmcid:PMC3582480 fatcat:tnq3q3pwobeinfrnybvn7ybqz4
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