A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
doi:10.7150/ijbs.14872 pmid:27489496 pmcid:PMC4971731 fatcat:zauryjewgvcmbcmp2q5wgaomnq
Primary squamous cell carcinoma of pancreas (SCCP) is an extremely rare pathological subtype of pancreatic cancer of ductal origin. Due to its rarity, most previous studies on SCCP focused on case reports or series and the clinio-pathological characteristics of SCCP patients remain unclear. A retrospective analysis of SCCP patients registered in the Surveillance, Epidemiology and End Results (SEER) database from 1988 to 2016 were performed, and clinical characteristics and prognosis of thesedoi:10.21037/gs-20-317 pmid:33842247 pmcid:PMC8033057 fatcat:tyhwlafy5jgvla265tlosnej64
more »... ients were also further determined. A total of 373 patients diagnosed with SCCP were identified. Most SCCP patients 154/243 (63.4%) SCCP patients had distant metastases. The prognosis of SCCP patients was poor with a median overall survival (mOS) of only 3.0 months (95% CI, 2.0-5.0). The 6-month, 1-year and 2-years survival rate were 25.6%, 13.2% and 5.7%, respectively. The prognosis of SCCP patients became much worse with the increasing age (P=0.01) and distant metastases (P<0.01). Cancer-directed surgery, chemotherapy and radiotherapy could significantly prolong the survival time for SCCP patients (P<0.01 for all). Multivariate Cox analysis showed that only distant metastases were independent prognostic factors of worse survival in SCCP patients (HR =1.58, 95% CI, 1.18-2.12). Conversely, both cancer-directed surgery and chemotherapy were an independent protective factor that decreased the risk of death by 66% (HR =0.18, 95% CI, 0.11-0.29) and 46% (HR =0.54, 95% CI, 0.43-0.68) for SCCP patients. SCCP is a rare type of pancreatic malignancies with poor prognosis. The present study could provide some useful information for future management and prospective studies for SCCP patients.
Currently, genomic characterization has become standard of care for tumor types such as non-small cell lung cancer, breast cancer, melanoma, and colorectal cancer. A deep understanding of genomic alterations in different tumor types would help identify potentially actionable genomic changes which occur across a wide variety of tumor types. A basket trial is a new type of clinical trial for which eligibility is based on the presence of a specific genomic alteration, irrespective of histology.doi:10.3389/fonc.2019.00229 pmid:31032221 pmcid:PMC6473081 fatcat:3woivystnfhcvkbv53lkozlsse
more »... ket trials are phase II screening trials for the off-label use of a targeted drug in patients with the same genomic alterations for which it was approved. Intractable cancer refers to a type or condition of cancer which is unresponsive or resistant to treatment; intractable cancers may be classified into five subtypes as follows: hard-to-treat condition of common advanced cancer after multiple-line therapy, rare cancer in which no standard of care has been recommended, advanced cancer in which standard of care does not work well, cancer accompanied with organ dysfunction, and cancers in older or younger cancer patients. Previous studies have demonstrated that in basket trials, genomic-guided therapy yields clinical benefits in intractable cancer, thereby providing novel insights into the optimal clinical management of such cancers. In this review, we describe a novel way to classify intractable cancer, and summarize the current knowledge on such cancers. We additionally provide information on the role of basket trials in intractable cancer.
doi:10.4103/0366-6999.167368 pmid:26481756 pmcid:PMC4736894 fatcat:bi3hctqcanfrnmz42hthmp46fe
Liu et al. (2019) constructed a new type of low anode bias voltage photo-assisted electrochemical system. Under natural sunlight, the degradation test of bisphenol A was performed for 20 cycles. ...doi:10.3390/w13141915 fatcat:rxjelohsxfc25adsxhlu7bw2w4
Collection and/or assembly of data: Ying Liu, Wenzheng Fang, Ke Liu. Data analysis and interpretation: Xiaodong Jiao, Zhan Wang. Manuscriptwriting: Miaomiao Wang, Jiejun Wang, Yuan-sheng Zang. ... Author contributions Conception/Design: Jiejun Wang, Yuan-sheng Zang. Performing the experiment: Miaomiao Wang, Ying Liu, Wenzheng Fang. ...doi:10.18632/oncotarget.20693 pmid:29108276 pmcid:PMC5668009 fatcat:aoxpcu2ydffxne4saywyi5sswq
An experimental program to characterize the effect of voids on the strength of composite laminates is presented. The adequacy of a fracture criterion to represent the experimental data for the effect of voids on the flexure strength, tensile strength, and interlaminar shear strength of composite laminates is assessed. The experimental program investigates the effect of different pressures and dwell times on the critical void content. Laminates produced with carbon fiber/epoxy resindoi:10.1177/0021998306065289 fatcat:x3yuoo4szvg5pbit7lw5ybt4la
more »... l prepreg have been produced with an intentionally high void content. Short beam shear, three-point flexure, and tensile testing are used for mechanical evaluation and the results correlate to void volume fraction and ultrasonic absorption coefficient. The ultrasonic absorption coefficient is measured for all the specimens and its variation is approximately linear with the void content, corroborating previous experimental results. The effects of these factors on the strength of the composite laminates are discussed in terms of the fracture parameters involved in the fracture criterion. The critical void content is estimated for each case both in terms of void content and ultrasonic attenuation.
order to solve the problem of robustness or antidisturbance of the traditional PI speed controller in the permanent magnet synchronous motor. A fuzzy PI speed controller based on load torque feedback compensation is proposed for the permanent magnet synchronous motor. The combination of fuzzy PI control strategy and load feedback compensation method can enhance the robustness and disturbance rejection of the speed loop. According to the validated results of simulation and experiments, by usingdoi:10.14569/ijacsa.2015.060509 fatcat:kmcdcnmrkrdzzdmbb7tu33zp5y
more »... his PMSM speed controller, the robustness of the system speed control was enhanced markedly , and the capacity of antidisturbance was also improved significantly.
studies have also shown that the deposition of Aβ in the brain and its toxicity are directly related to metabolic disorders of zinc, copper, iron, and other metal ions in the cortex and the hippocampus (Liu ...doi:10.3389/fnins.2018.00632 pmid:30250423 pmcid:PMC6139360 fatcat:qiclcnemf5bddlqar5zvd5xgty
Xiaopeng Zhan: Writing -Original draft preparation. Sheng Kang: Supervision. Haibo Liu: Software, Validation. Yu Luo: Writing -Reviewing and Editing. Li Lin: Writing -Reviewing and Editing. ...doi:10.1016/j.gene.2020.100036 pmid:32793879 pmcid:PMC7412861 fatcat:fftnq37tsbbmrdb7bdvap2dyiu
The aberrant expression of long noncoding RNAs (lncRNAs) is implicated in cancer development and progression. However, the clinical significance and mechanism by which NONHSAT062994 regulates colorectal cancer (CRC) is unknown. We here reported that NONHSAT062994 was significantly downregulated in human CRC tissues and cell lines. Moreover, its expression was inversely correlated with tumor size and overall survival (OS) time in CRC patients. In CRC cells, the overexpression and knockdown ofdoi:10.18632/oncotarget.19827 pmid:28978149 pmcid:PMC5620289 fatcat:xtng26cvvfhdpgitfqwoyikama
more »... HSAT062994 inhibited and enhanced CRC cell growth, respectively, in vitro and in vivo. Mechanistically, NONHSAT062994 functioned as a tumor suppressor to inhibit CRC cell growth by inactivating Akt signaling. Notably, the NONHSAT062994 expression status was negatively correlated with the Akt downstream targets c-Myc and Cyclin D1 in clinical CRC samples. The current findings suggest that NONHSAT062994 plays a critical role in the development of CRC by regulating Akt signaling, and identified a candidate prognostic biomarker or potential therapeutic target for CRC patients.
The endoscopic transnasal approach has been proven to have advantages on the removal of the tumors in pterygopalatine fossa (PPF) and infratemporal fossa (ITF). Herein, this study aimed to describe a modified approach for resection of the tumors in these areas, both in cadaveric specimen and clinical patients. Methods: The 20 adult cadaveric specimens and five patients with tumors in PPF and ITF were enrolled in this study. For the cadaveric specimens, ten were simulated anterior transmaxillarydoi:10.1097/cm9.0000000000000142 fatcat:44jiga52e5cptjwzqwdy77b7oq
more »... approach and ten were performed modified endoscopic transnasal transmaxillary approach. The exposure areas were compared between two groups and main anatomic structure were measured. Surgery was operated in the five patients with tumors of PPF and ITF to verify the experience from the anatomy. Perioperative management, intraoperative findings and postoperative complications were recorded and analyzed. Results: The modified endoscopic transnasal transmaxillary approach provided as enough surgical exposure and high operability to the PPF and ITF as the anterior transmaxillary approach did. The diameter of maxillary artery in the PPF was 3.77 ± 0.78 mm (range: 2.06-4.82 mm), the diameter of middle meningeal artery in the ITF was 2.79 ± 0.61 mm (range: 1.54-3.78 mm). Four patients who suffered schwannoma got total removal and one of adenocystic carcinoma got subtotal removal. The main complications were facial numbness and pericoronitis of the wisdom tooth. No permanent complication was found. Conclusions: With the widespread use of neuroendoscopy, the modified endoscopic transnasal transmaxillary approach is feasible and effective for the resection of tumors located in PPF and ITF, which has significant advantages on less trauma and complications to the patients.
Wengui and Sheng  started from the Mohr-Coulomb criterion, based on the representation method of the microelement strength of the rock that obeys the Weibull distribution, and established a damage-softening ...doi:10.2478/amns.2021.2.00048 fatcat:do67omtce5fldbn4iezuhfnjlq
Ionization and dissociation of 2-and 3-methyl cyclopentanones have been investigated in molecular beams by their irradiation with intense 394 and 788 nm laser fields with pulse duration of 90 fs and intensity of 3 Â 10 13 -4 Â 10 14 W/cm 2 . The analysis of the resulting mass spectra allowed us to discern the effects of methyl substitution and its position on the outcome of ionization/dissociation processes induced by the intense femtosecond laser field. Generalized Keldysh-Faisal-Reiss (g-KFR)doi:10.1016/j.cplett.2013.09.009 fatcat:p4d5cfirwjeqrbp26fuuj23iqu
more »... and ab initio G3(MP2,CCSD)//B3LYP/6-31G ⁄ /RRKM theoretical calculations helped to uncover the formation mechanism of major ionic fragments observed in the mass spectra including C 5 H 10
« Previous Showing results 1 — 15 out of 2,827 results