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More than 21 members of 17.6, a Drosophila retrotransposon, were isolated and their possible structural changes were examined by restriction mapping, blot hybridization, heteroduplex analysis and nucleotide sequence determination of long terminal repeats (LTRs). At least 7 members were found to suffer with terminal or internal long deletions. No pair of LTRs having an identical nucleotide sequence was found either within an element or between elements. Although an initiation site for thedoi:10.1093/nar/14.12.4765 pmid:3014436 pmcid:PMC311490 fatcat:kdf2vphljrbqzpdfuxp2tdwfd4
more »... ble genome-sized transcript of 17.6, a potential substrate for reverse transcription on translocation, was identified within the left-hand LTR, our results as a whole support the notion that the majority of 17.6s have continued to reside for a long period of time at their present chromosomal loci and hence the rate of translocation of 17.6 is very low.
Formal analysis: Shunji Hattori, Yuki Taga, Haruki Senoo. Funding acquisition: Shunji Hattori, Yuki Taga. ... Investigation: Shunji Hattori, Tomomi Kiriyama-Tanaka, Masashi Kusubata, Yuki Taga, Katsuyuki Imai. Methodology: Shunji Hattori, Tomomi Kiriyama-Tanaka, Masashi Kusubata, Yuki Taga, Katsuyuki Imai. ...doi:10.1371/journal.pone.0258699 pmid:34714842 pmcid:PMC8555803 fatcat:dvslciq55baijatslajjnw7alu
Two Scottish Fold mixed cats are described in this report. Case 1 is a mixed Scottish Fold and Munchkin cat. Extremities of this cat resembled the Munchkin cat, while the ear pinna were folded forward like the Scottish Fold cat. Case 2 is a mixed Scottish Fold and American Curl cat. The ear pinna were curled caudally like the American Curl. Severe exostosis in the hind leg was observed in radiographs taken around one year of age in both cats. Both cats were dominant homozygous for c.1024G>T ofdoi:10.1292/jvms.20-0299 pmid:33162427 pmcid:PMC7804039 fatcat:kggviz3y2betpkfoomuwkx4qxu
more »... he transient receptor potential vanilloid 4 gene, responsible for osteochondrodysplasia in the Scottish Fold cat. Cross breeding with Scottish Fold cats could produce unknown phenotypes, and should be avoided.
こうした特性は，例えば，脳活動測定にお いて実施が容易でノイズの影響を抑えるといったこと や，潜在ヒントによる解決促進効果(Hattori, Sloman, & Orita, 2013)の継時的変化を明らかにするといった 研究の新しい展開も可能にする。しかし，難易度を統 制して反復測定したい場合などには，RAT-TMA13 の 79 問という問題数は十分ではない。 ... 洞 察 RAT は Batchelder & Alexander(2012)が挙げた洞察課題の特徴を多く有 しているが，孵化効果(Sio & Ormerod, 2009)や手が かりの呈示による促進効果(Hattori, Sloman, & Orita, 問題番号 刺激語 推定パラメータ 実験 2 問題 正解 μ σ 正答率 Aha 体験 A B C X 内因性 外因性 ...doi:10.4992/jjpsy.89.17201 fatcat:os5r3zg5xvhi3dg3gbqt4ok4ai
Animal glues derived from collagen-rich tissue are widely used as adhesives and binders in artworks. Identification of the animal source of glue is important not only to understand the artistic technique and historical background, but also to conduct appropriate treatment for restoration and conservation of artworks. Recently, mass spectrometric approaches have been used for species identification of glue. However, it appears that the existing methods were not applied to samples containingdoi:10.1186/s40494-018-0209-y fatcat:2fylfnsv4repbmgjz2dfkjmsly
more »... ple animal sources, and the range of target species has been limited because of incomplete sequence information of collagen in public databases. In the present study, we established a novel method for discrimination of glues from eight animals applicable to samples with multiple animal origins. Trypsindigested glue samples were analyzed by LC-MS in multiple reaction monitoring mode, and the animal source was determined based on the detection patterns of 12 type I collagen-derived marker peptides. Using the databaseindependent method, we successfully identified the animal source of commercial products and found the declared species for some glues to be incorrect. In addition, some products were identified to contain two different animal origins. Relative abundance of the animal origins in several impure glues was estimated using the marker peptides, which helped to speculate the reason for the detection of multiple species. We analyzed a painting (The Harvest by Camille Pissarro, 1882) and clarified that glues used in the ground and size layers of the canvas were derived from cattle (~ 65%) and sheep (~ 35%).
Genes to Cells
In addition to the radially expansive and complicated dendrites of A number of cell-autonomous programs have been discovered that control morphogenesis of dendritic arbors of da neurons Hattori et al. ... The low-yeast dependent hyperarborization is also reminiscent of an overexpression phenotype of insulin growth factor II mRNA binding protein (Imp) (see Fig 5A, 5C, and 5I in Hattori et al., 2013) ...doi:10.1111/gtc.12451 pmid:27868313 fatcat:r6tu6bwe5rdktmm5aid7zesypm
Sheet-type heaters were prepared using polyimide as a matrix with a mixture of two types of vapor-grown nanocarbon fillers, VGCF and cup-stacked carbon nanotubes (CSNT) , and their electrical resistivity, thermal expansion and filler dispersion properties were evaluated. By using the heat resistant polymer, polyimide, it was expected that the positive temperature coefficient (PTC) effects appear at higher temperatures. The results showed that the nanocarbons were dispersed homogeneously anddoi:10.7209/tanso.2007.329 fatcat:ts6f3g3a5ffybalrga3k3hxc44
more »... the temperature dependence of the electrical resistivity could be controlled by the addition of two types of nanocarbon fillers. The optimum PTC properties were observed for the samples with the mixture of VGCF and CSNT at 30 wt % of total nanocarbons.
We consider an autonomous and decentralized mobile robotic swarm that does not require an advanced communication system; moreover, each robot must pass a narrow space preserving the distance with other robots. The control barrier function (CBF) method is useful for robotic swarms to guarantee collision avoidance. However, introducing CBF inequalities can cancel other objectives and sometimes causes a deadlock problem. Therefore, we introduce a coupled oscillator system to generate asymmetricdoi:10.3390/sym13030478 fatcat:bfcl2jex2jhdbifarfv43x3sli
more »... bal order by itself to avoid deadlock. By generating an effective global order in the swarm, each robot adequately moves to a target position without requiring high-cost communication systems.
Purpose] The purpose of this study was to investigate whether the life-space of older adults after discharge can be predicted, and to clarify the factors associated with life-space prediction and actual life-space. [Participants and Methods] This prospective cohort study included 33 patients who were discharged to home. We evaluated the patients' predicted life-space (LSA) of 2 months after discharge, as well as BBS, TUG, FES-I, and FIM at the time of discharge, and LSA was re-evaluated 2doi:10.1589/rika.33.891 fatcat:yhtocybfijgo5agfcheeo66sfu
more »... after discharge from hospital. We analyzed the relationship between predicted LSA and actual LSA, and factors associated to LSA. [Results] There was a strong correlation between predicted LSA and actual LSA. TUG was associated with both the predicted and actual LSA, whereas BBS was only associated with actual LSA. [Conclusion] It is possible to predict the life-space of older adults after discharge. In addition, the results suggest that mobility is associated with predicted and actual life space.
Yuki Nishino, M.T., Hirokuni Kakinuma, C.T.AC), Kazumasa Matsumoto, M.D., Makoto Ohbu, M.D., and Isao Okayasu, M.D. ... Hattori is Assistant Professor, Department of Clinical Cytology, School of Allied Health Sciences, Kitasato University. Ms. ...doi:10.1159/000325792 pmid:17718119 fatcat:c2u2onlatzc6tn32wgquhl4jhu
Four diastereomers of tetradenolide, a cytotoxic -pyrone isolated from Tetradenia riparia, were synthesized stereoselectively using Z-selective Horner-Emmons reaction followed by acid catalyzed lactonization. Making comparison of the 1 H and 13 C NMR spectral data of the four diastereomers with those of the reported value of natural product did not lead to determine the relative stereochemistry of the natural tetradenolide. Thus detailed investigation of the spectral data of the relateddoi:10.1016/j.tetlet.2014.05.109 fatcat:7jpgxmoy6jdn7e2by4c3dpw6my
more »... ds led us to revise the structure of tetradenolide as deacetylboronolide. Tetradenolide is an antimicrobial, phytotoxic and cytotoxic -pyrone isolated by Luc Van Puyvelde and De Kimpe from Tetradenia riparia. 1 The related compound (+)-deacetylboronolide was isolated Luc Van Puyvelde and co-workers from the same plant, Tetradenia riparia (Hochst) N. E. Br. (Labiatae) 2 and (+)-boronolide was isolated from Tetradenia fruticosa Benth and Tetradenia barbera (N. E. Br.) Codd, respectively. 3,4 As to the biological activity of boronolides, anti-malarial activity was reported ( Figure 1 ). 2,5 Many reports of the syntheses of (+)-boronolide and (+)-deacetylboronolide have been published so far. 6 However, synthetic study of teradenolide has not been reported yet. The reported structure of tetradenolide was shown in Figure 1 and the relative stereochemistry and optical rotation value of this compound were not reported. 1
Kobunshi ronbunshu (Tokyo)
The synthesis of dendrimers with a 1,3,5-triazine ring at the branch point by the convergent technique was investigated. First, 2,4 dichloro-6-(p-nitroanilino) -1,3,5-triazine (DCNT) was obtained by the reaction of cyanuric chloride with p -nitroaniline . Subsequently , DCNT was subjected to the reaction with two folds of aniline followed by the reduction of NO2 group giving rise to the first gen eration dendron (G1-A) having reactive NH2 group at the focal point . The second generation dendrondoi:10.1295/koron.57.646 fatcat:pxarraj37zbxvfyku625z4j33q
more »... (G2-A) was also secured by the analogous reaction of DCNT with G1-A. Although the reaction of DCNT with G2-A afforded a mixture of G3-N (1:2 adduct) and 1:1 adduct, the direct reduction of these crude products provided the third generation dendron (G3-A) in low yield . The dendrimers up to the second genaration ([G2]3-C) could ultimately be synthesized by the coupling of each dendron with cyanuric chloride . Since the obtained dendrimers have imine-like nitrogen-linked 1 ,3,5-triazine and benzene rings alternately, they were supposed to be relatively planar . The characteristics of triazine dendrimers are also described .
The different effects of deoxynivalenol (DON) on intestinal barrier and stem cells by its route of exposure remain less known. We explored the toxic effects of DON on intestinal barrier functions and stem cells after DON microinjection (luminal exposure) or addition to a culture medium (basolateral exposure) using three-dimensional mouse intestinal organoids (enteroids). The influx test using fluorescein-labeled dextran showed that basolateral DON exposure (1 micromolar (µM) disrupteddoi:10.3390/toxins12100610 pmid:32987679 fatcat:3htjts57anbt3e54bwywoep6uq
more »... barrier functions in enteroids compared with luminal DON exposure at the same concentration. Moreover, an immunofluorescence experiment of intestinal epithelial proteins, such as E-cadherin, claudin, zonula occludens-1 (ZO-1), and occludin, exhibited that only basolateral DON exposure broke down intestinal epithelial integrity. A time-lapse analysis using enteroids from leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-enhanced green fluorescence protein (EGFP) transgenic mice and 5-ethynyl-2-deoxyuridine (EdU) assay indicated that only the basolateral DON exposure, but not luminal DON exposure, suppressed Lgr5+ stem cell count and proliferative cell ratio, respectively. These results revealed that basolateral DON exposure has larger impacts on intestinal barrier function and stem cells than luminal DON exposure. This is the first report that DON had different impacts on intestinal stem cells depending on the administration route. In addition, RNA sequencing analysis showed different expression of genes among enteroids after basolateral and luminal DON exposure.
We investigated the characteristics of extracellular matrix (ECM) in the soft tissue of two frozen baby woolly mammoths ( Mammuthus primigenius ) that died and were buried in Siberian permafrost approximately 40,000 years ago. Morphological and biochemical analyses of mammoth lung and liver demonstrated that those soft tissues were preserved at the gross anatomical and histological levels. The ultrastructure of ECM components, namely a fibrillar structure with a collagen-characteristic patterndoi:10.1101/2021.04.12.439423 fatcat:z2ysrvwqsvc4fnp5cpllp5c6my
more »... f cross-striation, was clearly visible with transmission and scanning electron microscopy. Type I and type IV collagens were detected by immunohistochemical observation. Quantitative amino acid analysis of liver and lung tissues of the baby mammoths indicated that collagenous protein is selectively preserved in these tissues as a main protein. Type I and type III collagens were detected as major components by means of liquid chromatography–mass spectrometry analysis after digestion with trypsin. These results indicate that the triple helical collagen molecule, which is resistant to proteinase digestion, has been preserved in the soft tissues of these frozen mammoths for 40,000 years.
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