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Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis

Yajie Sun, Zhuo Sun, Yukai Chen, Guohua Deng
2018 Journal of Ophthalmology  
Authors' Contributions Yajie Sun collected the data and drafted this manuscript; Zhuo Sun participated in the collection of the data and technique support; Yukai Chen performed examination; Guohua Deng  ...  Yajie Sun and Zhuo Sun contributed equally to the work presented here and should therefore be regarded as equivalent authors. Stem Cells International  ... 
doi:10.1155/2018/1875627 pmid:29670766 pmcid:PMC5836395 fatcat:2gwoff3mqbchrklztmcrg2s5ai

Day-ahead economic dispatch of microgrid based on game theory

Lu Sun, Qingshan Xu, Xi Chen, Yukai Fan
2020 Energy Reports  
Utility and users are two important subjects in power dispatching, and each participant wants to maximize its benefits. That is to say, utility and users are engaged in an interest game with each other. In this paper, a day-ahead economic dispatch strategy which can solve mixed integer programming problem based on game theory is proposed. First, build the model of the microgrid. Second, set optimization objectives of utility and users and analyze constraints. Last, propose a dispatch strategy
more » ... ensure that utility and users gain the maximum benefits. A case study verifies the effectiveness of the proposed approach. c
doi:10.1016/j.egyr.2019.11.131 fatcat:ldujhzgldjc7ni62znf6zyhpoe

Photoresponse and carrier transport of protocrystalline silicon multilayer films

Wei Yu, HaiRong Zhu, Yi Zhao, YuKai Sun, HaiJiang Lu, GuangSheng Fu
2012 Chinese Science Bulletin  
Alternating multilayer films of hydrogen diluted hydrogenated protocrystalline silicon (pc-Si:H) were prepared using a plasma-enhanced chemical vapor deposition technique. The microstructure of the deposited films and photoresponse characteristics of their Schottky diode structures were investigated by Raman scattering spectroscopy, Fourier transform infrared spectroscopy and photocurrent spectra. Microstructure and optical absorption analyses suggest that the prepared films were pc-Si:H
more » ... yer films with a two-phase structure of silicon nanocrystals (NCs) and its amorphous counterpart and the band gap of the films showed a decreasing trend with increasing crystalline fraction. Photocurrent measurement revealed that silicon NCs facilitate the spatial separation of photo-generated carriers, effectively reduce the non-radiative recombination rate, and induce a photoresponse peak value shift towards the short-wavelength side with increasing crystallinity. However, the carrier traps near the surface defects of silicon NCs and their spatial carrier confinement result in a significant reduction of the diode photoresponse in the longwavelength region. An enhancement of the photoresponse from 350 to 1000 nm was observed when applying an increased bias voltage in the diode, showing a favorable carrier transport and an effective collection of photo-generated carriers was achieved. Both the spatial separation of the restricted electron-hole pairs in silicon NCs and the de-trapping of the carriers at their interface defects are responsible for the red-shift in photoresponse spectra and enhancement of external quantum efficiency. The results provide fundamental data for the carrier transport control of high-efficiency pc-Si:H solar cells.
doi:10.1007/s11434-012-5190-3 fatcat:ivi2tgdijzaznilgrgnv7ge4ai

Messenger RNA expression of chickenCLOCKgene in the response toCampylobacter jejuniinoculation

Xiaoyi Liu, Liying Liu, Maozhi Zhang, Ning Yang, Yukai Qi, Yu Sun, Xianyao Li
2015 Poultry Science  
Campylobacter jejuni (C. jejuni) is a leading cause of human bacterial gastroenteritis worldwide. Previous research has shown that circadian rhythm plays a critical role in host response to C. jejuni colonization. The CLOCK gene is one of the core genes regulating circadian rhythms and shows significant expression on 7 d post-C. jejuni inoculation. The objective of this study was to investigate temporal and spatial expression of chicken CLOCK gene post-C. jejuni inoculation. Cecal and splenic
more » ... A were isolated from 2 distinct chicken breeds and used to compare the mRNA expression of CLOCK gene between inoculated and noninoculated chickens within each breed and between breeds within each of inoculated and noninoculated groups. Our results showed that the CLOCK gene was significantly down-regulated at 20 h postinoculation (hpi) in cecum and spleen in Jiningbairi chicken. CLOCK gene was significantly down-regulated at 4 and 16 hpi and up-regulated at 8 hpi in cecum and spleen in specific pathogen free white leghorn noninoculated chicken. The findings suggested that expression of CLOCK gene was significantly changed post C. jejuin inoculation. This change was affected by genetic background, tissue, and time points postinoculation.
doi:10.3382/ps/pev203 pmid:26223235 fatcat:lkrjtwmzfbginpkvsw7qan4ctu

Distinct vitellogenin domains differentially regulate immunological outcomes in invertebrates

Weikang Sun, Hao Li, Yuehong Zhao, Longwei Bai, Yukai Qin, Qun Wang, Weiwei Li
2020 Journal of Biological Chemistry  
The classical role of Vitellogenin (Vg) is providing energy reserves for developing embryos, but its roles appear to extend beyond this nutritional function, and its importance in host immune defense is garnering increasing research attention. However, Vg-regulated immunological functions are dependent on three different domains within different species and remain poorly understood. In the present study, we confirmed three conserved VG domains — LPD_N, DUF1943 and VWD — in the Chinese mitten
more » ... b (Eriocheir sinensis), highlighting functional similarities of Vg in vertebrates and invertebrates. Of these three domains, DUF1943 and VWD showed definitive bacterial binding activity via interaction with the signature components on microbial surfaces, but this activity was s not exhibited by the LPD_N domain. Antibacterial assays indicated that only the VWD domain inhibits bacterial proliferation, and this function may be conserved between different species due to the conserved amino acid residues. To further explore the relationship between Vg and polymeric immunoglobulin receptor (pIgR), we expressed EspIgR and the three Eriocheir sinensis-Vg (EsVg) domains in HEK293T cells, and co-immunoprecipitation assay demonstrated that only the DUF1943 domain interacts with EspIgR. Subsequent experiments demonstrated that EsVg regulates hemocyte phagocytosis by binding with EspIgR through the DUF1943 domain, thus promoting bacterial clearance and protecting the host from bacterial infection. To the best of our knowledge, our work is the first to report distinct domains in Vg inducing different immunological outcomes in invertebrates, providing new evidence that pIgR acts as a phagocytic receptor for Vg.
doi:10.1074/jbc.ra120.015686 pmid:33177064 pmcid:PMC7949091 fatcat:mfe7nsp4abahlocn3frqcmvby4

Improving the Efficiency and Effectiveness for BERT-based Entity Resolution

Bing Li, Yukai Miao, Yaoshu Wang, Yifang Sun, Wei Wang
2021 AAAI Conference on Artificial Intelligence  
BERT has set a new state-of-the-art performance on entity resolution (ER) task, largely owed to fine-tuning pretrained language models and the deep pair-wise interaction. Albeit being remarkably effective, it comes with a steep increase in computational cost, as the deep-interaction requires to exhaustively compute every tuple pair to search for coreferences. For ER task, it is often prohibitively expensive due to the large cardinality to be matched. To tackle this, we introduce a siamese
more » ... k structure that independently encodes tuples using BERT but delays the pair-wise interaction via an enhanced alignment network. This siamese structure enables a dedicated blocking module to quickly filter out obviously dissimilar tuple pairs, and thus drastically reduces the cardinality of fine-grained matching. Further, the blocking and entity matching are integrated into a multi-task learning framework for facilitating both tasks. Extensive experiments on multiple datasets demonstrate that our model significantly outperforms state-of-the-art models (including BERT) in both efficiency and effectiveness.
dblp:conf/aaai/LiMWSW21 fatcat:p4mkv6aanjak7ggwoolbzbxup4

Nonlinear System Identification of an All Movable Fin with Rotational Freeplay by Subspace-Based Method

Sun Yukai, Yang Chao, Wu Zhigang, Bai Liuyue
2020 Applied Sciences  
To interpret the nonlinear system identification of multi-degree-of-freedom vibrating structures with freeplay, an estimation procedure based on subspace method in time domain is developed in this paper. Two types of freeplay, namely, central freeplay and offset freeplay, are estimated. Besides, the frequency response function matrices of the underlying linear system and overlying linear system are identified. By considering an all movable fin from a portion of a supersonic flutter test
more » ... containing freeplay on the rigid rotating motion, two series of numerical experiments are applied for demonstration. Results show that the proposed approach indicates a high and reliable recognition of freeplay regions and the nominal linear system. The limitations of the method in this study are also discussed.
doi:10.3390/app10041205 fatcat:7uplo4kq6fba5hm6te7iwibeda

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents [article]

Weizheng Liang, Guipeng Li, Huanhuan Cui, Yukai Wang, Wencheng Wei, Siyue Sun, Diwen Gan, Rui Chen, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou (+2 others)
2021 bioRxiv   pre-print
Gao Q, Sun W, Ballegeer M, Libert C, Chen W. Predominant contribution of cis-regulatory 550 divergence in the evolution of mouse alternative splicing. Mol Syst Biol. 2015;11(7):816.  ...  Hou J, Wang X, McShane E, Zauber H, Sun W, Selbach M, et al. Extensive allele-specific 554 translational regulation in hybrid mice. Mol Syst Biol. 2015;11(8):825. Epub 2015/08/09. doi: 557 12.  ... 
doi:10.1101/2021.03.01.433326 fatcat:qqmpjevit5a6rliytei7qwvqpm

Two-Dimensional TeB Structures with Anisotropic Carrier Mobility and Tunable Bandgap

Yukai Zhang, Xin Qu, Lihua Yang, Xin Zhong, Dandan Wang, Jian Wang, Baiyang Sun, Chang Liu, Jian Lv, Jinghai Yang
2021 Molecules  
Two-dimensional (2D) semiconductors with desirable bandgaps and high carrier mobility have great potential in electronic and optoelectronic applications. In this work, we proposed α-TeB and β-TeB monolayers using density functional theory (DFT) combined with the particle swarm-intelligent global structure search method. The high dynamical and thermal stabilities of two TeB structures indicate high feasibility for experimental synthesis. The electronic structure calculations show that the two
more » ... uctures are indirect bandgap semiconductors with bandgaps of 2.3 and 2.1 eV, respectively. The hole mobility of the β-TeB sheet is up to 6.90 × 102 cm2 V−1 s−1. By reconstructing the two structures, we identified two new horizontal and lateral heterostructures, and the lateral heterostructure presents a direct band gap, indicating more probable applications could be further explored for TeB sheets.
doi:10.3390/molecules26216404 pmid:34770813 pmcid:PMC8588529 fatcat:aximpkh2fjfntpnjtygemvsmq4

Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses

Tianyan Liu, Yu Zhang, Yukai Cao, Shan Jiang, Rui Sun, Jiechao Yin, Zhenqiu Gao, Guiping Ren, Zhenzhong Wang, Qingzhong Yu, Guangchao Sui, Xu Sun (+3 others)
2020 Gene Therapy  
The direct oncolytic effect of Newcastle disease virus (NDV) depends on the following two aspects: the susceptibility of cancer cells to virus infection and the ability of virus itself to lyse cancer cells. First, we investigate the susceptibility of cancer cells to NDV infection, HepG2, MDA-MB-231, and SH-SY5Y cells were susceptible, A549, MCF7, and LoVo cells were less susceptible. To investigate the molecular mechanism responsible for cancer cell susceptibility, transcriptome sequencing was
more » ... arried out. We found that the levels of alpha-sialic acid acyltransferase were upregulated in MDA-MB-231 cells compared with MCF7 cells, and the interferon was downregulated. Second, to optimize the oncolytic capacity of the wild-type rClone30, a series of chimeric viruses rClone30-Anh(HN), rClone30-Anh(F), and rClone30-Anh(HN-F) were constructed by exchanging the HN gene, F gene or both of non-lytic rClone30 strain with lytic strain Anhinga. rClone30-Anh(F) and rClone30-Anh(HN-F) enhanced the oncolytic effect of the rClone30, and this enhancement is more obvious in the susceptible cells. The oncolytic mechanism of rClone30-Anh(F) was analyzed by transcriptome analyses, in comparison with rClone30, rClone30-Anh(F) upregulated the expression of ATG5, Beclin 1, and MAP1LC3B, thus activating autophagy and promoting the production of syncytia. In conclusion, our study provides a strategy to enhance the oncolytic effect of rClone30.
doi:10.1038/s41434-020-0145-9 pmid:32409746 pmcid:PMC8674137 fatcat:alw2i5kgsncpbdj4sobsvh67ai

Application of a 3D Bioprinted Hepatocellular Carcinoma Cell Model in Antitumor Drug Research

Lejia Sun, Huayu Yang, Yanan Wang, Xinyu Zhang, Bao Jin, Feihu Xie, Yukai Jin, Yuan Pang, Haitao Zhao, Xin Lu, Xinting Sang, Hongbing Zhang (+4 others)
2020 Frontiers in Oncology  
Copyright © 2020 Sun, Yang, Wang, Zhang, Jin, Xie, Jin, Pang, Zhao, Lu, Sang, Zhang, Lin, Sun, Huang and Mao.  ... 
doi:10.3389/fonc.2020.00878 pmid:32582546 pmcid:PMC7283506 fatcat:l3ivazs2ibdq7dbjt3amkjnqxe

Gromov Rigidity of Bi-Invariant Metrics on Lie Groups and Homogeneous Spaces

Yukai Sun, East China Normal University, P.R. of China, Xianzhe Dai, UCSB, USA
2020 Symmetry, Integrability and Geometry: Methods and Applications  
Gromov asked if the bi-invariant metrics on a compact Lie group are extremal compared to any other metrics. In this note, we prove that the bi-invariant metrics on a compact connected semi-simple Lie group G are extremal (in fact rigid) in the sense of Gromov when compared to the left-invariant metrics. In fact the same result holds for a compact connected homogeneous manifold G/H with G compact connect and semi-simple.
doi:10.3842/sigma.2020.068 fatcat:jwjzmwbx5vbjrc4hb4gyk45ra4

Extremality of Bi-invariant Metrics on Lie Groups and Homogeneous Spaces [article]

Yukai Sun, Xianzhe Dai
2020 arXiv   pre-print
Gromov asked if the bi-invariant metric on an n dimensional compact Lie group is extremal compared to any other metrics. In this note, we prove that the bi-invariant metric on an n dimensional compact connected semi-simple Lie group G is extremal in the sense of Gromov when compared to the left invariant metrics. In fact the same result holds for a compact connected homogeneous Riemannian manifold G/H with the Lie algebra of G having trivial center.
arXiv:2005.00161v2 fatcat:qak36iqilvapfk5u25yzf3tpiy

A flying Schrödinger cat in multipartite entangled states [article]

Zhiling Wang, Zenghui Bao, Yukai Wu, Yan Li, Weizhou Cai, Weiting Wang, Yuwei Ma, Tianqi Cai, Xiyue Han, Jiahui Wang, Yipu Song, Luyan Sun (+2 others)
2021 arXiv   pre-print
Schr\"odinger's cat originates from the famous thought experiment querying the counterintuitive quantum superposition of macroscopic objects. As a natural extension, several "cats" (quasi-classical objects) can be prepared into coherent quantum superposition states, which is known as multipartite cat states demonstrating quantum entanglement among macroscopically distinct objects. Here we present a highly scalable approach to deterministically create flying multipartite Schr\"odinger cat
more » ... by reflecting coherent state photons from a microwave cavity containing a superconducting qubit. We perform full quantum state tomography on the cat states with up to four photonic modes and confirm the existence of quantum entanglement among them. We also witness the hybrid entanglement between discrete-variable states (the qubit) and continuous-variable states (the flying multipartite cat) through a joint quantum state tomography. Our work demonstrates an important experimental control method in the microwave region and provides an enabling step for implementing a series of quantum metrology and quantum information processing protocols based on cat states.
arXiv:2112.01199v1 fatcat:vhu6qddjnrhehi7f6egle3g5di

Application of Homogenized Load-Bearing Ring Hypothesis in Roadway Supporting

Quntao Zhang, Jianwei Zheng, Xiaodong Sun, Wenzhou Li, Kang Yi, Yukai Fu, Jiulin Shi, Shuai Wang, Biao Liu, Qi Wang, Tao Meng
2022 Shock and Vibration  
Artificial support system takes advantages of self-bearing capacity of surrounding rock mass in roadway support, which is one of the important supporting ideas in modern times. The implementation way of an artificial support system is worthy of deep investigation. In this study, an HLBR hypothesis was proposed with comprehensive consideration of mechanical properties of surrounding rock mass based on the reinforced arch theory and axial variation theory. A model of bearing structure in
more » ... ng rock mass was constructed, and the stress state on the bearing structure was analyzed. It was believed that when the axial ratio (k) of this bearing structure is equal to the lateral stress factor (λ) (which is the optimal axial ratio), the tangential stress on the bearing boundary reaches the minimum and is in uniform distribution. At this moment, the roadway and the supporting structure can make good use of the self-carrying capacity of surrounding rock mass, which is conducive to lowering the stress distribution level of surrounding rock mass. According to prestress diffusion characteristics of bolt, some ways to achieve HLBR were proposed, which were the optimal axial ratio design, difference support and local grouting modification, and finally performance of the original support design in a belt roadway of the mining district IV of a mine in Shanxi Province. A new supporting scheme was provided according to the HLBR hypothesis. In addition, the FLAC3D strain-softening model was modified by C++, which was used to interpret the reasonability of the suggested supporting scheme. The proposed HLBR hypothesis discloses ways to use self-capacity of surrounding rock mass. This study provides a new idea for roadway sectional design and roadway support design, which are beneficial to maintaining the stability of surrounding rock mass in roadways.
doi:10.1155/2022/1038231 fatcat:uh6ovgeorrbvnggih633pvx4qm
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