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Hypoglycemic Syncope Induced by a Combination of Cibenzoline and Angiotensin Converting Enzyme Inhibitor

Akiyoshi Ogimoto, Mareomi Hamada, Hideyuki Saeki, Go Hiasa, Tomoaki Ohtsuka, Hidetoshi Hashida, Yuji Hara, Takafumi Okura, Yuji Shigematsu, Kunio Hiwada
2001 Japanese Heart Journal  
A 65-year-old Japanese woman with dilated cardiomyopathy, hypothyroidism and refractory sustained ventricular tachycardia experienced a near-death hypoglycemic syncope. The attack seemed to be induced by a high level of serum insulin, probably due to cibenzoline and by concomitant use of an angiotensin converting enzyme inhibitor (ACEI). Additionally, decreased food intake because of a severe toothache may have contributed to the deterioration of her condition. This case warns cardiologists
more » ... a combined cibenzoline and ACEI therapy can provoke serious adverse effects such as hypoglycemic syncope in the elderly. Therefore, the possibility of a hypoglycemic attack associated with these drugs should be explained to patients who are in poor condition. (Jpn Heart J 2001; 42: 255-259)
doi:10.1536/jhj.42.255 pmid:11384085 fatcat:dvme2wiquvdhfa3gvdyhlmktdq

Food Chemical Studies of Oats. V

Eiji TAKAHASHI, Shun-ichi TASE, Yûji SAEKI
1935 Nippon Nogeikagaku-kaishi  
doi:10.1271/nogeikagaku1924.11.3_199 fatcat:66ip5urntzgwjkrlyn3sfn6vcu

Determination of a small amount of selenium in ores

1959 Bunseki Kagaku  
doi:10.2116/bunsekikagaku.8.422 fatcat:qt7vuxdfp5hm5ehsf6h7mewi2a

Stability evaluation f coal-water mixtures by internal structural stress

1988 Journal of Chemical Engineering of Japan  
Saeki is now with Nippon Steel Corporation. 602 pared by following the preparation method proposed by Usui et aLnA2A6) Coal was ground under 3mmin diameter, then further pulverized by two-stage ball mills  ... 
doi:10.1252/jcej.21.602 fatcat:g5rkdlitkzhd5fu2uucffdolza

Use of Thallium-201 Myocardial Scintigraphy for the Prediction of the Response to β-Blocker Therapy in Patients With Dilated Cardiomyopathy

Yuji Hara, Mareomi Hamada, Tomoaki Ohtsuka, Akiyoshi Ogimoto, Hideyuki Saeki, Jun Suzuki, Tsuyoshi Matsunaka, Shigeru Nakata, Yuji Shigematsu
2002 Circulation Journal  
The Second Department of Internal Medicine, Ehime University School of Medicine and *The Department of Radiology, Ehime University School of Medicine, Ehime, Japan Mailing address: Yuji Hara, MD, The Second  ... 
doi:10.1253/circj.66.1139 pmid:12499621 fatcat:won4j6wjm5e7dintmhv4wxunmy

Antiarrhythmic Drug, Cibenzoline, can Directly Improve the Left Ventricular Diastolic Function in Patients With Hypertrophic Cardiomyopathy

Mareomi Hamada, Yuji Shigematsu, Yuji Hara, Makoto Suzuki, Tomoaki Ohtsuka, Go Hiasa, Akiyoshi Ogimoto, Hideyuki Saeki, Jun Suzuki, Kunio Hiwada
2001 Japanese Circulation Journal - English Edition  
ypertrophic cardiomyopathy (HCM) is functionally characterized by normal or supernormal left ventricular systolic function and impaired left ventricular diastolic function, and the severity of left ventricular diastolic dysfunction is related to exercise capacity, clinical symptoms and even prognosis. 1-3 The impairment of left ventricular diastolic function in patients with HCM is closely related to intracellular Ca 2+ overload and is also known to be frequency dependent. 4 Therefore, calcium
more » ... ntagonists are a rational choice for the treatment of HCM and many studies have reported improvement of diastolic function with these agents. However, the effect of calcium antagonists is often insufficient in many patients with HCM. The class Ia antiarrhythmic drug, cibenzoline, is known to have a calcium channel-blocking property, 5,6 and it has recently been reported that cibenzoline can attenuate the left ventricular pressure gradient (LVPG) and also improve the transmitral Doppler flow patterns in patients with hypertrophic obstructive cardiomyopathy (HOCM). 7-9 However, it is unknown whether this beneficial effect on left ventricular diastolic function is due to a direct effect of cibenzoline or the result of attenuation of the LVPG. We therefore investigated whether cibenzoline directly improves The effect of cibenzoline on left ventricular diastolic function was investigated in patients with hypertrophic cardiomyopathy (HCM). Before and 2 h after an oral administration of 200 mg of cibenzoline, echocardiographic, apexcardiographic and gated radionuclide angiographic studies were performed in 12 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 7 with hypertrophic nonobstructive cardiomyopathy (HNCM). After administration of cibenzoline, the left ventricular pressure gradient decreased from 96±33 mmHg to 29±22 mmHg (<0.0001). Fractional shortening decreased from 53.3±7.5 to 45.4±6.2% (p=0.0008) in patients with HOCM and from 49.9±8.7 to 40.9±7.5% (p=0.0039) in patients with HNCM. On the other hand, E-wave velocity increased and A-wave velocity decreased in both groups. The time between the second heart sound and O point was shortened from 253±53 to 176±21 ms (p<0.0001) in patients with HOCM and from 245±54 to 185±44 ms (p=0.0050) in patients with HNCM. The time to peak filling rate was shortened from 248±79 to 190±40 ms (p=0.0072) in patients with HOCM and from 218±33 to 163±26 ms (p=0.0052) in patients with HNCM. These results indicate that in patients with HCM, cibenzoline suppresses left ventricular systolic function, but can markedly improve left ventricular diastolic dysfunction through its direct action. (Jpn Circ J 2001; 65: 531 -538)
doi:10.1253/jcj.65.531 pmid:11407736 fatcat:a6ivef5uv5d6hmh63hmqzodcw4

Attenuation of Biventricular Pressure Gradients by Cibenzo-line in an 18-Year-Old Patient With Hypertrophic Obstructive Cardiomyopathy

Go Hiasa, Mareomi Hamada, Yuji Shigematsu, Yuji Hara, Tomoaki Ohtsuka, Akiyoshi Ogimoto, Hideyuki Saeki, Jun Suzuki, Tsuyoshi Matsunaka, Hironobu Hamada, Takafumi Okura, Kunio Hiwada
2002 Circulation Journal  
doi:10.1253/circj.66.1173 pmid:12499627 fatcat:dgg5jjgemjdlhf6465wy4apxhy

Pneumothorax in patients with idiopathic pulmonary fibrosis: a real-world experience

Ryo Yamazaki, Osamu Nishiyama, Kyuya Gose, Sho Saeki, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda
2021 BMC Pulmonary Medicine  
Background Some patients with idiopathic pulmonary fibrosis (IPF) develop pneumothorax. However, the characteristics of pneumothorax in patients with IPF have not been elucidated. The purpose of this study was to clarify the clinical course, actual management, and treatment outcomes of pneumothorax in patients with IPF. Methods Consecutive patients with IPF who were admitted for pneumothorax between January 2008 and December 2018 were included. The success rates of treatment for pneumothorax,
more » ... spital mortality, and recurrence rate after discharge were examined. Results During the study period, 36 patients with IPF were admitted with pneumothorax a total of 58 times. During the first admission, 15 patients (41.7%) did not receive chest tube drainage, but 21 (58.3%) did. Of the 21 patients, 8 (38.1%) received additional therapy after chest drainage. The respective treatment success rates were 86.6% and 66.7% in patients who underwent observation only vs chest tube drainage. The respective hospital mortality rates were 13.3% and 38.0%. The total pneumothorax recurrence rate after hospital discharge was 34.6% (n = 9). Conclusions Pneumothorax in patients with IPF was difficult to treat successfully, had a relatively poor prognosis, and showed a high recurrence rate.
doi:10.1186/s12890-020-01370-w pmid:33407311 fatcat:hkjcdtd5m5bhvblxxote5uthcu

Iron source effect on BaFe12O19 preparation through citrate route

Shinichi KIKKAWA, Kentaro AIBA, Yuji MASUBUCHI, Isao SAEKI
2009 Journal of the Ceramic Society of Japan  
Both magnetization and coercivity should be controlled on BaFe12O19 for its usage in magnetic recording. Preparation of BaFe12O19 was studied in citrate route by changing the kinds of iron source. Stoichiometric mixtures of iron compounds with Ba(NO3)2 were dissolved in distilled water. They were mixed with citric acid aqueous solution and then condensed on a hot plate to their gelatinous products. Their prefired products below 450°C were pelletized and then fired in a temperature range between
more » ... 750 and 900°C. The product from iron nitrate was a mixture of α-Fe2O3, BaFe2O4 and a small amount of BaFe12O19. The product from Fe(acac)3 was pure BaFe12O19 fine powder with a crystallite size of < 90 nm. The fine powdered product at 850°C had a saturation magnetization of 58.5 emu·g -1 and a coercivity of 5.5 kÖe.
doi:10.2109/jcersj2.117.15 fatcat:4iuohhvmw5h63ninbqbllqprqy

Snowmelt by Heat Transported from Shallow Underground

NOTO Yuji, KAWAKAMI Tomonori, SAEKI Takashi, SERIKAWA Yuka
2014 Journal of Ecotechnology Research  
Journal of EcotechnologyResearch, 17[3-4] (2014) NOTO Yuji et al. Snowmelt by Heat Transported from Shallow Underground  ... 
doi:10.11190/jer.17.131 fatcat:a6cxovlxc5gdbod35riac7xgnu

Extractions and Spectroscopic Studies of Various Metals with Diglycolamide-Type Tridentate Ligands

Yuji SASAKI, Morihisa SAEKI, Kazuharu YOSHIZUKA
2019 Solvent extraction research and development, Japan  
Three tridentate extractants and three masking reagents including O, N, and S donors have been developed and their properties are compared and discussed. The extractants are N,N,N′,N′-tetraoctyl-diglycolamide (TODGA), methylimino-N,N′-dioctylacetamide (MIDOA) and N,N,N′,N′-tetraoctyl-thiodiglycolamide (TDGA(C8)) together with masking agents having the same central frame but with short alkyl chains. The results of the present study indicate that TODGA can extract mainly hard acid metals
more » ... to groups 2-4,13-15 in the periodic table. MIDOA can extract soft acid metals and oxyanions (groups 5-10, 16), and TDGA can extract soft acid metals (groups 10-11). Some spectrophotometric studies (UV-vis., IR, and NMR) indicate the stoichiometry and the effect of donor atoms for metal-complexation. The ΔHf values, the heat generation during complex formation, obtained by chemical calculation by DFT theory show a reverse-correlation with their extraction ability. Introduction Recently, tridentate extractants and ligands have been developed and studied worldwide [1-6]. Tridentate ligands can complex effectively with metals with 6 and 9 coordination sites with 1 : 2 and 1 : 3 metal-ligand complex stochiometries, rather than monodentate and bidentate extractants. The strong extractabilities and high complexation abilities for metals by tridentate ligands have been reported in many papers [1, 4, 6] . One of the most important tridentate extractant is TODGA (N,N,N′,N′-tetraoctyl-diglycolamide) [5] . This compound has three oxygen donors (two carbonyl oxygen donors and an ether oxygen atom) attached with diamide groups outside of the central frame. Based on the HSAB principle [7], oxygen donors are preferred for hard acid metals, metals belonging groups 2-4 in the periodic table. TODGA can dissolve in n-dodecane and shows a very high distribution ratio (D) for actinides (An) and lanthanides (Ln) from nitric acid. Therefore, TODGA is a useful extractant for metal separation from high level radioactive liquid waste [8-12]. TODGA is composed of C, H, O, N atoms and complete gasification takes place on combustion, thus producing less secondary waste. N and S donor extractants, which are similar to TODGA, can be produced by substitution of the O atom at the ether position in TODGA. The N-compound with a methyl group attached is termed as MIDOA (methylimino-N,N′-dioctylacetamide) and the S-compound is TDGA (N,N,N′,N′-tetraoctyl-thiodiglycolamide) [6, 13-16]. These extractants can be synthesized by changing the initial materials to methylimino-diacetic acid or thiodiacetic acid from the diglycol acid of TODGA. Both N and S donors are soft donors and complexing well with soft acid metals used in all calculations. Input coordinates were obtained from X-ray crystal structure data available from the Cambridge Crystallographic Data Centre (CCDC). These calculations were terminated when the forces are smaller than the cutoff value over several cycles even though the displacement was larger than the cutoff value. The DFT calculations were performed using the Gaussian03 program package. The heats of formations of the metal complexes, metal ions, extractants, and anions (Hf,metal complex , H f,metal , H f,TDGA , and H f,anion ) were obtained from these calculations. The ΔH f values were obtained by subtracting the sum of H f,metal , H f,TDGA , and H f,anion from H f,metal complex and were compared with the information obtained from the solvent extraction experiments (i.e., the apparent extraction constants). Results and Discussion Matal extraction by three extractants Results on metal extraction using TODGA, MIDOA and TDGA are reported elsewhere [26, [30] [31] . In this work, the extraction data are reconfirmed, obtained under the same conditions, new data added and plotted in Figure 2 (a)-(f). In these figures, the results by the three extractants are compared. Figure 2(a) shows the results for Sr, Nd,
doi:10.15261/serdj.26.21 fatcat:rjnminc3jzhdlotenrnfbwhmfu

Influenza vaccination in hemodialysis patients

1981 The Kurume Medical Journal  
doi:10.2739/kurumemedj.28.159 fatcat:atq4fiwatbbk3hedyiv5k7n3um


Nobuki MATSUNAMI, Yuji SAEKI, Munehisa YAMATO, Tetsuhiko NAKAMURA, Kiyotaka OKUNO, Zenji IWASA, Masayuki YASUTOMI
1987 The journal of the Japanese Practical Surgeon Society  
児期(15歳 以下)の 乳癌 は きわ めて稀 で あ り, 著者 らの検索 に よる と,本 邦 の報告 例 はわず か に18例 をみ るにす ぎない.症 例数 が非 常 に少 な いため,小 児 乳癌 の特徴.予 後 な どに つい て不 明な点 が多 い.今回,我 々は13歳 女 児 の非浸 潤性 乳頭 腺管 癌 の1例 を経験 した ので,症 例 報告 をす る とと もに若 干 Yuji  ...  SAEKI, Munehisa YAMATO, Tetsuhiko NAKAMURA, Kiyotaka OKUNO, Zenji IWASA and Masayuki YASUTOMI First Department of Surgery, Kinki University School of Medicine 5号 小 児 乳癌 の1例 631 A CASE OF CHILDHOOD BREAST  ... 
doi:10.3919/ringe1963.48.627 fatcat:xxqzmw6p3zekzlyhlcixoxl7ou

The effect of pressure on pseudorotaxane formation by using the slipping method

Yuji Tokunaga, Nanae Wakamatsu, Akihiro Ohbayashi, Koichiro Akasaka, Susumu Saeki, Kenji Hisada, Tatsuhiro Goda, Youji Shimomura
2006 Tetrahedron Letters  
Graphical Abstract + 0 > V (activation volume) high pressure Volume TS pseudorotaxane Abstract-By using high-pressure conditions the formation of pseudorotaxane via the slipping approach is accelerated. Analysis of the effects of pressure on the rate constants affords activation volumes for the pseudorotaxane forming, slipping reactions. 1. (a) Balzai, V.; Credi, A.; Raymo, F. M.; Stoddart, J. F. Angew. Chem., Int. Ed. 2000, 39, 3348-3391; (b) Ballardini, R.; Balzani, V.; Credi, A.; Gandolfi,
more » ... T.; Venturi, M. Acc. Chem. Brancato, G.; Fanti, M.; Leigh, D. A.; Shimizu, T.; Slawin, A. M. Z.; Wong, J. K. Y.; Zerbetto, F.; Zhang, S.
doi:10.1016/j.tetlet.2006.02.107 fatcat:ixsgren5mza3xdggfndvdjmhha


Zenji IWASA, Yuji SAEKI, Nobuki MATSUNAMI, Munehisa YAMATO, Kazuyoshi KUROOKA, Akira TANAKA, Kiyotaka OKUNO, Takeshi FUKUHARA, Masayuki YASUTOMI
1986 The journal of the Japanese Practical Surgeon Society  
doi:10.3919/ringe1963.47.321 fatcat:uwkey63hl5eevjldstaysthioy
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