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EVALUATING IMAGE QUALITY OF A MAGNETIC RESONANCE IMAGER
MRI 装置の画質評価

TOSHIAKI MIYACHI, YOSHIYUKI HANAFUSA, HIROYUKI NARITA, YUJI Kondoh, YUJI YAGAMI, MASATAKA ACHIWA, FUMIO TANAKA, KATSUMI ARAKI, TAMOTSU KAWAI
1993 Japanese Journal of Radiological Technology  
An attempt was made to evaluate the imaging quality of various maglletic resonance imaging ( MRI ) modalities . Eight models were measured ( four O . 5Tand four 1 . 5Tmachines )using the same pharltolll . The results were thcn comparcd considering signal
doi:10.6009/jjrt.kj00003501359 fatcat:45eo6qdhcrd5jpkuoqvieh72pi

Expression of T-Cadherin in Basal Keratinocytes of Skin

Shuxia Zhou, Norihisa Matsuyoshi, Yoshiki Miyachi, Sheng-Ben Liang, Tamotsu Takeuchi, Yuji Ohtsuki
2002 Journal of Investigative Dermatology  
T-cadherin is a unique member of the cadherin superfamily that shares the ectodomain organization with classical cadherins, but lacks both transmembrane and cytoplasmic regions and is instead anchored to the plasma membrane through a glycosyl-phosphatidylinositol (GPI) moiety. The function of T-cadherin has not been revealed yet. The special structure of T-cadherin might endow this molecule with speci®c intracellular targeting properties and functions that are distinct from classical cadherins.
more » ... T-cadherin was originally cloned from chicken embryo brain and then was also found in mouse and human nervous and cardiovascular systems; however, T-cadherin in the keratinocytes and skin tissue is still an unknown area that remains to be explored. To test whether the unusual truncated T-cadherin is expressed in keratinocytes, we performed the reverse transcriptase-polymerase chain reaction of T-cadherin, as well as several classical cadherins (E-, P-, and N-cadherin), on the mouse keratinocyte cell line Pam212, ®broblast NIH3T3, and melanoma cell B16. The result indicated that mouse keratinocytes expressed the mRNA of truncated T-cadherin apart from classical cadherins, E-, and P-cadherin. To con®rm the expression of T-cadherin in mouse keratinocytes, immunocytochemistry staining was carried out on Pam212 cells by using rabbit anti-T-cadherin antibody and rat antimouse E-and P-cadherin antibody. The result of immuno¯uorescence staining proved that T-cadherin was expressed in mouse ker-atinocytes. In order to analyze the distribution patterns of T-cadherin and classical cadherins on the keratinocytes, 3D scanning was performed by using a confocal microscope. From the Z-sections and XZ-sections, it was clearly demonstrated that T-cadherin was distributed diffusely on the whole cell surface, while E-and P-cadherin were concentrated on the cell±cell contacts. To examine the expression and the localization of T-cadherin on skin tissue, the frozen sections of the mouse back skin were immunohistochemically labeled by using anti-T-cadherin antibody. It was found that T-cadherin was intensively expressed only on the basal cell layer of the mouse skin. Apart from mouse keratinocytes and mouse skin, we further examined the expression of T-cadherin in human keratinocytes and human skin by western blot, immunocytochemistry, and immunohistochemistry staining. The same results were achieved with human samples. In this study, we found and veri®ed that T-cadherin was expressed on the mouse and human keratinocytes and speci®cally localized on the basal cell layer of skin. The nature of T-cadherin function and its mechanism of localization at the basal cell layer of skin are important issues to be addressed concerning this unique member of the cadherin family and its physiologic and pathologic roles in the skin. Key words: basal cell/ epidermis/ keratinocyte/ T-cadherin.
doi:10.1046/j.1523-1747.2002.01795.x pmid:12060406 fatcat:ef6stapkmnewjpnrdobdqrojxm

Management of Hilar Cholangiocarcinoma

Jane I. Tsao, Yuji Nimura, Junichi Kamiya, Naokazu Hayakawa, Satoshi Kondo, Masato Nagino, Masahiko Miyachi, Michio Kanai, Katsuhiko Uesaka, Koji Oda, Ricardo L. Rossi, John W. Braasch (+1 others)
2000 Annals of Surgery  
Objective To compare the experience and outcome in the management of hilar cholangiocarcinoma at one American and one Japanese medical center. Summary Background Data Controversies surround the issues of extent of resection for hilar cholangiocarcinoma and whether the histopathology of such cancers are similar between patients treated in America and in Japan. Methods Records were reviewed of 100 patients treated between 1980 and 1995 at the Lahey Clinic in the United States, and of 155 patients
more » ... treated between 1977 and 1995 at Nagoya University Hospital in Japan. Selected pathologic slides of resected cancers were exchanged between the two institutions and reviewed for diagnostic concordance. Results In the Lahey cohort, there were 25 resections, 53 cases of surgical exploration with biliary bypass or intubation, and 22 cases of percutaneous transhepatic biliary drainage or endo-scopic biliary drainage without surgery. In the Nagoya cohort, the respective figures were 122, 10, and 23. The overall 5-year survival rate of all patients treated (surgical and nonsurgical) during the study periods was 7% in the Lahey cohort and 16% in the Nagoya cohort. The overall 10-year survival rates were 0% and 12%, respectively. In patients who underwent resection with negative margins, the 5-and 10-year survival rates were 43% and 0% for the Lahey cohort and 25% and 18% for the Nagoya cohort. The surgical death rate for patients undergoing resection was 4% for Lahey patients and 8% for Nagoya patients. Of the patients who underwent resection, en bloc caudate lobectomy was performed in 8% of the Lahey patients and 89% of the Nagoya patients. Histopathologic examination of resected cancers showed that the Nagoya patients had a higher stage of disease than the Lahey patients.
doi:10.1097/00000658-200008000-00003 pmid:10903592 pmcid:PMC1421125 fatcat:bzax6tjgnnhtnn3wmb4ccs3svu

Loss of T-Cadherin (CDH13, H-Cadherin) Expression in Cutaneous Squamous Cell Carcinoma

Tamotsu Takeuchi, Sheng-Ben Liang, Norihisa Matsuyoshi, Shuxia Zhou, Yoshiki Miyachi, Hiroshi Sonobe, Yuji Ohtsuki
2002 Laboratory Investigation  
We previously reported that T-cadherin (CDH13, H-cadherin), a unique cadherin molecule, was expressed on the basal cell layer in normal murine and human epidermis. In the present study, T-cadherin expression in archival human skin specimens comprising a spectrum of human squamous cell neoplasia was investigated. T-cadherin expression was observed in both normal epidermal basal cells and adnexal epithelial cells of formalin-fixed and paraffin-embedded tissue sections. Western immunoblotting also
more » ... revealed that mature T-cadherin protein was expressed in cultured human skin tissue equivalent. Atypical keratinocytes in 27 of 53 specimens of actinic keratosis and 23 of 30 specimens of Bowen's disease expressed T-cadherin. In contrast, T-cadherin was focally expressed in 6 of 56 invasive cutaneous squamous cell carcinomas. To explore the molecular mechanism of down-regulation of T-cadherin expression in invasive squamous cell carcinoma, loss of heterozygosity, genetic alternations, and methylation status in the 5Ј region of the T-cadherin gene were investigated. Loss of heterozygosity at intron 1 of the T-cadherin gene was observed in 8 of 28 informative cases of invasive squamous cell carcinoma. Although no structural genomic alternations were found by sequence analysis, aberrant promoter methylation of the T-cadherin gene was found in 12 of 28 invasive squamous cell carcinomas. T-cadherin expression was restored in cultured A431 cells, in which aberrant methylation was found by treatment with the demethylating agent 5Ј-aza-2-deoxycytidine. These findings suggest that a combination of deletion and aberrant methylation of the T-cadherin gene may play a role in loss of gene expression in a considerable number of invasive cutaneous squamous cell carcinomas.
doi:10.1097/01.lab.0000025391.35798.f1 fatcat:kfb4dnhju5gmjbsojgbmu4cybu

Dose–response relationship between sports activity and musculoskeletal pain in adolescents

Masamitsu Kamada, Takafumi Abe, Jun Kitayuguchi, Fumiaki Imamura, I-Min Lee, Masaru Kadowaki, Susumu S. Sawada, Motohiko Miyachi, Yuzuru Matsui, Yuji Uchio
2016 Pain  
Physical activity has multiple health benefits but may also increase the risk of developing musculoskeletal pain (MSP). However, the relationship between physical activity and MSP has not been well characterized. This study examined the dose-response relationship between sports activity and MSP among adolescents. Two school-based serial surveys were conducted 1 year apart in adolescents aged 12 to 18 years in Unnan, Japan. Self-administered questionnaires were completed by 2403 students.
more » ... tions between time spent in organized sports activity and MSP were analyzed cross-sectionally (n 5 2403) and longitudinally (n 5 374, students free of pain and in seventh or 10th grade at baseline) with repeated-measures Poisson regression and restricted cubic splines, with adjustment for potential confounders. The prevalence of overall pain, defined as having pain recently at least several times a week in at least one part of the body, was 27.4%. In the cross-sectional analysis, sports activity was significantly associated with pain prevalence. Each additional 1 h/wk of sports activity was associated with a 3% higher probability of having pain (prevalence ratio 5 1.03, 95% confidence interval 5 1.02-1.04). Similar trends were found across causes (traumatic and nontraumatic pain) and anatomic locations (upper limbs, lower back, and lower limbs). In longitudinal analysis, the risk ratio for developing pain at 1-year follow-up per 1 h/wk increase in baseline sports activity was 1.03 (95% confidence interval 5 1.02-1.05). Spline models indicated a linear association (P , 0.001) but not a nonlinear association (P $ 0.45). The more the adolescents played sports, the more likely they were to have and develop pain.
doi:10.1097/j.pain.0000000000000529 pmid:26894915 pmcid:PMC4866582 fatcat:fcepri6v2vbj5d2zfdurpwmsy4

The contribution of Nintendo Wii Fit series in the field of health: a systematic review and meta-analysis

Julien Tripette, Haruka Murakami, Katie Rose Ryan, Yuji Ohta, Motohiko Miyachi
2017 PeerJ  
The search and data extraction were performed by two independent researchers (Murakami H and Tripette J) and any discrepancies were resolved by a third contributor (Miyachi M) .  ...  Yuji Ohta contributed reagents/materials/analysis tools, reviewed drafts of the paper.  ...  Motohiko Miyachi conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.  ... 
doi:10.7717/peerj.3600 pmid:28890847 pmcid:PMC5590553 fatcat:bcci5i662nc4jk6loq3m2e6qwy

Endovascular treatment of spinal vascular lesion in Japan: Japanese Registry of Neuroendovascular Therapy (JR-NET) and JR-NET2

Wataro Tsuruta, Yuji Matsumaru, Shigeru Miyachi, Nobuyuki Sakai
2013 Neurologia medico-chirurgica  
investigator; Nobuyuki sakai, kobe city Medical center General hospital, kobe, Japan: investigators; akio hyodo, Dokkyo Medical university koshigaya hospital, koshigaya, Japan (17c-1, 20c-2), shigeru Miyachi  ...  university, Niigata, Japan, shigeki kobayashi, chiba Emergency Medical center, chiba, Japan, Masaki komiyama, Osaka city General hospital, Osaka, Japan, Naoya kuwayama, Toyama university, Toyama, Japan, Yuji  ... 
pmid:24305018 pmcid:PMC4508696 fatcat:f2splhk3jnarjbcbzk4lvaymr4

Gossypiboma Mimicking Gastrointestinal Stromal Tumor Causing Intestinal Obstruction: A Case Report

Yurika Kawamura, Naotaka Ogasawara, Sayuri Yamamoto, Makoto Sasaki, Naohiko Kawamura, Shinya Izawa, Yuji Kobayashi, Seiji Kamei, Masahiko Miyachi, Kunio Kasugai
2012 Case Reports in Gastroenterology  
A 41-year-old woman was admitted to our hospital with abdominal pain that developed about 1 year after a Cesarean section. Pelvic computed tomography (CT) revealed diffuse dilation of the small intestine with fluid shadows and a pelvic tumor 55 mm in diameter. The density of the tumor, which was not enhanced by intravenous contrast medium, was diffuse and similar to that of muscular tissue, whereas the density of a capsule surrounding the mass was relatively high. T1-and T2-weighted pelvic
more » ... tic resonance imaging (MRI) of the tumor revealed the same diffuse low-intensity signals as muscular tissue, and diffuse high-intensity signals, respectively. The CT and MRI findings were consistent with those of a gastrointestinal stromal tumor (GIST) causing ileus of the small intestine. As inserting an ileus tube did not improve her symptoms, the patient was scheduled for tumor resection. The operative findings revealed a hard, solid tumor adhering to the surrounding small intestine. The macroscopic findings revealed that the tumor consisted of layers of stratified gauze surrounded by a thick granulomatous wall. The gossypiboma was considered to have originated from gauze that had been left behind after the Cesarean section. If a patient has a history of surgery, the possibility of gossypiboma should be considered when CT or MRI findings indicate features of GIST.
doi:10.1159/000338833 pmid:22679410 pmcid:PMC3369411 fatcat:qddzs5gqtzam3cqeohk6rok5pi

Endovascular Treatment of Spinal Vascular Lesion in Japan: Japanese Registry of Neuroendovascular Therapy (JR-NET) and JR-NET2

Wataro TSURUTA, Yuji MATSUMARU, Shigeru MIYACHI, Nobuyuki SAKAI
2014 Neurologia medico-chirurgica  
investigator; Nobuyuki sakai, kobe city Medical center General hospital, kobe, Japan: investigators; akio hyodo, Dokkyo Medical university koshigaya hospital, koshigaya, Japan (17c-1, 20c-2), shigeru Miyachi  ...  university, Niigata, Japan, shigeki kobayashi, chiba Emergency Medical center, chiba, Japan, Masaki komiyama, Osaka city General hospital, Osaka, Japan, Naoya kuwayama, Toyama university, Toyama, Japan, Yuji  ... 
doi:10.2176/nmc.oa2013-0201 pmid:26236818 fatcat:f22s64ahnzadxaybjuxkihdmcy

Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to thesrc-homology region 2

Masaaki Adachi, Masuo Sekiya, Toshiki Miyachi, Keiki Matsuno, Yuji Hinoda, Kohzoh Imai, Akira Yachi
1992 FEBS Letters  
Prorein-tyrosine phosphorylation and dcphosphorylntion are directly associated with cellular growlh. signal transduction, and ncoplastic trnnsformation. Here we report the isolation of a complementary DNA @DNA) clone encoding a novel protein-tyrosinc phosphatasc (PTP) from a human T cell PEER cDNA library. The predicted open reading frame encodes a -68.kDa protein composed of 593 amino acids which contains LWO src-homology region 2's (SH2 domains) at the N terminus; this PTP is dcsibflated as
more » ... -PTP3. Northern blot analysis revealed that SH-PTP3 mRNA was expressed throughout many tissues and the transcriptional size wns consistent al about 6.0 kb. As with olhcr SH2 domains in x-family kinascs, the SH2 domains of SH-PTP3 may play a crucial role in interactions with tyrosinc phosphorylnlcd signding proteins, including itself and protein tyrosine kinascs (PTKs), to regulute targets' enzyme activity. Protein-tyrosine phosphatasc; Protein lyrosine kinase; src-Homology region 2
doi:10.1016/0014-5793(92)81500-l pmid:1281790 fatcat:22n2anywj5guraiip2yphh2ia4

22. 伝導性サンプル (人体) の受信感度に与える影響(MRI-5 受信技術)

Toshiaki Miyachi, Harumasa Kasai, Toshiaki Sakakibara, Katsuhiro Ichikawa, Yasujiroh Hirose, Yuji Yagami, Masakazu Kamiya, Takusei Yoshida, Hiromichi Iwata
1990 Japanese Journal of Radiological Technology  
doi:10.6009/jjrt.kj00003321815 fatcat:kliqbz6bergc3ku5k45qrvcklq

FUNDAMENTAL AND CLINICAL STUDIES ON CEFUZONAM IN THE FIELD OF PEDIATRICS
小児科領域におけるCefuzonamの基礎的, 臨床的検討

KUNIYOSHI KUNO, SUSUMU HAKAMADA, YUKINORI MIYACHI, TAKAHIRO NAKASHIMA, FUMIO HAYAKAWA, KIYOKUNI MIURA, YUJI MIYAJIMA
1987 The Japanese Journal of Antibiotics  
doi:10.11553/antibiotics1968b.40.405 fatcat:zfgkhlq23rf57dkkw3zsn5eymq

An immuno-histochemical review of EGF receptors in tumors of the epidermis
表皮系の腫ようにおけるEGFリセプターの免疫組織化学的検討

Mayumi FUJITA, Yoshiki MIYACHI, Naoko DOSAKA, Kenzo TAKAHASHI, Mari SAWAMI, Yuji HORIGUCHI, Sadao IMAMURA
1989 Skin Cancer  
抗EGFリ セ プ * Mayumi FUJITA, Yoshiki MIYACHI, Naoko DOSAKA, Kenzo TAKAHASHI, Marl SAWAMI, Yuji HORIGUCHI, Sadao タ ー 抗 体 はEGFリ セ プ タ ー のN末 端 で あ る EGF結 合 部 位 と反 応 し, EGFの 結 合 と拮 抗 す る7)。  ... 
doi:10.5227/skincancer.4.143 fatcat:kgzrahub2jesjcryc2szu7mcji

A Case of Adult Intestinal Intusuhception after Transperitoneal Nephrectomy
開腹下腎摘出術後に発症した成人腸重積症の1例

Norimasa Koide, Yuji Nimura, Junichi Kamiya, Satoshi Kondo, Masato Nagino, Masahiko Miyachi, Hiroto Akiyama
1996 The Japanese Journal of Gastroenterological Surgery  
日 臨 外 医 会 誌53: 2706-2710, 1992 A Case of Adult Intestinal Intussusception after Transperitoneal Nephrectomy Norimasa Koide, Yuji Nimura, Junichi Kamiya, Satoshi Kondo, Masato Nagino, Masahiko Miyachi and  ... 
doi:10.5833/jjgs.29.1702 fatcat:zm7cs6xvrrglrc4bwqzkbcyqpu

Major Hepatic Resection for Biliary Carcinoma in the Elderly
高齢者胆道癌における大量肝切除術の問題点

Michio Kanai, Yuji Nimura, Naokazu Hayakawa, Junichi Kamiya, Satoshi Kondo, Masato Nagino, Masahiko Miyachi, Katsuhiko Uesaka, Shinichi Mizuno
1996 The Japanese Journal of Gastroenterological Surgery  
, Junichi Kamiya, Satoshi Kondo, Masato Nagino, Masahiko Miyachi, Katsuhiko Uesaka and Shinichi Mizuno The First Department of Surgery, Nagoya University School of Medicine We retrospectively evaluated  ...  Ann Surg 211: 141-145, 1990 6) 早 川直 和, 二 村 雄 次, 神 谷 順一 ほ か: 高齢 者 の肝 切 除 にお け る侵襲 範 囲 と術 後 合 併 症-悪 Major Hepatic Resection for Biliary Carcinoma in the Elderly Michio Kanai, Yuji Nimura, Naokazu Hayakawa  ... 
doi:10.5833/jjgs.29.2038 fatcat:2c7xxztgzfc4zdpo5b4nbucb4m
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