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The Micro-Analysis for Composition in DPT Ferroelectrics To cite this article: Xu Yuhuan and Wang Hong 1985 Jpn. J. Appl. Phys. 24 236 View the article online for updates and enhancements. ... Xu et al This content was downloaded from IP address 18.104.22.168 on 26/07/2018 at 20:00 Related content Point Defect Characteristics of High-k Double Rare-Earth-Doped BaTiO 3 Ceramics with Diffuse ...doi:10.7567/jjaps.24s2.236 fatcat:x2jhdkxpwrc4vdv2crrlnrshye
Surface-enhanced Raman spectroscopy (SERS) is a powerful sensing technique capable of capturing ultrasensitive fingerprint signal of analytes with extremely low concentration. However, conventional SERS probes are passive nanoparticles which are usually massively applied for biochemical sensing, lacking controllability and adaptability for precise and targeted sensing at a small scale. Herein, we report a "rod-like" magnetic nanomotor-based SERS probe (MNM-SP) that integrates a mobile anddoi:10.34133/2020/7962024 pmid:32566931 pmcid:PMC7293755 fatcat:5wyofpue35fxhizhn5ya2ysoqe
more »... llable platform of micro-/nanomotors with a SERS sensing technique. The "rod-like" structure is prepared by coating a thin layer of silica onto the self-assembled magnetic nanoparticles. Afterwards, SERS hotspots of silver nanoparticles (AgNPs) are decorated as detecting nanoprobes. The MNM-SPs can be navigated on-demand to avoid obstacles and target sensing sites by the guidance of an external gradient magnetic field. Through applying a rotating magnetic field, the MNM-SPs can actively rotate to efficiently stir and mix surrounding fluid and thus contact with analytes quickly for SERS sensing. Innovatively, we demonstrate the self-cleaning capability of the MNM-SPs which can be used to overcome the contamination problem of traditional single-use SERS probes. Furthermore, the MNM-SPs could precisely approach the targeted single cell and then enter into the cell by endocytosis. It is worth mentioning that by the effective mixing of intracellular biocomponents, much more informative Raman signals with improved signal-to-noise ratio can be captured after active rotation. Therefore, the demonstrated magnetically activated MNM-SPs that are endowed with SERS sensing capability pave way to the future development of smart sensing probes with maneuverability for biochemical analysis at the micro-/nanoscale.
Phosphate-modified baker's yeast (PMBY) was used as a novel bio-sorbent for the adsorption of Pb2+ from aqueous solution.doi:10.1039/c7ra13545a pmid:35542041 pmcid:PMC9078495 fatcat:i6pwhexwajc23nuc7kyfvpjsym
Self-propelling micro/nano-motors have attracted great attention due to their controllable active motion and various functional attributes. To date, a variety of technologies have been reported for the fabrication of micro/nano-motors. However, there are still several challenges that need to be addressed. One of them is to endow micro/nano-motors with multi-functionalities by a facile fabrication process. Here, we present a universal approach, adopted from the emulsion templating method, fordoi:10.3390/mi9020083 pmid:30393358 pmcid:PMC6187295 fatcat:e5o4mg7h4fallbtvzplfvxkxne
more »... fabrication of Janus micro-motors. With a one-step process, magnetic nanoparticles and fluorescent dyes are simultaneously embedded into the microparticles. The self-propelled motors can be used as an active label or fluorescent tracer through manipulation of their motion using magnetic guidance.
Currently, mobile edge computing (MEC) is one of the most popular techniques used to respond to real-time services from a wide range of mobile terminals. Compared with single-phase systems, commercial services in MEC can be modeled as phased-mission systems (PMS) and are much more complex, because of the dependencies across the phases. Over the past decade, researchers have proposed a set of new algorithms based on BDD for fault tree analysis of a wide range of PMS with various missiondoi:10.1155/2020/8823952 fatcat:uwcquqhsrjdldjezb3z2armufu
more »... nts and failure behaviors. The analysis to be performed on a fault tree can be either qualitative or quantitative. For the quantitative fault tree analysis of PMS by means of BDD, much work has been conducted. However, for the qualitative fault tree analysis of PMS by means of BDD, no much related work can be found. In this paper, we have presented some efficient methods to calculate the MCS encoding by a PMS BDD. Firstly, three kinds of redundancy relations-inclusive relation, internal-implication relation, and external-implication relation-within the cut set are identified, which prevent the cut set from being minimal cut set. Then, three BDD operations, IncRed, InImpRed, and ExImpRed, are developed, respectively, for the elimination of these redundancy relations. Using some proper combinations of these operations, MCS can be calculated correctly. As an illustration, some experimental results on a benchmark MEC system are given.
Regional innovation system is importance driving force for regional economic development. In modern times, lowcarbon economy becomes more and more important and government -industry-research integration plays important role in low-carbon innovation and regional innovation system. This paper focuses on study of govern-industryresearch integration based on low-carbon innovation system through analysis of regional low-carbon element, network and system dynamic model. Through above analysis, itdoi:10.1016/j.egypro.2011.03.428 fatcat:ibzfprgi2rb5xhtqv3d7ff6pv4
more »... s to clearly understand operational mechanism of such integration in regional low-carbon system.
Serum proteome analysis provides a potential promising approach in disease diagnosis and therapeutic monitoring. However, the large dynamic range of proteins, high-abundant proteins, excess of salt and lipid in serum makes the analysis very challenging. Therefore, it is imperative to improve the dissolution of proteins in twodimensional gel electrophoresis (2-DE), and enhance the ability to analyze the proteome of serum under a wide variety of physiological conditions. This study examined thedoi:10.4172/jpb.1000032 fatcat:hfhpcmulwzhkpnvjn5smbtbewa
more »... fects of various combinations of depletion highabundant protein, precipitated means, hot SDS treatment and IPG strips with different pH on 2-DE map for mouse serum. Finally the removal of high-abundant proteins in serum by the ProteoExtract TM Albumin Removal column, ethanol precipitation, the heating with 2.5% SDS and 2.3% DTT to denature sample at 95 o C for 3 min, and IEF on pH 4-7 IPG strips (17cm) with 100 µg depleted serum proteins are generally recommended for serum proteome analysis on 2-DE by silver staining, which can effectively improve the resolution and intensity of low-abundant proteins. The optimized conditions help to produce a better reference 2-DE gel of serum samples for following identification potential novel disease markers.
Zygotic genome activation (ZGA) is one of the most critical events at the beginning of mammalian preimplantation embryo development (PED). The mechanisms underlying mouse ZGA remain unclear although it has been widely studied. In the present study, we identified that tricho-rhino-phalangeal syndrome 1 (TRPS1), an atypical GATA family member, is an important factor for ZGA in mouse PED. We found that the Trps1 mRNA level peaked at the one-cell stage while TRPS1 protein did so at thedoi:10.1080/15384101.2019.1577650 pmid:30712485 pmcid:PMC6422480 fatcat:mhdhm55ok5bzfil72p2j4w6yiy
more »... stage. Knockdown of Trps1 by the microinjection of Trps1 siRNA reduced the developmental rate of mouse preimplantation embryos by approximately 30%, and increased the expression of ZGA marker genes MuERV-L and Zscan4d via suppressing the expression of major histone markers H3K4me3 and H3K27me3. Furthermore, Trps1 knockdown decreased the expression of Sox2 but increased Oct4 expression. We conclude that TRPS1 may be indispensable for zygotic genome activation during mouse PED.
Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. It causes severe viral pneumonia and is associated with a high fatality rate. However, the pathogenesis, comparative pathology and inflammatory cell response of rhesus macaques and common marmosets experimentally infected with MERS-CoV are unknown. We describe the histopathological, immunohistochemical, and ultrastructural findings from rhesus macaque and common marmosetdoi:10.1371/journal.pone.0172093 pmid:28234937 pmcid:PMC5325479 fatcat:ygmbdbembzahfayal3yprf27fa
more »... models of MERS-CoV infection. The main histopathological findings in the lungs of rhesus macaques and common marmosets were varying degrees of pulmonary lesions, including pneumonia, pulmonary oedema, haemorrhage, degeneration and necrosis of the pneumocytes and bronchial epithelial cells, and inflammatory cell infiltration. The characteristic inflammatory cells in the lungs of rhesus macaques and common marmosets were eosinophils and neutrophils, respectively. Based on these observations, the lungs of rhesus macaques and common marmosets appeared to develop chronic and acute pneumonia, respectively. MERS-CoV antigens and viral RNA were identified in type I and II pneumocytes, alveolar macrophages and bronchial epithelial cells, and ultrastructural observations showed that viral protein was found in type II pneumocytes and inflammatory cells in both species. Correspondingly, the entry receptor DDP4 was found in type I and II pneumocytes, bronchial epithelial cells, and alveolar macrophages. The rhesus macaque and common marmoset animal models of MERS-CoV can be used as a tool to mimic the oncome of MERS-CoV infections in humans. These models can help to provide a better understanding of the pathogenic process of this virus and to develop effective medications and prophylactic treatments. et al. (2017) Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus. PLoS ONE 12(2): e0172093. Abbreviations: MERS, middle east respiratory syndrome; CoV, coronavirus; ISH, in situ hybridization; IHC, immunohistochemistry; DDP4, dipeptidyl peptidase 4; CD, cluster of differentiation. Pathology of MERS-CoV infection PLOS ONE |
BACKGROUND The management of Gustilo and Anderson grade III injury remains difficult, particularly due to the incidence of wound infections, delayed fracture union, and traumatic extremity amputation. However, little data is available on delayed skin graft or flap reconstructions of Gustilo grade III injury, especially using new technologies of wound coverage, such as vacuum sealing drainage (VSD) combined with limited internal and/or external fixation. MATERIAL AND METHODS Between June 2008pmid:27564219 pmcid:PMC5003148 fatcat:ksoy2b44grcm7myfq6stao7b5u
more »... May 2013, we performed the VSD technique combined with limited internal and/or external fixation on 38 patients (22 males and 16 females, with a mean age of 36.5 years) with Gustilo and Anderson grade III injury. VSD was regularly changed and delayed skin grafts or flaps were used to cover the defect. Two patients were lost to follow-up, and the remaining 36 were available for evaluation. The complications, wound healing, infections, and bony union were assessed for a mean duration of 2.5 years (range, 1-4 years). RESULTS Complications were seen in 5 of the 36 cases: 2 cases had infection alone, 1 case had delayed union or nonunion, 1 case had infection and delayed union, and 1 case had wound necrosis, infection, and nonunion. VSD was regularly changed 2-6 times. Morphological appearance and functional recovery were satisfactory in all cases. CONCLUSIONS Using VSD before skin grafts or flaps coverage, combined with limited internal and/or external fixation, is a suitable option for Gustilo and Anderson grade III injury.
Journal of Magnetics
In this paper, magnetorheological fluids (MRFs) based on micro-sized iron particles dispersed in silicone oil are presented. The iron particles are modified by adding different ratios of oleic acid and lauric acid as surfactants to the suspensions. Lauric acid was found to reduce the stability of the MRFs, and more lauric acid results in a higher rate of sedimentation. Further study showed that the formation and structure of lauric acid may result in the sedimentation of micrometer-sizeddoi:10.4283/jmag.2015.20.3.317 fatcat:nf7me4dksnd7poty536utg3hsq
more »... es. Meanwhile, the electro-resistance of MRF in this paper shows a decrease from beyond 6000 MΩ to 190 Ω with an increase in the external field from 0 mT to 400 mT.
A mouse model of spontaneous latent tuberculosis infection (LTBI) that mimics LTBI in humans is valuable for drug/vaccine development and the study of tuberculosis. However, most LTBI mouse models require interventions, and a spontaneous LTBI mouse model with a low bacterial load is difficult to establish. In this study, mice were IV-inoculated with 100 CFU Mycobacterium tuberculosis H37Rv, and a persistent LTBI was established with low bacterial loads (0.5∼1.5log 10 CFU in the lung; <4log 10doi:10.3389/fmicb.2015.01490 pmid:26779146 pmcid:PMC4705449 fatcat:wokrfs3zqvbdjmjt3x4y3ggfta
more »... U in the spleen). Histopathological changes in the lung and spleen were mild during the first 20 weeks post-inoculation. The model was used to demonstrate the comparative effects of prophylactic and therapeutic administration of Ganoderma lucidum extract (spores and spores lipid) in preventing H37Rv replication in both lung and spleen. H37Rv was inhibited with prophylactic use of G. lucidum extract relative to that of the untreated control and therapy groups, and observed in the spleen and lung as early as post-inoculation week 3 and week 5 respectively. H37Rv infection in the therapy group was comparable to that of the untreated control mice. No significant mitigation of pathological changes was observed in either the prophylactic or therapeutic group. Our results suggest that this new LTBI mouse model is an efficient tool of testing anti-tuberculosis drug, the use of G. lucidum extract prior to M. tuberculosis infection may protect the host against bacterial replication to some extent.
AbstractMantle cell lymphoma (MCL) is a relatively rare subtype of non-Hodgkin's lymphoma. To identify molecular biomarkers in MCL, we performed immunohistochemistry tissue arrays using biopsies from 64 MCL patients diagnosed in West China Hospital from 2012 to 2016. TP53 mutation status in those patients was also examined by sequencing. The sequencing results showed TP53 mutations were highly heterogeneous in MCL. We identified four novel TP53 mutations in MCL: P151R, G199R, V218E, and G325R.doi:10.1038/s41598-021-91433-7 pmid:34099776 fatcat:sbckhzol4bgdtadv2gq4ru5anm
more »... he MCL patients with TP53 mutations had inferior progression-free survival (PFS, p = 0.002) and overall survival (OS, p = 0.011). Tissue array results showed the expression of p53, Sox11, or Pax5 alone did not correlate with the patient PFS and OS. However, the MCL patients with triple-positive expression of p53/Sox11/Pax5 had inferior PFS (p = 0.008) and OS (p = 0.002). Such risk stratification was independent to the mantle cell lymphoma international prognostic index (MIPI), Ki-67 value, and TP53 mutation status of the patients. The triple-positive patients might represent a subtype of high-risk MCL. Our findings might indicate a novel way to stratify MCL and predict patients' prognosis.
Optical Properties and Linear Electro-Optic Effect in Ferroelectric Single Crystal KNSBN To cite this article: Xu Yuhuan et al 1985 Jpn. J. Appl. ... The Linear Electro-Optic Effect of (Ba 1-Phase transition of some ferroelectric niobate crystals with tungsten-bronze structure at low temperatures Yuhuan Xu et al -This content was downloaded from IP ...doi:10.7567/jjaps.24s2.278 fatcat:qlby2xnshnd4nlohrgmsjxyvtm
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