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IFIP Advances in Information and Communication Technology
As early as 1995, Tao  studied on color differences between apples and potatoes using machine vision, Zhou-Long  detected the image edge and Shen Zuo-rui  distinguished the geometrical characteristic ...doi:10.1007/978-3-642-27275-2_55 fatcat:p5adg4yndvcv3ot7tomtpijf7m
Despite improvement in motor symptoms, the effect of dopaminergic medications on cognition in patients with Parkinson's disease (PD) is less clear. The purpose of this study was to reveal levodopa-induced acute changes in the functional connectivity of the striatum in patients with PD compared with matched untreated patients and healthy volunteers. Methods Twenty-two patients with PD underwent functional magnetic resonance imaging both ON and OFF dopamine-replacement therapy on two consecutivedoi:10.1371/journal.pone.0161935 pmid:27611959 pmcid:PMC5017636 fatcat:d64ylrj7bffodifbnvv5ccpnou
more »... ays. Twenty-eight normal aging volunteers also did them without taking in levodopa. Three caudate seeds and two putamen seeds were selected to calculate functional connectivity intensity. Results Motor symptoms measured by UPDRS were significantly worse in PD OFF than PD ON. Decreased functional connectivity in PD OFF compared to controls was detected in the following seed regions: dorsal caudate, ventral putamen and dorsal putamen. Increases in connectivity in PD ON compared to controls were found in the primary and supplementary motor areas and the associative prefrontal and parietal regions, while decreases in anterior cingulate, ventromedial prefrontal cortex, and parahippocampal gyrus. For the ventral striatal seeds, decreased connectivity in PD ON compared to PD OFF was found in the ventromedial prefrontal and orbitofrontal regions, dorsolateral prefrontal regions. For the dorsal PLOS ONE | striatal seeds, increased connectivity in PD ON compared to PD OFF was observed in the primary and secondary motor areas. Conclusion Our results suggest that levodopa significantly changes the motor and cognitive networks of the cortico-striatal pathways. This knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy. Altered Functional Connectivity of the Striatum in PD PLOS ONE |
Adzuki bean (Vigna angularis) is one of the most important legume crops in Asian countries like China, Japan and Korea due to its nutritious protein and starch contents. In spite of its economic importance, gene expression analysis system for gene function verification of adzuki bean is still absent. Therefore, reference genes for gene expression analysis based on the quantitative real time PCR (qRT-PCR) were screened in current study. A total of nine general housekeeping genes, including ACT,doi:10.1371/journal.pone.0168479 pmid:27992593 pmcid:PMC5161372 fatcat:xsq2yvxwuzhwlknujzq5jeoqaa
more »... box, ZMPP, GAPDH, EF, PP2A, UBC, UBN and PTB were evaluated for their expression stability by qRT-PCR in four adzuki bean cultivars, three different tissues, four abiotic stress and one biotic stress. The best group of candidates as reference genes were as follows: PTB and ACT for different cultivars; EF and UBN for different tissues; ACT and ZMPP for biotic stress and waterlogging stress; Fbox and UBC for salinity-alkalinity stress; Fbox and PTB for drought stress. Our results will provide a more accurate and reliable normalization of qRT-PCR data in adzuki bean.
Background-Pulmonary arterial remodeling characterized by increased vascular smooth muscle proliferation is commonly seen in life-threatening disease, pulmonary arterial hypertension (PAH). Clinical studies have suggested a correlation between osteoprotegerin serum levels and PAH severity. Here, we aimed to invhestigate vascular osteoprotegerin expression and its effects on pulmonary arterial smooth muscle cell proliferation in vitro and in vivo, as well as examine the signal transductiondoi:10.1161/circgenetics.116.001591 pmid:28077433 fatcat:tncyucdzknaorfghbsc7xxdtnm
more »... ys mediating its activity. Methods and Results-Serum osteoprotegerin levels were significantly elevated in patients with PAH and correlated with disease severity as determined by the World Health Organization (WHO) functional classifications and 6-minute walking distance tests. Similarly, increased osteoprotegerin expression was observed in the pulmonary arteries of hypoxia plus SU5416-and monocrotaline-induced PAH animal models. Moreover, osteoprotegerin disruption attenuated hypoxia plus SU5416-induced PAH progression by reducing pulmonary vascular remodeling, whereas lentiviral osteoprotegerin reconstitution exacerbated PAH by increasing pulmonary arterial smooth muscle cell proliferation. Furthermore, pathway analysis revealed that osteoprotegerin induced pulmonary arterial smooth muscle cell proliferation by interacting with integrin α v β 3 to elicit downstream focal adhesion kinase and AKT pathway activation. Conclusions-Osteoprotegerin facilitates PAH pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation, suggesting that it may be a potential biomarker and therapeutic target in this disease. Osteoprotegerin was initially identified as a secreted decoy receptor for receptor activator of nuclear factor-κB ligand and tumor necrosis factor-related apoptosis-inducing ligand to regulate bone metabolism and cell survival, respectively. However, recent clinical and experimental data have also linked osteoprotegerin to a range of cardiovascular disorders, including pulmonary hypertension (PAH). Here, we found that serum osteoprotegerin levels were increased in patients with PAH and correlated with disease severity. Moreover, pulmonary arteries from hypoxia plus SU5416-and monocrotaline-induced PAH animal models also showed elevated osteoprotegerin expression. Notably, OPG −/− mice exhibited decreased pulmonary vascular smooth muscle cell proliferation and mitigated the increased right ventricular systolic pressure and ventricular wall thickening observed in wild-type hypoxia plus SU5416-induced PAH controls. Lentiviral osteoprotegerin reconstitution enhanced pulmonary vascular remodeling characterized by pulmonary arterial smooth muscle cell proliferation, medial wall thickening, and pulmonary artery muscularization. Pathway analysis revealed that these effects resulted from a direct interaction between osteoprotegerin and integrin α v β 3 , which subsequently triggered focal adhesion kinase/AKT pathway activation. Taken together, our data suggest that osteoprotegerin facilitates PAH pathogenesis and thus may be a potential biomarker and therapeutic target in this disease.
EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling Ankang Lu, 1,2 Caojian Zuo, 1,2,3 Yuhu He, 1,2 Guilin Chen, 1 Lingjuan Piao, 1,4 Jian Zhang, 1 Bing ... Xiao, 1 Yujun Shen, 1 Juan Tang, 1 Deping Kong, 1 Sara Alberti, 1,5 Di Chen, 1 Shenkai Zuo, 1 Qianqian Zhang, 1 Shuai Yan, 1 Xiaochun Fei, 6 Fei Yuan, 6 Bin Zhou, 1 Shengzhong Duan, 1 Yu Yu, 1 Michael ...doi:10.1172/jci77656 pmid:25664856 pmcid:PMC4362262 fatcat:lgnritiuovg2lciurgt2cxyx5u
Vitamin D insufficiency has been associated with chronic inflammatory diseases. However, the underlying mechanisms remain unclear. Results: Vitamin D inhibits COX-2-mediated inflammatory response by modulating the Akt/NF-B signaling pathway via direct up-regulation of thioesterase superfamily member 4. Conclusion: Vitamin D plays novel roles in anti-inflammation. Significance: Supplemental vitamin D could protect against chronic inflammatory diseases by targeting THEM4/Akt/NF-B signaling.doi:10.1074/jbc.m113.517581 pmid:24619416 pmcid:PMC4002078 fatcat:cry22krggbhjzhtyv5wjuys5xu
more »... uate vitamin D status has been linked to increased risk of type 2 diabetes and cardiovascular disease. Inducible cyclooxygenase (COX) isoform COX-2 has been involved in the pathogenesis of such chronic inflammatory diseases. We found that the active form of vitamin D, 1,25(OH) 2 D produces dose-dependent inhibition of COX-2 expression in murine macrophages under both basal and LPS-stimulated conditions and suppresses proinflammatory mediators induced by LPS. Administration of 1,25(OH) 2 D significantly alleviated local inflammation in a carrageenan-induced paw edema mouse model. Strikingly, the phosphorylation of both Akt and its downstream target IB␣ in macrophages were markedly suppressed by 1,25(OH) 2 D in the presence and absence of LPS stimulation through up-regulation of THEM4 (thioesterase superfamily member 4), an Akt modulator protein. Knockdown of both vitamin D receptor and THEM4 attenuated the inhibitory effect of 1,25(OH) 2 D on COX-2 expression in macrophages. A functional vitamin D-responsive element in the THEM4 promoter was identified by chromatin immunoprecipitation and luciferase reporter assay. Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-B/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease. 3 The abbreviations used are: 1,25(OH) 2 D, 1,25-dihydroxy-vitamin D; VDR, vitamin D receptor; VDRE, vitamin D-responsive element; COX, cyclooxygenase; PG, prostaglandin; THEM4, thioesterase superfamily member 4; NSAID, nonsteroidal anti-inflammatory drug; KD, knockdown; FFA, free fatty acid.
Yuhu Zuo analyzed the data with suggestions by Yanting Qu and Aimin Zhou wrote the manuscript. All authors read and approved the final manuscript. ...doi:10.3390/ijms16059732 pmid:25938968 pmcid:PMC4463614 fatcat:j4meywqkzrg2rgojiqu757oogi
Although state forest enterprises were compensated for losses incurred through the NFPP, villagers managing collective forests were not (Zuo, 2002a) . ... Repeated program deficiencies are inherent in their design and their insular design processes, both characteristic of more recent programs (Zuo, 2002a,b) . ...doi:10.1016/j.forpol.2005.08.007 fatcat:j6uemzhkxvbhdm6z3vlvlbww5q
The Yuhu yeshi, written by the monk Wen Ying X~, was organized in a way that resembles neither the YuLan nor the Guangji. Clearly the Buddhist tradition was an influential factor in the Yuhu. ... However, the wisdom of Yang Zuo and others like him has its origins (or at least interactions) in folklore and popular religious traditions. ...doi:10.1163/26669323-01101003 fatcat:dr6cbeb4dze43ngncpnbbc7neq
(Summary) 2003k:62127 62G05 (62B10) Yang, Yuhu (with Chang, Zongyu; Zhang, Ce; Wang, Yu Xin!) A new method to mechanism kinematic chain isomorphism identification. (English summary) Mech. Mach. ... Ed. 30 (2002), no. 4, 394-396. 58K 15 (34C05) Yang, Yu Yue (with Tan, Zuo Wen; Cao, You An) Automorphisms of strictly upper triangular matrix rings over commutative rings. (Chinese. ...
Test-Retest NYU Resting-State Datasets The test-retest resting-state fMRI datasets with 25 normal participants were drawn from the Human Connectome Project (http://www.nitrc.org/projects/nyu_trt; Zuo ... The components IC1-IC4 were referred to the wellknown default mode network (DMN; Raichle et al., 2001; Damoiseaux et al., 2006; De Luca et al., 2006) , which were divided into four sub-networks (Zuo ...doi:10.3389/fnins.2017.00510 pmid:28943838 pmcid:PMC5596109 fatcat:qklbgilowve7diq5bjr5wbrzpq
(English summary) 2002m:03087 Zuo, Jing Extensive domains based on extension of matter-elements. (Chinese. ... (English summary) 2002d:03047 Fang, Jin Xuan On the convergence theorems of generalized fuzzy integral sequence (English summary) 2002g:28021 Feng, Yuhu Sums of independent fuzzy random variables. ...
2020 39th Chinese Control Conference (CCC)
Wei Wang Xianpeng Wang xiaoping wang Yanwu Wang Yaonan Wang yingchun wang Zhanshan Wang Zhiwen Wang Zidong Wang Changyun Wen Ai-Guo Wu Fen Wu Huaining Wu Ligang Wu Min Wu Yongjian Wu Yuhu ... Bowen Zhou Donghua Zhou Kemin Zhou Ping Zhou Tong Zhou Wuneng Zhou Jihong Zhu Li Zhu Quanmin Zhu Quanxin Zhu Zhiliang Zhu Yan Zhuang Guangdeng Zong Qun Zong Yuanyuan Zou Yun Zou Zhiqiang Zuo ...doi:10.23919/ccc50068.2020.9188457 fatcat:m3742xch3vcllhbyl3j6u3bwsu
2021 40th Chinese Control Conference (CCC)
Zhong Bin Zhou Bowen Zhou Donghua Zhou Jin Zhou Kemin Zhou Qingrui Zhou Tong Zhou Wuneng Zhou Jihong Zhu Quan-Min Zhu Shuqian Zhu Guangdeng Zong Qun Zong Yuanyuan Zou Yun Zou Zhiqiang Zuo ... Wang Wei Wang Xiaoping wang Yan-Wu Wang Yaonan Wang Youqing Wang Yu-Long Wang Zhanshan Wang Zhiwen Wang Zidong Wang Changyun Wen Aiguo Wu Fen Wu Huaining Wu Junfeng Wu Ligang Wu Min Wu Yuhu ...doi:10.23919/ccc52363.2021.9549573 fatcat:pjy23hrtz5aoxlujwyefzs4ykq
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