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Lifetime-based memory management for distributed data processing systems

Lu Lu, Xuanhua Shi, Yongluan Zhou, Xiong Zhang, Hai Jin, Cheng Pei, Ligang He, Yuanzhen Geng
2016 Proceedings of the VLDB Endowment  
In-memory caching of intermediate data and eager combining of data in shuffle buffers have been shown to be very effective in minimizing the re-computation and I/O cost in distributed data processing systems like Spark and Flink. However, it has also been widely reported that these techniques would create a large amount of long-living data objects in the heap, which may quickly saturate the garbage collector, especially when handling a large dataset, and hence would limit the scalability of the
more » ... system. To eliminate this problem, we propose a lifetime-based memory management framework, which, by automatically analyzing the userdefined functions and data types, obtains the expected lifetime of the data objects, and then allocates and releases memory space accordingly to minimize the garbage collection overhead. In particular, we present Deca, a concrete implementation of our proposal on top of Spark, which transparently decomposes and groups objects with similar lifetimes into byte arrays and releases their space altogether when their lifetimes come to an end. An extensive experimental study using both synthetic and real datasets shows that, in comparing to Spark, Deca is able to 1) reduce the garbage collection time by up to 99.9%, 2) to achieve up to 22.7x speed up in terms of execution time in cases without data spilling and 41.6x speedup in cases with data spilling, and 3) to consume up to 46.6% less memory.
doi:10.14778/2994509.2994513 fatcat:tvthy74novd4verc5b3xnr5p3a

CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells

Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhang
2020 Reproduction  
Polycystic ovary syndrome (PCOS) is a common endocrine disorder accompanied by chronic low-grade inflammation; its etiology is still undefined. This study investigated the expression of CXCL12, CXCR4, and CXCR7 in PCOS rats and their role in regulation of apoptosis. To accomplish this, we established an in vivo PCOS rat model and studied KGN cells (human ovarian granulosa cell line) in vitro. In PCOS rats, the ovarian expression of CXCL12, CXCR4, and CXCR7 was reduced, and the apoptosis rate of
more » ... granulosa cells was increased, accompanied by decreased expression of BCL2 and increased expression of BAX and cleaved CASPASE3 (CASP3). We further showed that recombinant human CXCL12 treatment upregulated BCL2, downregulated BAX, and cleaved CASP3 in KGN cells to inhibit their apoptosis in a concentration-dependent manner; moreover, the effect of CXCL12 was weakened by CXCR4 antagonist AMD3100 and anti-CXCR7 neutralizing antibody. In conclusion, PCOS rats showed decreased CXCL12, CXCR4, and CXCR7 expression and increased apoptosis rate of ovarian granulosa cells. Further, in human KGN cells, CXCL12 regulated the expression of BAX, BCL2, and cleaved CASP3 to inhibit apoptosis through CXCR4- and CXCR7-mediated signal transmission. These findings may provide a theoretical and practical basis for illuminating the role of proinflammatory cytokines in the pathogenesis of PCOS.
doi:10.1530/rep-20-0451 pmid:33258800 fatcat:wxhedmzseja57ehutmmcsvizei

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis

Ting Geng, Yifan Sun, Lin Cheng, Yuming Cao, Ming Zhang, Zhidan Hong, Ling Ma, Yuanzhen Zhang
2022 Frontiers in Endocrinology  
An association between endometriosis and luteinized unruptured follicle syndrome (LUFs) has long been identified. Although inactivating mutation of luteinizing hormone/choriogonadotropin receptor (LHGCR) results in LUFs, whether LHCGR contributes to promoting LUFs in endometriosis remains elusive. To investigate the effect of LHCGR signaling in the development of endometriosis-associated LUFs and dissect the underlying mechanism in vivo mouse endometriosis model was established to measure the
more » ... fect on ovarian folliculogenesis. In vitro cultures of primary human GCs collected from patients undergoing in vitro fertilization were performed and treated with human chorionic gonadotropin (hCG), dibutyryl cyclic-AMP (db-cAMP), LHCGR or CCAAT/enhancer binding protein-α (C/EBPα) small interfering RNA to identify the potential mechanisms. KGN cell line was used to investigate the mechanistic features of transcriptional regulation. Results showed an increased incidence of LUFs was observed in mice with endometriosis. The expression of LHCGR was decreased in the GCs of endometriosis mice. In in vitro cell models, LHCGR signaling increased the expression of C/EBPα and cyclooxygenase-2(COX-2), while inhibiting C/EBPα mitigated the induced COX-2 expression. Mechanically, C/EBPα bounded to the promoter region of COX-2 and increased the transcriptional activity under the stimulation of hCG or db-cAMP. Taken together, this study demonstrated that the LHCGR signaling was reduced in GCs of endometriosis and resulted in a decrease in gonadotropin-induced COX-2 expression. Our study might provide new insights into the dysfunction of GCs in endometriosis.
doi:10.3389/fendo.2022.853563 pmid:35600595 pmcid:PMC9114297 fatcat:cl25ff7mpfgfjekgthk7ttnsdq

Lifetime-Based Memory Management for Distributed Data Processing Systems [article]

Lu Lu, Xuanhua Shi, Yongluan Zhou, Xiong Zhang, Hai Jin, Cheng Pei, Ligang He, Yuanzhen Geng
2016 arXiv   pre-print
In-memory caching of intermediate data and eager combining of data in shuffle buffers have been shown to be very effective in minimizing the re-computation and I/O cost in distributed data processing systems like Spark and Flink. However, it has also been widely reported that these techniques would create a large amount of long-living data objects in the heap, which may quickly saturate the garbage collector, especially when handling a large dataset, and hence would limit the scalability of the
more » ... system. To eliminate this problem, we propose a lifetime-based memory management framework, which, by automatically analyzing the user-defined functions and data types, obtains the expected lifetime of the data objects, and then allocates and releases memory space accordingly to minimize the garbage collection overhead. In particular, we present Deca, a concrete implementation of our proposal on top of Spark, which transparently decomposes and groups objects with similar lifetimes into byte arrays and releases their space altogether when their lifetimes come to an end. An extensive experimental study using both synthetic and real datasets shows that, in comparing to Spark, Deca is able to 1) reduce the garbage collection time by up to 99.9%, 2) to achieve up to 22.7x speed up in terms of execution time in cases without data spilling and 41.6x speedup in cases with data spilling, and 3) to consume up to 46.6% less memory.
arXiv:1602.01959v3 fatcat:ds2xqnfi35d2rlt52gqaakey64

Author Index

2021 2021 IEEE 10th Data Driven Control and Learning Systems Conference (DDCLS)  
············· 1328 Li, Xi ······················ 242 Li, Xiangyang ············ 1379 Liu, Chengyuan ··········· 523 Liu, Fei ······················· 372 ······························ 1291 Liu, Geng  ...  Yanjun ··············· 673 Liao, Changchao ·········· 1528 Liao, Wudai ················ 871 Lin, Jia ····················· 1246 Lin, Na ······················· 704 Lin, Wenqi ················· 1081 Lin, Yuanzhen  ... 
doi:10.1109/ddcls52934.2021.9455569 fatcat:4d7hpbglkrgntk3ynq3bdzktxu

Table of Contents

2021 2021 IEEE MTT-S International Wireless Symposium (IWS)  
Spoof Surface Plasmons (invited) Jingjing Zhang, Xinxin Gao, Tiejun Cui, Yu Luo (Southeast University) 10:45 -11:15 Robust Dispersion-reconfigurable Topological Waveguide (invited) Zijian ZHANG, Yuanzhen  ...  Predistortion Long Chen, Wenhua Chen, Yunfan Wang, Zhenghe Feng (Tsinhgua University) 17:15 -17:30 Small-Signal Behavioral Model for GaN HEMTs based on Long-Short Term Memory Networks Mingqiang Geng  ... 
doi:10.1109/iws52775.2021.9499582 fatcat:skfckfvzezggplsdal2ng4or3m

New generation SAR for Earth environment observation

GUO Huadong, WU Wenjin, ZHANG Ke, LI Xinwu
2022 Acta Geodaetica et Cartographica Sinica  
DOI:10.1080/17538947.2019.1593526 [51] REN Yuanzhen, GUO Huadong, LIU Guang, et al.  ...  Singapore: Springer Singapore, 2019. [50] GUO Huadong, REN Yuanzhen, LIU Guang, et al. The angular characteristics of Moon-based Earth observations[J].  ... 
doi:10.11947/j.agcs.2022.20220098 doaj:a591ac66a86f40eda00ae872434ac1db fatcat:atr6bvxez5do7ky4vtep5pkaji

Structure, bioactivities and applications of the polysaccharides from Tricholoma Matsutake: a review

Mengjiao LI, Yukun ZHANG, Qi LU, Yuanzhen GAO, Ting YE, Chao WANG, Dongming XING
2022 Food Science and Technology  
Studies have found that TMP at a dose of 400 μmg/ kg has a hypotensive effect on spontaneously hypertensive rats (SHRs) (Geng et al., 2016) .  ... 
doi:10.1590/fst.44922 fatcat:qfl2twfxffagdeyca2jkgeo53m

Bibliography [chapter]

2021 Recharging China in War and Revolution, 1882–1955  
Fumu zuori shu 1 [Old writing of my father and mother: Letters and diaries of Li Rui and Fan Yuanzhen, 1938-1960]. Hong Kong: Time International Publishing, 2005.  ...  "San nian li Sulian zhuanjia gei women de bangzhu he jinhou women ruhe geng hao de xiang Sulian xuexi" [Assistance rendered by the Soviet Union in the past three years and how we should learn from the  ... 
doi:10.1515/9781501758966-016 fatcat:2twexccvwncp7a3qyxnwzny43e

Mechanisms with Illustrations in Ancient Books [chapter]

Kuo-Hung Hsiao, Hong-Sen Yan
2013 History of Mechanism and Machine Science  
He was a magistrate of Jingde County in Xuan Province (宣州旌德縣) in the 1st year (AD 1295) of Era Yuanzhen (元貞) of the reign of Emperor Chengzong (成宗) of the Yuan Dynasty, and then he became another magistrate  ...  The author of Tian Gong Kai Wu《天工開物》, Song Ying-xing (宋應星, AD 1587-1666) with his adult name as Chang Geng (長庚), was born in Fengxing County of Jiangxi Province (江西省奉新縣) in the 15th year (AD 1587) of Era  ... 
doi:10.1007/978-3-319-02009-9_2 fatcat:keryrau6yndnlcy5z5h5jcofia

Report from Dagstuhl Seminar 17441 Big Stream Processing Systems

Tilmann Rabl, Sherif Sakr, Martin Hirzel, Martin Hirzel, Tilmann Rabl, Sherif Sakr, Tilmann Rabl, Sherif Sakr, Martin Hirzel, Dagstuhl Reports
Dagstuhl Reports   unpublished
Geng Main reference Lu Lu, Xuanhua Shi, Yongluan Zhou, Xiong Zhang, Hai Jin, Cheng Pei, Ligang He, Yuanzhen Geng: "Lifetime-Based Memory Management for Distributed Data Processing Systems", PVLDB 9(12  ...  Katsipoulakis (University of Pittsburgh, US) License Creative Commons BY 3.0 Unported license © Yongluan Zhou Joint work of Lu Lu, Xuanhua Shi, Yongluan Zhou, Xiong Zhang, Hai Jin, Cheng Pei, Ligang He, Yuanzhen  ... 
fatcat:7qppxmxm4ffn3fnj4bj2c56xti

STELES AND STATUS: EVIDENCE FOR THE EMERGENCE OF A NEW ELITE IN YUAN NORTH CHINA

Tomoyasu Iiyama
2016 Journal of Chinese History  
Wang Shanqing 王善慶 of Hunyuan, Liu Fujin 劉福進 of Qimaocun 戚 毛村, Zhang Rong 張榮 of Zhangjiazhuang 張家莊, Zhang Zhongxin 張仲信 of Zangjiazhuan 藏家莊, Bai Zhongrong 白仲榮 of Xiliucun, X Xde □□德 of Xiliucun, and He Geng  ...  Zhongyuan 張仲元 of Xiliucun 西劉村, Wang Boxiang 王伯祥 of Sunjiawan 孫家 灣, Zhang X 張□ of Bicun 畢村, Wang Jin 王進 of Anping 安平, Liu Xin 劉信 of Yaocun, Hu Deshan 胡德山 of Bicun, Jia Shichang 賈世昌 of Xujiacun 戌家村, Yin Yuanzhen  ... 
doi:10.1017/jch.2016.1 fatcat:6taspe2s7zhpfixngg4ghq2ehy

CCC 2019 Author Index

2019 2019 Chinese Control Conference (CCC)   unpublished
TAO Binbin . . . . . . . . . . . . . . . . . 898 TAO Cui . . . . . . . . . . . . . . . . . . . 7180 TAO Duan . . . . . . . . . . . . . . . . . 4537 TAO Gang. . . . . . . . . . . . . . . . . .4931 TAO Geng  ...  FENG Xiaoke . . . . . . . . . . . . . . 3970 . . . . . . . . . . . . . . . . . . . . . . . . . . . .4147 FENG Xiaoxue . . . . . . . . . . . . . 8494 FENG Yu . . . . . . . . . . . . . . . . . . 5427 FENG Yuanzhen  ... 
doi:10.23919/chicc.2019.8866074 fatcat:bqdgpcq3m5gf7ky4fjy23ndhfq

CCC 2020 Contents

2020 2020 39th Chinese Control Conference (CCC)   unpublished
JIN Xin, WANG Zhengxin, LU Yanling, FENG Yuanzhen, ZHENG Cong 4554 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  ...  WANG Xudong, ZHAO Jin, GENG Tao 1028 DFNN Based Information Fusion Technology for Early Warning of Marine Organism Detection in Nuclear Power Plant . . . . . . . . . . . . . . . . . . . . . . . . . . .  ... 
doi:10.23919/ccc50068.2020.9188973 fatcat:7t2dwrbc3zdcjnyijypuga7yhe

Table of contents

2019 2019 Chinese Control Conference (CCC)   unpublished
LI Zuxin, XIA Weifeng, FENG Yuanzhen, LI Yongmin 1411 Robust Synchronization of Complex-Valued Neural Networks with Probabilistic Delay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  ...  WANG Mingxiang, GENG Zhiyong, PENG Xiuhui 485 Disturbance-observer-based Tracking Control for A Two-link Robotic Manipulators with External Disturbances . . . . . . . . . . . . . . . . . . . . . . . .  ... 
doi:10.23919/chicc.2019.8866607 fatcat:bkwxxogrqvcmfpmqiek3xgnuoe
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