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Reply to the "Comment on 'A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress'" by Li Wang, Fang Li, Zhichun Feng, Yuan Shi

Niels Rochow, Christoph Fusch, Ponnambalam Ravi Selvaganapathy
2021 Advanced Science  
doi:10.1002/advs.202100831 pmid:34194955 pmcid:PMC8224426 fatcat:r7kngep56ndjhcyo2b2d6ji6iu

Brachial-Ankle Pulse Wave Velocity as a Predictor of Mortality in Elderly ChineseNovelty and Significance

Chang-Sheng Sheng, Yan Li, Li-Hua Li, Qi-Fang Huang, Wei-Fang Zeng, Yuan-Yuan Kang, Lu Zhang, Ming Liu, Fang-Fei Wei, Ge-Le Li, Jie Song, Shuai Wang (+1 others)
2014 Hypertension  
Our study was conducted in the framework of the Chronic Disease Detection and Management in the Elderly (≥60 years) Program supported by the municipal government of Shanghai. 27, 28 In a newly urbanized suburban town, 30 km from the city center, we invited all residents ≥60 years to take part in comprehensive examinations of cardiovascular disease and risk. The Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, approved the study protocol. All subjects gave
more » ... tten informed consent. A total of 4140 subjects (participation rate 90%) were enrolled in the period from 2006 to 2011 and followed up for vital status and cause of death till June 30, 2013. We excluded 101 subjects from the present analysis, because brachial-ankle PWV was not measured (n=63) or because of missing other information (n=38). We further excluded 163 subjects with an ankle-brachial index <0.90 (n=107) or Abstract-Pulse wave velocity (PWV) is a measure of arterial stiffness and predicts cardiovascular events and mortality in the general population and various patient populations. In the present study, we investigated the predictive value of brachial-ankle PWV for mortality in an elderly Chinese population. Our study subjects were older (≥60 years) persons living in a suburban town of Shanghai. We measured brachial-ankle PWV using an automated cuff device at baseline and collected vital information till June 30, 2013, during follow-up. The 3876 participants (1713 [44.2%] men; mean [±SD] age, 68.1±7.3 years) included 2292 (59.1%) hypertensive patients. PWV was on average 17.8 (±4.0) m/s and was significantly (P<0.0001) associated with age (r=0.48) and in unadjusted analysis with all-cause (n=316), cardiovascular (n=148), stroke (n=46), and noncardiovascular mortality (n=168) during a median follow-up of 5.9 years. In further adjusted analysis, we studied the risk of mortality according to the decile distributions of PWV. Only the subjects in the top decile (23.3-39.3 m/s) had a significantly (P≤0.003) higher risk of all-cause mortality (hazard ratio relative to the whole study population, 1.56; 95% confidence interval, 1.16-2.08), especially in hypertensive patients (hazard ratio, 1.86; 95% confidence interval, 1.31-2.64; P=0.02 for the interaction between PWV and hypertension). Similar trends were observed for cardiovascular, stroke, and noncardiovascular mortality, although statistical significance was not reached (P≥0.08). In conclusion, brachial-ankle PWV predicts mortality in elderly Chinese on the conditions of markedly increased PWV and hypertension. (Hypertension. 2014;64:1124-1130.) • Online Data Supplement
doi:10.1161/hypertensionaha.114.04063 pmid:25259749 fatcat:xud6ckxwsrbc5fvuisebqmglpm

Interaction Theory of Hazard-Target System [article]

Ji Ge, Yu-Yuan Zhang, Kai-Li Xu, Ji-Shuo Li, Xi-Wen Yao, Chun-Ying Wu, Shuang-Yuan Li, Fang Yan, Jin-Jia Zhang, Qing-Wei Xu
2021 arXiv   pre-print
Major accidents (e.g., the Space Shuttle Challenger disaster in the USA, the Bhopal Disaster in India, Fukushima nuclear accident in Japan, Tianjin Port fire and explosion accident in China) have occurred all over the world. Safety scientists are always trying to understand why these accidents happened and how to prevent these accidents. Accident models and theories form the basis for many safety research fields and practices such as investigation of accidents, design of a safer system and
more » ... ion making on safety related field. There is no universally accepted model with useful elements relating to understanding accident causation, although many accident causation models exist. Based on STAMP and RMF, we proposed a new theory named the Interaction Theory of Hazard-Target System (ITHTS) that incorporate human, organisational and technological characteristics in the same framework. Accident analysis methods provide the necessary information to analysis the accident in a specific setting. In order to solve the issues that current accident analysis methods still face, we proposed a new systemic accident analysis method based on ITHTS and STPA. We choose Tianjin Port fire and explosion accident in China as a case study to demonstrate the viability of the Interaction Theory of Hazard-target System and the applicability of the new accident analysis method. It is concluded that ITHTS can explain the phenomena in safety practice and the new accident analysis method can be application in the explanation and analysis of major accident.
arXiv:2105.04340v1 fatcat:qmtkuk7wprhkpn7hhvir6xrb4m

Glucocorticoid receptor repression mediated by BRCA1 inactivation in ovarian cancer

Yuan-Yuan Fang, Da Li, Chen Cao, Chun-Yan Li, Ting-Ting Li
2014 BMC Cancer  
BRCA mutations are the main known hereditary factor for ovarian cancer. Notably, emerging evidence indicates that the glucocorticoid receptor (GR) has drawn considerable interest in ovarian cancer development. However, dynamic cross-talk between BRCA1 and GR signaling pathways are poorly understood. Methods: The regulatory effects of BRCA on GR were assessed in 146 serous ovarian cancer patients (28 pairs of BRCA1-mutated or not, 23 pairs of BRCA2-mutated or not, and 22 pairs with
more » ... d BRCA1 promoter or not). BRCA1 promoter methylation was analyzed by bisulfite sequencing using primers flanking the core promoter region. Expression levels of BRCA1 and GR were assessed by immunohistochemistry and real-time PCR. Regression analysis was used to examine the possible relationship between BRCA1 and GR expression levels. The knockdown and overexpression of BRCA1 were achieved using a lentiviral vector in 293 T cells, SKOV3 ovarian cancer cells, and primary non-mutated and BRCA1-mutated ovarian cancer cells. Results: GR expression levels were unchanged in non-BRCA1-mutated, non-BRCA2-mutated and BRCA2-mutated ovarian cancer compared to their normal tissues; BRCA1 repression (BRCA1 mutation or BRCA1 promoter hypermethylation) ovarian cancer showed decreased GR levels compared to normal tissue; there was a positive correlation between BRCA1 and GR expression in human ovarian cancer specimens; BRCA1 knockdown was effective at inhibiting GR expression, and overexpression of BRCA1 induces an increase in GR levels in ovarian cancer cells. Conclusions: These results suggest that GR may be a potential target for BRCA1 in ovarian cancer progression.
doi:10.1186/1471-2407-14-188 pmid:24629067 pmcid:PMC4004164 fatcat:53wmwgr2cbeuxkqd5jry67jpoa

Visual Identification of Light-Driven Breakage of the Silver-Dithiocarbamate Bond by Single Plasmonic Nanoprobes

Peng Fei Gao, Bin Fang Yuan, Ming Xuan Gao, Rong Sheng Li, Jun Ma, Hong Yan Zou, Yuan Fang Li, Ming Li, Cheng Zhi Huang
2015 Scientific Reports  
Insight into the nature of metal-sulfur bond, a meaningful one in life science, interface chemistry and organometallic chemistry, is interesting but challenging. By utilizing the localized surface plasmon resonance properties of silver nanoparticles, herein we visually identified the photosensitivity of silver-dithiocarbamate (Ag-DTC) bond by using dark field microscopic imaging (iDFM) technique at single nanoparticle level. It was found that the breakage of Ag-DTC bond could be accelerated
more » ... ctively by light irradiation, followed by a pH-dependent horizontal or vertical degradation of the DTC molecules, in which an indispensable preoxidation process of the silver was at first disclosed. These findings suggest a visualization strategy at single plasmonic nanoparticle level which can be excellently applied to explore new stimulus-triggered reactions, and might also open a new way to understand traditional organic reaction mechanisms.
doi:10.1038/srep15427 pmid:26493773 pmcid:PMC4616019 fatcat:xmuxr7rkibc43n4fqfbun4ehpi

Chinese expert consensus on the management of hypertension in the very elderly

Jing Li, Yi-Xin Hu, Wen Wang, Ning-Yuan Fang, Xin-Zheng Lu, Lin Pi, Mei-Lin Liu, Wei-Min Li, Yan-Fang Li, Peng Qu, Qi Hua, Qing He (+15 others)
2016 Journal of Geriatric Cardiology  
doi:10.11909/j.issn.1671-5411.2016.12.011 pmid:28321236 pmcid:PMC5351824 fatcat:kggqjup22ndipe4tceere7ypem

L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70

Long-Long Luo, Yong-Fang Li, Hui-Min Shan, Li-Ping Wang, Fang Yuan, Yuan-Yuan Ma, Wan-Lu Li, Ting-Ting He, Yu-Yang Wang, Mei-Jie Qu, Huai-Bin Liang, Zhi-Jun Zhang (+3 others)
2019 CNS Neuroscience & Therapeutics  
L-glutamine is an antioxidant that plays a role in a variety of biochemical processes. Given that oxidative stress is a key component of stroke pathology, the potential of L-glutamine in the treatment of ischemic stroke is worth exploring. In this study, we investigated the effect and mechanisms of action of L-glutamine after cerebral ischemic injury. L-glutamine reduced brain infarct volume and promoted neurobehavioral recovery in mice. L-glutamine administration increased the expression of
more » ... t-shock protein 70 (HSP70) in astrocytes and endothelial cells. Such effects were abolished by the coadministration of Apoptozole, an inhibitor of the ATPase activity of HSP70. L-glutamine also reduced oxidative stress and neuronal apoptosis, and increased the level of superoxide dismutase, glutathione, and brain-derived neurotrophic factor. Cotreatment with Apoptozole abolished these effects. Cell culture study further revealed that the conditioned medium from astrocytes cultured with L-glutamine reduced the apoptosis of neurons after oxygen-glucose deprivation. L-glutamine attenuated ischemic brain injury and promoted functional recovery via HSP70, suggesting its potential in ischemic stroke therapy.
doi:10.1111/cns.13184 pmid:31218845 pmcid:PMC6698979 fatcat:egzmlxqt2bhqvjzh2vtcpqsrqa

A case report

Hai Chen, Zhi-qiang Hu, Yao Fang, Xiao-xue Lu, Li-da Li, Yuan-li Li, Xu-hu Mao, Qian Li
2018 Medicine  
A 63-year-old male patient suffered from diabetes, hypertension, and a bladder tumor. He had undergone radical cystectomy and ileal neobladder construction 1 year prior to this admission. He came to our emergency room complaining of abdominal pain after recent alcohol consumption. Muscle guarding and abdominal rebounding pain developed after conservative treatment for 1 day. The next day, emergency laparotomy for acute peritonitis revealed two small perforations in the neobladder and calculus
more » ... rmation within it. In addition, severe intraperitoneal adhesion was noted. After removing the neobladder stone and repairing the neobladder, a Foley catheter was inserted for urine drainage. The patient's postoperative recovery was excellent.
doi:10.1097/md.0000000000011208 pmid:29952975 pmcid:PMC6039618 fatcat:modsr4nik5elpi53wi55lw6yxe

Phase transition and thermal expansion properties of ZrV2-xPxO7

Yuan Huan-Li, Yuan Bao-He, Li Fang, Liang Er-Jun
2012 Wuli xuebao  
ZrV2−xPxO7 (x = 0, 0.4, 0.8, 1.0) solid solutions are prepared using a solid state reaction method. Powder X-ray diffraction (XRD) analysis reveals that the as-prepared solid solutions are of single-phase cubic type in crystal structure. Temperature dependent Raman spectroscopic studies demonstrate that the phase transition temperature of ZrV2−xPxO7 decreases with the increase of the content of P. ZrV2O7, ZrV1.6P0.4O7, ZrV1.2P0.8O7 and ZrVPO7 transform from a 3 × 3 × 3 superstructure to a 1 × 1
more » ... × 1 normal structure at about 373 K, 363 K 273 K and 213 K, respectively. The results of thermal expansion testing indicate that the temperature of positive thermal expansion changes to negative thermal expansion with the increase of P content. The temperatures of positive-tonegative thermal expansion of ZrV2−xPxO7 are 429 K, 403 K, 372 K, 390 K, 398 K and 435 K for x = 0, 0.2, 0.4, 0.6, 0.8 and 1, respectively. Two phase change transformations are demonstrated in ZrV2−xPxO7 materials in our work, which is beneficial for preparing the negative thermal expansion materials at room temperature using ZrV2O7.
doi:10.7498/aps.61.226502 fatcat:abvi6gemk5fxje3ejkrhvkc4qq

miR-378b Regulates Insulin Sensitivity by Targeting Insulin Receptor and p110α in Alcohol-Induced Hepatic Steatosis

Yuan-yuan Li, Yu-juan Zhong, Qi Cheng, Ying-zhao Wang, Yuan-yuan Fan, Cheng-fang Yang, Zuheng Ma, Yong-wen Li, Li Li
2020 Frontiers in Pharmacology  
Numerous studies have shown that alcohol can cause alcoholic liver damage by activating oxidative stress, inhibiting liver fat-acid metabolism, and increasing liver lipid synthesis (Li et al., 2017; Li  ...  Histopathological Analysis Histopathological analysis was carried out as previously described with minor modification (Li et al., 2017) .  ...  Copyright © 2020 Li, Zhong, Cheng, Wang, Fan, Yang, Ma, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fphar.2020.00717 pmid:32508647 pmcid:PMC7251170 fatcat:mydalmlsybgn5jgdrfde22r37e

The prevalence, incidence, management and risks of atrial fibrillation in an elderly Chinese population: a prospective study

Li-Hua Li, Chang-Sheng Sheng, Bang-Chuan Hu, Qi-Fang Huang, Wei-Fang Zeng, Ge-Le Li, Ming Liu, Fang-Fei Wei, Lu Zhang, Yuan-Yuan Kang, Jie Song, Shuai Wang (+3 others)
2015 BMC Cardiovascular Disorders  
Acknowledgments We gratefully acknowledge the voluntary participation of all study participants and the expert technical assistance of Jie Wang, Li Zheng, Yi Zhou, and Wei-Zhong Zhang (The Shanghai Institute  ... 
doi:10.1186/s12872-015-0023-3 pmid:25953603 pmcid:PMC4427946 fatcat:2uy62azmsjbwvhybmfwzvebaoi

Prevalence, awareness, treatment and control of hypertension in elderly Chinese

Chang-Sheng Sheng, Ming Liu, Yuan-Yuan Kang, Fang-Fei Wei, Lu Zhang, Ge-Le Li, Qian Dong, Qi-Fang Huang, Yan Li, Ji-Guang Wang
2013 Hypertension Research  
We also appreciate the expert assistance of Jie Wang, Li Zheng, Wei-Zhong Zhang and Yi Zhou (The Shanghai Institute of Hypertension, China).  ... 
doi:10.1038/hr.2013.57 pmid:23759756 fatcat:fktrddhmqffdpk6hp64zj43puu

Parabrachial nucleus circuit governs neuropathic pain-like behavior

Li Sun, Rui Liu, Fang Guo, Man-qing Wen, Xiao-lin Ma, Kai-yuan Li, Hao Sun, Ceng-lin Xu, Yuan-yuan Li, Meng-yin Wu, Zheng-gang Zhu, Xin-jian Li (+4 others)
2020 Nature Communications  
We thank Yu-dong Zhou, Kun Chen, Hong-bin Yang, Hui-Fang Lou, and Li-Ya Zhu for technical support. This work was supported by the National Natural Science  ... 
doi:10.1038/s41467-020-19767-w pmid:33239627 fatcat:m4vn24u5avchxcazk7bf6n5iya

Nicotinamide adenine dinucleotide (NAD) may affect DNA methyltransferase 1 through regulation of BRCA1 in ovarian cancer

Yuan-Yuan Fang, Fang-Fang Bi, Yi-Ming Zhou, Wu-Ping Sun, Chun-Yan Li, Qian Liu, Yue Zhao, Da Li
2015 American Journal of Cancer Research  
Nicotinamide adenine dinucleotide (NAD) is a crucial molecule of energy production and signal transduction processes that have been linked to ovarian cancer development. Notably, emerging evidence has led to considerable interest in the role of DNA methyltransferase 1 (DNMT1) in the initiation and progression of ovarian cancer. However, dynamic crosstalk between NAD and DNMT1 is poorly understood. Here, we show that DNMT1 levels are upregulated, along with increased NAD levels in
more » ... ed ovarian cancer cells. In contrast, DNMT1 levels are not affected by increasing NAD levels in BRCA1-mutated ovarian cancer cells. Mechanistically, BRCA1 inactivity-mediated loss of H3K9ac enrichment around the core promoter inhibits DNMT1 transcription. Consistent with this, BRCA1 levels correlate with DNMT1 levels (R = 0.534, R < 0.001) in human ovarian cancer specimens. Therefore, these results highlight a novel regulatory effect of NAD on DNMT1, and further correlate the physiological properties of NAD metabolism with DNMT1-mediated biological processes. All of this may improve our understanding of the basic molecular mechanism underlying NAD- and DNMT1-related ovarian cancer progression.
pmid:26045998 pmcid:PMC4449447 fatcat:v46ttwa7mbeybkitp7rnotsg6a

Applicability Evaluation of Simplified Cognitive Behavioral Therapy

Li Zhang, Zhipei Zhu, Fang Fang, Yuan Shen, Na Liu, Chunbo Li
2018 Shanghai Archives of Psychiatry  
I have confirmed all the information included in this article is correct.Authors' contributionsLi Zhang, Zhipei Zhu, Fang Fang, Yuan Shen and Na Liu were responsible for carrying out the specific steps  ...  Li Zhang wrote the manuscript for the present study. Chunbo Li provided guidance and revision on study design, implementation and paper writing.on March 20, 2020 by guest.  ... 
doi:10.11919/j.issn.1002-0829.217098 pmid:29736130 pmcid:PMC5936036 fatcat:yb3aknhlcjfnlhq6tjd5pm7wmi
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