Filters








15,604 Hits in 3.6 sec

Defining cognitive and functional profiles in schizophrenia and affective disorders

Yu-Chi Huang, Yu Lee, Chun-Yi Lee, Pao-Yen Lin, Chi-Fa Hung, Sheng-Yu Lee, Liang-Jen Wang
2020 BMC Psychiatry  
Among the participant groups, categorical and continuous variables were compared using the chi-square test and one-way analysis of variance (ANOVA), respectively.  ... 
doi:10.1186/s12888-020-2459-y pmid:32005199 fatcat:pfho2irvmnc6bnny2mmmeij4gu

Hero

Ying Wang, Liang Qiao, Chang Xu, Yepang Liu, Shing-Chi Cheung, Na Meng, Hai Yu, Zhiliang Zhu
2021 Zenodo  
Hero is developed as an online tool (http://www.hero-go.com/) to help Golang developers deal with dependency management (DM) issues, by automatically diagnosing their root causes and customizing fixing suggestions. Its main features are: 1) constructing and visualizing a dependency model for a Golang project under test; Specially, the dependency model shows the dependency relationships among the client project's downstream and upstream projects and their corresponding library-referencing modes;
more » ... 2) diagnosing DM issues; 3) providing their detailed root causes and customized fixing solutions with analyses of potential benefits and consequences incurring to the ecosystem if certain fixing solutions are taken. For more detailed information, please refer to the "ABOUT" page of Hero.
doi:10.5281/zenodo.4457961 fatcat:6cjzvaorvjcr5affegvxzdjgui

Hero

Ying Wang, Liang Qiao, Chang Xu, Yepang Liu, Shing-Chi Cheung, Na Meng, Hai Yu, Zhiliang Zhu
2021 Zenodo  
Hero is developed as an online tool (http://www.hero-go.com/) to help Golang developers deal with dependency management (DM) issues, by automatically diagnosing their root causes and customizing fixing suggestions. Its main features are: 1) constructing and visualizing a dependency model for a Golang project under test; Specially, the dependency model shows the dependency relationships among the client project's downstream and upstream projects and their corresponding library-referencing modes;
more » ... 2) diagnosing DM issues; 3) providing their detailed root causes and customized fixing solutions with analyses of potential benefits and consequences incurring to the ecosystem if certain fixing solutions are taken. For more detailed information, please refer to the "ABOUT" page of Hero.
doi:10.5281/zenodo.4457960 fatcat:myfvdcelbndzdcxqvhkls3c5tq

The fractal geometry of the surface ruptures of the 1999 Chi-Chi earthquake, Taiwan

Young-Fo Chang, Chien-Chih Chen, Chieh-Yu Liang
2007 Geophysical Journal International  
Chi-Chi earthquake is the largest seismic event which occurred in the island during the twentieth century.  ...  We calculated the fractal dimension (D) and b value of Gutenberg-Richter law for 6-month aftershocks of the Chi-Chi earthquake for the fault area, and find that the surface ruptures exhibit self-similar  ...  Segments The coseismic ground displacement of the Chi-Chi earthquake, obtained from GPS data (CGS 1999a; Yu et al. 2001a) , strong motion seismogram (Shin 2000; , and field measurement (CGS 1999a; Lin  ... 
doi:10.1111/j.1365-246x.2007.03420.x fatcat:jdfntm2hvzbbhcpoxycezc4hii

Validation of the Chinese Version of the Schizophrenia Cognition Rating Scale

Kuan-Wei Huang, Pao-Yen Lin, Yu Lee, Yu-Chi Huang, Chi-Fa Hung, Sheng-Yu Lee, Chih-Ken Chen, Liang-Jen Wang
2022 Psychiatry Investigation  
Between-group differences with respect to categorical variables were assessed using the chi-squared test, while those with respect to continuous variables were assessed using the independent t test.  ... 
doi:10.30773/pi.2021.0322 pmid:35903053 pmcid:PMC9334803 fatcat:p4nzrmjc4rgkrd4zv46rxhz3gq

Bone marrow-stimulating techniques in arthroscopic rotator cuff repair: a systematic review protocol

Liang-Tseng Kuo, Chi-Lung Chen, Pei-An Yu, Yu-Shiun Tsai, Wei-Hsiu Hsu, Ching-Chi Chi, Jae Chul Yoo
2018 BMJ Open  
IntroductionBone marrow-stimulating (BMS) techniques during arthroscopic rotator cuff repair surgery theoretically enhance the biological component for healing and hence improve tendon healing, but their efficacy remains unproven. The purpose of this review is to determine the effects and associated harms of BMS in arthroscopic rotator cuff repair surgery.Methods and analysisWe will perform a systematic review and meta-analysis of randomised-controlled trials (RCTs) and retrospective cohort
more » ... ies (RCS) that compare outcomes following BMS use against no use of BMS during arthroscopic rotator cuff repair surgery. We will search the databases including the Cochrane Central Register of Controlled Trials, Medline and Embase, and clinical trial registries for relevant studies. We will include studies published from start of indexing until 23 August 2018. Two reviewers will independently assess the eligibility for studies. For each included trial, we will conduct duplicate independent data extraction and risk of bias assessment. We will use the Cochrane Collaboration tool to assess the risk of bias of included RCTs, while we will use the Risk Of Bias In Non-randomised Studies - of Interventions tool to evaluate the risk of bias of RCS. We will perform a random-effects meta-analysis in calculating the pooled risk estimates when appropriate. We will assess the overall quality of the data for each individual outcome using the Grading of Recommendations, Assessments, Development and Evaluation approach. The primary outcomes are tendon healing rate, overall pain and shoulder functions. The secondary outcomes are the proportion of participants with adverse events related to interventions, the range of motion and the proportion of participants with return to previous activities.Ethics and disseminationWe will report this review according to the guidance of the PRISMA statement. The results of this review will be disseminated through conference presentations and publications in peer-reviewed journals.PROSPERO registration numberCRD42018087161.
doi:10.1136/bmjopen-2018-022086 fatcat:z3am6vxsjfh4bllunsrpuic5de

GaussBits

Rong-Hao Liang, Kai-Yin Cheng, Liwei Chan, Chuan-Xhyuan Peng, Mike Y. Chen, Rung-Huei Liang, De-Nian Yang, Bing-Yu Chen
2013 CHI '13 Extended Abstracts on Human Factors in Computing Systems on - CHI EA '13  
We also thank Neng-Hao Yu for his valuable comments on the capacitance tag technology.  ...  We hope that the broader CHI community can apply this technique to develop more novel designs to exploit the quiescent meanings [24] of tangible interactions.  ... 
doi:10.1145/2468356.2479537 dblp:conf/chi/LiangCCPCLYC13 fatcat:iuzvpxygkfbqvex5uzzfxdpm2a

A new macrocyclic diterpenoid from Anisomeles indica

Chen-Liang Chao, Hui-Chi Huang, Hsiou-Yu Ding, Jenn-Haung Lai, Hang-Ching Lin, Wen-Liang Chang
2019 Figshare  
A new macrocyclic diterpenoid, 4β,5β-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts of Anisomeles indica (L.) O. Kuntze (Labiatae). The structure of 1 was established on the basis of spectral evidence. Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.
doi:10.6084/m9.figshare.7887884.v1 fatcat:wz4dje52snbfbl5eezxtgblfmi

Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders

Ruei-An Chen, Chun-Yi Lee, Yu Lee, Chi-Fa Hung, Yu-Chi Huang, Pao-Yen Lin, Sheng-Yu Lee, Liang-Jen Wang
2019 PeerJ  
Hung and Yu-Chi Huang performed the experiments. • Yu Lee conceived and designed the experiments, performed the experiments. • Pao-Yen Lin analyzed the data. • Sheng-Yu Lee conceived and designed the  ...  experiments, contributed reagents/materials/analysis tools. • Liang-Jen Wang conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis  ... 
doi:10.7717/peerj.7432 pmid:31396459 pmcid:PMC6679906 fatcat:etqg52rgljchxkfaoob66rle6a

Check Reliability Based Bit-Flipping Decoding Algorithms for LDPC Codes [article]

Chi-Yuan Chang, Yu T. Su, Yu-Liang Chen, Yin-Chen Liu
2010 arXiv   pre-print
We introduce new reliability definitions for bit and check nodes. Maximizing global reliability, which is the sum reliability of all bit nodes, is shown to be equivalent to minimizing a decoding metric which is closely related to the maximum likelihood decoding metric. We then propose novel bit-flipping (BF) decoding algorithms that take into account the check node reliability. Both hard-decision (HD) and soft-decision (SD) versions are considered. The former performs better than the
more » ... l BF algorithm and, in most cases, suffers less than 1 dB performance loss when compared with some well known SD BF decoders. For one particular code it even outperforms those SD BF decoders. The performance of the SD version is superior to that of SD BF decoders and is comparable to or even better than that of the sum-product algorithm (SPA). The latter is achieved with a complexity much less than that required by the SPA.
arXiv:1001.2503v1 fatcat:pywl2fz6lrcxlgezf7phpoplri

The potential dysfunction of otolith organs in patients after mumps infection

Yu-Juan Zhou, Jing Yu, Yong-Zhen Wu, Liang Tian, Zhao Han, Jing Wang, Fang-Lu Chi, Chen-Chi Wu
2017 PLoS ONE  
(PDF) Author Contributions Conceptualization: Jing Wang, Fang-Lu Chi. Formal analysis: Yu-Juan Zhou, Jing Yu, Yong-Zhen Wu, Liang Tian, Zhao Han. Funding acquisition: Jing Wang, Fang-Lu Chi.  ...  Chi-square tests were used to compare the response rates of the VEMPs. Wilcoxon's signed-rank test was used to compare the threshold values of the VEMPs between the affected and unaffected ears.  ... 
doi:10.1371/journal.pone.0181907 pmid:28746415 pmcid:PMC5528881 fatcat:ffxjxlbmtfhjxdxq5yiudr5vve

Higher frequency but random distribution of EGFR mutation subtypes in familial lung cancer patients

Kuo-Hsuan Hsu, Jeng-Sen Tseng, Chih-Liang Wang, Tsung-Ying Yang, Chien-Hua Tseng, Hsuan-Yu Chen, Kun-Chieh Chen, Chi-Ren Tsai, Cheng-Ta Yang, Sung-Liang Yu, Kang-Yi Su, Chong-Jen Yu (+8 others)
2016 OncoTarget  
Despite the advancement of epidermal growth factor receptor (EGFR) inhibitors in lung cancer therapy, it remains unclear whether EGFR mutation status in familial lung cancers is different from that of sporadic cases. In this multicenter retrospective
doi:10.18632/oncotarget.10715 pmid:27449093 pmcid:PMC5288187 fatcat:ljk7cbfdhbeazmlf6g5dogds5i

HPV infection and p53 inactivation in pterygium

Yi-Yu Tsai, Chi-Chung Chang, Chun-Chi Chiang, Kun-Tu Yeh, Pei-Liang Chen, Chi-Huang Chang, Ming-Chih Chou, Huei Lee, Ya-Wen Cheng
2009 Molecular Vision  
Our recent report indicated that tumor suppressor gene (p53) mutations and protein aberrant expression were detected in pterygium. Inactivation of p53 by Human papillomavirus (HPV) 16/18 E6 plays a crucial role in cervical tumorigenesis. In this study, we further speculate that p53 inactivation may be linked with HPV infection in pterygium pathogenesis. To investigate the involvement of HPV 16/18 E6 in p53 inactivation in pterygium, the association between HPV 16 or HPV 18 infection, the HPV E6
more » ... oncoprotein, and p53 protein expression was analyzed in this study. HPV 16/18 infection was detected by nested-polymerase chain reaction (nested-PCR), the p53 mutation was detected by direct sequencing, and the p53 and the HPV 16/18 E6 proteins were studied using immunohistochemistry on 129 pterygial specimens and 20 normal conjunctivas. The HPV 16/18 was detected in 24% of the pterygium tissues (31 of 129) but not in the normal conjunctiva, and the HPV16/18 E6 oncoprotein was detected in 48.3% of HPV 16/18 DNA-positive pterygium tissues (15 of 31). In addition, p53 protein negative expression in pterygium was correlated with HPV16/18 E6 oncoprotein expression but not with a p53 mutation. HPV 16/18 E6 contributes to HPV-mediated pterygium pathogenesis as it is partly involved in p53 inactivation and is expressed in HPV DNA-positive pterygium.
pmid:19503739 pmcid:PMC2690956 fatcat:lo67ll2t2fcxnczrqrgdm7qa7m

Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions

Kuo-An Wu, Chih-Ching Wu, Chi-De Chen, Chi-Ming Chu, Li-Jane Shih, Yu-Ching Liu, Chih-Liang Wang, Hsi-Hsien Lin, Chia-Yu Yang
2017 Scientific Reports  
Patients with pneumonia and parapneumonic ���� (PPE) have elevated mortality and a poor prognosis. The aim of this study was to discover novel biomarkers to help distinguish between uncomplicated PPE (UPPE) and complicated PPE (CPPE). Using an iTRAQ-based quantitative proteomics, we id���� 766 proteins in pleural ����� from PPE patients. In total, 45 of these proteins were ����� as upregulated proteins in CPPE. Four novel upregulated candidates (BPI, NGAL, AZU1, and calprotectin) were selected
more » ... nd further ���� using enzyme-linked immunosorbent assays (ELISAs) on 220 patients with pleural ����� due to ����� causes. The pleural ��� levels of BPI, NGAL, AZU1, and calprotectin were ������� elevated in patients with CPPE. Among these four biomarkers, BPI had the best diagnostic value for CPPE, with an AUC value of 0.966, a sensitivity of 97%, and a ������ of 91.4%. A logistic regression analysis demonstrated a strong association between BPI levels > 10 ng/ml and CPPE (odds ratio = 341.3). Furthermore, the combination of pleural ��� BPI levels with LDH levels improved the sensitivity and ������ to 100% and 91.4%, respectively. Thus, our ��� s provided a comprehensive ���� proteome data set for PPE biomarker discovery and revealed novel biomarkers for the diagnosis of CPPE. Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific Repo Rts | 7: 4026 |
doi:10.1038/s41598-017-04189-4 pmid:28642494 pmcid:PMC5481374 fatcat:b2rda37cxffhloqnezoyzptfni

KRAS Mutation Is a Predictor of Oxaliplatin Sensitivity in Colon Cancer Cells

Yu-Lin Lin, Jau-Yu Liau, Shan-Chi Yu, Da-Liang Ou, Liang-In Lin, Li-Hui Tseng, Yih-Leong Chang, Kun-Huei Yeh, Ann-Lii Cheng, Ajay Goel
2012 PLoS ONE  
Molecular biomarkers to determine the effectiveness of targeted therapies in cancer treatment have been widely adopted in colorectal cancer (CRC), but those to predict chemotherapy sensitivity remain poorly defined. We tested our hypothesis that KRAS mutation may be a predictor of oxaliplatin sensitivity in CRC. KRAS was knocked-down in KRAS-mutant CRC cells (DLD-1 G13D and SW480 G12V ) by small interfering RNAs (siRNA) and overexpressed in KRAS-wild-type CRC cells (COLO320DM) by KRAS-mutant
more » ... tors to generate paired CRC cells. These paired CRC cells were tested by oxaliplatin, irinotecan and 5FU to determine the change in drug sensitivity by MTT assay and flow cytometry. Reasons for sensitivity alteration were further determined by western blot and real-time quantitative reverse transcriptase polymerase chain reaction (qRT -PCR). In KRASwild-type CRC cells (COLO320DM), KRAS overexpression by mutant vectors caused excision repair cross-complementation group 1 (ERCC1) downregulation in protein and mRNA levels, and enhanced oxaliplatin sensitivity. In contrast, in KRASmutant CRC cells (DLD-1 G13D and SW480 G12V ), KRAS knocked-down by KRAS-siRNA led to ERCC1 upregulation and increased oxaliplatin resistance. The sensitivity of irinotecan and 5FU had not changed in the paired CRC cells. To validate ERCC1 as a predictor of sensitivity for oxaliplatin, ERCC1 was knocked-down by siRNA in KRAS-wild-type CRC cells, which restored oxaliplatin sensitivity. In contrast, ERCC1 was overexpressed by ERCC1-expressing vectors in KRAS-mutant CRC cells, and caused oxaliplatin resistance. Overall, our findings suggest that KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells by the mechanism of ERCC1 downregulation.
doi:10.1371/journal.pone.0050701 pmid:23209813 pmcid:PMC3508995 fatcat:gs5jmm5qmfftlgmclbvutr672y
« Previous Showing results 1 — 15 out of 15,604 results