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doi:10.4048/jbc.2011.14.1.72 pmid:21847399 pmcid:PMC3148517 fatcat:hih7av5mmjcbvfxqhl7dbjdpmm
We report a case of a young patient with recurrent posterior circulation infarction that may have been associated with an anomalous occipital bony process compressing the vertebral artery. ... Young age stroke work-up including thorough cardiac, intra-and extracranial vascular evaluation and laboratory tests for the hypercoagulable state or connective tissue disease yielded unremarkable results ... Background Cerebral infarction in young people is rare. ...doi:10.1186/s12883-014-0252-6 pmid:25519166 pmcid:PMC4302142 fatcat:kzs2tgsnxncyjen2l5dwg7z5gq
Synchronous bilateral breast cancer is extremely rare in men and has not, up to date, been reported in Korea. A 54-year-old man presented with a palpable mass in the right breast. The right nipple was retracted and bilateral axillary accessory breasts and nipples were present. On physical examination, a 2 cm-sized mass was palpated directly under the right nipple, and, with squeezing, bloody discharge developed in a single duct of the left nipple. There was no palpable mass in the left breast,doi:10.4048/jbc.2012.15.2.248 pmid:22807945 pmcid:PMC3395751 fatcat:hyfu7xmstrek7lk4tezndccbhy
more »... nd axillary lymph nodes were not palpable. Physical examination of external genitalia revealed a unilateral undescended testis on the left side. Synchronous bilateral breast cancer was diagnosed using mammography, ultrasonography, and core-needle biopsy. Histopathological examination revealed invasive ductal carcinoma in the right breast and ductal carcinoma in situ in the left breast. Bilateral total mastectomy, sentinel lymph node biopsy, and excision of accessory breasts in the axilla were performed.
The authors wish to make the following corrections to this paper [...]doi:10.3390/jcm8030389 pmid:30897780 pmcid:PMC6463134 fatcat:hx7uwqvghbgz7axnzj5bwjqjpa
Purpose: Tortuosity and atherosclerosis of the abdominal aorta are commonly observed in the elderly. Few studies about aortic tortuous changes have been performed. This study was carried out to investigate the relationship between aortic tortuous and atherosclerotic changes. Methods: We included 2,920 patients by reviewing computerized tomography scans in Chungbuk National University Hospital during 2007. We classified the abdominal aorta into straight (I form) and tortuous forms (T form),doi:10.5758/kjves.2011.27.4.145 fatcat:k7dbwyoomzb4jlznb3ydf7777y
more »... ed as a deviation involving more than half the aortic diameter. The T form was further subdivided into 2 types (C type, 1 curve; T type, >2 curves). The calcification index (CI) was also measured. The tortuosity index (TI) was measured in 60 patients each with the I form and the C and S types. We analyzed relationships between tortuosity and clinical variables. Results: The incidence of tortuosity was 56.2%, and in the 7th, 8th, 9th decades of life it was 61.7%, 77.3%, and 91.0%, respectively. In univariate analysis, age, female sex, hypertension, and CI were statistically significant. In multivariate analysis, CI was not statistically significant between the I and T forms but significant between the I form and the S type. TI in the T form was lower than in the I form. However, no difference was seen between the I form and C type. Conclusion: A tortuous change of the abdominal aorta was seen earlier and more frequently than an atherosclerotic change and were associated with aging, calcification, and hypertension. Aortic calcification was associated with more complex tortuous changes.
Transarterial chemoembolization (TACE) is frequently used for treatment of unresectable hepatocellular carcinoma (HCC) and can also be used for case of liver metastases from rectal cancer. Although it is recognized as safe and effective treatment, various complications have been reported. However, post-TACE duodenal perforation with duodenal and esophageal ischemia has not been reported in the literature. A 43-year-old male had experienced duodenal perforation combined with duodenal and lowerdoi:10.1097/md.0000000000003987 pmid:27399074 pmcid:PMC5058803 fatcat:bfdgfyntmrhvjhaqn4opxzi2qu
more »... ophageal ischemia after 8 times of repeated TACE for recurrent and unresectable HCCs, that was confirmed on esophagogastroduodenoscopy and abdominal computed tomography. Interestingly, operative findings showed complete recovery of duodenal ischemia except perforation, and he recovered with just the segmental duodenectomy and gastrojejunostomy. We report a case of duodenal perforation with necrosis and esophageal ischemia after 8th TACE for unresectable HCC. Although this complication is rare and unexpected, it may result in severe sequelae requiring surgical repair. The careful procedure during TACE followed by post-TACE careful monitoring is required in patients with posthepatectomy or repeated TACE, especially in the case with unusual clinical manifestations. Abbreviations: APCT = abdominal pelvic computed tomography, CT = computed tomography, EGD = esophagogastroduodenoscopy, HCC = hepatocellular carcinoma, PCD = percutaneous drain, TACE = transarterial chemoembolization.
Woo-Jin Han (Netmarble IGS) and all other men-tees of the camp. ...arXiv:1809.10636v1 fatcat:a5ck5krbujbwvosul7rydrtqya
Several lines of evidence indicate that deregulation of apoptosis is involved in the mechanisms of cancer development. Caspase-8 activation plays a central role in the initiation phase of apoptosis. The aim of this study was to explore the possibility that genetic alteration of CASPASE-8 gene is involved in the development of human cancers, including gastric cancers. We have analyzed the entire coding region of human CASPASE-8 gene for the detection of somatic mutations in 162 gastricpmid:15705878 fatcat:u6uxao7ueve7bpaonws3roidi4
more »... (40 early and 122 advanced cancers), 185 non-small cell lung cancers, 93 breast carcinomas, and 88 acute leukemias by PCR-single-strand conformation polymorphism. Of the cancers analyzed, 13 cancers harbored CASPASE-8 somatic mutations. Interestingly, all of the mutations were detected in the advanced gastric cancers (10.7% of the 122 samples). We expressed the tumor-derived caspase-8 mutants in 293T, 293, and HT1080 cells and found that most of the mutants (9 of the 10 mutations tested) markedly decreased the cell death activity of caspase-8. In addition, in the cells with the inactivating caspase-8 mutants, cleavage of poly(ADP-ribose)polymerase was markedly reduced compared with that of wild-type caspase-8. The occurrence of CASPASE-8 mutation and the inactivation of cell death activity by the mutants suggest that CASPASE-8 gene mutation may affect the pathogenesis of gastric cancers, especially at the late stage of gastric carcinogenesis.
AbstractOral microbiota can alter cancer susceptibility and progression by modulating metabolism and inflammation. We assessed the association between the oral microbiome and lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). We collected a total of 54 saliva samples from patients with OSCC before surgery. LN metastasis was assessed based on postoperative pathological examination. We used QIIME2, linear discriminant analysis effect size (LEfSe), and PICRUSt2 methods to analyzedoi:10.1038/s41598-021-02638-9 pmid:34848792 pmcid:PMC8633319 fatcat:sjd5gmq7m5ahdoo23oyocdbamu
more »... crobial dysbiosis. A random forest classifier was used to assess whether the oral microbiome could predict LN metastasis. Among the 54 OSCC samples, 20 had LN metastasis, and 34 had no evidence of metastasis. There was a significant difference in β-diversity between the metastasis and no metastasis groups. Through LEfSe analysis, the metastasis group was enriched in the genera Prevotella, Stomatobaculum, Bifidobacterium, Peptostreptococcaceae, Shuttleworthia and Finegoldia. Pathways related to signal peptidase II were predominant in the no metastasis group. The RF model showed a modestly high accuracy for predicting metastasis. Differences in microbial community composition and functions were observed in the oral microbiome of patients with OSCC with and without LN metastasis. However, the finding that specific taxa may be associated with LN metastasis should be verified in a further prospective study.
This observation suggests that children and young adults may be more susceptible to novel influenza A (H1N1). ... It is also possible that there is a case-ascertainment bias because more of the young people are tested as part of outbreaks in schools than elderly people (5) . ...doi:10.3348/kjr.2009.10.6.531 pmid:19885308 pmcid:PMC2770827 fatcat:dnxbbg6dybfddeugbjugfdldki
Pulmonary sarcoidosis often involves mediastinal or hilar lymph nodes in the lung parenchyma. Mediastinoscopy is the gold standard for diagnosis, but it is invasive and expensive. Transbronchial needle aspiration using conventional bronchoscope is less invasive than mediastinoscopy, but its diagnostic accuracy is in question due to the blind approach to targeting lymph nodes. Transbronchial needle aspiration (TBNA) via endobronchial ultrasound (EBUS) has high diagnostic value due to directdoi:10.4046/trd.2010.68.5.267 fatcat:dcho57zt3bhotmdagx7ibckc5a
more »... lization of lymph nodes and to its relatively safeness. The purpose of this study was to assess the usefulness of EBUS-TBNA in the diagnosis of pulmonary sarcoidosis. Methods: Twenty-five patients with symptoms of sarcoidosis were enrolled into this study. Core tissue was obtained for a definitive diagnosis. Endobronchial biopsy, transbronchial lung biopsy, and bronchoalveolar lavage were performed to verify diagnosis. For patients without a confirmed diagnosis after the above procedures were performed, the additional procedures of mediastinoscopy or video-associated thoracoscopic surgery were performed to confirm a final diagnosis. Results: A total 25 EBUS procedures were done and 50 lymph nodes were aspirated. Thirty-three (37) out of 50 lymph nodes were consistent with non-caseating granuloma, confirming sarcoidosis as the final diagnosis. Sarcoidosis was the final diagnosis for all 25 patients, and 21 required EBUS-TBNA for a final diagnosis. There were no complications associated with the procedure. Conclusion: EBUS-TBNA is already a well-known procedure for diagnosing mediastinal or hilar lymphadenopathy. We used EBUS-TBNA for the diagnosis of pulmonary sarcoidosis and our results showed 84% diagnostic accuracy and no complications related to the procedure. EBUS-TBNA is a reliable and practical diagnostic modality in the diagnosis of pulmonary sarcoidosis.
A recent report revealed that phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) gene is somatically mutated in several types of human cancer, suggesting the mutated PIK3CA gene as an oncogene in human cancers. However, because the previous report focused the mutational search primarily on colon cancers, the data on PIK3CA mutations in other types of human cancers have been largely unknown. Here, we performed mutational analysis of the PIK3CA gene by polymerase chain reaction-single-stranddoi:10.1038/sj.onc.1208304 pmid:15608678 fatcat:c5eyckefizgg3go7jj2dbx2twy
more »... formation polymorphism assay in 668 cases of common human cancers, including hepatocellular carcinomas, acute leukemias, gastric carcinomas, breast carcinomas, and non-small-cell lung cancers. We detected PIK3CA somatic mutations in 26 of 73 hepatocellular carcinomas (35.6%), 25 of 93 breast carcinomas (26.9%), 12 of 185 gastric carcinomas (6.5%), one of 88 acute leukemias (1.1%), and three of 229 non-small-cell lung cancers (1.3%). Some of the PIK3CA mutations were detected in the early lesions of breast cancer carcinoma, hepatocellular carcinoma, and gastric carcinomas, suggesting that PIK3CA mutation may occur independent of stage of the tumors. The high incidence and wide distribution of PIK3CA gene mutation in the common human cancers suggest that alterations of lipid kinase pathway by PIK3CA mutations contribute to the development of human cancers.
Gut and Liver
Background/Aims: This study was performed to determine whether low-dose aspirin and/or clopidogrel can induce gastrointestinal bleeding and gastroduodenal mucosal injury. Methods: A total of 387 patients who underwent coronary angiography at Seoul National University Bundang Hospital were assigned to one of three antiplatelet treatment groups: (1) control, (2) 100-mg enteric coated aspirin, and (3) 100-mg enteric coated aspirin plus clopidogrel. The incidences of gastroduodenal mucosal injurydoi:10.5009/gnl.2008.2.2.99 pmid:20485618 pmcid:PMC2871580 fatcat:qrtc5bplfzfdfbwzirby7upa7y
more »... d gastrointestinal bleeding were prospectively evaluated, and risk factors for gastrointestinal bleeding were analyzed. Results: The rate of gastroduodenal mucosal injury was higher in the aspirin-plus-clopidogrel group than in the aspirin group (p=0.012), and higher in the aspirin group than in the control group (p=0.049). The rate of gastrointestinal bleeding was significantly higher in the aspirin-plus-clopidogrel group (9.4%) than in the control group (2.4%, p=0.048). The risk factors for gastrointestinal bleeding were older age (≥60 years) and the presence of at least two comorbid disorders. Conclusions: Low-dose enteric coated aspirin was found to be safe in patients with coronary artery disease, but the addition of clopidogrel increased the rate of gastrointestinal bleeding. Combined clopidogrel and aspirin should be used with caution in older patients having at least two comorbid conditions.
A 43-year-old man, who received total gastrectomy five years ago for advanced gastric cancer, underwent a screening colonoscopy and abdominal CT scan. Abdominal CT scan revealed no abnormal findings. Colonoscopy revealed polyps at the rectum, which were removed by polypectomy. The patient did not complain of abdominal pain or discomfort throughout the procedure. But, he developed right upper quadrant abdominal pain on the next day after colonoscopy. Abdominal CT scan revealed the distendeddoi:10.4166/kjg.2013.61.1.42 pmid:23354349 fatcat:4frkc34kvzf25kwskknvhs5ry4
more »... ladder with mild wall thickening and suspicious sandy stones or sludge in the gallbladder. The patient underwent an open cholecystectomy. Pathology was compatible with acute cholecystitis. We should be aware of and consider cholecystitis in the differential diagnosis for patients with abdominal pain after colonoscopy.
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