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Dovepress Dovepress 2458 Li et al ... ChenZw, Li ZH, wang JS, et al. Adv Funct Mater. 24:522-529. ©2013 wILeY-vCH verlag GmbH & Co. ...doi:10.2147/ijn.s68600 pmid:25848263 pmcid:PMC4383220 fatcat:zcq7loh4dza4zfpplrrccjrsaa
, Li, Qian & Shi Table 1. ... Cell exterior (low GSH) Cell interior (high GSH) PEGylation cleavage Release into nuclear Inorganic nanoparticles Drug DNA or RNA Endocytosis future science group Review Dong, Tang, Li ...doi:10.2217/nnm.15.38 pmid:26139127 fatcat:j4muwfq435aenfwkod7r6pnb7u
Acknowledgments Houyi Li and Yongchao Liu have contributed equally to this work. We would like to thank Yanminng Fang for building the Alipay datasets. Here is the Data Protection Statement: 1. ...arXiv:2104.10569v1 fatcat:j3ga42ycjfektdcyk4qrg57ibm
BMC Medical Genetics
The human paraoxonase (PON) gene family has three isoforms: PON1, PON2 and PON3. These genes are implicated as potential risk factors of cerebrovascular disease and can prevent oxidative modification of low-density lipoproteins and atherosclerosis. This study evaluated the association between the genetic variants of all three PON genes and the risks of total stroke, ischemic stroke and hemorrhagic stroke in the Han Chinese population. Methods: A total of 1016 subjects were recruited, includingdoi:10.1186/1471-2350-14-16 pmid:23356507 pmcid:PMC3562169 fatcat:j2r4iamjzbbzfm7y4czl32iwfy
more »... 08 healthy controls and 498 patients (328 with ischemic stroke and 170 with hemorrhagic stroke). A total of 11 single nucleotide polymorphisms (SNPs) covering the PON genes were genotyped for statistical analysis. Two of the 11 SNPs (rs662 and rs854560) were contextualized in a meta-analysis of ischemic stroke. Results: The presence of rs705381 (−162) in the promoter region of PON1 was significantly associated with total stroke (P adjusted = 0.0007, OR = 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (P adjusted = 0.0017, OR = 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke. There was also a nominal association between rs854571 (−824) and total stroke. Meta-analysis demonstrated a significant nominal association between rs662 and ischemic stroke, but there was no evidence of an association between rs662 and ischemic stroke risk in a single site association study. Conclusions: These findings indicate that polymorphisms of PON1 gene may be a risk factor of stroke.
For certain diseases, the continuous long-term monitoring of the physiological condition is crucial. Therefore, non-invasive monitoring methods have attracted widespread attention in health care. This review aims to discuss the non-invasive monitoring technologies for human health based on photoacoustic spectroscopy. First, the theoretical basis of photoacoustic spectroscopy and related devices are reported. Furthermore, this article introduces the monitoring methods for blood glucose, blooddoi:10.3390/s22031155 pmid:35161900 pmcid:PMC8839463 fatcat:blxgiba2kbbmbmttnes7gvfe74
more »... gen, lipid, and tumors, including differential continuous-wave photoacoustic spectroscopy, microscopic photoacoustic spectroscopy, mid-infrared photoacoustic detection, wavelength-modulated differential photoacoustic spectroscopy, and others. Finally, we present the limitations and prospects of photoacoustic spectroscopy.
Pulse magneto-oscillation (PMO) was developed as a novel technique to refine the solidification structure of pure aluminium. Its grain refining mechanism was proposed. The PMO refinement mechanism is that the nucleus falls off from the mould wall and drifts into the melt under the action of PMO. The solidification structure of Al melt depends on the linear electric current density, and also the discharge and oscillation frequencies. The radial pressure of PMO sound wave is the major factor thatdoaj:4b7de288cb8d4f9d84272990ecd0b45d fatcat:lrgqdi3clvelrh5nb422hxgqiy
more »... contributes to the migration of nucleus into the melt.
AbstractEpilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different types of epilepsy in humans, hence non-human primate models of epilepsy are required. The common marmoset (Callithrix jacchus) is a New World monkey that is widely used to study brain function. Here,doi:10.1186/s13041-022-00901-2 pmid:35144651 pmcid:PMC8832845 fatcat:dl4aannndjfhnmlgtbp7nyy4my
more »... we present a natural marmoset model of generalized epilepsy. In this unique marmoset family, generalized epilepsy was successfully induced by handling operations in some individuals. We mapped the marmoset family with handling-sensitive epilepsy and found that the epileptic phenotype can be inherited. These marmosets were more sensitive to the epilepsy inducers pentylenetetrazol. Using electrocorticogram (ECoG) recordings, we detected epileptiform discharge in marmosets with a history of seizures. In summary, we report a family of marmosets with generalized seizures induced by handling operations. This epileptic marmoset family provides insights to better understand the mechanism of generalized epilepsy and helps to develop new therapeutic methods.
Author Contributions: Yongyong Li, Huili Gong and Lin Zhu derived the methods, performed data analysis, and wrote the manuscript. ... Xiaojuan Li made important suggestions on data processing and analysis, and discussed the results. Conflicts of Interest: The authors declare no conflict of interest. ...doi:10.3390/w9010064 fatcat:lzka4mkabbcuhhsrnebuwsyz5m
Microstructural evolution, interfacial reaction and fracture during vacuum brazing of 50Mo-50Re alloys using amorphous alloy Fe-5.6Si-2.6B(wt%) were investigated. A binary intermetallic compound, σ(Mo 2 Re 3 ) formed as parallel contiguous layers in the diffusion zone. In addition, Fe from the braze alloy, in combination with dissolved Mo from the substrate, formed two layers of binary compounds μ-Mo 6 Fe 7 and λ-MoFe 2 , adjacent to diffusion zone. The unreacted Fe-based filler metaldoi:10.1590/1980-5373-mr-2018-0730 fatcat:bpnfflqijfgjhjx4w3cd274deq
more »... as α-Fe solid solution. Fracture analysis showed that the mode of failure was mainly transgranular cleavage with partly intergranular and the fracture located on the interface of 50Mo-50Re alloy and the central area of brazing seam.
Li reports grants from the National Natural Science Foundation of China, grants from the National Key R&D Program of China, during the conduct of the study; Dr. ...doi:10.1016/j.ebiom.2018.07.037 pmid:30100396 pmcid:PMC6116472 fatcat:3iv3akmlprde5p2rxtgfsvx2ta
Recent genome-wide association study showed rs10940346 locus near EMB gene was significantly associated with schizophrenia and suggested that EMB gene is one of the potentially causal genes for schizophrenia, but no causal variant has been identified. Our study aims to further verify EMB gene is a susceptibility gene for schizophrenia and to identify potentially causal variants in EMB gene that lead to schizophrenia. Targeted sequencing for the un-translated region and all exons of EMB gene wasdoi:10.1186/s12888-020-02513-3 pmid:32213169 fatcat:fek6zmnaorg4naeyca5wenmkrq
more »... performed among 1803 patients with schizophrenia and 997 healthy controls recruited from Chinese Han population. A total of 58 high-quality variants were identified in case and control groups. Seven of them are nonsynonymous rare variations, EMB: p.(Ala52Thr), p.(Glu66Gly), p.(Ser93Cys), p.(Ala118Val), p.(Ile131Met), p.(Gly163Arg) and p.(Arg238Tyr), but none of them reached statistical significance. Among them, p.(Ile131Met), p.(Gly163Arg) and p.(Arg238Tyr), were predicted to be deleterious variants. In addition, a common variant, rs3933097 located in 3'-UTR of EMB gene, achieved allelic and genotypic significance with schizophrenia (Pallele = 3.82 × 10- 6, Pgenotype = 3.18 × 10- 5). Our research first presented a comprehensive mutation spectrum of exons and un-translated region in EMB gene for schizophrenia and provided additional evidence of EMB gene being a susceptibility gene for schizophrenia. However, further functional validations are necessary to reveal its role in the etiology of schizophrenia.
., 2011; Li et al., 2011) . In the field of the land subsidence, BPN model has been successfully used to simulate the land subsidence in some coastal cities (Li et al., 2005; Li et al., 2008) . ... Li et al. (2009) combined BPN with GA to simulate land subsidence and the model had one input layer, which is the variation of groundwater level. ...doi:10.1007/s11769-013-0589-6 fatcat:lavkh6sla5fxjhunwyrpudm4cy
It approximately lied on the line y = x, indicating that the results were unbiased. ... We could see that it approximately lied on the line y = x, indicating that the results were unbiased. Application of SHEsisPlus to serum uric acid level data for epistasis detection. ...doi:10.1038/srep24095 pmid:27048905 pmcid:PMC4822172 fatcat:duy72254frflxobcr7hieqwfoa
In this study, a multifunctional graphene based nanohybrid, termed as GN/Fe 3 O 4 /PF127, is engineered via a facile one-pot process consisting of simultaneous reduction of graphene oxide/Fe 3 O 4 and subsequent assembly of Pluronic F127 (PF127) onto graphene nanosheets (GNs). The unique aromatic and planar structure of GNs allows the attachment of multiple functional components including MRI contrast agent (Fe 3 O 4 nanoparticles) and an aromatic anticancer drug like doxorubicin (DOX), as welldoi:10.1088/0957-4484/25/6/065602 pmid:24434914 fatcat:3sekudacvzc3ff422qz3t7pr5q
more »... as PF127 coating which imparts physiological dispersivity and stability to the nanohybrid. The successful assembly process is revealed by TEM observation, size and FITR monitoring. In contrast with the primitive graphene or its oxide derivative, the resulting GN/Fe 3 O 4 /PF127 nanohybrids have shown high biological dispersion and MRI effect for diagnosis due to the incorporation of superparamagnetic Fe 3 O 4 nanoparticles without evident cytotoxicity. Moreover, the GN/Fe 3 O 4 /PF127 nanohybrid exhibits a photothermal effect due to the considerable optical absorption in the near-infrared region of GNs. The GN/Fe 3 O 4 /PF127 nanohybrid could be a further platform for chemophototherapy assisted by the therapeutic DOX. Cellular toxicity assays indicated that the DOX-loaded GN/Fe 3 O 4 /PF127 nanohybrid showed a remarkable cytotoxicity to HeLa cells and the cytotoxic effect was intensified when subjected to photoirradiation. Confocal laser scanning microscopy (CLSM) and flow cytometric analysis (FCAS) revealed that the nanohybrid could be easily uptaken into HeLa cells.
computed tomography (CT) scan will show the whirl sign which is due to the twisted intestine and sigmoid mesocolon, with the medial deviated cecum and descending colon, 8, 21 however Dovepress Li ... The intestinal pneumatosis (arrow) can also be seen in the upper and right lower abdomen. submit your manuscript | www.dovepress.com DovePress International Journal of General Medicine 2020:13 1266 Li ...doi:10.2147/ijgm.s279870 pmid:33269002 pmcid:PMC7701158 fatcat:mn4ie6w3lnezzikjmvcwb3gp5u
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