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Prediction of intensive care unit mortality based on missing events [article]

Tatsuma Shoji, Hiroshi Yonekura, Sato Yoshiharu, Yohei Kawasaki
2021 medRxiv   pre-print
AbstractBackgroundThe increasing availability of electronic health records has made it possible to construct and implement models for predicting intensive care unit (ICU) mortality using machine learning. However, the algorithms used are not clearly described, and the performance of the model remains low owing to several missing values, which is unavoidable in big databases.MethodsWe developed an algorithm for subgrouping patients based on missing event patterns using the Philips eICU Research
more » ... nstitute (eRI) database as an example. The eRI database contains data associated with 200,859 ICU admissions from many hospitals (>400) and is freely available. We then constructed a model for each subgroup using random forest classifiers and integrated the models. Finally, we compared the performance of the integrated model with the Acute Physiology and Chronic Health Evaluation (APACHE) scoring system, one of the best known predictors of patient mortality, and the imputation approach-based model.ResultsSubgrouping and patient mortality prediction were separately performed on two groups: the sepsis group (the ICU admission diagnosis of which is sepsis) and the non-sepsis group (a complementary subset of the sepsis group). The subgrouping algorithm identified a unique, clinically interpretable missing event patterns and divided the sepsis and non-sepsis groups into five and seven subgroups, respectively. The integrated model, which comprises five models for the sepsis group or seven models for the non-sepsis group, greatly outperformed the APACHE IV or IVa, with an area under the receiver operating characteristic (AUROC) of 0.91 (95% confidence interval 0.89–0.92) compared with 0.79 (0.76–0.81) for the APACHE system in the sepsis group and an AUROC of 0.90 (0.89–0.91) compared with 0.86 (0.85–0.87) in the non-sepsis group. Moreover, our model outperformed the imputation approach-based model, which had an AUROC of 0.85 (0.83–0.87) and 0.87 (0.86–0.88) in the sepsis and non-sepsis groups, respectively.ConclusionsWe developed a method to predict patient mortality based on missing event patterns. Our method more accurately predicts patient mortality than others. Our results indicate that subgrouping, based on missing event patterns, instead of imputation is essential and effective for machine learning against patient heterogeneity.Trial registrationNot applicable.
doi:10.1101/2021.02.28.21252249 fatcat:yfadcw3hbbb2nowtaktn6afdky

Correction to: Prophylactic sivelestat for esophagectomy and in-hospital mortality: a propensity score-matched analysis of claims database

Chikashi Takeda, Masato Takeuchi, Yohei Kawasaki, Hiroshi Yonekura, Isao Nahara, Aki Kuwauchi, Satomi Yoshida, Shiro Tanaka, Koji Kawakami
2020 Journal of Anesthesia  
In the original version of the article, the Tables 2 and 3 was published incorrectly. The correct version of Tables 2 and 3 are given below.
doi:10.1007/s00540-019-02726-1 pmid:31932943 fatcat:irmjysc4njgjbf2fzswfyaarma

Influence of Institution-Based Factors on Preoperative Blood Testing Prior to Low-Risk Surgery: A Bayesian Generalized Linear Mixed Approach

Kazuki Ide, Hiroshi Yonekura, Yohei Kawasaki, Koji Kawakami
2017 Computational and Mathematical Methods in Medicine  
Statistical analysis and interpretation of data were performed by Kazuki Ide, Yohei Kawasaki, and Hiroshi Yonekura.  ...  Study concept and design were performed by Kazuki Ide and Yohei Kawasaki. Acquisition of data was performed by Hiroshi Yonekura and Koji Kawakami.  ... 
doi:10.1155/2017/3624075 pmid:29362591 pmcid:PMC5738628 fatcat:6g6gsmbpn5akray5ndvqyehswq

Changes in ovarian morphology and hormone concentrations associated with reproductive seasonality in wild large Japanese field mice (Apodemus speciosus)

Kazuki Komatsu, Kohsuke Murata, Tsugumi Iwasaki, Syun Tokita, Shiina Yonekura, Satoshi Sugimura, Yohei Fujishima, Akifumi Nakata, Tomisato Miura, Hideaki Yamashiro
2021 Animal Reproduction  
Wild large Japanese field mice (Apodemus speciosus) responses to cyclic seasonal changes are associated with physiological and behavioral changes. However, the detailed regulation of oogenesis in the ovary during the seasonal reproductive cycle in wild large Japanese field mice has not been studied. We assessed the dynamics and changes in ovarian morphology and hormone concentrations associated with reproductive seasonality throughout the year. The stages of the ovarian morphological breeding
more » ... cle of wild large Japanese field mice were classified as breeding, transition, and non-breeding periods during the annual reproductive cycle. Measurement of blood estradiol concentrations throughout the year showed that the levels in September and October were higher than those in other months. It is presumed that follicle development starts from a blood estradiol concentration of 38.4 ± 27.1 pg/mL, which marks a shift from the transitional season to the breeding season, followed by the transition to the non-breeding season at 26.1 ± 11.6 pg/mL. These results suggest that seasonal follicle development in wild rodents is correlated with estradiol regulation. We consider this species to be an alternative animal model for studying seasonal reproductive changes and the effects of environmental changes.
doi:10.1590/1984-3143-ar2021-0067 pmid:35035541 pmcid:PMC8747936 fatcat:77mjs4uuwva6vb65krbvnbqgyi

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)

Moritoki Egi, Hiroshi Ogura, Tomoaki Yatabe, Kazuaki Atagi, Shigeaki Inoue, Toshiaki Iba, Yasuyuki Kakihana, Tatsuya Kawasaki, Shigeki Kushimoto, Yasuhiro Kuroda, Joji Kotani, Nobuaki Shime (+214 others)
2021 Acute Medicine & Surgery  
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created as revised from J-SSCG 2016 jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in September 2020 and published in February 2021. An English-language version of these guidelines was created based on the contents of the original
more » ... apanese-language version. The purpose of this guideline is to assist medical staff in making appropriate decisions to improve the prognosis of patients undergoing treatment for sepsis and septic shock. We aimed to provide high-quality guidelines that are easy to use and understand for specialists, general clinicians, and multidisciplinary medical professionals. J-SSCG 2016 took up new subjects that were not present in SSCG 2016 (e.g., ICU-acquired weakness [ICU-AW], post-intensive care syndrome [PICS], and body temperature management). The J-SSCG 2020 covered a total of 22 areas with four additional new areas (patient- and family-centered care, sepsis treatment system, neuro-intensive treatment, and stress ulcers). A total of 118 important clinical issues (clinical questions, CQs) were extracted regardless of the presence or absence of evidence. These CQs also include those that have been given particular focus within Japan. This is a large-scale guideline covering multiple fields; thus, in addition to the 25 committee members, we had the participation and support of a total of 226 members who are professionals (physicians, nurses, physiotherapists, clinical engineers, and pharmacists) and medical workers with a history of sepsis or critical illness. The GRADE method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 79 GRADE-based recommendations, 5 Good Practice Statements (GPS), 18 expert consensuses, 27 answers to background questions (BQs), and summaries of definitions and diagnosis of sepsis were created as responses to 118 CQs. We also incorporated visual information for each CQ according to the time course of treatment, and we will also distribute this as an app. The J-SSCG 2020 is expected to be widely used as a useful bedside guideline in the field of sepsis treatment both in Japan and overseas involving multiple disciplines.
doi:10.1002/ams2.659 pmid:34484801 pmcid:PMC8390911 fatcat:y2usqwfkznhvhpjarqy7sxgpzy

FANTOM5 CAGE profiles of human and mouse samples

Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama, Tsugumi Kawashima, Miki Kojima (+166 others)
2017 Scientific Data  
In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis
more » ... pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.
doi:10.1038/sdata.2017.112 pmid:28850106 pmcid:PMC5574368 fatcat:cel5hhhtardinak67mbl2okvhe

Adjuvant chemotherapy with tegafur/uracil administration after transcatheter arterial chemoembolization for advanced hepatocellular carcinoma

Hiroki Ueda, Hiroto Tanaka, Yohei Kida, Hiroko Fukuchi, Masakazu Ichinose
2008 Oncology Reports  
Yonekura et al demonstrated that UFT and its metabolites, γ-hydroxybutyric acid (GHB) and γ-butyrolactone (GBL), inhibited tumor angiogenesis (15) .  ... 
doi:10.3892/or.19.5.1355 fatcat:g6bji4vn6zedlglswph5fj3ly4

ARDS Clinical Practice Guideline 2021

Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito, Shotaro Matsumoto, Eishu Nango (+216 others)
2022 Journal of Intensive Care  
Background The joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021. Methods The 2016 edition of the Clinical Practice Guideline covered clinical questions (CQs) that targeted only adults, but the present guideline includes 15 CQs for children in addition to 46 CQs for adults. As with the previous edition,
more » ... we used a systematic review method with the Grading of Recommendations Assessment Development and Evaluation (GRADE) system as well as a degree of recommendation determination method. We also conducted systematic reviews that used meta-analyses of diagnostic accuracy and network meta-analyses as a new method. Results Recommendations for adult patients with ARDS are described: we suggest against using serum C-reactive protein and procalcitonin levels to identify bacterial pneumonia as the underlying disease (GRADE 2D); we recommend limiting tidal volume to 4–8 mL/kg for mechanical ventilation (GRADE 1D); we recommend against managements targeting an excessively low SpO2 (PaO2) (GRADE 2D); we suggest against using transpulmonary pressure as a routine basis in positive end-expiratory pressure settings (GRADE 2B); we suggest implementing extracorporeal membrane oxygenation for those with severe ARDS (GRADE 2B); we suggest against using high-dose steroids (GRADE 2C); and we recommend using low-dose steroids (GRADE 1B). The recommendations for pediatric patients with ARDS are as follows: we suggest against using non-invasive respiratory support (non-invasive positive pressure ventilation/high-flow nasal cannula oxygen therapy) (GRADE 2D), we suggest placing pediatric patients with moderate ARDS in the prone position (GRADE 2D), we suggest against routinely implementing NO inhalation therapy (GRADE 2C), and we suggest against implementing daily sedation interruption for pediatric patients with respiratory failure (GRADE 2D). Conclusions This article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL: The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries.
doi:10.1186/s40560-022-00615-6 pmid:35799288 pmcid:PMC9263056 fatcat:vurxx2n6srbl3kpgdjrv54jq2u

Repair of radiation damage

2002 Journal of Radiation Research  
Katsumi SAKAMOTO 1 , Yohei TOMINAGA 2 , Akinori EGASHIRA 1 , Shinobu KURA 1 , Yoshimichi NAKATSU 1 , Kunihiko SAKUMI 2 , Takashi YAO 3 , Masazumi TSUNEYOSHI 3 , Yusaku NAKABEPPU 2 , Teruhisa TSUZUKI 1  ...  pyrimidine bases were dependent on the salt concentration, ssDNA versus dsDNA, and the base opposite damage. 80 Purification and Characterization of Schizosaccharomyces pombe Nth Homologue Shin-Ichiro YONEKURA  ... 
doi:10.1269/jrr.43.444 fatcat:qrkrgk25yber7ckvektbudtuni


2018 Nippon Saikingaku Zasshi  
実希 P-404 Maeyama, Jun-ichi 前山 順一 P-137 〃 P-331 Maharjan, Bhagwan P-057 Maki, Jun 牧 純 P-165 Makimura, Koichi 槇村 浩一 P-011 〃 P-123 〃 P-340 Makino, Toshiaki 牧野 利明 P-384 Maki-Yonekura  ...  〃 P-100 Maruyama, Masato 丸山 真達 P-094 Masui, Takashi 桝井 貴史 P-380 〃 P-410 Masukagami, Yumiko 枡鏡 優美子 P-334 Masuzawa, Toshiyuki 増澤 俊幸 P-008 Matoba, Yasuyuki 的場 康幸 P-389 Matoba, Yohei  ... 
doi:10.3412/jsb.73.156 pmid:29479021 fatcat:lpjvphrpovbrjlw6ni2kxtu344

Name Index (索引)

2014 Seibutsu Butsuri  
Iqbal) 3P107 Maki, Kosuke (槇 亙介) 3SEA-02 3P065 3P066 Maki-Yonekura, Saori (眞木 さおり) 3P310 Makihara, Hikari (槇原 光) 1P169 Makino, Fumiaki (牧野 文信) 2P019 Makino, Yoshiteru (槙野 義輝) 2P240 2P247  ...  勇人) 1P181 Maruno, Takahiro (丸野 孝浩) 1P076 Maruta, Shinsa (丸田 晋策) 3P158 Maruta, Shinsaku (丸田 晋策) 1P145 2P101 3P167 Maruyama, Natsumi (丸山 夏未) 1P094 Maruyama, Takuma (丸山 拓真) 3P289 Maruyama, Yohei  ... 
doi:10.2142/biophys.54.s304 fatcat:peea6nluwvfblmtz7fj6m7bd7e

The Roles of S100 Proteins and RAGE in Melanoma [chapter]

Estelle Leclerc
2011 Breakthroughs in Melanoma Research  
can be generated from splicing (RAGE_v1) or shedding by ADAM10 (Ohe et al. 2010; Hudson et al. 2008; Galichet, Weibel, and Heizmann 2008; Raucci et al. 2008; Zhang et al. 2008; Ding and Keller 2005; Yonekura  ...  The Roles of S100 Proteins and RAGE in Melanoma, Breakthroughs in Melanoma Research, Dr Yohei Tanaka (Ed.), ISBN: 978-953-307-291-3, InTech, Available from:  ... 
doi:10.5772/18899 fatcat:xqpmom74tna7hezmfdr2or7m3y

Name Index (索引)

2013 Seibutsu Butsuri  
(宮川 伸) 3SCA-07 Miyakawa, Takeshi (宮川 毅) 1P023 2P019 2P020 2P183 3P016 3P017 Miyake, Jun (三宅 淳) 1P192 1P293 1P309 Miyake, Norio (三宅 倫生) 2P097 Miyamoto, Tadashi (宮本 直) 1P138 Miyanoiri, Yohei  ...  Iqbal) 2P102 Maki, Koichiro (牧 功一郎) 2SEA-03 Maki, Kosuke (槇 亙介) 3P064 3P065 3P066 Maki-Yonekura, Saori (眞木 さおり) 1P291 Makihara, Hikari (槇原 光) 2P040 Makino, Takaki (牧野 貴樹) 1P285 Makino, Yoshiteru  ... 
doi:10.2142/biophys.53.s265 fatcat:o632jkr43bcmlezcwdkhswlisa

Abstracts from the 37th Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry

2016 Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)  
P-26 Electrophysiological and anatomical approaches to understanding color vision processing in Drosophila melanogaster Taro Yonekura, Hiroyoshi Miyakawa, Takako Morimoto and Yoici Seki, Tokyo Univ Pharm  ...  P-20 Evaluating adaptive evolution of vision in nocturnal and diurnal hawkmoth species Tokiho Akiyama, Yohey Terai and Kentaro Arikawa, Dept Evolutionary Studies of Biosystems, SOKENDAI Irradiance and  ... 
doi:10.3330/hikakuseiriseika.33.3 fatcat:6no36wsmk5eu5duvnhvye4oheu

Abstracts from the 38th Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry

2016 Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)  
Keywords: moth, rhabdom, screening pigments P-036 Chromatic information processing in the central nervous system of Drosophila melanogaster Taro YONEKURA, Takako MORIMOTO, Yoichi SEKI, School of Life  ...  Keywords: Honeybee, Dopamine, Reproductive organs P-014 Genital autocleaning in the male cricket Mikihiko KUMASHIRO, Yohei TSUJI, Masashi HIRATOU, Masaki SAKAI, Grad. Sch. Nat. Sci.  ... 
doi:10.3330/hikakuseiriseika.33.145 fatcat:cbhctxib7nfvlcxkfajcpgb7xi
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