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Li, Y. W., M. L., L. G., Q. W., Z. L., J. Z. and X. Z. performed the experiment. H. Li, Y. W., M. L., H. Liang and Y. L. wrote the manuscript. Y. L. and H. Liang designed the experiment. ...doi:10.1101/2021.11.30.470684 fatcat:hlim75523jbilpz6apellnmnr4
Clostridiaceae, Lachnospiraceae, Ruminococcaceae ↓ Blautia, Ruminococcus 30 66.3 (5.1) MMSE; MTA / / / / ↑ Bifidobacterium, Blautia, Dorea, Escherichia, Lactobacillus, Streptococcus Li ...doi:10.3390/jcm9072042 pmid:32610630 pmcid:PMC7409059 fatcat:4s3cfx3suvd3nno3jcnddw6yym
Joint analysis of multiple phenotypes has gained growing attention in genome-wide association studies (GWASs), especially for the analysis of multiple intermediate phenotypes which measure the same underlying complex human disorder. One of the multivariate methods, MultiPhen (O' Reilly et al. 2012), employs the proportional odds model to regress a genotype on multiple phenotypes, hence ignoring the phenotypic distributions. Despite the flexibilities of MultiPhen, the properties and performancedoi:10.1371/journal.pone.0140348 pmid:26479245 pmcid:PMC4610695 fatcat:ke3oxkyujbaibd4ysa6q5ovjyu
more »... f MultiPhen are not well understood, especially when the phenotypic distributions are non-normal. In fact, it is well known in the statistical literature that the estimation is attenuated when the explanatory variables contain measurement errors. In this study, we first established an equivalence relationship between MultiPhen and the generalized Kendall tau association test, shedding light on why MultiPhen can perform well for joint association analysis of multiple phenotypes. Through the equivalence, we show that MultiPhen may lose power when the phenotypes are nonnormal. To maintain the power, we propose two solutions (ATeMP-rn and ATeMP-or) to improve MultiPhen, and demonstrate their effectiveness through extensive simulation studies and a real case study from the Guangzhou Twin Eye Study.
对于碳纳 米管的手性可控生长而言, 目前选择性最高的方法是 Li等 [129~132] 发展的基于钨基双金属催化剂的生长策略. ...doi:10.1360/ssc-2020-0115 fatcat:gcwz2foapbdntiaoczvkho6ohu
It was under debate whether cryptogenic stroke patients benefited from patent foramen ovale (PFO) closure. We sought to determine secondary prevention strategy in these patients. Methods: Scientific databases were searched for randomized controlled trials enrolling cryptogenic stroke patients with PFO who underwent PFO closure or medical therapy. The random-effect model was used to analyze the outcomes. Results: We identified 6 trials enrolling 3630 participants in this meta-analysis. Whendoi:10.1097/md.0000000000011965 pmid:30142823 pmcid:PMC6112940 fatcat:xcdfs6ombrhblo4ocf5xhodh5y
more »... red with medical therapy, PFO closure reduced risks of recurrent stroke (risk ratio [RR] 0.52, 95% confidence interval [CI] 0.29-0.93) and composite of stroke and transient ischemic attack (TIA) (RR 0.60, 95% CI 0.46-0.80). And no differences in all-cause death (RR 0.80, 95% CI 0.37-1.72) and cardiovascular death (RR 1.47, 95% CI 0.36-5.94) between 2 groups were observed. The risks of major bleeding (RR 0.96, 95% CI 0.47-1.96) and any serious adverse event (RR 1.03, 95% CI 0.92-1.16) did not differ between 2 groups. Yet, PFO closure increased risk of atrial fibrillation (RR 4.25, 95% CI 2.10-8.60). Conclusion: PFO closure, as compared with medical therapy, was associated with decreased risk of recurrent stroke and increased risk of atrial fibrillation in cryptogenic stroke patients with PFO.
BackgroundProficient mismatch repair (pMMR) colorectal adenocarcinoma (CRAC) metastasizes to a greater extent than MMR-deficient CRAC. Prognostic biomarkers are preferred in clinical practice. However, traditional biomarkers screened directly from sequencing are often not robust and thus cannot be confidently utilized.MethodsTo circumvent the drawbacks of blind screening, we established a new strategy to identify prognostic biomarkers in the conserved and specific oncogenic pathway and itsdoi:10.3389/fonc.2021.727752 pmid:34692502 pmcid:PMC8529276 fatcat:qkzj4uvyqbddtemrical54fkqa
more »... atory RNA network. We performed RNA sequencing (RNA-seq) for messenger RNA (mRNA) and noncoding RNA in six pMMR CRAC patients and constructed a glycosylation-related RNA regulatory network. Biomarkers were selected based on the network and their correlation with the clinicopathologic information and were validated in multiple centers (n = 775).ResultsWe constructed a competing endogenous RNA (ceRNA) regulatory network using RNA-seq. Genes associated with glycosylation pathways were embedded within this scale-free network. Moreover, we further developed and validated a seven-glycogene prognosis signature, GlycoSig (B3GNT6, GALNT3, GALNT8, ALG8, STT3B, SRD5A3, and ALG6) that prognosticate poor-prognostic subtype for pMMR CRAC patients. This biomarker set was validated in multicenter datasets, demonstrating its robustness and wide applicability. We constructed a simple-to-use nomogram that integrated the risk score of GlycoSig and clinicopathological features of pMMR CRAC patients.ConclusionsThe seven-glycogene signature served as a novel and robust prognostic biomarker set for pMMR CRAC, highlighting the role of a dysregulated glycosylation network in poor prognosis.
., 2017; Li et al., 2017b Li et al., , 2019b Petrov et al., 2017; Heintz-Buschart et al., 2018; Lin et al., 2018 Lin et al., , 2019 Qian et al., 2018; Aho et al., 2019; Barichella et al., 2019; Pietrucci ... et al., 2017b Li et al., , 2019b Lin et al., 2018; Qian et al., 2018) [except one study from Taiwan ]. ...doi:10.1093/brain/awaa201 pmid:32844199 fatcat:ytxwkoq2urfafjz3ppixq2hnzu
As people concern themselves with environmental problems, the right to emit carbon dioxide becomes a new resource with business value that is incorporated in firms' budgets. This paper studies the optimal emission abatement decision for firms in a supply chain, considering emission costs. Four Stackelberg models are established that differ in free emission allowance allocation schemes and emission abatement cost-sharing schemes. On comparing optimal solutions in the models, the results showdoi:10.3390/su10072110 fatcat:at5r7rkx65bjbhes6if5ixqjra
more »... regardless of which free emission allowance allocation scheme or emission abatement cost-sharing scheme is adopted, upstream firms tend to set a higher emission reduction rate. If supply chain firms aim for a higher emission reduction rate, they should advocate that upstream and downstream firms establish emission abatement cost-sharing contracts. The upstream firms should undertake larger emission reduction costs, and use free emission allowance allocation schemes based on emission intensity; the optimal emission reduction rate is related to carbon price, and the relationship may not be monotonous, affected by the difficulty of reducing emissions.
BMC Public Health
The paper aimed to examine the association between obesity status and successful aging among elderly adults in China and further find gender differences in the effect of components of successful aging on obesity status. The data came from the follow-up survey(2015) of China Health and Retirement Longitudinal Study (CHARLS) and 4019 dwellers age 60 and over are included. Obesity status were defined by the body mass index (BMI) according to Chinese criteria. Successful aging was defined followingdoi:10.1186/s12889-020-08899-9 pmid:32448262 pmcid:PMC7245862 fatcat:l576yoe5bjgxbfuynjmpw7g5em
more »... Rowe and Kahn's multidimensional model. Multivariable logistic regression was used to estimate the relationship between obesity status and successful aging. The rate of successful aging in men and women was 18.87 and 9.48% respectively. For BMI, the proportion of population with underweight, overweight and obesity in men was 10.29, 23.04 and 29.63% respectively and that in women was 1.40, 11.69 and 9.47%. Men with obesity (OR = 1.587 95% CI 1.087 ~ 2.316) has an positive relationship with successful aging than normal weight men; Women with underweight (OR = 0.197 95% CI 0.058 ~ 0.824) has an negative relationship with successful aging than normal weight women; Meanwhile, no matter men and women, the relationship between obesity status and successful aging were not significant among oldest adults(≥75 years). Obesity status was significantly association with successful aging in young older adults (60-74 years), and the components of successful aging differently were related with the obesity status of male and female.
(e) IQE of TCP: Ce,Li, TCP:Ce,Na and TCP:Ce,K. Fig. 7 . 7 Fig. 7. (a) XPS spectra monitoring the valence states of Li, Na, and K. ... These phosphors are named TCP:Ce,Li, TCP:Ce,Na, and TCP:Ce,K, respectively. ...doi:10.6084/m9.figshare.19009529.v1 fatcat:h4upncwpzjgmzhuhzavaqgju5e
Ractopamine is a β-adrenoreceptor agonist that excites sympathetic nerves. It has been used to increase cattle weight, for breeding, and to enhance muscle content in some countries. The concentration allowed in the environment is below 10 parts per billion (ppb). However, there are increasing concerns about the effect of longterm ractopamine on health. Our study aimed to investigate the potential effects of a "safe" dosage of ractopamine on urinary tract by using genitourinary cell cultures anddoi:10.1007/s00604-018-2680-2 pmid:29594543 fatcat:lzjihaxntrhtljtvhnq7cc7r5a
more »... our well-established translational model, Drosophila melanogaster. The results showed that ractopamine dose-dependently induces cytotoxicity in SV40 MES 13 and SV-HUC-1 cells. After 21 days of 10 ppb ractopamine administration, the rate of crystal formation in the ractopamine group significantly increased. We also found that long-term administration of ractopamine to flies decreases their climbing ability and shortens their lifespan. Overall, the long-term effects of ractopamine on the urinary tract system were evident in our cell and animal studies. In particular, renal mesangial and urothelial cells are more susceptible to damage; urolithiasis and neurological damage are other possible side effects of ractopamine. These effects on the human urinary tract should be further investigated.
Copyright © 2021 Li, Zhang and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fimmu.2021.656097 pmid:33868300 pmcid:PMC8044362 fatcat:rfximpebwzeu7l3a7a2nnsbje4
Journal of Cancer
Neuronal pentraxin 2 (NPTX2), a secretory protein of neuronal pentraxins, was first identified in the nervous system. Several studies have shown that expression levels of NPTX2 are associated with the development of various cancers. However, whether NPTX2 is involved in prostate cancer progression is unclear. Herein, we found that NPTX2 is significantly reduced in prostate cancer tissues and cancer cell lines compared to control prostate tissues and control prostatic epithelial cell lines.doi:10.7150/jca.65214 pmid:35069913 pmcid:PMC8771508 fatcat:wumiedel4jaw5fu6wtb5jo3dtq
more »... ermore, the NPTX2 promoter is highly methylated in prostate cancer cells. Consistently, NPTX2 could be restored by treatment with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (decitabine, 5-AZA-dC). Overexpression of NPTX2 inhibited prostate cancer cell proliferation both in vitro and in vivo. In conclusion, our study demonstrated that NPTX2 acts as a tumor suppressor gene in prostate cancer.
Phytoplankton density can be influenced by a wide range of factors whereas the role of suspended particulate matter (SPM) are not clear in river that annually subjected to hydrodynamics shift. Here, spatial-temporal variation of environmental parameters and phytoplankton density were studied from January 2013 to December 2014 in Yulin River, a tributary of the Three Gorges Reservoir, China. Laboratory experiments were conducted to elucidate the key parameter and interpret how it impacteddoi:10.1038/s41598-017-13235-0 pmid:29044136 pmcid:PMC5647362 fatcat:l7t462jkcfbpro4xqf7wetn6z4
more »... ankton density. SPM is negatively correlated with phytoplankton density. Despite SPM in Yulin River revealed weaker NH 3 -N, NO 3 -N and PO 4 -P adsorption capabilities in comparison to that in other aquatic ecosystems, increase of water velocity from 0.1 to 0.8 m/s led to approximately 6.8-times increase of light attenuation rate. In experiments evaluating the aggregation of Chlorella pyrenoidosa upon SPM, floc size showed 7.4 to 22% fold increase compared to the SPM or algae itself, which was due to the interaction between SPM and phytoplankton extracellular polymeric substances. Our results suggest that SPM could contribute to the variation of phytoplankton density through the integrated process including light attenuation, nutrient adsorption and algae aggregation. This is the first evaluation of the multiple processes underlying the impact of SPM on phytoplankton. Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 SCiEnTifiC REPORTS | 7: 13518 |
Wuli huaxue xuebao
The diameter-controlled growth of single-walled carbon nanotubes (SWNTs) is one of the key issues of SWNT synthesis and application. To guarantee that SWNTs grow with desired diameters, it is necessary to control catalyst size and modulate growth conditions. SWNTs with diameters of 0.9-1.2 nm are highly desirable for nearinfrared fluorescence bioimaging and serving as effective single-photon sources for the development of quantum devices. Herein, we used an FeCo/MgO catalyst to grow bulk SWNTsdoi:10.3866/pku.whxb202101055 fatcat:nwtuoab67zfrhivu22smewctr4
more »... ith diameters in the range and studied the influence of catalysts and chemical vapor deposition (CVD) growth conditions on the diameter of SWNTs. The preparation of catalyst precursors is a key step in obtaining catalyst nanoparticles of small size. In the impregnation process, we used three different types of metal salts, namely, sulfates, acetates, and nitrates, to prepare the catalysts. The metal sulfates, which exhibit the weakest hydrolysis ability, were found to grow SWNTs with the smallest diameters. Lowering the immersion pH, which suppresses the hydrolysis of metal ions, was also favorable for growing smaller SWNTs. Moreover, the addition of complexing agent molecules such as ethylenediaminetetraacetic acid during the impregnation process, which inhibits the hydrolysis of metal ions as well, further confined the diameter distribution of the resultant SWNTs. During the solution drying process, metal salts hydrolyze into metal hydroxides and oxides. Under mild hydrolysis conditions, the produced hydroxide and oxide particles are smaller and more likely to be uniformly distributed on the surface of the supports. Therefore, it is more favorable to produce catalysts with controlled sizes under mild hydrolysis conditions, which are preferred for diameter control of the resultant SWNTs. In the CVD growth process, we used either ethanol or methane as the carbon source and found that, under our experimental conditions, the SWNTs grown from ethanol had smaller diameters than those from methane. The hydrogen content in the CVD process also affects diameter distribution of SWNTs. As the carbon-tohydrogen ratio decreased, SWNTs with larger diameters disappeared, and the number of SWNTs with smaller diameters increased. During the CVD process, the carbon-to-hydrogen ratio determines the carbon feeding rate to the catalysts. At a low carbon feeding rate, catalysts of large sizes are underfed and unable to grow SWNTs, whereas smaller catalysts are in a favorable condition for growth. Therefore, the average diameter of the SWNTs decreased as the carbon-to-hydrogen ratio decreased.
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