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Multi-modal retrieval is a challenge due to heterogeneous gap and a complex semantic relationship between different modal data. Typical research map different modalities into a common subspace with a one-to-one correspondence or similarity/dissimilarity relationship of inter-modal data, in which the distances of heterogeneous data can be compared directly; thus, inter-modal retrieval can be achieved by the nearest neighboring search. However, most of them ignore intra-modal relations anddoi:10.3390/electronics9030466 fatcat:32bdzztgx5g3vbrrxutyfebufq
more »... ated semantics between multi-modal data. In this paper, we propose a deep multi-modal metric learning method with multi-scale semantic correlation to deal with the retrieval tasks between image and text modalities. A deep model with two branches is designed to nonlinearly map raw heterogeneous data into comparable representations. In contrast to binary similarity, we formulate semantic relationship with multi-scale similarity to learn fine-grained multi-modal distances. Inter-modal and intra-modal correlations constructed on multi-scale semantic similarity are incorporated to train the deep model in an end-to-end way. Experiments validate the effectiveness of our proposed method on multi-modal retrieval tasks, and our method outperforms state-of-the-art methods on NUS-WIDE, MIR Flickr, and Wikipedia datasets.
[Figure: see text].doi:10.1126/sciadv.abi9283 pmid:34705515 pmcid:PMC8550238 fatcat:rrwr63kysza67g5ejn6cgf5kde
The human stomach is a complex and diverse microbial ecosystem. Consecutive alternations of gastric microbiota occur in gastric carcinogenesis, while the changing pattern during this process remains controversial across studies. We aim to identify the changes in the diversity and composition of gastric mucosal microbiota in gastric tumorigenesis. We will search through PubMed, EMBASE and Cochrane databases, as well as conference proceedings and references of review articles for observationaldoi:10.1136/bmjopen-2020-045810 pmid:33653765 pmcid:PMC7929888 fatcat:hb55lcpgbvhwpj3q6f4ezoggxu
more »... icles reporting either the relative abundance of bacteria at the phylum or genus level or at least one of the alpha diversity indexes respectively and clearly in both gastric cancer and non-cancer groups. Selection of studies and data extraction will be performed independently by two researchers. Disagreements will be resolved through discussion. Risk of bias will be assessed using the modified Newcastle-Ottawa Scale. Quantitative analyses will be performed using a random effects model, where the effect measurement will be expressed as the MD. Ethical approval for this systematic review is not required, as the study is based exclusively on published documents and will not include any individual data. Findings of this study are expected to be disseminated through peer-reviewed journals or conference proceedings. CRD42020206973.
Ulcerative colitis (UC)-related post-colectomy enteritis is a very rare condition that is characterized by diffuse small-bowel mucosal inflammation following colectomy and could be very dangerous. In previously reported cases, corticosteroid therapy seemed to be the optimal choice for inducing remission; however, the patient studied herein presented with severe diarrhoea and hypovolemic shock and failed to achieve full remission with corticosteroid therapy. Case presentation: We describe thedoi:10.1186/s12876-019-0974-4 fatcat:6cnalbnskrgxhpjaawjqdayusa
more »... e of a patient with severe pan-enteritis presenting with life-threatening diarrhoea complicated with hypovolemic shock and acute kidney injury after colectomy and ileal pouch anal anastomosis (IPAA) for UC; this patient was successfully treated by ileostomy closure after failing to achieve full remission with corticosteroid therapy. Next, we review other cases of post-colectomy enteritis reported in the literature and propose a flow-chart for its diagnosis and initial treatment. Conclusion: Post-colectomy enteritis can be dangerous, and the early awareness of this condition plays a vital role. Additionally, in patients who do not respond well to corticosteroid or immunosuppressant therapy, early closure of the ileostomy and re-establishment of the natural faecal stream could be important considerations.
Conventional methods of intestinal inspection play an essential role in the assessment of bowel diseases and other relevant health issues, yet fail to obtain intestinal conditions in real time because of radiation limits and operation inconvenience. Herein, a flexible, skin-mounted device is developed for longterm, real-time monitoring, and for the evaluation of bowel sounds based on the integration of a threedimensional printed elastomeric resonator with flexible electronics. The device isdoi:10.1007/s11432-019-9906-1 fatcat:f7jm2h5nq5gjdgt3nvn4nxwcnm
more »... ble of being flexibly attached to abdominal surfaces without performance degradation during breathing. Clinical tests conduct in a normal volunteer and in patients with mechanical intestinal obstruction or paralytic ileus illustrate the usefulness of the device in capturing the characteristics of bowel sounds. Furthermore, a demonstration of collection and classification of bowel sounds by the flexible device based on machine learning methods can serve as a reference for possible applications of the system in the auxiliary diagnosis of bowel problems. et al. A flexible skin-mounted wireless acoustic device for bowel sounds monitoring and evaluation. Sci China Inf Sci, 2019, 62(10): 202402, https://doi.
Hong Yang, and Dr. Yamin Lai from Department of ...doi:10.21037/hbsn-21-82 fatcat:z3pw2engsrdxthfs4wwlryrvoa
. • Shuangna Yang, Gang Xu and Yingyun Li prepared figures and/or tables, approved the final draft. • Hede Gong contributed reagents/materials/analysis tools, approved the final draft. • Chuansheng Wu ...doi:10.7717/peerj.7721 pmid:31579603 pmcid:PMC6765358 fatcat:svkaw6wqbzhwbgzrx7xj5x2ata
; https://doi.org/10.1101/2020.10.23.352765 doi: bioRxiv preprint 390 391 Chenyan Lu, Yizhe Ma, and Panpan Yang took part in human glucose clamp performance. ... Jingya Ye, Xuan Ye and415Wanzi Jiang were responsible for data collection, analysis and writing of the first draft of manuscript. 416 Zhenzhen 416 Fu and Yingyun Gong contributed to the human glucose ...doi:10.1101/2020.10.23.352765 fatcat:pj7lmjealzbr5mcftclk4dfaje
It has been suggested that serum branched-chain amino acids (BCAAs) are associated with the incident, progression and prognostic of type 2 diabetes. However, the role of BCAAs in metabolic dyslipidemia (raised triglycerides (TG) and reduced high-density lipoprotein cholesterol (HDL-C)) remains poorly understood. This study aims to investigate 1) the association of serum BCAAs with total cholesterol (TC), TG, HDL-C and low-density lipoprotein cholesterol (LDL-C) and 2) the association betweendoi:10.1186/s12944-016-0291-7 pmid:27457614 pmcid:PMC4960685 fatcat:gvsebnloyzdwjh3xat2b27k3ee
more »... um BCAAs levels and risk of metabolic dyslipidemia in a community population with different glucose homeostasis. Methods: Demographics data and blood samples were collected from 2251 Chinese subjects from the Huaian Diabetes Protective Program (HADPP) study. After exclusion for cardiovascular disease (CVD), serious hepatic or nephritic diseases and others, 1320 subjects remained for analysis (789 subjects with hemoglobin A1c (HbA1c) > 5.7, 521 with HbA1c ≤ 5.7). Serum BCAAs level was measured by liquid chromatography-tandem mass spectrometry (LC MS/MS). The association of BCAAs with lipids or with the risk of metabolic dyslipidemia was analyzed. Results: Elevated serum BCAAs (both total and individual BCAA) were positively associated with TG and inversely associated with HDL-C in the whole population. These correlations were still significant even after adjustment for confounding factors (r = 0.165, p < 0.001 for TG; and r = -0.126, p < 0.001 for HDL-C). For reduced HDL-C, we found higher odds risk (OR) of Valine (Val) in high HbA1c group than in the low one (OR = 1.055, p < 0.001 vs OR = 1.032, p = 0.059). Compared with that in the first quartile, the multivariable-adjusted OR (95 % CI) of the 4 th quartile of serum total BCAAs level for reduced 5.854) in high HbA1c group and 2.329 (1.284, 4.227) in low group, for raised TG was 3.305 (2.120, 5.152) and 2.972 (1.706, 5.176), and for metabolic dyslipidemia was 3.703 (2.261, 6.065) and 3.702 (1.877, 7.304), respectively (all p < 0.01). Conclusion: Elevated serum BCAAs level are positively associated with incident metabolic dyslipidemia. In addition, glucose homeostasis could play a certain role in BCAAs-related dyslipidemia.
JAMA Network Open
Severe anxiety may even lead to withdrawal from a colonoscopy and increase the risk of adverse advents. 32 Yang et al 33 concluded that patients who underwent a colonoscopy had a higher level of anxiety ... Yang, A. Yang, Wu. Acquisition, analysis, or interpretation of data: Chen, Zhao, Xie, Shi, Y. Yang. Drafting of the manuscript: Chen, Zhao, Shi. Critical revision of ...doi:10.1001/jamanetworkopen.2021.35576 pmid:34807255 pmcid:PMC8609410 fatcat:42xr3slugfgcnmol7jnubaylyi
With the gradual upgradation of global energy consumption and the associated development of multi-energy sources, the pace of unified energy planning and design has been accelerated and the concept of multi-energy system (MES) has been formed. The industrial structure of industrial park (IP) consists of production and marketing of multi-energy sources, which makes IP become an ideal application scenario for MES. The coupling between multi-sources raises the complexity level of IP, whichdoi:10.35833/mpce.2018.000776 fatcat:tu6xmtx3pbdjbptpvfio4s4z54
more »... the demand side analysis in IP as it enables customers to actively participate in energy planning and development. This paper presents the concept and operation strategies of integrated demand response (IDR), and its model classification is analyzed in detail. Optimization model and IDR with varying time period are studied in IP to determine their impacts on the system. A detailed survey of different techniques in both operation strategies and model classification is presented and the classification is based on pros and cons. Finally, key issues and outlooks are discussed. Index Terms--Industrial park (IP), multi-energy system (MES), integrated demand response (IDR), integrated direct load control (IDLC), demand side management (DSM), demand side comfort index.
Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here, we found that the expression of lectin family member Siglec1 was upregulated by viral infection in macrophages, which was dependent on the IFN/JAK/STAT1 signaling pathway. Siglec1doi:10.1038/cr.2015.108 pmid:26358190 pmcid:PMC4650625 fatcat:4xeual527jbj3dzhffjucx7qju
more »... was found to negatively regulate viral infection-triggered type I IFN production. Mechanistically, Siglec1 associates with DAP12 to recruit and activate the scaffolding function of SHP2; SHP2 then recruits E3 ubiquitin ligase TRIM27, which induces TBK1 degradation via K48-linked ubiquitination at Lys251 and Lys372. Therefore, viral infection-induced upregulation of Siglec1 feedback loop inhibits type I IFN production and suppresses antiviral innate immune responses. Our study outlines a novel mechanism of negative regulation of type I IFN production, which may help virus to escape immune elimination.
Authors' Contributions Wen Hu, Luning Sun, and Yingyun Gong contributed equally to this work. ...doi:10.1155/2016/8173905 pmid:27528871 pmcid:PMC4977397 fatcat:fzbbbgsyabfgxorfw3nqqxakn4
YANG, ZHOU, ET AL. benefit on the overall survival of HCC patients in cohorts 2 and 3 ( Fig. 2A,B; Supporting Fig. S1A ). ... YANG, ZHOU, ET AL. HEPATOLOGY, July 2017 pivotal roles in IFN effector signaling, and their interaction regulated by IFIT3 may be more important in IFN downstream signaling. ...doi:10.1002/hep.29156 pmid:28295457 fatcat:jugnua2o5rbxfkumcaqtnmx5im
The Journal of Immunology Type I IFN-Inducible Downregulation of MicroRNA-27a Feedback Inhibits Antiviral Innate Response by Upregulating Siglec1/TRIM27 Qingliang Zheng,* ,1 Jin Hou, †,1 Ye Zhou, † Yingyun ... Yang,* and Xuetao Cao* , † Upon recognition of viral components by pattern recognition receptors, including TLRs and retinoic acid-inducible gene I-like helicases, cells are activated to produce type ...doi:10.4049/jimmunol.1502134 pmid:26700765 fatcat:5msicc62szeqhbzmd6ie4dxe3u
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