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Morphological predictors of posterior communicating artery aneurysms rupture

Nan Lv, Nan Lv, Yibin Fang, Ying Yu, Jinyu Xu, Jianmin Liu, Qinghai Huang, Yibin Fang, Ying Yu, Jinyu Xu, Jianmin Liu, Qinghai Huang
<span title="">2015</span> <i title="Translational Neuroscience and Clinics"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3rlksftjt5hx5hqyzeevgzdub4" style="color: black;">Translational Neuroscience and Clinics</a> </i> &nbsp;
Citation Lv N, Fang YB, Yu Y, Xu JY, Liu JM, Huang QH. Morphological predictors of posterior communicating artery aneurysms rupture. Transl. Neurosci. Clin. 2015, 1(2): 86-91.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18679/cn11-6030/r.2015.010">doi:10.18679/cn11-6030/r.2015.010</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/evkzlsng55fb5myobd4dqfja3q">fatcat:evkzlsng55fb5myobd4dqfja3q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200310192445/http://www.tncjournal.com/EN/article/downloadArticleFile.do?attachType=PDF&amp;id=148787&amp;WebShieldDRSessionVerify=C6p89WB5Y3aMtqsoVYJn" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fa/bf/fabfc7b784e3ace2d70781874e2de394ed322f1d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18679/cn11-6030/r.2015.010"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Modeling, Simulation and Analysis of Intermediate Fixed Piezoelectric Energy Harvester

Yulong Wang, Yaran Lv, Baozhan Lv, Ying Zhang
<span title="2022-04-30">2022</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a2yvk5xhdnhpxjnk6yd33uudqq" style="color: black;">Energies</a> </i> &nbsp;
To address the problem that piezoelectric energy harvesters are difficult to apply in certain environments, this paper establishes the theoretical study of the intermediate fixed disc piezoelectric energy harvester (IFDPEH) based on the unimorph under concentrated force. The reliability of the model was indirectly verified by numerical simulation and Computer-Aided Engineering (CAE) simulation. The effects of load, radius ratio (piezoelectric layer/intermediate support), thickness ratio
more &raquo; ... ectric layer/total thickness), and elastic modulus ratio (substrate/piezoelectric layer) on electrical energy were studied. The results indicate that the radius/thickness ratios of the IFDPEH based on aluminum and beryllium bronze are 0.05/0.31 and 0.05/0.48, respectively. In addition, through parameter comparison, it is found that the most important parameters affecting IFDPEH power are radius ratio and large load. The results are demonstrated to be meaningful for broadening the application of piezoelectric energy harvesters by the derived closed-form equations for the electrical energy along the diameters of the piezoelectric discs in the z-direction.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/en15093294">doi:10.3390/en15093294</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7xyhftlulralzljivrnpoit4ru">fatcat:7xyhftlulralzljivrnpoit4ru</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220504003426/https://mdpi-res.com/d_attachment/energies/energies-15-03294/article_deploy/energies-15-03294.pdf?version=1651316846" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d2/6e/d26ee680059f72b47df9787d27dbaf8ac8b4eeaf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/en15093294"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Effect of Electroless Nickel Plating on Properties of Iron Matrix Composites

Xuefei Lv, Ying Lv, Shukun Gan
<span title="">2018</span> <i title="AIDIC Servizi S.r.l."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5re6yojrfja7da72zowrdasgca" style="color: black;">Chemical Engineering Transactions</a> </i> &nbsp;
Iron matrix composites are a kind of high-performance, low-cost metal matrix composites. They are the most promising metal matrix composites. In order to overcome the problem of reinforced particles and molten iron not infiltrating, the application of electroless nickel plating can solve it successfully. Based on the principle of electroless nickel plating, this paper studies the erosion and wear resistance of iron matrix reinforced composite. The experimental results show that the electroless
more &raquo; ... ickel plating on the surface of the reinforced particles can achieve better bonding with the iron matrix and improve the infiltration of the matrix. Different particle volume fractions and different particle sizes have a greater influence on the erosion wear resistance of iron matrix composites. The larger the volume fraction of particles, the greater the volume wear, and when the particle volume fraction is the same, the erosion wear of the iron matrix composites increases with particle size.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3303/cet1866007">doi:10.3303/cet1866007</a> <a target="_blank" rel="external noopener" href="https://doaj.org/article/cc37b64ad7054bb9a1c275211162d865">doaj:cc37b64ad7054bb9a1c275211162d865</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lfzrhk5eszhafae66m2e54irn4">fatcat:lfzrhk5eszhafae66m2e54irn4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210603220146/https://www.aidic.it/cet/18/66/007.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d7/d6/d7d661038cf4d1e79827defffa3dbc0bcefbbf84.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3303/cet1866007"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

The strategy and financial analysis of Luckin Coffee

Ming Yang, Ying-ying Lv
<span title="2019-09-30">2019</span> <i title="Encyclopaedic Publishing Pte Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/24yh4l3zz5fibeyvgluq3z4bba" style="color: black;">Economics and Management Science</a> </i> &nbsp;
Luckin breaks through the traditional mode and creates the miracle of the new retail mode of coffee.We analyze this new retail mode from different aspects: Luckin爷s operating strategy, competitor, SWOT analysis and so on, and we also give some suggestions that can help Luckin deal with some potential problems and seize the opportunity.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.36012/ems.v1i1.957">doi:10.36012/ems.v1i1.957</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/s36ig2y2ezegtgllu3g2ddxtgq">fatcat:s36ig2y2ezegtgllu3g2ddxtgq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210328164429/http://encyclopub.com/ems/article/download/957/949" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4d/1c/4d1cac0d24193c32f8ea49f4aa1a0d36a93503fa.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.36012/ems.v1i1.957"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation

Chunxiao Li, Wenjing Gao, Ying Gao, Canqing Yu, Jun Lv, Ruoran Lv, Jiali Duan, Ying Sun, Xianghui Guo, Weihua Cao, Liming Li
<span title="2018-05-12">2018</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vjgpqrqckbe5xfxuw2ce3r5nfa" style="color: black;">Aging</a> </i> &nbsp;
The DNA methylation age, a good reflection of human aging process, has been used to predict chronological age of adults and newborns. However, the prediction model for children and adolescents was absent. In this study, we aimed to generate a prediction model of chronological age for children and adolescents aged 6-17 years by using age-specific DNA methylation patterns from 180 Chinese twin individuals. We identified 6,350 age-related CpGs from the epigenome-wide association analysis (N=179).
more &raquo; ... 16 known age-related sites in children were confirmed. 83 novel CpGs were selected as predictors from all age-related loci by elastic net regression and they could accurately predict the chronological age of the pediatric population, with a correlation of 0.99 and the error of 0.23 years in the training dataset (N=90). The predictive accuracy in the testing dataset (N=89) was high (correlation=0.93, error=0.62 years). Among the 83 predictors, 49 sites were novel probes not existing on the Illumina 450K BeadChip. The top two predictors of age were on the PRKCB and REG4 genes, which are associated with diabetes and cancer, respectively. Our results suggest that the chronological age can be accurately predicted among children and adolescents aged 6-17 years by 83 newly identified CpG sites.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/aging.101445">doi:10.18632/aging.101445</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29754148">pmid:29754148</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5990383/">pmcid:PMC5990383</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uffac7p2affr3odkoywfa5vxsy">fatcat:uffac7p2affr3odkoywfa5vxsy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190218201842/http://pdfs.semanticscholar.org/1000/da73776dfc6b0007b0f0c05f6ffb930bbee5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/10/00/1000da73776dfc6b0007b0f0c05f6ffb930bbee5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/aging.101445"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990383" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Metamaterial Lensing Devices

Jiangtao Lv, Ming Zhou, Qiongchan Gu, Xiaoxiao Jiang, Yu Ying, Guangyuan Si
<span title="2019-07-04">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dstyyzbt45gknhqqjsh45p55h4" style="color: black;">Molecules</a> </i> &nbsp;
In recent years, the development of metamaterials and metasurfaces has drawn great attention, enabling many important practical applications. Focusing and lensing components are of extreme importance because of their significant potential practical applications in biological imaging, display, and nanolithography fabrication. Metafocusing devices using ultrathin structures (also known as metasurfaces) with superlensing performance are key building blocks for developing integrated optical
more &raquo; ... ts with ultrasmall dimensions. In this article, we review the metamaterial superlensing devices working in transmission mode from the perfect lens to two-dimensional metasurfaces and present their working principles. Then we summarize important practical applications of metasurfaces, such as plasmonic lithography, holography, and imaging. Different typical designs and their focusing performance are also discussed in detail.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules24132460">doi:10.3390/molecules24132460</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31277470">pmid:31277470</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6650915/">pmcid:PMC6650915</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wlnkjhjisjfp3oyv437xnngffy">fatcat:wlnkjhjisjfp3oyv437xnngffy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191121133515/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6650915&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a7/1f/a71f005571439ae8998ed687bd1536ee8bf82f67.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules24132460"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650915" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Variational Minimizing Parabolic Orbits for the 2-Fixed Center Problems [article]

Ying Lv, Shiqing Zhang
<span title="2012-07-13">2012</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Using variational minimizing methods,we prove the existence of an odd symmetric parabolic orbit for the 2-fixed center problems with weak force type homogeneous potentials.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1207.3130v1">arXiv:1207.3130v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/f75fguscivgkdax2dllaa5whw4">fatcat:f75fguscivgkdax2dllaa5whw4</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/arxiv-1207.3130/1207.3130.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1207.3130v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells

Ying Wang, Jiayi Song, Hongyan Bian, Jiaqi Bo, Shuangyu Lv, Weitong Pan, Xinrui Lv
<span title="2019-07-03">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lmacdxojgngeph5zd4uw3mehdm" style="color: black;">Molecular and Cellular Biochemistry</a> </i> &nbsp;
Apelin participates in cardiovascular functions, metabolic disease, and homeostasis disorder. However, the biological function of apelin in liver diseases, especially liver fibrosis is still under investigation. The present study aimed to investigate the expression of apelin in nonalcoholic fatty liver disease (NAFLD) and the mechanism of apelin promoting hepatic fibrosis through ERK signaling in hepatic stellate LX-2 cells. The results showed that the ALT and AST levels in serum were increased
more &raquo; ... in the mice fed HFC. The histological staining revealed that hepatocellular steatosis and ballooning degeneration was severe, and fibrogenesis appeared as increased pericellular collagen deposition along with pericentral (lobular) collagen deposition in the mice fed HFC. Immunochemistry and qRT-PCR results showed that the expression of apelin and profibrotic genes was higher as compared to the control group. The in vitro experiments demonstrated that apelin-13 upregulated the transcription and translation levels of collagen type I (collagen-I) and α-smooth muscle actin (α-SMA) in LX-2 cells. The immunofluorescent staining, qRT-PCR, and Western blot results showed that the overexpression of apelin markedly increased the expression of α-SMA and cyclinD1. The LX-2 cells treated with apelin-13 displayed an increased expression of pERK1/2 in a time-dependent manner, while the pretreatment with PD98059 abolished the apelin-induced expression of α-SMA and cyclinD1. Furthermore, the in vivo and in vitro assays suggested a key role of apelin in promoting liver fibrosis, and the underlying mechanism might be ascribed to the apelin expression of profibrotic genes via ERK signaling pathway.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11010-019-03581-0">doi:10.1007/s11010-019-03581-0</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31270645">pmid:31270645</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6745032/">pmcid:PMC6745032</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y2bvgldvozdsbm3btrpsnogut4">fatcat:y2bvgldvozdsbm3btrpsnogut4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200225232204/https://link.springer.com/content/pdf/10.1007/s11010-019-03581-0.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6f/9e/6f9ec571644bda274f634ad0c343075c591c55cc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11010-019-03581-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745032" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Screening of feature genes of the ovarian cancer epithelia with DNA microarray

Huanchun Ying, Jing Lv, Tianshu Ying, Jun Li, Qing Yang
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vmbrt56gsfd3bllmmkc2sojrma" style="color: black;">Journal of Ovarian Research</a> </i> &nbsp;
Objective: We aimed to screen differentially expressed genes (DEGs) of ovarian surface epithelia in order to provide beneficial help for early diagnosis and treatment of ovarian cancer with DNA microarrays. Methods: We extracted the microarray expression profile GSE14407 from Gene Expression Omnibus database which conducted gene expression profiling analysis of 12 ovarian surface epithelia (OSE) and 12 laser capture microdissected serous ovarian cancer epithelia (CEPI) samples. The DEGs between
more &raquo; ... OSE and CEPI were identified by Limma package of R language. Cluster analysis was employed to compare the differences of gene expression patterns between OSE and CEPI. Furthermore, DEGs were analyzed with Functional classification tool, GenMAPP software and GENECODIS. Results: We identified 1229 DEGs including 592 down-regulated genes and 637 up-regulated genes. Pathway analysis showed that cell cycle was the most significant pathway and the DEGs related with cell cycle were almost up-regulated. Module mining analysis showed that the up-regulated DEGs were related with signal transduction while the down-regulated DEGs were related with lipid metabolism pathway and cytoskeletal structure. Conclusion: The genes related with cell cycle, lipid metabolism and cytoskeletal structure may be the treatment targets for ovarian cancer.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1757-2215-6-39">doi:10.1186/1757-2215-6-39</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23738901">pmid:23738901</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3683326/">pmcid:PMC3683326</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2fuenxttm5aqri2rbhy4y7pmau">fatcat:2fuenxttm5aqri2rbhy4y7pmau</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170829185229/https://ovarianresearch.biomedcentral.com/track/pdf/10.1186/1757-2215-6-39?site=http://ovarianresearch.biomedcentral.com" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/29/e7/29e790fab8423be71151b120d7d131fbfc1d3002.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1757-2215-6-39"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683326" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Effects of sympathetic histamine on vasomotor responses of blood vessels in rabbit ear to electrical stimulation

Ying-Ying Chen, Jun Lv, Xiao-Yan Xue, Gong-Hao He, Ying Zhou, Min Jia, Xiao-Xing Luo
<span title="">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/urataqivtzgh5klmiluxki3kp4" style="color: black;">Neuroscience Bulletin</a> </i> &nbsp;
Objective To investigate the effects of histamine receptor antagonists on vasoconstriction induced by electrical stimulation (ES) on posterior auricular nerve, and to explore the pre-and post-synaptic effects of sympathetic histamine on the vasomotor responses of vascular smooth muscle in rabbit ear. Methods ES was applied to posterior auricular nerves of the whole rabbit ear at 10 Hz, 20 Hz and 40 Hz, respectively. Besides, the whole ear was perfused with different histamine receptor
more &raquo; ... s under constant perfusion pressure, and the changes in the flow rate of perfusate were observed. Results The flow rate of venous outflow was decreased by ES at all the 3 frequencies. The ES-induced vasoconstriction at 20 Hz and 40 Hz could be partly inhibited by H 1 receptor antagonist chlorpheniramine (P < 0.05). After exhaustion of histamine in mast cells by pretreatment with specific mast cell degranulator compound 48/80, chlorpheniramine could still inhibit the ES-induced flow rate reduction. In contrast, H 2 receptor antagonist cimetidine could enhance the 40-Hz ES-induced flow rate reduction (P < 0.05). Moreover, ES-induced vasoconstriction at the 3 frequencies could all be enhanced by H 3 receptor antagonist thioperamide (P < 0.05). Conclusion Stimulation on the auricular nerve may evoke histamine release from sympathetic nerves rather than from mast cells. Moreover, the functions of sympathetic histamine vary from pre-synaptic modulation to post-synaptic vasoconstriction or vasodilatation, via activation of different histamine receptors.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12264-010-1126-6">doi:10.1007/s12264-010-1126-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20502501">pmid:20502501</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5560296/">pmcid:PMC5560296</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tq66hd2wnvhehl6chy55del3wy">fatcat:tq66hd2wnvhehl6chy55del3wy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191028053730/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5560296&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/03/96/03962f1af9ad1ad0cbabd59a8548be31384da5ab.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12264-010-1126-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560296" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The prophylactic effects of BIFICO on the antibiotic-induced gut dysbiosis and gut microbiota

Jiannong Wu, Tieer Gan, Ying Zhang, Guolian Xia, Shu Deng, Xin Lv, Bingxin Zhang, Bin Lv
<span title="2020-09-09">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iqgcr2nv5jdhrngtntzkov3vvq" style="color: black;">Gut Pathogens</a> </i> &nbsp;
Background The aim of this study is to evaluate the prophylactic effects of probiotic mixture BIFICO on antibiotic-induced gut dysbiosis (AIGD) and the influence on the change of the gut microbiota. Methods We conducted a prospective, randomized, controlled study and divided 196 patients who required intravenous beta-lactam antibiotics into three groups: a control group (no probiotics), a regular group (840 mg of BIFICO), and a double-dosage group (1680 mg of BIFICO). The symptoms of
more &raquo; ... related diarrhea, bloating and abdominal pain and the incidence of AIGD were evaluated 7 days and 8–14 days after antibiotic use, with 10 patients in each group. 16S rDNA sequencing was performed to detect changes of the gut microbiota. Results Within 7 days of the initiation of antibiotic treatment, the incidences of AIGD in the control group, regular group (840 mg of BIFICO), and double-dosage group (1680 mg of BIFICO) were 21.88%, 14.93%, and 6.15% respectively. On days of 8–14th, the incidences of AIGD in the control group, regular group, and double-dosage group were 25%, 14.93%, and 4.62%, respectively. The incidence of AIGD in the double-dosage group within 7 days and 14 days were both significantly lower than that in relevant control group (P < 0.05). On day 14, the incidence of AIGD in the double-dosage group was lower than that in the regular group (P < 0.05). The number of operational taxonomic units (OTUs) in the control group after antibiotic treatment was significantly reduced compared to that prior to treatment, while those of the regular and double-dosage groups were stable. The species abundance, especially Parabacteroides, Phascolarctobacterium and Roseburia, of the double-dosage group was greater than that of the regular group and the control group. Conclusions BIFICO may reduce the occurrence of AIGD in a dose-dependent manner and can stabilize the gut microbiota balance.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13099-020-00379-0">doi:10.1186/s13099-020-00379-0</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32944084">pmid:32944084</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7488247/">pmcid:PMC7488247</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w5ee3chznfhkhpofsss5g5lnoe">fatcat:w5ee3chznfhkhpofsss5g5lnoe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200919071446/https://gutpathogens.biomedcentral.com/track/pdf/10.1186/s13099-020-00379-0" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e3/51/e351706175f27421a9bbbc0fe2394bc208eb2686.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13099-020-00379-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488247" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

16-nor Limonoids from Harrisonia perforata as promising selective 11β-HSD1 inhibitors

Xiao-Hui Yan, Ping Yi, Pei Cao, Shi-Ying Yang, Xin Fang, Yu Zhang, Bin Wu, Ying Leng, Ying-Tong Di, Yang Lv, Xiao-Jiang Hao
<span title="2016-11-11">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tnqhc2x2aneavcd3gx5h7mswhm" style="color: black;">Scientific Reports</a> </i> &nbsp;
Two new 16-nor limonoids, harperspinoids A and B (1 and 2), with a unique 7/5/5/6/5 ring system, have been isolated from the plant Harrisonia perforate together with a known one, Harperforin G (3). Their structures were elucidated by NMR spectroscopy, X-ray diffraction analysis and computational modelling. Compound 1 exists as polymorphic crystals. Conformations of 1 in solution were further discussed based on the computational results. These compounds exhibited notable inhibitory activity
more &raquo; ... st the 11β-HSD1 enzyme. Compound 3 had potencies for the inhibition of human 11β-HSD1 with high selectivity against 11β-HSD2 (IC 50 0.58 μM, SI > 174). Molecular docking and quantitative structure-activity relationship studies revealed a mixed regulatory mechanism. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme primarily responsible for the regulation of intracellular cortisol levels 1,2 . Inhibition of 11β-HSD1 is an attractive therapeutic approach for the treatment of obesity and other elements of metabolic syndrome, such as type 2 diabetes mellitus 3 . Up to now, a number of potent and selective 11β-HSD1 inhibitors have been reported, some of which are progressing in different phases of clinical trials 4 . However, most of the candidates are synthetic chemicals, and natural compounds or their derivatives with highly promising selectivity are still scarce 5 . Limonoids with diverse structures and significant bioactivities have become a hot topic in the field of natural products and synthetic chemistry 6 . Their occurrence in the plant kingdom is confined mainly within the Meliaceae and Rutaceae families and less frequently within the Cneoraceae, Ptaeroxylaceae, and Harrisonia genera of Simaroubaceae 6,7 . Harrisonia perforata is the only species of this genus grown in China, and its root and leaves have been applied in Chinese folk medicine for the treatment of wound healing and malaria 8 . Previous investigations of the chemical constituents of this plant have revealed an array of structurally diverse chromones, quassinoids, polyketides, and highly rearranged limonoids 9-13 . Recently, unprecedented quassinoids and limonoid derivatives with notable biological properties have been discovered and evaluated by our group 14-16 . As part of our continuous effort to search for bioactive natural products 17-20 , two new 16-nor limonoids, harperspinoids A and B (1 and 2) , with a unique 7/5/5/6/5 ring system, as well as a known one, Harperforin G (3), were isolated from the aerial parts of the title plant (Fig. 1) . Herein, the isolation, structural elucidation, and inhibitory effects of 1-3 on 11β-HSD1 are described. Results and Discussion The air-dried plant material powder (25.0 kg) was extracted with MeOH three times, and the combined extracts were concentrated, followed by suspension in water. The water layer was then extracted with petroleum ether and EtOAc. Isolation of the EtOAc extracts (560 g) yielded compounds 1 (26 mg), 2 (5.9 mg), and 3 (37 mg). Harperspinoid A (1) was obtained as colourless crystals with the specific rotation [α] D 16 + 27.3. It possessed a molecular formula C 25 H 28 O 7 with 12 degrees of unsaturation, as deduced from HRESIMS (m/z 463.1744
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/srep36927">doi:10.1038/srep36927</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27833136">pmid:27833136</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5105127/">pmcid:PMC5105127</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vnxmvom54bgavbqx5lere5kfde">fatcat:vnxmvom54bgavbqx5lere5kfde</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190226135522/http://pdfs.semanticscholar.org/6e12/b5dbfd41ebf1ff968643e58be246b5e6445c.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6e/12/6e12b5dbfd41ebf1ff968643e58be246b5e6445c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/srep36927"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105127" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

An Ontology Based Approach to Construct Behaviors in Web Information Systems [chapter]

Lv-an Tang, Hongyan Li, Zhiyong Pan, Dongqing Yang, Meimei Li, Shiwei Tang, Ying Ying
<span title="">2005</span> <i title="Springer Berlin Heidelberg"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2w3awgokqne6te4nvlofavy5a4" style="color: black;">Lecture Notes in Computer Science</a> </i> &nbsp;
System behaviors specify the major functions of domain specific Web Information Systems (WIS). Traditional techniques can not satisfy various requirements or manage innumerous data while developing WIS behaviors. People appeal to a smart tool for implementing the WIS behaviors. This article makes the following contributions: (1) Proposes the concept of domain ontology and behavior ontology to describe the contents and operations of WIS; (2) Extends traditional ECA model to characterize the
more &raquo; ... ers, parameters, actions as well as validations of WIS behaviors; (3) Analyses the relationships between domain ontology and behavior ontology with rule sets; (4) Implements a tool named WISE Builder with four algorithms to help users building behavior ontology with domain ontology; (5)Shows the feasibility of this technique in a real application case.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/11563952_18">doi:10.1007/11563952_18</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bin2zdn4ardsnlcnc6rnddfrqe">fatcat:bin2zdn4ardsnlcnc6rnddfrqe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809153836/http://www.cis.pku.edu.cn/system/webs/Papers/WAIM2005TANG.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2c/ad/2cad47833f0c641dcd38941256756e8f2e779e8b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/11563952_18"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Bearing fault identification based on ASMOTE-CFR

Guangbin Wang, Huanke Cheng, Ping Wang, Ying Lv
<span title="2020-06-29">2020</span> <i title="JVE International Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/piydmkckj5hd3il4e6gck6zoea" style="color: black;">Vibroengineering PROCEDIA</a> </i> &nbsp;
Aiming at the problem of data unbalance caused by the lack of bearing failure test data, the paper proposes a collaborative filtering recommendation (CFR) method for adaptive Smote (ASMOTE) resampling and matrix decomposition of minority samples (ASMOTE-CFR). The method first adopts adaptive Smote method to synthesize different number of new sample equalization test data sets according to the data distribution. and then a variety of typical feature values such as time domain, frequency domain,
more &raquo; ... ime frequency domain, etc. are extracted to obtain the bearing feature matrix, and then a scoring matrix that accurately describes the bearing state is designed and based on the matrix Based on the decomposed collaborative filtering algorithm, a set of collaborative filtering recommendation system for bearing state recognition is proposed. Using this method, different forms of fault data on the outer ring of the rolling bearing were identified and verified. The accuracy of identification reached more than 98 %. Compared with the recognition accuracy of the collaborative filtering recommendation algorithm, this method improved 8 %.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21595/vp.2020.21520">doi:10.21595/vp.2020.21520</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/eaw6vsmwpbhhrhqtnjskiu4ur4">fatcat:eaw6vsmwpbhhrhqtnjskiu4ur4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200808201948/https://www.jvejournals.com/article/21520/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d3/cc/d3ccb63a40dd80248dbbaea7f884f1c3ed74f16e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21595/vp.2020.21520"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Succinylation Improves the Thermal Stability of Egg White Proteins

Dabo He, Ying Lv, Qigen Tong
<span title="2019-10-21">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dstyyzbt45gknhqqjsh45p55h4" style="color: black;">Molecules</a> </i> &nbsp;
Succinylation can improve the thermal stability of various proteins. In this study, succinylated egg white protein (SEWP) samples with different succinylation degrees were prepared by adding various succinic anhydride additives to egg white protein (EWP). The thermal stability of SEWP and the conformational structure under various succinylation degrees were investigated. With the increase in succinylation degree, the turbidity of heated SEWP solution (90 °C for 30 min) markedly declined. The
more &raquo; ... ted SEWP solution with high succinylation degree (37.63%, 66.57%, and 72.37%) was transparent. Moreover, the result of differential scanning calorimetry confirmed that the thermal stability of succinylated EWP increased. The results of intrinsic fluorescence spectra and Fourier-transform infrared spectroscopy illustrate that succinylation changed the conformational structure of EWP. Succinylation increased the electrostatic repulsion and decreased the surface hydrophobicity, and it changed the aggregation morphology of EWP. Cross-linked spherical aggregates of low succinylation degree transformed to thready aggregates of a high succinylation degree. Thus, succinylation improved the thermal stability of EWP.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules24203783">doi:10.3390/molecules24203783</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31640198">pmid:31640198</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6832609/">pmcid:PMC6832609</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xf736acsqre3lhcjmdqvy5pe6q">fatcat:xf736acsqre3lhcjmdqvy5pe6q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208133725/https://res.mdpi.com/d_attachment/molecules/molecules-24-03783/article_deploy/molecules-24-03783.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/6c/436c113fceea7cf62ac4a086f3506efdfeb59175.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules24203783"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832609" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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