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Expression and Clinical Significance of miRNA-34a in Colorectal Cancer

Zhi-Bin Ma, Xiao-Lin Kong, Gang Cui, Cui-Cui Ren, Ying-Jie Zhang, Sheng-Jin Fan, Ying-Hua Li
2014 Asian Pacific Journal of Cancer Prevention  
The aim of this study was to investigate differences of miRNA-34a expression in benign and malignant colorectal lesions. Materials and Methods: Samples of cancer, paraneoplastic tissues and polyps were selected and total RNA was extracted by conventional methods for real-time PCR to detect the miRNA-34a expression. In addition, the LOVO colorectal cancer cell line was cultured, treated with the demethylating agent 5-azacytidine and screened for differentially expressed miRNA-34a. Results: After
more » ... the drug treatment, the miRNA-34a expression of colorectal cancer cell line LOVO was increased and real-time PCR showed that levels of expression in both cell line and colorectal cancer tissues were low, as compared to paraneoplastic tissue (p<0.05). Polyps tissues had significantly higher expression than paraneoplastic and colorectal cancer samples (p<0.05). Conclusions: miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation.
doi:10.7314/apjcp.2014.15.21.9265 fatcat:4rtyrxqt75agdnlxl4kkuhyw2q

Correction to: The old CEACAMs find their new role in tumor immunotherapy

Zi-Wen Han, Zhi-Wu Lyv, Bin Cui, Ying-Ying Wang, Jun-Ting Cheng, Ying Zhang, Wen-Qi Cai, Yang Zhou, Zhao-Wu Ma, Xian-Wang Wang, Xiao-Chun Peng, Shu-Zhong Cui (+3 others)
2020 Investigational new drugs  
Correction is needed to the original version of this article.
doi:10.1007/s10637-020-00967-6 pmid:32572666 fatcat:wx7whz7xxvggdekbt7a2r2unha

The effect of anti-dementia drugs on Alzheimer disease-induced cognitive impairment

Cui-Cui Cui, Yong Sun, Xin-Yi Wang, Yuan Zhang, Ying Xing
2019 Medicine  
Author contributions Data curation: Cui-cui CUI, Yong Sun. Supervision: Ying Xing.  ...  Cui et al. Medicine (2019) 98:27 Medicine  ... 
doi:10.1097/md.0000000000016091 pmid:31277107 pmcid:PMC6635177 fatcat:xr746ytefbclxl3bpy4quzzuzi

Graph Attention Tracking [article]

Dongyan Guo, Yanyan Shao, Ying Cui, Zhenhua Wang, Liyan Zhang, Chunhua Shen
2020 arXiv   pre-print
Siamese network based trackers formulate the visual tracking task as a similarity matching problem. Almost all popular Siamese trackers realize the similarity learning via convolutional feature cross-correlation between a target branch and a search branch. However, since the size of target feature region needs to be pre-fixed, these cross-correlation base methods suffer from either reserving much adverse background information or missing a great deal of foreground information. Moreover, the
more » ... al matching between the target and search region also largely neglects the target structure and part-level information. In this paper, to solve the above issues, we propose a simple target-aware Siamese graph attention network for general object tracking. We propose to establish part-to-part correspondence between the target and the search region with a complete bipartite graph, and apply the graph attention mechanism to propagate target information from the template feature to the search feature. Further, instead of using the pre-fixed region cropping for template-feature-area selection, we investigate a target-aware area selection mechanism to fit the size and aspect ratio variations of different objects. Experiments on challenging benchmarks including GOT-10k, UAV123, OTB-100 and LaSOT demonstrate that the proposed SiamGAT outperforms many state-of-the-art trackers and achieves leading performance. Code is available at:
arXiv:2011.11204v1 fatcat:44o25ix2dvevnidrxwwqwwplhu

Generation of human blastocyst-like structures from pluripotent stem cells [article]

Yong Fan, Zhe-Ying Min, Samhan Alsolami, Cui-Qing Zhong, Zheng-Lai Ma, Ke Zhong, Wen-Di Pei, Pu-Yao Zhang, Xiang-Jin Kang, Ying-Ying Zhang, Hai-Ying Zhu, Mo Li (+1 others)
2021 bioRxiv   pre-print
Human blastocysts are comprised of the first three cell lineages of the embryo: trophectoderm, epiblast, and primitive endoderm, all of which are essential for early development and organ formation1,2. However, due to ethical concerns and restricted access to human blastocysts, we lack a comprehensive understanding of early human embryogenesis. To bridge this knowledge gap, we need a reliable model system that recapitulates early stages of human embryogenesis. Here we report a
more » ... (3D), two-step induction protocol for generating blastocyst-like structures (EPS-blastoids) from human extended pluripotent stem (EPS) cells. Morphological and single-cell transcriptomic analyses revealed that EPS-blastoids contain key cell lineages and are transcriptionally similar to human blastocysts. Furthermore, EPS-blastoids also exhibited the developmental potential to undergo post-implantation morphogenesis in vitro to form structures with a cellular composition and transcriptome signature similar to human embryos that had been cultured in vitro for 8 or 10 days. In conclusion, human EPS-blastoids provide a new experimental platform for studying early developmental stages of the human embryo.
doi:10.1101/2021.03.09.434313 fatcat:k5vexieeive4xglgrshcvfzufu

A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence [article]

Jun Liu, Xiaowei Ma, Chao Cui, Ying Wang, Philip R. Deenik, Lina Cui
2020 bioRxiv   pre-print
Cui from the University of New Mexico  ... 
doi:10.1101/2020.03.27.010827 fatcat:hcevs5qdtve4nn5b7gkrrobxme

4-Hydroxy-3-methoxybenzaldehyde nicotinoylhydrazone monohydrate

Xue-Fang Shi, Chang-Ying Liu, Bo Liu, Cui-Cui Yuan
2007 Acta Crystallographica Section E  
E63, o1295-o1296 [] 4-Hydroxy-3-methoxybenzaldehyde nicotinoylhydrazone monohydrate Xue-Fang Shi, Chang-Ying Liu, Bo Liu and Cuisource: fine-focus sealed tube Graphite  ... 
doi:10.1107/s1600536807006708 fatcat:o3xs75eqtzdhppgvqhfmvlvtwm

Difference in glycerol levels between leukemia and normal bone marrow stem cells

2014 Oncology Letters  
Aquaglyceroporin 9 (AQP9) is considered to be involved in numerous types of carcinogenic processes, particularly in liver carcinoma. AQP9 expression is significantly decreased in the human hepatocellular carcinoma when compared with the non-tumourigenic liver, which leads to increased resistance to apoptosis. In addition, AQP9 is permeable to glycerol and urea. The involvement of AQP9 in leukemia has not been fully delineated. It is proposed that abnormal proliferation of hematopoietic stem
more » ... s (HSCs) contributes to leukemia carcinogenesis. Therefore, the present study aimed to investigate the possible roles of AQP9 in HSCs and its effect on the intracellular glycerol content. HSCs and non-HSCs (nHSCs) were isolated via magnetic-activated cell sorting and then subjected to flow cytometry for evaluation of purity. White blood cells (WBCs) were isolated from peripheral blood from healthy volunteers. Furthermore, AQP9 expression was examined at the mRNA and protein levels using western blotting and reverse transcription-polymerase chain reaction (RT-PCR). The glycerol content of HSCs, nHSCs and WBCs was evaluated by ELISA. Finally, in order to observe the morphology of HSCs and nHSCs, a blood smear was conducted and the cells were observed with Wright-Giemsa staining. The results indicated that the glycerol content in the HSCs was markedly greater than that in the nHSCs. AQP9 mRNA and protein expression was not detected in the HSCs and nHSCs, but was identified in the WBCs. Moreover, the HSC morphological characteristics included round or oval cells with round, slightly oval or irregularly shaped nuclei. Additionally, the nuclei occupied almost the entire cell, were located in the middle or were biased toward one side, and were stained light purple or red. Overall, our results indicated that intracellular glycerol is involved in HSC proliferation, despite the fact that glycerol is not mediated by AQP9. Hence, our findings may be useful in further understanding the mechanism of leukemia carcinogenesis, and these data may be valuable in developing future therapeutic strategies.
doi:10.3892/ol.2014.2142 pmid:24959239 pmcid:PMC4063588 fatcat:vvwohqgqxjhxtlafwgn7gjs4cm

Sample-based Federated Learning via Mini-batch SSCA [article]

Chencheng Ye, Ying Cui
2021 arXiv   pre-print
(Corresponding author: Ying Cui.) m (ω, x n ), m = 1, 2, . . . , M. t. F m (ω) ≤ s m , m = 1, 2, . . .  ... 
arXiv:2103.09506v1 fatcat:a2l7olbjrzg4faq6s4ray7pur4

What is Health Economics [article]

Ying Cui, Rajna Golubic, Cassandra Gould van Praag, Emmanuel Selvaraj, Laurence SJ Roope
2022 Zenodo  
Project administration: Ying Cui, Rajna Golubic, Cassandra D. Gould van Praag, Laurence S. Roope, and Emmanuel Selvaraj. Resources: Ying Cui, Rajna Golubic, [...]  ...  Investigation: Ying Cui, Rajna Golubic, Cassandra D. Gould van Praag, Laurence S. Roope, and Emmanuel Selvaraj. Methodology: Ying Cui, Rajna Golubic, Cassandra D. Gould van Praag, Laurence S.  ... 
doi:10.5281/zenodo.7070753 fatcat:pw4qhyvgm5e4vndamrjbrkfity

What is Health Economics [article]

Ying Cui, Rajna Golubic, Cassandra Gould van Praag, Emmanuel Selvaraj, Laurence SJ Roope
2022 Zenodo  
Software: Ying Cui and Cassandra D. Gould van Praag. Supervision: Laurence S. Roope. Visualization: Ying Cui and Cassandra D.  ...  Project administration: Ying Cui, Rajna Golubic, Cassandra D. Gould van Praag, Laurence S. Roope, and Emmanuel Selvaraj. Resources: Ying Cui, Rajna Golubic, Cassandra D.  ...  Ying Cui, 2 Cassandra Gould van Praag * , 3 Rajna Golubic, 4 Emmanuel Selvaraj, 5 Laurence Roope 1 Nuffield Department of Surgical Sciences/Lead Technologist, 2 Wellcome Centre for Integrative Neuroimaging  ... 
doi:10.5281/zenodo.7071057 fatcat:r2nj2qbuevfl7kwt7j2gtue5dq

Globally stabilized bent carbon–carbon triple bond by hydrogen-free inorganic–metallic scaffolding Al4F6

Ying-ying Xue, Ying Zhang, Zhong-hua Cui, Yi-hong Ding
2020 RSC Advances  
We report a novel C2Al4F6-01 with metal–inorganic Al4F6-scaffolding, which differs from hitherto known bent-CC types, which all involve carbon-based scaffoldings.
doi:10.1039/d0ra02280b pmid:35517486 pmcid:PMC9055247 fatcat:snxz65banbhsbl65bjm72a3kfm

Exercise Intervention Associated with Cognitive Improvement in Alzheimer's Disease

Meng Ying Cui, Yang Lin, Ji Yao Sheng, Xuewen Zhang, Ran Ji Cui
2018 Neural Plasticity  
Alzheimer's disease (AD) is a progressive neurodegenerative disease with the syndrome of cognitive and functional decline. Pharmacotherapy has always been in a dominant position for the treatment of AD. However, in most cases, drug therapy is accompanied with clinical delays when older adults have suffered from cognitive decline in episodic memory, working memory, and executive function. On the other hand, accumulating evidence suggests that exercise intervention may ameliorate the progression
more » ... f cognitive impairment in aging ones while the standard strategy is lacking based on different levels of cognitive decline especially in mild cognitive impairment (MCI) and AD. MCI is the preclinical stage of AD in which neurodegeneration may be reversed via neuroplasticity. Therefore, taking exercise intervention in the early stage of MCI and healthy aging at the risk of AD could slow down the process of cognitive impairment and provide a promising cost-effective nonpharmacological therapy to dementia.
doi:10.1155/2018/9234105 pmid:29713339 pmcid:PMC5866875 fatcat:l3mpazeunfdnpifqywz3wn7yz4

Trusted QoS Assurance Approach for Composite Service

Meng Cai, Ying Cui, Yang Yu, Ying Xue, Han Luo, Hao Peng
2021 Security and Communication Networks  
The characteristics of service computing environment, such as service loose coupling, resource heterogeneity, and protocol independence, propose higher demand for the trustworthiness of service computing systems. Trust provisioning for composite services has become a hot research spot worldwide. In this paper, quality of service (QoS) planning techniques are introduced into service composition-oriented QoS provisioning architecture. By QoS planning, the overall QoS requirement of the composite
more » ... ervice is decomposed into separate QoS requirement for every constituent atom service, the QoS level of which can subsequently be satisfied through well-designed service entity selection policies. For any single service entity, its QoS level is variable when the deployment environment or the load of service node changes. To mitigate the uncertainty, we put forward QoS preprocessing algorithms to estimate the future QoS levels of service entities with their history execution data. Then, based on the modeling of composite service and QoS planning, we design three algorithms, which include the time preference algorithm, cost/availability (C/A) preference algorithm, and Euclidean distance preference algorithm, to select suitable atomic services meeting the user's requirements. Finally, by combining genetic algorithm and local-search algorithm, we propose memetic algorithm to meet the QoS requirements of composite service. The effectiveness of the proposed methods by which the QoS requirements can be satisfied up to 90% is verified through experiments.
doi:10.1155/2021/9934138 fatcat:gxmeum4ydzan7j4b7d6yeq2xzm

Stochastic Successive Convex Approximation for General Stochastic Optimization Problems [article]

Chencheng Ye, Ying Cui
2019 arXiv   pre-print
One key challenge for solving a general stochastic optimization problem with expectations in the objective and constraint functions using ordinary stochastic iterative methods lies in the infeasibility issue caused by the randomness over iterates. This letter aims to address this main challenge. First, we obtain an equivalent stochastic optimization problem which is to minimize the weighted sum of the original objective and the penalty for violating the original constraints. Then, we propose a
more » ... tochastic successive convex approximation (SSCA) method to obtain a stationary point of the original stochastic optimization problem. Using similar techniques, we propose a parallel SSCA method to obtain a stationary point of a special case of the general stochastic optimization problem which has decoupled constraint functions. We also provide application examples of the proposed methods in power control for interference networks. The proposed SSCA and parallel SSCA methods achieve empirically higher convergence rates and lower computational complexities than existing ones, benefiting from the elegant way of balancing the objective minimization and constraint satisfaction over random iterates.
arXiv:1908.11015v1 fatcat:ns45bdfukfhs5lh3tmay5xq6uu
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