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PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis

Wenjie Zhang, Jiajie Hou, Xiaochen Wang, Runqiu Jiang, Yin Yin, Jie Ji, Lei Deng, Xingxu Huang, Ke Wang, Beicheng Sun
<span title="2015-03-19">2015</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yubgl6cdcrekxpjzhshpw23l3i" style="color: black;">OncoTarget</a> </i> &nbsp;
Autophagy plays a critical role in the progression of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Protein tyrosine phosphatase receptor type O (PTPRO) was recently identified as a tumor suppressor, but little is known about its role in NASH. Here, we investigated the role of PTPRO-dependent autophagy in insulin resistance, lipid metabolism, and hepatocarcinogenesis. Wild-type (WT) and ptpro −/− mice were fed a high-fat diet (HFD) for another 16 weeks after
more &raquo; ... osamine (DEN) injection to induce NASH. Ptpro −/− mice exhibited severe liver injury, insulin resistance, hepatosteatosis and autophagy deficiency compared with WT littermates. PTPRO deletion also promoted the induction of lipogenic target genes and decreases in β-oxidation-related genes. Increased activation of AKT and accumulation of cytoplasmic p53 was detected in ptpro −/− mice, which in combination repressed autophagy. Intriguingly, hyperinsulinemia involving AKT activation was also exacerbated in HFD-fed mice due to PTPRO deletion. Activation of AKT induced stabilization of the MDMX/MDM2 heterocomplex, thus promoting p53 accumulation in the cytoplasm. Inhibition of AKT restored autophagy and p53 accumulation in hepatocytes, indicating that AKT acts upstream of p53. Due to hyperinsulinemia and autophagy deficiency, a HFD could aggravate steatohepatitis in ptpro −/− mice. Importantly, the expression of PTPRO was much decreased in human steatohepatitis, which was associated with increased p62 accumulation. Together, these data indicate that PTPRO regulates insulin and lipid metabolism via the PI3K/Akt/MDM4/MDM2/ P53 axis by affecting autophagy. Oncotarget 9421
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.3353">doi:10.18632/oncotarget.3353</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25826083">pmid:25826083</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4496227/">pmcid:PMC4496227</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/amtxvesryfcfrbagca4zrc34wm">fatcat:amtxvesryfcfrbagca4zrc34wm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180720092453/http://www.oncotarget.com/index.php?journal=oncotarget&amp;page=article&amp;op=download&amp;path%5B%5D=3353&amp;path%5B%5D=7405" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/89/69/8969d61387741aa869109030c6b94af8441834b9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.3353"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496227" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The mechanisms of contextual cuing effect based on objects' topological properties

Jie MA, Haoran DOU, Qian ZHUANG, Dongxue YIN, Ming LEI, Chao GAO, Yin ZHANG, Qiang LIU, Guang ZHAO
<span title="">2018</span> <i title="China Science Publishing &amp; Media Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mfnmmfyxkfh7fmnwss355xzx6a" style="color: black;">Acta Psychologica Sinica</a> </i> &nbsp;
The mechanisms of contextual cuing effect based on objects' topological properties MA Jie 1 ; DOU Haoran 1 ; ZHUANG Qian 1 ; YIN Dongxue 1 ; LEI Ming 1 ; GAO Chao 2 ; ZHANG Yin 1 ; LIU Qiang 1 ; ZHAO Guang  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3724/sp.j.1041.2018.00143">doi:10.3724/sp.j.1041.2018.00143</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hktxpc76zfdlleb6eepbkxehrm">fatcat:hktxpc76zfdlleb6eepbkxehrm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220304051226/http://journal.psych.ac.cn/xlxb/CN/article/downloadArticleFile.do?attachType=PDF&amp;id=4092" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/80/fd/80fd830cbd82259bc02a4d223bda2f75fc9ce683.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3724/sp.j.1041.2018.00143"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Analysis of Bridge-type Distributed-compliance Mechanism

Lei-Jie Lai, Xiao-Qia Yin, O.S. Es-Said, C.A. Huang
<span title="">2018</span> <i title="EDP Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4vlgvitw6fcmbay5hkyo2s2ime" style="color: black;">MATEC Web of Conferences</a> </i> &nbsp;
This paper analyses a class of bridge-type distributed-compliance mechanism, which has better performances than traditional bridge-type mechanisms using notch flexure hinges. An analytical model for the displacement amplification ratio and input stiffness calculations of the bridge-type mechanism is established based on the stiffness matrix method. The finite element analysis results are then given to validate the correctness of the analytical model. The differences of the analytical results
more &raquo; ... h respect to the finite element analysis results are less than 8%, which demonstrate the high accuracy of the analytical model. The influences of the geometric parameters on the amplification ratio and input stiffness of the mechanism are also investigated using the analytical model to provide theoretical guidelines for the practical design.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1051/matecconf/201821301005">doi:10.1051/matecconf/201821301005</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/muv3yj6oqbb2llnsrzqnccvrti">fatcat:muv3yj6oqbb2llnsrzqnccvrti</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430230937/https://www.matec-conferences.org/articles/matecconf/pdf/2018/72/matecconf_acmme2018_01005.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ac/33/ac33c33031080a108e3fc678c6b480f006fb2552.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1051/matecconf/201821301005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Tight security bounds for decoy-state quantum key distribution [article]

Hua-Lei Yin, Min-Gang Zhou, Jie Gu, Yuan-Mei Xie, Yu-Shuo Lu, Zeng-Bing Chen
<span title="2020-02-16">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The BB84 quantum key distribution (QKD) combined with decoy-state method is currently the most practical protocol, which has been proved secure against general attacks in the finite-key regime. Thereinto, statistical fluctuation analysis methods are very important in dealing with finite-key effects, which directly affect secret key rate, secure transmission distance and even the most important security. There are two tasks of statistical fluctuation in decoy-state BB84 QKD. One is the deviation
more &raquo; ... between expected value and observed value for a given expected value or observed value. The other is the deviation between phase error rate of computational basis and bit error rate of dual basis. Here, we provide the rigorous and optimal analytic formula to solve the above tasks, resulting higher secret key rate and longer secure transmission distance. Our results can be widely applied to deal with statistical fluctuation in quantum cryptography protocols.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2002.06530v1">arXiv:2002.06530v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/avkdcjvyhvhvtlxdjpszfejlmy">fatcat:avkdcjvyhvhvtlxdjpszfejlmy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321101532/https://arxiv.org/pdf/2002.06530v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2002.06530v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

COMPARATIVE PERFORMANCE OF GENE-BASED WARFARIN DOSING ALGORITHMS IN CHINESE PATIENTS

Tong Yin, Qiang Xu, Yu Liu, Hongjuan Wang, Jie Yang, Lei Gao, Yuxiao Zhang, Bin Xu, Caiyi Lu, Yusheng Zhao, Tong Yin
<span title="">2012</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7lqt6ebzpjauzbwhlfhrk25kge" style="color: black;">Heart</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/heartjnl-2012-302920c.4">doi:10.1136/heartjnl-2012-302920c.4</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tdiig5d6pfbdfd4ljkgcbkcuiy">fatcat:tdiig5d6pfbdfd4ljkgcbkcuiy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426121216/https://heart.bmj.com/content/heartjnl/98/Suppl_2/E128.3.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/33/f7/33f7399722fdbd424199abe381709663ae397215.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/heartjnl-2012-302920c.4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> bmj.org </button> </a>

Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report

Jie Jiao, Lei Wu, Jianyuan Yin, Xiaojiao Quan, Wei Chen, Jie Hu
<span title="2018-03-27">2018</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gryfylmjtnau5b3kr62ex5g6yy" style="color: black;">BMC Infectious Diseases</a> </i> &nbsp;
We describe a case of Guillain-Barre syndrome (GBS) associated with hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS associated with Hantavirus infection have been reported so far. Case presentations: A 62-year-old man presented intermittent fever, chill and oliguria. According to remarkable leukocytosis, atypical lymphocytes, thrombocytopenia and former dwelling in hemorrhagic fever-endemic area, he was suspected as hemorrhagic fever with renal syndromeand
more &raquo; ... ed with positive Hantavirus IgG. Later, the patient had symmetrical flaccid paralysis of all extremities. Electromyography showed peripheral nerve injury (mainly in axon). The patient was diagnosed as having acute motor sensory axonal neuropathy (AMSAN). After immunoglobulin infusion, patient showed progressive recovery and was transferred 3 weeks after his first admission to a rehabilitation center. Conclusions: Our case was the 6th reported case of GBS associated with hemorrhagic fever with renal syndrome. Moreover, we for the first time classified the subtype of GBS (AMSAN) based on the electrophysiology characteristics. GBS should be suspected in patients who are already diagnosed as hemorrhagic fever with renal syndrome when delayed symmetrical limb paralysis occurs. Until recent now, GBS was only reported in hemorrhagic fever patients in Europe and Asia, which termed as hemorrhagic fever with renal syndrome.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12879-018-3049-1">doi:10.1186/s12879-018-3049-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29587642">pmid:29587642</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5872525/">pmcid:PMC5872525</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4v6iorlbcvewjhjfry62pq6hzq">fatcat:4v6iorlbcvewjhjfry62pq6hzq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180721005209/https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-018-3049-1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/82/69/8269bd0475a16dc969d255b637840e113e139949.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12879-018-3049-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872525" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Incremental sparse saliency detection

Yin Li, Yue Zhou, Lei Xu, Xiaochao Yang, Jie Yang
<span title="">2009</span> <i title="IEEE"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/anlh4tvwprcrtoxv5d4h6a7rye" style="color: black;">2009 16th IEEE International Conference on Image Processing (ICIP)</a> </i> &nbsp;
By the guidance of attention, human visual system is able to locate objects of interest in complex scene. We propose a new visual saliency detection model for both image and video. Inspired by biological vision, saliency is defined locally. Lossy compression is adopted, where the saliency of a location is measured by the Incremental Coding Length(ICL). The ICL is computed by presenting the center patch as the sparsest linear representation of its surroundings. The final saliency map is
more &raquo; ... by accumulating the coding length. The model is tested on both images and videos. The results indicate a reliable and robust saliency of our method.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/icip.2009.5414465">doi:10.1109/icip.2009.5414465</a> <a target="_blank" rel="external noopener" href="https://dblp.org/rec/conf/icip/LiZXYY09.html">dblp:conf/icip/LiZXYY09</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/g4ivxgovkfacnfwqvdqy7gfgea">fatcat:g4ivxgovkfacnfwqvdqy7gfgea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20111226101209/http://www.pami.sjtu.edu.cn:80/demo/incremental_sparse_saliency.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ea/1f/ea1f8cde30cb523d2899ac96a7966befb3bb340b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/icip.2009.5414465"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Interpretations of the DAMPE electron data [article]

Qiang Yuan, Lei Feng, Peng-Fei Yin, Yi-Zhong Fan, Xiao-Jun Bi, Ming-Yang Cui, Tie-Kuang Dong, Yi-Qing Guo, Kun Fang, Hong-Bo Hu, Xiaoyuan Huang, Shi-Jun Lei, Xiang Li (+14 others)
<span title="2017-11-29">2017</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The DArk Matter Particle Explorer (DAMPE), a high energy cosmic ray and γ-ray detector in space, has recently reported the new measurement of the total electron plus positron flux between 25 GeV and 4.6 TeV. A spectral softening at ∼0.9 TeV and a tentative peak at ∼1.4 TeV have been reported. We study the physical implications of the DAMPE data in this work. The presence of the spectral break significantly tightens the constraints on the model parameters to explain the electron/positron
more &raquo; ... . The spectral softening can either be explained by the maximum acceleration limits of electrons by astrophysical sources, or a breakdown of the common assumption of continuous distribution of electron sources at TeV energies in space and time. The tentive peak at ∼1.4 TeV implies local sources of electrons/positrons with quasi-monochromatic injection spectrum. We find that the cold, ultra-relativistic e^+e^- winds from pulsars may give rise to such a structure. The pulsar is requird to be middle-aged, relatively slowly-rotated, mildly magnetized, and isolated in a density cavity. The annihilation of DM particles (m_χ∼1.5 TeV) into e^+e^- pairs in a nearby clump or an over-density region may also explain the data. In the DM scenario, the inferred clump mass (or density enhancement) is about 10^7-10^8 M_ (or 17-35 times of the canonical local density) assuming a thermal production cross section, which is relatively extreme compared with the expectation from numerical simulations. A moderate enhancement of the annihilation cross section via, e.g., the Sommerfeld mechanism or non-thermal production, is thus needed.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1711.10989v1">arXiv:1711.10989v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/drsalq5efzdslnc2am546tull4">fatcat:drsalq5efzdslnc2am546tull4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200824200205/https://arxiv.org/pdf/1711.10989v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/72/6b/726b49ce9035777e9c27f38ac7820bbf555da601.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1711.10989v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Deep Human Answer Understanding for Natural Reverse QA [article]

Rujing Yao, Linlin Hou, Lei Yang, Jie Gui, Qing Yin, Ou Wu
<span title="2020-11-29">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
This study focuses on a reverse question answering (QA) procedure, in which machines proactively raise questions and humans supply the answers. This procedure exists in many real human-machine interaction applications. However, a crucial problem in human-machine interaction is answer understanding. The existing solutions have relied on mandatory option term selection to avoid automatic answer understanding. However, these solutions have led to unnatural human-computer interaction and negatively
more &raquo; ... affected user experience. To this end, the current study proposes a novel deep answer understanding network, called AntNet, for reverse QA. The network consists of three new modules, namely, skeleton attention for questions, relevance-aware representation of answers, and multi-hop based fusion. As answer understanding for reverse QA has not been explored, a new data corpus is compiled in this study. Experimental results indicate that our proposed network is significantly better than existing methods and those modified from classical natural language processing deep models. The effectiveness of the three new modules is also verified.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1912.00398v2">arXiv:1912.00398v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/75gazqruinfehma6aqenudi3ze">fatcat:75gazqruinfehma6aqenudi3ze</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201203212903/https://arxiv.org/pdf/1912.00398v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c4/c2/c4c2e57d54382fcccb63eae8cf530b723f02f08b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1912.00398v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Using Verbal Probability to Measure Uncertainty:Features and Problems

Xue-Lei DU, Jie-Hong XU, Yin SU, Shu LI
<span title="2013-05-25">2013</span> <i title="China Science Publishing &amp; Media Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/en423nui4ver5lyhvyqoptbpky" style="color: black;">Advances in Psychological Science</a> </i> &nbsp;
Verbal probability is one of the ways of measuring uncertainty. People use verbal probability, such as "uncertain" and "possible", to describe the chance that an event will happen. Verbal probability differs from numerical probability, particularly in features of vagueness, non-probabilistic operation, and semantic feature. Some remarkable phenomena and problems arise and the quality of judgment and decision making suffer in one way or another when people use verbal probability, rather than
more &raquo; ... rical probability, to measure uncertainty. The role of verbal probability in risk decision making is understudied in spite of the fact that people often use verbal probability to communicate uncertainty in their daily lives and of the great differences between verbal probability and numerical probability. Suggestions are made for future work to focus on risk decision making using verbal probability and on other potential features (e.g., the relationship between verbal/numerical probability and the dual system model, cross-cultural differences in verbal probability) and their effects on risky choices, in order to further improve our understanding of the mechanism of risk decision making.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3724/sp.j.1042.2012.00651">doi:10.3724/sp.j.1042.2012.00651</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wb2yvcuol5du5fv25c2zrh3kbm">fatcat:wb2yvcuol5du5fv25c2zrh3kbm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220309045042/http://journal.psych.ac.cn/xlkxjz/CN/article/downloadArticleFile.do?attachType=PDF&amp;id=1459" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d8/b7/d8b7ad43bbac48ab6340c903d5f2bc14cd464305.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3724/sp.j.1042.2012.00651"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Methionine restriction on oxidative stress and immune response in dss-induced colitis mice

Gang Liu, Lei Yu, Jun Fang, Chien-An Andy Hu, Jie Yin, Hengjia Ni, Wenkai Ren, Veeramuthu Duraipandiyan, Shuai Chen, Naif Abdullah Al-Dhabi, Yulong Yin
<span title="2017-05-11">2017</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yubgl6cdcrekxpjzhshpw23l3i" style="color: black;">OncoTarget</a> </i> &nbsp;
Copyright: Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT A strong correlation exists between inflammatory bowel disease (IBD) and oxidative stress involving alterations of several key signaling pathways. It is known that methionine promotes reactive oxygen species (ROS)
more &raquo; ... duction; we therefore hypothesize that a methionine restriction diet would reduce ROS production, inflammatory responses, and the course of IBD. We generated a murine colitis model by dextran sodium sulfate (DSS) treatment and tested the effects of the methionine restriction diet. Forty-eight mice were randomly divided into four groups of equal size, which included a control (CON) group, an MR (methionine restriction diet) group, a DSS treated group and an MR-DSS treated group. Mice in the first two groups had unrestricted access to water for one week. Mice in the two DSS-treated groups had unrestricted access to 5% DSS solution supplied in the drinking water for the same period. Mice in the CON and DSS groups were given a basal diet, whereas mice in the MR-DSS and MR groups were fed a 0.14% MR diet. We found that DSS reduced daily weight gain, suppressed antioxidant enzyme expression, increased histopathology scores and activated NF-κB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling. We also showed that the MR diet upregulated catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, decreased myeloperoxidase (MPO), TNF-α and IL-1β, and reversed activation of the NF-κB signaling pathway in MR-DSS mice. Taken together, our results imply that the MR diet may be considered as an adjuvant in IBD therapeutics. www.impactjournals.com/oncotarget/
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.17812">doi:10.18632/oncotarget.17812</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28562346">pmid:28562346</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5546498/">pmcid:PMC5546498</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bey5sgfeqbbnloqx77677rjmju">fatcat:bey5sgfeqbbnloqx77677rjmju</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180725065329/http://www.oncotarget.com/index.php?journal=oncotarget&amp;page=article&amp;op=download&amp;path%5B%5D=17812&amp;path%5B%5D=57036" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.17812"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546498" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Secure Quantum Secret Sharing without Signal Disturbance Monitoring [article]

Hua-Lei Yin, Jie Gu, Yuan-Mei Xie, Wen-Bo Liu, Yao Fu, Zeng-Bing Chen
<span title="2021-04-21">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Quantum secret sharing (QSS) is an essential primitive for the future quantum internet, which promises secure multiparty communication. However, developing a large-scale QSS network is a huge challenge due to the channel loss and the requirement of multiphoton interference or high-fidelity multipartite entanglement distribution. Here, we propose a three-user QSS protocol without monitoring signal disturbance, which is capable of ensuring the unconditional security. The final key rate of our
more &raquo; ... ocol can be demonstrated to break the Pirandola-Laurenza-Ottaviani-Banchi bound of quantum channel and its simulated transmission distance can approach over 600 km using current techniques. Our results pave the way to realizing high-rate and large-scale QSS networks.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2104.10321v1">arXiv:2104.10321v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mfibxaolqfevvl2d5pgedp4lne">fatcat:mfibxaolqfevvl2d5pgedp4lne</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210925035429/https://arxiv.org/pdf/2104.10321v2.pdf" title="fulltext PDF download [not primary version]" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <span style="color: #f43e3e;">&#10033;</span> <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/56/ec/56ecb2c056bc196232439bf77889b72bd01382b8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2104.10321v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

FLT3 and NPM1 mutations in Chinese patients with acute myeloid leukemia and normal cytogenetics

Lei Wang, Wei-lai Xu, Hai-tao Meng, Wen-bin Qian, Wen-yuan Mai, Hong-yan Tong, Li-ping Mao, Yin Tong, Jie-jing Qian, Yin-jun Lou, Zhi-mei Chen, Yun-gui Wang (+1 others)
<span title="">2010</span> <i title="Zhejiang University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bkepz6pyyjc4ffgne2lo4fuegy" style="color: black;">Journal of Zhejiang University SCIENCE B</a> </i> &nbsp;
Mutations of fms-like tyrosine kinase 3 (FLT3) and nucleophosmin (NPM1) exon 12 genes are the most common abnormalities in adult acute myeloid leukemia (AML) with normal cytogenetics. To assess the prognostic impact of the two gene mutations in Chinese AML patients, we used multiplex polymerase chain reaction (PCR) and capillary electrophoresis to screen 76 AML patients with normal cytogenetics for mutations in FLT3 internal tandem duplication (FLT3/ITD) and exon 12 of the NPM1 gene. FLT3/ITD
more &raquo; ... tation was detected in 15 (19.7%) of 76 subjects, and NPM1 mutation in 20 (26.3%) subjects. Seven (9.2%) cases were positive for both FLT3/ITD and NPM1 mutations. Significantly more FLT3/ITD aberration was detected in subjects with French-American-British (FAB) M1 (42.8%). NPM1 mutation was frequently detected in subjects with M5 (47.1%) and infrequently in subjects with M2 (11.1%). FLT3 and NPM1 mutations were significantly associated with a higher white blood cell count in peripheral blood and a lower CD34 antigen expression, but not age, sex, or platelet count. Statistical analysis revealed that the FLT3/ITDpositive group had a lower complete remission (CR) rate (53.3% vs. 83.6%). Survival analysis showed that the FLT3/ITD-positive/NPM1 mutation-negative group had worse overall survival (OS) and relapse-free survival (RFS). The FLT3/ITD-positive/NPM1 mutation-positive group showed a trend towards favorable survival compared with the FLT3/ITD-positive/NPM1 mutation-negative group (P=0.069). Our results indicate that the FLT3/ITD mutation might be a prognostic factor for an unfavorable outcome in Chinese AML subjects with normal cytogenetics, while NPM1 mutation may be a favorable prognostic factor for OS and RFS in the presence of FLT3/ITD.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1631/jzus.b1000052">doi:10.1631/jzus.b1000052</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20872983">pmid:20872983</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2950237/">pmcid:PMC2950237</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xojbxknq7bf35meqgyb3xrx3wi">fatcat:xojbxknq7bf35meqgyb3xrx3wi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207231626/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2950237&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b3/27/b327092377390a2d4e2ee7df7375c06782980636.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1631/jzus.b1000052"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950237" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

An epidemiological investigation on nasal allergy in China
中国における鼻アレルギー疫学調査

Rang You, Yoshio TAGUCHI, Akira MIYOSHI, Shigeru HISAMITHI, Lei CHENG, Min YIN, Chi-Chang Xu, Ming-de YIN, Jie-Ren PENG, Jei-zhu CHEN, Takeyuki SAMBE, Osamu KUNII
<span title="">1998</span> <i title="JIBI TO RINSHO KAI"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/olh37aodcze5fkz54aldtsbtru" style="color: black;">Jibi to Rinsho</a> </i> &nbsp;
CHENG, Mill YIN, Chi-Chang Xu, Ming-de YIN(3), Jie-Ren PENG, Jei-zhu CHEN(4), Takeyuki SAMBE(5) andOsamuKUMI(6)  ...  ア レル ギ ー 三 好 彰 ・ 編 著. 29-34頁, 日本 評 論 社, 東 京, 1998.An epidemiological investigation on nasal allergy in China-A comparison with Japan-Rang You, Yoshio TAGUCHI(1), Akira MIYOSHI, Shigeru HISAMITHI(2), Lei  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.11334/jibi1954.44.4supplement3_634">doi:10.11334/jibi1954.44.4supplement3_634</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/beie6rk4wfgvderx3vtam43seu">fatcat:beie6rk4wfgvderx3vtam43seu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220509083445/https://www.jstage.jst.go.jp/article/jibi1954/44/4Supplement3/44_634/_pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a0/d7/a0d72aeeb7b5869589e1d3b2d930a52b07ae5be1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.11334/jibi1954.44.4supplement3_634"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Minimally Invasive Treatment of Mason Type II Radial Head Fracture by Intramedullary Pinning

Xu Gao, Hai‐lei Yin, Guang‐jie Zhou
<span title="2019-09-18">2019</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ixogx2chrbhl3kpdqqqwx4jp2m" style="color: black;">Orthopaedic Surgery</a> </i> &nbsp;
To evaluate the outcome of Mason type II radial head fractures treated by intramedullary pinning. From May 2013 to March 2017, we respectively reviewed 25 patients affected by Mason type II radial head fractures. A total of 12 patients who met criteria for inclusion and exclusion were collected and analyzed. They were all isolated displaced partial articular radial head fractures and treated with intramedullary pinning using titanium elastic nails (TEN). The patients comprised eight men and
more &raquo; ... women with the mean age of 40 years (range, 21-58 years). The clinical evaluation included the range of motion (ROM) in the elbow, the shortened disabilities of the arm, shoulder and hand questionnaire (QuickDASH), the visual analogue scale (VAS) for pain rating, and the Mayo Elbow Performance Score (MEPS). Follow-up radiographs to monitor related complications were evaluated as well. All patients were followed-up with a mean of 21.8 months (range, 12-28 months). The average range of elbow flexion-extension was barely unaffected in the injured side when compared to the uninjured side (139.08° ± 3.14° vs 140.16° ± 3.01°, P = 0.398) as were pronation of the forearm (86.50° ± 2.75° vs 87.83° ± 2.12°, P = 0.197) and supination of the forearm (87.41° ± 2.53° vs 88.17° ± 1.95°, P = 0.425). The MEPS was 93.75 ± 5.28 points (range, 85-100), the QuickDASH revealed good to excellent results with 2.33 ± 4.56 points (range, 0-14), and the VAS for pain was 0.33 ± 0.78 (range, 0-2). Only two patients had a minor complication with constant affection of the superficial branch of radial nerve. Intramedullary pinning technique in the treatment of Mason type II radial head fractures is minimally traumatic and effective and represents good to excellent results in adults.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/os.12540">doi:10.1111/os.12540</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31532071">pmid:31532071</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6819192/">pmcid:PMC6819192</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/chkf7ldiuffwxledrqngrb7kpy">fatcat:chkf7ldiuffwxledrqngrb7kpy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200506220206/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6819192&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c9/79/c97976879bd5fc76133e98300bb2f953823f4053.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/os.12540"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819192" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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