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Intracerebral hemorrhage (ICH) has the highest mortality rate of all stroke subtypes but an effective treatment has yet to be clinically implemented. Transforming growth factor‑β1 (TGF‑β1) has been reported to modulate microglia‑mediated neuroinflammation after ICH and promote functional recovery; however, the underlying mechanisms remain unclear. Non‑coding RNAs such as microRNAs (miRNAs) and competitive endogenous RNAs (ceRNAs) have surfaced as critical regulators in human disease. A knowndoi:10.3892/mmr.2021.12138 pmid:33955515 pmcid:PMC8127068 fatcat:qhckbomyf5bbhkrtidqjivds2a
more »... ‑93 target, nuclear factor erythroid 2‑related factor 2 (Nrf2), has been shown to be neuroprotective after ICH. It was hypothesized that TGF‑β1 functions as a ceRNA that sponges miR‑93‑5p and thereby ameliorates ICH injury in the brain. Short interfering RNA (siRNA) was used to knock down TGF‑β1 and miR‑93 expression was also pharmacologically manipulated to elucidate the mechanistic association between miR‑93‑5p, Nrf2, and TGF‑β1 in an in vitro model of ICH (thrombin‑treated human microglial HMO6 cells). Bioinformatics predictive analyses showed that miR‑93‑5p could bind to both TGF‑β1 and Nrf2. It was found that neuronal miR‑93‑5p was dramatically decreased in these HMO6 cells, and similar changes were observed in fresh brain tissue from patients with ICH. Most importantly, luciferase reporter assays were used to demonstrate that miR‑93‑5p directly targeted Nrf2 to inhibit its expression and the addition of the TGF‑β1 untranslated region restored the levels of Nrf2. Moreover, an miR‑93‑5p inhibitor increased the expression of TGF‑β1 and Nrf2 and decreased apoptosis. Collectively, these results identified a novel function of TGF‑β1 as a ceRNA that sponges miR‑93‑5p to increase the expression of neuroprotective Nrf2 and decrease cell death after ICH. The present findings provided evidence to support miR‑93‑5p as a potential therapeutic target for the treatment of ICH.
Proceedings of the 2015 6th International Conference on Manufacturing Science and Engineering
Although scenic spots make the use of various different technology in mangy business departments such as human resources management, inventory(warehouse) management, sales management, manufacturing workshop, financial department, office automation and so on. However, it is a big problem how to construct an E-Business Service Platform to make these components work in coordination. Besides, also it is important to connect the intranet system with outside systems. For examples, e-commerce, tourismdoi:10.2991/icmse-15.2015.5 fatcat:b7ym7dfgjrhwxffacrmsof62tm
more »... supply system, EDI, CRM. In this paper, it is put out the e-business service platform to fulfill this mission. The portal site, tourism statistics and analysis, e-commerce, tourism resources acquisition, 12301, electronic document exchange system, industry finance system could exchange their possessed data. On the other hand, the integration technology is also presented in the study. business Documentation, business search, authorization, responsibility identification, pay and settlement, credit collection, authentication, RFID, middleware, Heterogeneous systems interfaces, content analysis, rule engine, workflow engine are also mentioned in the research. The integration framework also contains the solution of putting these important technologies work well.
isotopes and elementary geochemistry of rocks from the early Eocene Lulehe Formation to the Miocene Youshashan Formation in the northern margin of Qaidam Basin, shows important variations in the Rb/Sr, MgO/CaO ... Correlation between Rb/Sr and MgO/CaO of the lutite samples in the study area. Figure 7 . 7 Figure 7. Correlation between Rb/Sr and MgO/CaO of the lutite samples in the study area. ... A-CN-K ternary diagram for lutites in the study area, A: Al2O3, CN: CaO Figure 10 . 10 Figure 10. A-CN-K ternary diagram for lutites in the study area, A: Al 2 O 3 , CN: CaO + Na 2 O, K: K 2 O. ...doi:10.3390/pr10051000 fatcat:f24ehcn2pbe7lhm56qhz5gktwy
2019 International Conference on Sensing, Diagnostics, Prognostics, and Control (SDPC)
Research Institute & Academy of Mathematics and Systems Science, Chinese Academy of Sciences) Research on Fault Diagnosis Method of Aircraft Secondary Distribution System Based on RBF Neural Network 377 Yetong ... Controller 273 Yang Liu (North China Vehicle Research Institute Beijing), Jiahui Zhang (North China Vehicle Research Institute Beijing), Jiangquan Liu (North China Vehicle Research Institute Beijing), Yuanfu Cao ...doi:10.1109/sdpc.2019.00004 fatcat:bq2r4vtoufdu3bucrwdgmgy5bq
* + Na2O), and K2O, respectively, and CaO* indicates that CaO has been corrected  . ... The index used to determine the weathering degree of the source area, widely used at present, is the chemical index of alteration (CIA = Al2O3/(Al2O3 + CaO* + Na2O + K2O) × 100), where CaO* represents ...doi:10.3390/min10060505 fatcat:4d4ih2dyrzaafhhsjdhkcy3624
The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospitaldoi:10.1016/j.bja.2017.08.002 pmid:29397122 fatcat:ot6rc4jhjbfefcnttjkmap2rke
more »... ity and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multilevel generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained 1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32-0.77); P<0.01], but no difference in complication rates [OR 1.02 (0.88-1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62-0.92); P<0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61-0.88); P<0.01; I2=89%). Conclusions Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine.
at the National Center for 485 Cardiovascular Diseases, and all the local collaborative sites during the study design 486 and operations (Appendix 9), particularly data collection by Na Tian, Yaping Cao ...doi:10.1016/s0140-6736(17)32476-5 pmid:29102087 fatcat:vhsodgnzejccfkfefmymc7hpui
Discussion As early as 2010, Cao H et al. ...doi:10.1038/srep20287 pmid:26830766 pmcid:PMC4735814 fatcat:cmubck67cjeh3dfc2h67qtczfe
The method was introduced for ordinary PLSR with X (regressors, descriptor variables) and Y (regressands, response variables) blocks by Le Cao  , improved by Karaman  , and extended to multi-block ...doi:10.3390/metabo10110456 pmid:33198236 fatcat:n3vhij2xyzb3bjwmj3b7se5nzq