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History of genome editing in yeast

Marcin G. Fraczek, Samina Naseeb, Daniela Delneri
2018 Yeast  
purposes.  ...  Although S. cerevisiae has been the main focus of many research groups, other non-conventional yeasts have also been studied and exploited for biotechnological purposes.  ...  Synthetic yeast may also be important for industrial purposes.  ... 
doi:10.1002/yea.3308 pmid:29345746 pmcid:PMC5969250 fatcat:56egnnxv2nggxlsnztnor4fy7u

Drug-induced apoptosis in yeast

B. Almeida, A. Silva, A. Mesquita, B. Sampaio-Marques, F. Rodrigues, P. Ludovico
2008 BBA - Molecular Cell Research  
) generation and altered mitochondrial functions.  ...  The evidence presented suggests that yeasts may be a powerful model for the screening/ development of PCD-directed drugs, overcoming the problem of cellular specificity in the design of antitumour drugs  ...  Black arrows indicate already known yeast apoptotic events. the induction of a mitochondria-independent cell death process [50] .  ... 
doi:10.1016/j.bbamcr.2008.01.005 pmid:18252203 fatcat:owdkcdewhja6tklckkhqmg4vsi

Lipids of yeasts

J B Rattray, A Schibeci, D K Kidby
1975 Bacteriological reviews  
Information, however, on the sequence of action of these enzymes is generally lacking, but evidence for a multiplicity of sterol biosynthetic pathways in yeast has been presented (84) .  ...  The major purpose of this review has been to describe and evaluate the present state of knowledge of yeast lipid biochemistry.  ... 
pmid:240350 pmcid:PMC413914 fatcat:dnuuq2ko3zhzdkjhytiht5bvzm

Yeast killer systems

W Magliani, S Conti, M Gerloni, D Bertolotti, L Polonelli
1997 Clinical Microbiology Reviews  
In this review, the biology, ecology, epidemiology, therapeutics, serology, and idiotypy of yeast killer systems are discussed.  ...  The killer phenomenon in yeasts has been revealed to be a multicentric model for molecular biologists, virologists, phytopathologists, epidemiologists, industrial and medical microbiologists, mycologists  ...  permitted the use of the killer system for biotyping of Bacteroides fragilis for epidemiological purposes.  ... 
doi:10.1128/cmr.10.3.369 fatcat:sdayr64szjgqxfi336enmszvhq

Yeast killer systems

W Magliani, S Conti, M Gerloni, D Bertolotti, L Polonelli
1997 Clinical Microbiology Reviews  
In this review, the biology, ecology, epidemiology, therapeutics, serology, and idiotypy of yeast killer systems are discussed.  ...  The killer phenomenon in yeasts has been revealed to be a multicentric model for molecular biologists, virologists, phytopathologists, epidemiologists, industrial and medical microbiologists, mycologists  ...  permitted the use of the killer system for biotyping of Bacteroides fragilis for epidemiological purposes.  ... 
pmid:9227858 pmcid:PMC172926 fatcat:p7enuazd4rdw5aohs43tj33fgu

Endophytic Yeast and Hosts: A Mutualistic Association Friendly to the Environment [chapter]

Esperanza del Pilar Infante Luna
2017 Old Yeasts - New Questions  
The results show that the endophytic yeasts can generate structural changes in the host as a starting point for further applied research and to propose other mechanisms of action.  ...  However, in order to obtain information that contributes to the selection and the implementation of a yeast able to interact with a broader spectrum of hosts and to help solve postharvest problems, it  ...  Are there new modes of action of these yeasts in activating the plant defense system?  ... 
doi:10.5772/intechopen.70326 fatcat:ma54grkdw5hubavyqt6gorm4bi

Advances in yeast genome engineering

Florian David, Verena Siewers
2014 FEMS Yeast Research  
However, the growing importance of yeast as a cell factory in metabolic engineering and chassis in synthetic biology demands methods for fast and efficient introduction of multiple targeted changes such  ...  Genome engineering based on homologous recombination has been applied to yeast for many years.  ...  Doyon et al. (2008) used a screening system similar to the lacZ system described above, where a MEL1 reporter gene was interrupted by the desired target gene and integrated into the yeast genome.  ... 
doi:10.1111/1567-1364.12200 pmid:25154295 fatcat:lmc4texumrcl7g6nmfjpyjsd6a

Yeast replicative life span ? the mitochondrial connection

S JAZWINSKI
2004 FEMS Yeast Research  
Mitochondria have been associated with aging in many experimental systems through the damaging action of reactive oxygen species.  ...  The results more generally point to the existence of a mechanism to "filter" damaged components from daughter cells, a form of checkpoint control.  ...  This pathology informs on events that occur during normal aging of yeasts, creating a phenocopy of an old yeast cell.  ... 
doi:10.1016/s1567-1356(04)00053-4 fatcat:4kwgweubynh7fd5cyiwqimlmvi

Protein synthesis in yeast

A. H. Cook
1963 Pure and Applied Chemistry  
few generations at least at, for practical purposes, the same time.  ...  On introducing such cells therefore into a new medium, there follows a lag period (Figure 18 ) during which both systems are renewed.  ... 
doi:10.1351/pac196307040621 fatcat:hqfqcygsuzdrlbnzhwqinu2yme

Yeast replicative life span – the mitochondrial connection

S JAZWINSKI
2004 FEMS Yeast Research  
Mitochondria have been associated with aging in many experimental systems through the damaging action of reactive oxygen species.  ...  The results more generally point to the existence of a mechanism to "filter" damaged components from daughter cells, a form of checkpoint control.  ...  This pathology informs on events that occur during normal aging of yeasts, creating a phenocopy of an old yeast cell.  ... 
doi:10.1016/j.femsyr.2004.04.005 pmid:15489194 fatcat:igk6pivjr5f2jdaqlejf56qecm

Yeast: A case study for a practical use of formal methods [chapter]

Paola Inverardi, Balachander Krishnamurthy, Daniel Yankelevich
1993 Lecture Notes in Computer Science  
This paper discusses a formal semantics for an existent event-action system, Yeast, developed at AT&T Bell Laboratories.  ...  Yeast is a good case study for the use of (trueconcurrent) semantic techniques since causal dependence among events, concurrency, nondeterminism and conflicting behaviour of specifications can all be modeled  ...  The next step will be moving towards ML as implementation language in order to achieve a better integration with the AT~zT software development environment in which Yeast is largely used.  ... 
doi:10.1007/3-540-56610-4_59 fatcat:szt2sn6arzhv5d4ntv3plwb24e

Prions of Yeast and Fungi

Reed B. Wickner, Herman K. Edskes, Marie-Lise Maddelein, Kimberly L. Taylor, Hiromitsu Moriyama
1999 Journal of Biological Chemistry  
Heterokaryon incompatibility is a normal event in the life of a fungus, with a physiological purpose.  ...  This work also revealed that prions can be the basis for inherited traits and initiated the use of the powerful yeast system to study this phenomenon.  ... 
doi:10.1074/jbc.274.2.555 pmid:9872986 fatcat:ggcb24avizhu3jzi6adm7ekuwa

Caenorhabditis elegans

2000 Yeast  
Such complimentary analyses can assist in the categorisation of chemicals for risk assessment purposes.  ...  by effects on system level resource allocation were associated with changes in gene expression following exposure to three toxic chemicals: cadmium, fluoranthene (FA) and atrazine (AZ).  ...  Acknowledgements This work was supported by a research grant from the UK Natural Environmental Research Council (NER/T/S/2001/00021) with additional support from AstraZeneca.  ... 
doi:10.1002/(sici)1097-0061(200004)17:1<37::aid-yea11>3.0.co;2-p pmid:10797600 pmcid:PMC2447038 fatcat:w3gvpbcagvhblpudtlbqshl5ya

Yeast Pol4 Promotes Tel1-Regulated Chromosomal Translocations

Jose F. Ruiz, Benjamin Pardo, Guillermo Sastre-Moreno, Andrés Aguilera, Luis Blanco, Sue Jinks-Robertson
2013 PLoS Genetics  
A major proportion of these events were specifically dependent on yeast DNA polymerase Pol4 activity.  ...  Herein, we have devised genetic assays in yeast to induce simultaneous DSBs in different chromosomes in vivo.  ...  Marcand for plasmids (pRS314-POL4, pRS314-pol4D367E) and yeast strains, T.H. Petes for the pKR5 plasmid, B. Gómez-González and F. Cortés-Ledesma for critical reading of the manuscript and D.  ... 
doi:10.1371/journal.pgen.1003656 pmid:23874240 pmcid:PMC3715435 fatcat:cnnaxza4qnfrdkja6jknaeetwu

Applications of computational modeling in metabolic engineering of yeast

Eduard J. Kerkhoven, Petri-Jaan Lahtvee, Jens Nielsen
2014 FEMS Yeast Research  
Generally, a microorganism's phenotype can be described by its pattern of metabolic fluxes. Although fluxes cannot be measured directly, inference of fluxes is well established.  ...  This review will give an overview about models available for metabolic engineering of yeast and discusses their applications.  ...  is generally referred to as systems biology.  ... 
doi:10.1111/1567-1364.12199 pmid:25156867 fatcat:vvc2mjqp3jb7fnjrftm6gvn2ty
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