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L'ouvrage de Zhang Yinde constitue une étude majeure consacrée à l'oeuvre de Mo Yan. ... La permanence de l'ironie dans l'écriture de Mo Yan motive Zhang Yinde à lui accorder le troisième chapitre de son étude. ...doi:10.1515/asia-2015-0044 fatcat:svn4jbfv7rfqrnqqve22lm4whu
The title of the book, "Mo Yan, le lieu de la fiction" (Mo Yan, the place of fiction), gives already an idea of the importance of territory in this study, as the focus is placed on one particular location ... Yinde Zhang leads us ably through Mo Yan's "creative and sensory journey." ...doi:10.4000/chinaperspectives.6875 fatcat:kswdszxelvapph7up65wz2hjw4
Paradoxical embolism (PDE) refers to direct passage of venous thrombi into the arterial circulation through an arteriovenous shunt. Case 1 presented with initial symptoms of shock and cerebral infarction. Case 2 developed middle cerebral artery occlusion during angiography. 2 cases were diagnosed as PDE. They received thrombolytic therapy and anticoagulant therapy. The patients had recovery. This report highlights the myriad clinical manifestations of PDE and underlines the importance ofdoi:10.1097/md.0000000000007332 pmid:28658147 pmcid:PMC5500069 fatcat:chsykfauazgubpnmdatw5tdbra
more »... ous history taking and physical examination for early diagnosis.
RT-qPCR was performed as previously described by Zhang et al (3) . The primer sequences are listed in Table II . Immunohistochemistry. ...doi:10.3892/ol.2019.10424 pmid:31423219 pmcid:PMC6607153 fatcat:3lufctgqqra4xewhz5p53srz2i
DOI  Zhang SX, Guo YQ, Boulianne GL. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. Gene, ... Zhang等  发现 一种新型的甲基转移酶(Melt)也能与loop区相结合, 第 33 卷 表 1 DPS 的结合蛋白与功能 结合蛋白 功能 文献来源 Notch 受体 DPS 的水解底物; 调控果蝇的生长与发育 [19, 20] Filamin 抑制 DPS 过量表达所造成的表型  Melt 促进 DPS 过量表达所造成的表型  Ubqn 拮抗 DPS 的功能, 引起细胞凋亡 ...doi:10.3724/sp.j.1005.2011.01164 pmid:22120070 fatcat:sc2xz2j4a5hondwynfbkybixnm
Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth, compared to other organs. Ovarian aging is considered as the pacemaker of female body aging, which drives the aging of multiple organs of the body. Hence, anti-ovarian aging hasdoi:10.18632/aging.101784 pmid:30674710 pmcid:PMC6366956 fatcat:oojoovd6cjcf7muxvuowaynx6q
more »... ecome a research topic broadly interesting to both biomedical scientists and pharmaceutical industry. A marked progress has been made in exploration of possible anti-ovarian agents or approaches, such as calorie restriction mimetics, antioxidants, autophagy inducers etc., over the past years. This review is attempted to discuss recent advances in the area of anti-ovarian aging pharmacology and to offer new insights into our better understanding of molecular mechanisms underlying ovarian aging, which might be informative for future prevention and treatment of ovarian aging and its related diseases.
Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53mediated myocardin transcription. Myocardin expression is upregulated upon H 2 O 2 and ischemia/reperfusion, and knockdown of myocardin inhibitsdoi:10.1038/s41467-017-02280-y pmid:29295976 pmcid:PMC5750208 fatcat:2gols6f6nfblzguht7gmtifctu
more »... y and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/ reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.
., 1991; Zhang et al., 1999) , saliva (Mithani et al., 2007; Wang et al., 2015) , and others. ... Analysis of protein biomarkers and nucleic acids has become very popular for cancer diagnosis (Huang et al., 2020) , risk stratification, and molecular targeting therapeutics (Zhang D. et al., 2019; ...doi:10.3389/fcell.2021.639233 pmid:33693004 pmcid:PMC7938321 fatcat:nojl4r5fvjeslhbtr7zbfa32ii
1. 河南大学黄河文明与可持续发展研究中心暨黄河文明传承与现代文明建设河南省协同创新中心, 开封 475001; 2. 河南大学环境与规划学院, 开封 475004) 摘要:集聚外部性是集聚影响工业污染排放的重要机制, 不同的集聚方式对应不同的污染排 放行为。以中国 31 个省市工业废水、 工业废气、 工业固废为例, 基于集聚外部性理论, 将工业集 聚分为专业化、 多样性、 相关多样性和非相关多样性等 4 种类型, 在分析工业污染排放强度空间 格局特征的基础上构建计量模型考察工业集聚与工业污染排放的关系, 结果表明: (1) 工业废 水、 废气、 固废污染强度的省域差异显著, 空间分布上均有不断集中的趋向。 (2) 多样性集聚比 专业化集聚更有利于降低工业污染排放强度。多样性集聚对工业废水强度下降的作用最大, 对废气和固废污染的减排作用较小。产业关联是多样性集聚发挥环境 "自净" 效应的重要条 件, 相关多样性有利于降低工业污染排放强度, 而非相关多样性会加剧污染排放。 (3) 从不同污 染型产业看, 废水污染型产业的专业化集聚有利于污染强度下降, 而废气和固废污染型产业专doi:10.31497/zrzyxb.20190312 fatcat:peymzzx2t5f7xogh2ierr25wfe
more »... 加剧污染排放, 污染型产业多样性发展均有利于污染强度下降。 (4) 不同集聚类型 对工业污染的影响存在着区域和污染类型的异质性。 (5) 要进一步降低工业污染, 应提高集聚 产业的多样化水平, 强化产业间的内在关联。同时, 应根据不同区域、 不同污染型产业、 不同工 业污染物制定差异化防治措施。 关键词:工业集聚; 相关多样性; 非相关多样性; 污染排放强度 产业集聚是基于分工深化而形成的空间组织形式,对国民经济发展有着重要的促进 作用 [1-2] 。然而,随着工业集聚程度上升,规模扩大和能耗增加所带来的诸如废水、废 气、固体废弃物正逐渐成为环境污染的主要源头。以 2015 年为例,全国工业 SO2占 SO2 排放总量的 83.73%,工业烟 (粉) 尘占烟 (粉) 尘排放总量的 80.14%。根据中华环保联 合会 2010 年对 18 家工业园区进行的一份调查显示,包括两家国家级、7 家省级、9 家县 市级在内的 18 家工业园区均存在不同程度的环境问题,其中水污染 18 家,占 100%,大 气污染 14 家,占 78%。所以,如何正确处理工业集聚与污染排放之间的关系已成为学术 界关注的重点问题。 当前,工业集聚对工业污染的影响已是人文-经济地理学科的研究热点之一 [3-4] ,学 术界对二者之间的关系形成了迥异的观点,核心争论是:工业集聚对污染而言是集中治
supported by the Beijing Municipal Administration of Hospital Ascent Plan (DFL20180701); Beijing Municipal Grant for Medical Talents Group on Peritoneal Surface Oncology (2017400003235J007) (both to Yan ...doi:10.21037/gs-20-893 pmid:33968683 pmcid:PMC8102231 fatcat:7ocgdolucbhnrk6ve44yc46724
The NMR data were in agreement with the literature values (Zhang 2001). Compound 6 was identified as ergosta-7,22-diene-3,6-dione. ... MTT assay In order to assay the cell toxicity with MTT method (Hussain 1993; Zhang 2000) , the hepG2 cells were divided into the BSA (Albumin from bovine serum) group and PA (palmitic acid) group. ...doi:10.6084/m9.figshare.5271505.v1 fatcat:vqnmyyernbakzl77odv6x3rsj4
Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibro-inflammatory condition. Forty-two cases with immunoglobulin G4-related sialadenitis (IgG4-RS) confirmed by histopathological and immunohistochemical assessment were studied to clarify the clinicopathologic characteristics of the salivary glands involved in IgG4-RS, especially the relationship between the histopathologic features and function of salivary glands or serum levels of IgG4. Methods: Clinical, serologic, imagingdoi:10.1186/s13075-015-0698-y pmid:26194097 pmcid:PMC4508811 fatcat:4jlqjcwh65cc5ozhbp457psptq
more »... d histopathological data of these cases were analyzed. CT volumes of submandibular, parotid, and lacrimal glands were calculated. The saliva flow rate was measured. Scintigraphy with 99mTc-pertechnetate was undertaken in 31 cases, and the concentration index (CI) and secretion index (SI) was calculated. Relationships between fibrosis severity and salivary gland function or serum IgG4 levels were analyzed. Results: The first symptom was swelling of bilateral submandibular or lacrimal glands. Physical examination showed multiple bilateral major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands were enlarged in IgG4 RS. Multiple enlarged cervical lymph nodes were noted in 30 patients. Saliva flow at rest was lower than normal in 34 cases; stimulated saliva flow was lower than normal in 15 cases. Secretory function was reduced more severely in the submandibular glands than in the parotid glands. Serum levels of IgG4 were elevated in 95.2% of cases and 78.6% patients had increased IgE levels. Serum IgG4 level was higher and saliva secretion lower as glandular fibrosis increased. Conclusions: Prominent changes in the morphology, histology, immunohistochemistry and secretion of the major salivary glands of IgG4-RS patients were accompanied by involvement of the lacrimal glands and cervical lymph nodes. Elevated IgE, allergic history, eosinophil infiltration suggest allergic reactions as a potential pathogenesis of IgG4-RS. Severity of glandular fibrosis correlated with salivary function and serum levels of IgG4.
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