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We also thank Dr Wei Zhu, Dr Yanming Fang for their guidance. ...arXiv:2207.11637v1 fatcat:dw4ddndjbbdnliu5j2hh6kibna
Hydrogen sulfide (H2S) has been recognized as the third gasotransmitter, following nitric oxide and carbon monoxide, and it exerts important biological effects in the body. Growing evidence has shown that H2S is involved in many physiological processes in the body. In recent years, much research has been carried out on the role of H2S in bone metabolism. Bone metabolic diseases have been linked to abnormal endogenous H2S functions and metabolism. It has been found that H2S plays an importantdoi:10.3389/fphar.2021.661601 fatcat:qildzyi2qjdwzfyhaddrznqkoi
more »... e in the regulation of bone diseases such as osteoporosis and osteoarthritis. Regulation of H2S on bone metabolism has many interacting signaling pathways at the molecular level, which play an important role in bone formation and absorption. H2S releasing agents (donors) have achieved significant effects in the treatment of metabolic bone diseases such as osteoporosis and osteoarthritis. In addition, H2S donors and related drugs have been widely used as research tools in basic biomedical research and may be explored as potential therapeutic agents in the future. Donors are used to study the mechanism and function of H2S as they release H2S through different mechanisms. Although H2S releasers have biological activity, their function can be inconsistent. Additionally, donors have different H2S release capabilities, which could lead to different effects. Side effects may form with the formation of H2S; however, it is unclear whether these side effects affect the biological effects of H2S. Therefore, it is necessary to study H2S donors in detail. In this review, we summarize the current information about H2S donors related to bone metabolism diseases and discuss some mechanisms and biological applications.
In 1977, archaeologists discovered the remains of a small east-west oriented city at the site of Wangchenggang 王 城岗 in Dengfeng 登封 County, Henan 河南 Province, which dated to the late Longshan period. The eastern part of the site was largely washed away by the Wudu 五渡 River, however the remaining western part of the site covered an area of roughly 8000 sq m. Inside the city the archaeologists discovered rammed earth structures which contained sacrificial victims in their foundations, as well asdoi:10.1515/char.2007.7.1.107 fatcat:pueo5ntnlzc2lja22hxm5ljbkm
more »... veral fragmentary pieces of bronze. Based on inscriptions and the archaeological discoveries of the time, the excavators suggested that this site may be the remains of the "Yangcheng 阳城 " founded by the Xia sovereign: Yu 禹. In 1996-2000, a division of the Xia-Shang-Zhou Chronology Project, "Research on the chronology of Xia Period: the early Xia Period analysis" collected samples from the late Longshan area of the site in order to ascertain its C 14 dates. In 2002-2005, two new archaeological projects were initiated around the site: "The pre-research on the origins of Chinese civilization project" carried out a surv e y o f t h e L o n g s h a n e r a s i t e s s u r r o u n d i n g Wangchenggang. The actual project later began archaeological work which focused on the periodization of the site, its structure, and settlement patterns in the surrounding area. During these two projects the ruins of a late Longshan period city was discovered. This city was found to have a surface area of over 300,000 sq m and was surrounded by a large moat. The northern wall of this city measured 350m long and 0.5-1.2m high. The northern moat measured 620m long, 15m wide and roughly 5m deep. The western moat measured 135m long, 15m wide and 1.5-2m deep. From the surrounding geography and cores taken across the site it became clear that the other moats and walls had been destroyed.
Nowadays consumer loan plays an important role in promoting the economic growth, and credit cards are the most popular consumer loan. One of the most essential parts in credit cards is the credit limit management. Traditionally, credit limits are adjusted based on limited heuristic strategies, which are developed by experienced professionals. In this paper, we present a data-driven approach to manage the credit limit intelligently. Firstly, a conditional independence testing is conducted toarXiv:2007.05188v1 fatcat:2uome7qm2vd3hdlz32hqnkkq64
more »... ire the data for building models. Based on these testing data, a response model is then built to measure the heterogeneous treatment effect of increasing credit limits (i.e. treatments) for different customers, who are depicted by several control variables (i.e. features). In order to incorporate the diminishing marginal effect, a carefully selected log transformation is introduced to the treatment variable. Moreover, the model's capability can be further enhanced by applying a non-linear transformation on features via GBDT encoding. Finally, a well-designed metric is proposed to properly measure the performances of compared methods. The experimental results demonstrate the effectiveness of the proposed approach.
The economic and banking importance of the small and medium enterprise (SME) sector is well recognized in contemporary society. Business credit loans are very important for the operation of SMEs, and the revenue is a key indicator of credit limit management. Therefore, it is very beneficial to construct a reliable revenue forecasting model. If the uncertainty of an enterprise's revenue forecasting can be estimated, a more proper credit limit can be granted. Natural gradient boosting approach,arXiv:2005.00718v1 fatcat:josy24qxxfbyrkft2icilygnpy
more »... ich estimates the uncertainty of prediction by a multi-parameter boosting algorithm based on the natural gradient. However, its original implementation is not easy to scale into big data scenarios, and computationally expensive compared to state-of-the-art tree-based models (such as XGBoost). In this paper, we propose a Scalable Natural Gradient Boosting Machines that is simple to implement, readily parallelizable, interpretable and yields high-quality predictive uncertainty estimates. According to the characteristics of revenue distribution, we derive an uncertainty quantification function. We demonstrate that our method can distinguish between samples that are accurate and inaccurate on revenue forecasting of SMEs. What's more, interpretability can be naturally obtained from the model, satisfying the financial needs.
Sugar transporters play important or even indispensable roles in sugar translocation among adjacent cells in the plant. They are mainly composed of sucrose–proton symporter SUT family members and SWEET family members. In rice, 5 and 21 members are identified in these transporter families, and some of their physiological functions have been characterized on the basis of gene knockout or knockdown strategies. Existing evidence shows that most SUT members play indispensable roles, while many SWEETdoi:10.3390/ijms222011198 pmid:34681858 pmcid:PMC8540626 fatcat:zuoy5l4oefblzinl3exyj7ahwu
more »... members are seemingly not so critical in plant growth and development regarding whether their mutants display an aberrant phenotype or not. Generally, the expressions of SUT and SWEET genes focus on the leaf, stem, and grain that represent the source, transport, and sink organs where carbohydrate production, allocation, and storage take place. Rice SUT and SWEET also play roles in both biotic and abiotic stress responses in addition to plant growth and development. At present, these sugar transporter gene regulation mechanisms are largely unclear. In this review, we compare the expressional profiles of these sugar transporter genes on the basis of chip data and elaborate their research advances. Some suggestions concerning future investigation are also proposed.
Quercus myrsinifolia Blume is an evergreen oak tree species native to East Asia, and is also one of the dominant trees of subtropical evergreen broad-leaved forests. In this study, we sequenced and analysed the complete chloroplast (cp) genome of the species. The circular genome is 160,803 bp in size, consisting of two copies of inverted repeat (IR) regions of 25,840 bp, one large single-copy (LSC) region of 90,223 bp, and one small single-copy (SSC) region of 18,900 bp. It encodes a total ofdoi:10.1080/23802359.2019.1667276 pmid:33365888 pmcid:PMC7706793 fatcat:uutmc73np5badcmd5ikxhyjfmq
more »... 4 unique genes, including 80 protein-coding genes, 30 tRNA genes, and four rRNA genes. Phylogenetic analysis based on 30 cp genome sequences indicated that Q. myrsinifolia was among the members of section Cyclobalanopsis, and was most closely related to Q. sichourensis.
The interspecific cross between Chrysanthemum 9 grandiflorum (Ramat.) Tzvel. 'rm20-12' (R, 2n = 54) and C. makinoi Matsum., and Nakai (M, 2n = 18) was achieved using embryo rescue, and a single backcross progeny using C. 9 grandiflorum 'rm20-12' as paternal parent was obtained. The morphology of the two independent F 1 hybrids (MR1 and MR2) differed from that of both parents. MR1 had a larger inflorescence diameter along with narrow leaves and a reduced number of ray and tubular florets. MR2doi:10.1007/s10681-010-0248-2 fatcat:fv67y2smfzcklm2q45uglcqv4a
more »... shorter and its inflorescence developed fewer tubular florets than either M or R. The BC 1 F 1 hybrid was similar to its maternal plant MR2 in terms of leaf length and width, inflorescence diameter and the number of ray florets, while it produced fewer tubular florets than either MR2 or R. The flower color in both F 1 hybrids was lavender, while the BC 1 F 1 plant bore purple flowers. The aphid resistance and heat tolerance of MR1, MR2 and the BC 1 F 1 hybrid were both significantly superior to that of C. 9 grandiflorum 'rm20-12'. Interspecific hybridization followed by backcrossing shows clear potential for cultivar improvement in chrysanthemum.
Quercus acutissima, an important endemic and ecological plant of the Quercus genus, is widely distributed throughout China. However, there have been few studies on its chloroplast genome. In this study, the complete chloroplast (cp) genome of Q. acutissima was sequenced, analyzed, and compared to four species in the Fagaceae family. The size of the Q. acutissima chloroplast genome is 161,124 bp, including one large single copy (LSC) region of 90,423 bp and one small single copy (SSC) region ofdoi:10.3390/ijms19082443 pmid:30126202 fatcat:4j4ffxz4zvbd3cyxmfwsre3e4u
more »... 9,068 bp, separated by two inverted repeat (IR) regions of 51,632 bp. The GC content of the whole genome is 36.08%, while those of LSC, SSC, and IR are 34.62%, 30.84%, and 42.78%, respectively. The Q. acutissima chloroplast genome encodes 136 genes, including 88 protein-coding genes, four ribosomal RNA genes, and 40 transfer RNA genes. In the repeat structure analysis, 31 forward and 22 inverted long repeats and 65 simple-sequence repeat loci were detected in the Q. acutissima cp genome. The existence of abundant simple-sequence repeat loci in the genome suggests the potential for future population genetic work. The genome comparison revealed that the LSC region is more divergent than the SSC and IR regions, and there is higher divergence in noncoding regions than in coding regions. The phylogenetic relationships of 25 species inferred that members of the Quercus genus do not form a clade and that Q. acutissima is closely related to Q. variabilis. This study identified the unique characteristics of the Q. acutissima cp genome, which will provide a theoretical basis for species identification and biological research.
There is currently an imbalance between the supply and demand of functional red blood cells (RBCs) in clinical applications, and this imbalance can be addressed by regenerating RBCs with a variety of in vitro methods. Induced pluripotent stem cells (iPSCs) can address the low supply of cord blood and the ethical issues in embryonic stem cell research and provide a promising strategy to eliminate immune rejection. However, no complete single-cell level differentiation pathway exists for thedoi:10.1101/859777 fatcat:d4o7vrcosrccngzwl4ohi7vywe
more »... derived RBC differentiation system. In this study, we used iPSC line BC1 to establish an RBC regeneration system and used the 10× Genomics single-cell transcriptome platform to map the cell lineage and differentiation trajectories on day 14 (D14) of the regeneration system. We found iPSC differentiation was not synchronized during embryoid body (EB) culture, and the D14 cells in the system mainly consisted of mesodermal and various blood cells, similar to yolk sac hematopoiesis. During asynchronous EB differentiation, iPSCs undergo three bifurcations before they enter erythroid differentiation, and the driver genes of each bifurcation were identified. The key roles of cell adhesion and estradiol in RBC regeneration were observed. This study provides systematically theoretical guidance for the optimization of the iPSC-derived RBC differentiation system.
The insulin-like growth factor binding protein 5 (IGFBP5), which is often dysregulated in human cancers, plays a crucial role in carcinogenesis and cancer development. However, the function and underlying mechanism of IGFBP5 in tumor growth and metastasis has been elusive, particularly in malignant human melanoma. Here, we reported that IGFBP5 acts as an important tumor suppressor in melanoma tumorigenicity and metastasis by a series of experiments including transwell assay, xenograft model, indoi:10.18632/oncotarget.4114 pmid:26010068 pmcid:PMC4653031 fatcat:wa3sy2ki7jdwrky7ynxrcfudwq
more »... vivo tumor metastasis experiment, and RNA-Seq. Overexpression of IGFBP5 in A375, a typical human melanoma cell line, inhibited cell malignant behaviors significantly, including in vitro proliferation, anchorage-independent growth, migration and invasion, as well as in vivo tumor growth and pulmonary metastasis. In addition, overexpression of IGFBP5 suppressed epithelial-mesenchymal transition (EMT), and decreased the expression of E-cadherin and the key stem cell markers NANOG, SOX2, OCT4, KLF4, and CD133. Furthermore, IGFBP5 exerts its inhibitory activities by reducing the phosphorylation of IGF1R, ERK1/2, and p38-MAPK kinases and abating the expression of HIF1α and its target genes, VEGF and MMP9. All these findings were confirmed by IGFBP5 knockdown in human melanoma cell line A2058. Taken together, these results shed light on the mechanism of IGFBP5 as a potential tumor-suppressor in melanoma progression, indicating that IGFBP5 might be a novel therapeutic target for human melanoma.
The present study was designed to clarify the effects of salinity and water intercross stresses on the growth and physiobiochemical characteristics ofTamarix chinensisseedlings by pots culture under the artificial simulated conditions. The growth, activities of SOD, POD, and contents of MDA and osmotic adjusting substances of three years old seedlings ofT. chinensiswere studied under different salt-drought intercross stress. Results showed that the influence of salt stress on growth was greaterdoi:10.1155/2014/765840 pmid:25140348 pmcid:PMC4130323 fatcat:4xfkk7qsavfnheeequ77h6gaxy
more »... than drought stress, the oxidation resistance of SOD and POD weakened gradually with salt and drought stresses intensified, and the content of MDA was higher under severe drought and mild and moderate salt stresses. The proline contents increased with the stress intensified but only significantly higher than control under the intercross stresses of severe salt-severe drought. It implied thatT. chinensiscould improve its stress resistance by adjusted self-growth and physiobiochemical characteristics, and the intercross compatibility ofT. chinensisto salt and drought stresses can enhance the salt resistance under appropriate drought stress, but the dominant factors influencing the physiological biochemical characteristics ofT. chinensiswere various with the changing of salt-drought intercross stresses gradients.
In this paper, the green development evaluation system and method which is useful in power grid were studied and established, and the indicators that affect the green development process of the power grid were analyzed and classified. In order to reflect the comprehensive indicators of the assessment indicators and their impact on the whole society, the system also includes indirect indicators of power generation enterprises, government and social organizations as the main body ofdoi:10.1051/e3sconf/201913601016 fatcat:njoxkik2nrfmpkcy7esqk2t3iq
more »... , as the expansion of the power grid's green development. In the calculation period, the TOPSIS method was introduced for evaluating the results and indicators of different companies in two provinces. This research will provide an important reference for energy companies to improve the internal assessment methods for environmental protection and green development.
(Li, Li, & Fang, 2018; Li, Li, Zang, et al., 2018) . Q. semecarpifolia and Q. engleriana, of Q. subg. Cerris sect. Ilex, are evergreen forest species endemic to China. ... ., & Fang, Y. (2021) . Evolutionary patterns of nucleotide substitution rates in plastid genomes of Quercus. Ecology and Evolution, 11, 13401-13414. https://doi. org/10.1002/ece3.8063 ...doi:10.1002/ece3.8063 pmid:34646478 pmcid:PMC8495791 fatcat:7urcft2yqbd6bkeumgq5mz57ca
Classical swine fever virus (CSFV) infection causes significant losses of pigs, which is characterized by hemorrhage, disseminated intravascular coagulation and leucopenia. The swine vascular endothelial cell is a primary target cell for CSFV. The aim of this study was to determine the role of CSFV infection in inducing oxidative stress (OS) in vascular endothelial cells. Results: We demonstrated that CSFV infection induced oxidative stress in swine umbilical vein endothelial cells (SUVECs),doi:10.1186/s12917-014-0279-3 pmid:25439655 pmcid:PMC4270048 fatcat:5wa4puiemjexndv753u2eej5yu
more »... racterized by the induction of reactive oxygen species (ROS) production and the elevations of porcine antioxidant proteins thioredoxin (Trx), peroxiredoxin-6 (PRDX-6) and heme oxygenase-1 (HO-1) expression. Furthermore, cyclooxygenase-2 (COX-2), a pro-inflammatory protein related to oxidative stress, was up-regulated while anti-inflammatory protein peroxisome proliferator-activated receptor-γ (PPAR-γ), an important mediator in vascular functional regulation, was down-regulated in the CSFV infected cells. In addition, antioxidants showed significant inhibitory effects on the CSFV replication, indicating a close relationship between CSFV replication and OS induced in the host cells. Conclusions: Our results indicated that CSFV infection induced oxidative stress in SUVECs. These findings provide novel information on the mechanism by which CSFV can alter intracellular events associated with the viral infection.
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