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Molecular Dynamics Simulations of Xe Behaviors at the Grain Boundary in UO2

Yaping Xia, Zhen Wang, Li Wang, Yangchun Chen, Zhixiao Liu, Qingqing Wang, Lu Wu, Huiqiu Deng
2022 Metals  
In this study, we investigated the behavior of xenon (Xe) bubbles in uranium dioxide (UO2) grain boundaries using molecular dynamics simulations and compared it to that in the UO2 bulk. The results show that the formation energy of Xe clusters at the Σ5 grain boundaries (GBs) is much lower than in the bulk. The diffusion activation energy of a single interstitial Xe atom at the GBs was approximately 1 eV lower than that in the bulk. Furthermore, the nucleation and growth of Xe bubbles in the Σ5
more » ... GBs at 1000 and 2000 K were simulated. The volume and pressure of bubbles with different numbers of Xe atoms were simulated. The bubble pressure dropped with increasing temperature at low Xe concentrations, whereas the volume increased. The radial distribution function was computed to explore the configuration evolution of Xe bubbles. The bubble structures in the GB and bulk material at the same temperature were also compared. Xe atoms were more regular in the bulk, whereas multiple Xe atoms formed a planar structure at the GBs.
doi:10.3390/met12050763 fatcat:rg47sktztvfirpretmudd27p2q

Localized bullous pemphigoid: a case report

Yiman Wang, Xuming Mao, Yangchun Liu, Li Li
2020 Annals of Translational Medicine  
Bullous pemphigoid (BP) is a senile autoimmune blistering disease with autoantibodies against the basement membrane. Less than 20 cases of localized BP in young adults have been reported and the understanding of localized BP is very limited. An unusual location of localized BP is here described. A 30-year-old woman presented with a 4-month history of itchy erythema on her trunk. The lesion, well-demarcated erythema and maculopapules in bra's shape, had been misdiagnosed as contact dermatitis.
more » ... boratory finding was notable for serum autoantibodies to BP antigen 180 (BP180). Histopathological examination revealed a subepidermal blister with eosinophils and neutrophils infiltration. Salt-split indirect immunofluorescence revealed linear deposition of IgG at the dermoepidermal junction. After treating her with minocycline 200 mg and nicotinamide 1,500 mg per day, all lesions resolved within 1 month. Localized BP is usually misdiagnosed. It starts from various triggers and has a more benign disease course. It should be emphasized that a long-term follow-up of patients with localized BP may be important for management of the chronic disease, given a relatively high risk of developing generalized BP.
doi:10.21037/atm.2020.01.104 pmid:32309396 pmcid:PMC7154478 fatcat:s3dm54c24ffmvp3fs6wax7btey

Low Levels of SPARC are Associated with Tumor Progression and Poor Prognosis in Human Endometrial Carcinoma

Ling Wang, Wei Wang, Yangchun Xu, Qiang Wang
2020 OncoTargets and Therapy  
OncoTargets and Therapy 2020:13 submit your manuscript | www.dovepress.com DovePress 11559 Dovepress Wang et al OncoTargets and Therapy downloaded from https://www.dovepress.com/ by 207.241.232.187 on  ...  OncoTargets and Therapy 2020:13 submit your manuscript | www.dovepress.com DovePress 11563 Dovepress Wang et al OncoTargets and Therapy downloaded from https://www.dovepress.com/ by 207.241.232.187 on  ... 
doi:10.2147/ott.s277795 pmid:33204109 pmcid:PMC7667597 fatcat:56bwoqt65jc5xjd32lln2k3mge

Further Study of Circulating Antibodies to P16, CD25 and FOXP3 in Hepatocellular Carcinoma

Jiaxin Wang, Yangchun Xu, Yanjun Wang, Xuan Zhang, Guizhen Zhang
2019 OncoTargets and Therapy  
Yanjun Wang and Yangchun Xu carried out recruitment of HCC patients and control subjects as well as collected clinical information.  ...  Jiaxin Wang designed and performed laboratory work, and drafted the manuscript.  ... 
doi:10.2147/ott.s226404 pmid:31819529 pmcid:PMC6897059 fatcat:b5krecar5jfzpdsq6rmsyiohum

Porosity in fiber laser formation of 5A06 aluminum alloy

Yangchun Yu, Chunming Wang, Xiyuan Hu, Jun Wang, Shengfu Yu
2010 Journal of Mechanical Science and Technology  
The mechanism of porosity formation and its suppression methods in laser formation of aluminum alloy have been studied using a 4kW fiber laser to weld 5A06 aluminum alloy with SAl-Mg5 filler. It was found that the porosity formation is closely related to the stability of the keyhole and fluctuation of the molten pool in the laser welding aluminum alloy. The filling wire increased the instability of the keyhole and weld pool, thus further increasing the amount of gas cavities in the joint.
more » ... rication of a suitable gap for the butt joint can provide a natural passage for the flow of the liquid metal, which can weaken, and even completely eliminate the disturbance of the filling wire on the formation of keyhole. The gap can also provide a passage for the escape of the bubble. Thus, this method can greatly decrease the sheet's susceptibility to porosity. Moreover, for a thin sheet, if the power of the laser is sufficient to form a keyhole with stable penetration through the weld sheet, a weld bead without porosity can also be obtained because closing the keyhole is almost impossible.
doi:10.1007/s12206-010-0309-4 fatcat:x6wjdhm7dja3bhjj3iriokzzha

Aquaporin 3 facilitates chemoresistance in gastric cancer cells to cisplatin via autophagy

Xuqiang Dong, Yao Wang, Yangchun Zhou, Jianfei Wen, Shoulin Wang, Lizong Shen
2016 Cell Death Discovery  
Cisplatin (cDDP) remains one of the first-line chemotherapeutic agents for gastric cancer (GC) treatment, and resistance to cDDP is the major limitation in its clinical application. Mechanisms of cDDP resistance have been shown to be varied and complicated. Aquaporin 3 (AQP3) has been demonstrated to be overexpressed in GC tissues and is thought to be involved in GC carcinogenesis and progression. However, the role of AQP3 in chemosensitivity of GC to cytotoxic agents remains unknown. In this
more » ... udy, we show that AQP3 overexpression induced resistance to cDDP in AGS cells (Po0.05), and AQP3 knockdown increased the chemosensitivity in MGC803 and SGC7901 cells (Po0.05). Moreover, cDDP treatment enhanced AQP3 expression in MGC803, SGC7901 and AGS cells. AQP3 overexpression promoted the conversion of LC3-I to LC3-II in AGS cells, whereas AQP3 knockdown inhibited this conversion in MGC803 and SGC7901 cells. AQP3 upregulation increased Atg5 and Beclin-1 expression, and inhibited P62 expression in AGS cells, whereas AQP3 knockdown showed the opposite results in MGC803 and SGC7901 cells. Chloroquine (CQ), an autophagy inhibitor, enhanced the cytotoxicity of cDDP in GC cells, and CQ reversed the chemoresistance to cDDP caused by AQP3 overexpression in GC cells. Together, our data demonstrate that AQP3 facilitates cisplatin resistance in gastric cancer cells via autophagy, and suggest that the development of AQP3-based tumor therapeutics could play a key role in future GC treatment strategies.
doi:10.1038/cddiscovery.2016.87 pmid:27867537 pmcid:PMC5107998 fatcat:bimaqlc4dng6vooubjgfjjuhvq

Application of Financial Cloud in the Sustainable Development of Smart Cities

Yangchun Cao, Guangyu Zhang, Chunyao Ou, Wei Wang
2020 Complexity  
This article first investigates the status of financial cloud development in smart cities and studies the sustainable development of smart cities. Secondly, it investigates the construction of the evaluation model, using the power of the financial cloud, through exploratory factor analysis, selecting the principal component analysis method to extract the factors, for screening and dimensionality reduction of the indicators, and making hypotheses. We used confirmatory factor analysis to
more » ... the structural equation. The measurement model analyzes and validates the assumptions of the previous stage and finally determines the sustainable development evaluation index system. Then, starting from the scoring coefficient matrix of the exploratory factor analysis of the final model, the variance contribution rate of each common factor is weighted to construct a comprehensive evaluation model to calculate the comprehensive evaluation score. For the comprehensive evaluation score of the sustainable development level of the smart city, SPSS software performs cluster analysis, performs regional clustering, and determines the level of urban development. Finally, by comparing the sustainable development levels of smart cities, the related causes of the gaps are analyzed. Key factors affecting the sustainable development of smart cities are identified, and corresponding countermeasures are proposed.
doi:10.1155/2020/8882253 fatcat:tctam3syqzcelkdv24jl7jvwui

Investor Sentiment and the Predictability of Asset Returns: Evidence from China

Changsheng Hu, Yongfeng Wang, Yangchun Chi
2013 Social Science Research Network  
In contrast to previous studies, we redefine the category of "rationality" from the perspective of investors' pursuit for wealth maximization. Using the data from Chinese stock market, this paper studies the impact of rational and irrational sentiment on asset returns from short-term to long-run. We find that irrational sentiment has stable positive predictability on the future returns in short term while it is a reverse indicator in the long run. Meanwhile, the rational sentiment accurately
more » ... ecasts both the future short-term and long-run returns. Our findings indicate that the predictability of investor sentiment on returns is closely related to time interval chosen in research and the level of feedback between investor sentiment and asset prices. Keywords: rational sentiment, irrational sentiment, predictability of asset returns _____________________________________________________________________________________________ Changsheng Hu et al J. Chem. Pharm. Res., 2014, 6(6):577-585 ____________________________________________________________________________
doi:10.2139/ssrn.2198751 fatcat:xxzdexwwivaebar52l623cuv4e

Effects of Point Defects on the Stable Occupation, Diffusion and Nucleation of Xe and Kr in UO2

Li Wang, Zhen Wang, Yaping Xia, Yangchun Chen, Zhixiao Liu, Qingqing Wang, Lu Wu, Wangyu Hu, Huiqiu Deng
2022 Metals  
(Li Wang), Z.W., Y.X., Y.C., Z.L., Q.W. and W.H.; validation, Y.X., Z.W., L.W. (Li Wang), Y.C., Z.L., Q.W. and L.W. (Lu Wu); formal analysis, L.W.  ...  (Li Wang), Z.W., Y.X., Y.C., Z.L. and Q.W.; investigation, L.W. (Li Wang); resources, Z.W., Z.L. and Q.W.; data curation, Y.C. and W.H.; writing-original draft, L.W.  ... 
doi:10.3390/met12050789 fatcat:c5jlpr7esraj7nlabbst5ijl2a

Nitrogen Management Based on Visible/Near Infrared Spectroscopy in Pear Orchards

Jie Wang, Xiaojun Shi, Yangchun Xu, Caixia Dong
2021 Remote Sensing  
Figure S1 the schematic diagram of spectral acquisition by the plant probe and leaf clip (picture was adapt from Wang et al., 2017) .  ...  Wang et al. (2015) demonstrated that it was more useful to estimate the area-based leaf N content (expressed by the unit of g/cm 2 ) than that of the mass-based leaf N content (expressed by the unit of  ... 
doi:10.3390/rs13050927 doaj:8423159de73241958782cf160a2a171f fatcat:5ulhbbn4xzg5hb4ftu4immdh4u

Potential role of aquaporin 3 in gastric intestinal metaplasia

Haijian Zhao, Xiaojun Yang, Yangchun Zhou, Weiming Zhang, Yao Wang, Jianfei Wen, Zhihong Zhang, Lizong Shen
2015 OncoTarget  
Gastric intestinal metaplasia (GIM) is a pre-cancerous condition and a pivotal step in the formation of gastric cancer (GC). Aquaporin 3 (AQP3) has been found to be expressed in goblet cells rather than mucus-secreting glands. To investigate the characteristics of GIM in non-cancerous tissues adjacent to GC, as well as the expression and role of AQP3 in GIM tissues, 16 patients diagnosed with gastric adenocarcinoma of intestinal type located in the lesser curve of the antrum were consecutively
more » ... nrolled in this study. A new pathological technology called "gastric mucosal sausage roll" was introduced. GIM was determined according to the updated Sydney system, and AQP3 expression in goblet cells was determined by immunohistochemistry. GIM was found in all stomach specimens, and its incidence increased with progression to GC (P < 0.001). GIM prevalence displayed remarkable association with the distance to GC in the anterior gastric wall tissues (P = 0.016) and tissues toward the cardia (P = 0.014), such that GIM was more common in the areas closer to GC (P < 0.001). AQP3 was found to be expressed in 67.71% of parts with GIM, and AQP3 immunoreactivity was identified more frequently in severe GIM areas (P < 0.001). In short, the incidence and severity of GIM correlated with the distance from GC, and AQP3 was differentially expressed in goblet cells, with most AQP3-positive goblet cells presenting in severe GIM. Together, this study suggests that AQP3 may play an important role in gastric carcinogenesis from GIM.
doi:10.18632/oncotarget.5370 pmid:26506416 pmcid:PMC4770747 fatcat:fdlynckifvdanf424nudaz5y7e

Parasites and competitors suppress bacterial pathogen synergistically due to evolutionary trade-offs

Xiaofang Wang, Zhong Wei, Mei Li, Xueqi Wang, Anqi Shan, Xinlan Mei, Alexandre Jousset, Qirong Shen, Yangchun Xu, Ville-Petri Friman
2016 Evolution  
Parasites and competitors are important for regulating pathogen densities and subsequent disease dynamics. It is, however, unclear to what extent this is driven by ecological and evolutionary processes. Here, we used experimental evolution to study the eco-evolutionary feedbacks among Ralstonia solanacearum bacterial pathogen, Ralstonia-specific phage parasite, and Bacillus amyloliquefaciens competitor bacterium in the laboratory and plant rhizosphere. We found that while the phage had a small
more » ... ffect on pathogen densities on its own, it considerably increased the R. solanacearum sensitivity to antibiotics produced by B. amyloliquefaciens. Instead of density effects, this synergy was due to phage-driven increase in phage resistance that led to trade-off with the resistance to B. amyloliquefaciens antibiotics. While no evidence was found for pathogen resistance evolution to B. amyloliquefaciens antibiotics, the fitness cost of adaptation (reduced growth) was highest when the pathogen had evolved in the presence of both parasite and competitor. Qualitatively similar patterns were found between laboratory and greenhouse experiments even though the evolution of phage resistance was considerably attenuated in the tomato rhizosphere. These results suggest that evolutionary trade-offs can impose strong constraints on disease dynamics and that combining phages and antibioticproducing bacteria could be an efficient way to control agricultural pathogens. K E Y W O R D S : Experimental evolution, fitness cost, interference competition, phage therapy, Ralstonia solanacearum, trade-off.
doi:10.1111/evo.13143 pmid:27925169 pmcid:PMC5347860 fatcat:vzfz4ebglnf6vnrz3uby62z7sq

The adsorption and aggregation properties of dendritic cationic tetrameric surfactants

Yangchun Xie, Jie Li, Zuofeng Li, Tong Sun, Yipeng Wang, Guangmiao Qu
2018 RSC Advances  
Wang, 34, 35 and many fundamental studies have begun to spring up.  ...  Wang and coworker 16, 17, [34] [35] [36] [37] synthesized a series of oligomeric surfactants and studied their physicochemical properties in the solution, in which the star-shaped hexameric quaternary  ... 
doi:10.1039/c8ra06900j pmid:35558498 pmcid:PMC9088746 fatcat:66vmkes56va2zihrnmzvdadvpy

Addressing severe slope failure hazards along Sichuan-Tibet Highway in Southwestern China

Shang Yanjun, Yue Zhongqi, Yang Zhifa, Wang Yangchun, Liu Da'an
2003 Episodes  
This paper presents the results of recent field investigations on the geological hazards along the Sichuan-Tibet Highway in Southwestern China. It was found that one section of the highway has been facing severe problems in slope failure. This is the section between Linzhi and Basu and it has been the most dangerous part of the highway system to road users over the last fifty years. Based on the examination of structural geology, Quaternary geology, stratigraphy and petrography, this paper
more » ... nts the classification, distribution and hazard levels of the slope failures along the highway section. The failures usually occurred in slopes comprising Quaternary glacial deposits, fluvio-lacustrine deposits and residual soils. They can be classified as landslides, mud-rock flows, grain flows on slopes and rock avalanches. They are caused by four main factors: a) intense active tectonic movements, b) on-going alpine canyon relief, c) heavy precipitation and d) irrational human activities. The paper further discusses the engineering measures adopted by the relevant organizations over the past fifty years. Based on the investigations, the paper summarizes some useful recommendations to effectively address and mitigate the severe slope failure hazard problem for safe operation of the highway and future railway systems.
doi:10.18814/epiiugs/2003/v26i2/003 fatcat:5s32pdxv3bcbvdy2c4fqzbqd3y

Introduction of a precocious metamorphosis BmNPV infection in the latter half of the fifth instar silkworm larvae [article]

Pingzhen Xu, meirong zhang, xueyang wang, yangchun wu
2020 bioRxiv   pre-print
Xueyang Wang 475 prepared the illustrations and collected the data; Yangchun Wu suggested important 476 research points. All authors have read and approved the final version of the 477 manuscript.  ...  Dong XL, Liu TH, Wang W, Pan CX, Du GY, Wu YF, et al. BmNHR96 participate BV entry of BmN-SWU1 cells via affecting the 599 cellular cholesterol level. Biochem Biophys Res Commun. ):1484-90.  ... 
doi:10.1101/2020.09.24.311290 fatcat:g3xzpdbjqzdtfkexb7d4p6hk6i
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