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We study simultaneous photonic and phononic crystal slabs created in Z-cut lithium niobate membranes. Bandgaps for guided waves are identified using the three-dimensional finite element method (FEM). Three lattices are considered: the square, the hexagonal, and the honeycomb lattices. We investigate the evolution of band gaps as a function of geometrical parameters such as hole radius and membrane thickness. We show the existence of dual photonic and phononic bandgaps in the triangular latticedoi:10.1364/oe.22.016288 pmid:24977880 fatcat:swvwcmi4nnd5hiwd2uk5aop3oy
more »... or suitable geometrical parameters and specific modal symmetries for both the elastic and the electromagnetic fields.
Rolland are consultants for Boston Scientific. The authors declare no other conflict of interest. ...doi:10.3390/cancers12061557 pmid:32545572 pmcid:PMC7353030 fatcat:yvc6dkddrvbobm7y4edj2ex4uq
In this short paper, accelerated three-dimensional computer simulations of vascular trees development, preserving physiological and haemodynamic features, are reported. The new computation schemes deal: (i) with the geometrical optimization of each newly created bifurcation; and (ii) with the recalculation of blood pressures and radii of vessels in the whole tree. A significant decrease of the computation time is obtained by replacing the global optimization by the fast updating algorithmdoi:10.1016/s0169-2607(01)00200-0 pmid:12507789 fatcat:5qr3didcl5aptijgghske75hvm
more »... ng more complex structure to be simulated. A comparison between the new algorithms and the previous one is illustrated through the hepatic arterial tree.
Duris K, Manaenko A, Suzuki H, Rolland W, Tang J, Zhang JH. Sampling of CSF via the cisterna magna and blood collection via the heart affects brain water content in a rat SAH model. ... Duris K, Manaenko A, Suzuki H, Rolland WB, Krafft PR, Zhang JH. α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in ...doi:10.1007/s12975-013-0257-2 pmid:23894255 pmcid:PMC3719879 fatcat:2w4pf63akjfzfmdf4xlfemvhge
The objective of this study is to show how computational modeling can be used to increase our understanding of liver enhancement in dynamic computer tomography. It relies on two models: (1) a vascular model, based on physiological rules, is used to generate the 3D hepatic vascular network; (2) the physical process of CT acquisition allows to synthesize timed-stamped series of images, aimed at tracking the propagation of a contrast material through the vessel network and the parenchyma. Thedoi:10.1016/s0010-4825(02)00056-2 pmid:12485631 fatcat:mbtchbwuavamta5mkm4uftjz2i
more »... ed models are used to simulate the enhancement of a hyper-vascular tumor at di erent acquisition times, showing a maximum conspicuity during the arterial phase. ?
Etienne Garin ⇑ Yan Rolland Eveline Boucher Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France ⇑ Corresponding author. ...doi:10.1016/j.jhep.2012.11.050 pmid:23318603 fatcat:lm7a7quntfgy3kx6qp6g6r4noe
International Symposium on Optoelectronic Technology and Application 2014: Imaging Spectroscopy; and Telescopes and Large Optics
The papers included in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. The papers published in these proceedings reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting fromdoi:10.1117/12.2178979 fatcat:lqb5fc64dfcwfgbhv4ozrg2qdy
more »... liance thereon. Please use the following format to cite material from this book: Publication of record for individual papers is online in the SPIE Digital Library. SPIEDigitalLibrary.org Paper Numbering: Proceedings of SPIE follow an e-First publication model, with papers published first online and then in print and on CD-ROM. Papers are published as they are submitted and meet publication criteria. A unique, consistent, permanent citation identifier (CID) number is assigned to each article at the time of the first publication. Utilization of CIDs allows articles to be fully citable as soon as they are published online, and connects the same identifier to all online, print, and electronic versions of the publication. SPIE uses a six-digit CID article numbering system in which: The first four digits correspond to the SPIE volume number. The last two digits indicate publication order within the volume using a Base 36 numbering system employing both numerals and letters. These two-number sets start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B ... 0Z, followed by 10-1Z, 20-2Z, etc. The CID Number appears on each page of the manuscript. The complete citation is used on the first page, and an abbreviated version on subsequent pages. Numbers in the index correspond to the last two digits of the six-digit CID Number.
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, the mechanism of sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in the control of cholesterol homeostasis, is expressed in the intestine, but its role in this organ remains unclear. We have generated transgenic mice over-expressing SR-BI primarily in the intestine by using the mouse SR-BI gene under the control of intestinal specificdoi:10.1074/jbc.m508868200 pmid:16421100 pmcid:PMC2034750 fatcat:yenfviu4lzaizii6lrscqgea5m
more »... "apolipoprotein (apo) C-III enhancer coupled with apo A-IV promoter". We found SR-BI overexpression with respect to the natural protein along the intestine and at the top of the villosities. After feeding a meal containing 14 C cholesterol and 3 H triolein, SR-BI transgenic mice presented a rise of intestinal absorption of both lipids that was not due to a defect in chylomicron clearance nor to a change in the bile flow or the bile acid content. Nevertheless, SR-BI transgenic mice showed a decrease of total cholesterol, but an increase of triglyceride content in plasma without any change in the HDL apo A-I level. Thus, we describe for the first time a functional role in vivo for SR-BI in cholesterol but also in triglyceride intestinal absorption.
, Yan  URL de la notice ... bone samples: Influence of slice thickness Type de publication Article de revue Auteur Guggenbuhl, Pascal , Chappard, Daniel , Garreau, Mireille , Bansard, Jean-Yves , Chalès, Gérard , Rolland ...doi:10.1016/j.ejrad.2007.08.003 pmid:17869469 fatcat:r322h23w3fafxhvlviv2evyfey
Selective internal radiation therapy (SIRT) is an innovative treatment of hepatocellular carcinoma (HCC). The albumin-bilirubin (ALBI) score was designed to better evaluate liver functions in HCC. Methods: We studied, retrospectively, data from patients treated with SIRT for HCC. The primary endpoint was the occurrence of radioembolization-induced liver disease (REILD). The secondary endpoint was overall survival (OS). Results: 222 patients were studied. The ALBI grade 1 patients haddoi:10.3390/cancers13153794 fatcat:gjxg3eee4nhulfpu2tkjttgbku
more »... ly less REILD (3.4%) after the first SIRT than ALBI grade 2 or 3 patients (16.8%, p = 0.002). Of the 207 patients with data, 77 (37.2%) had a worsening of ALBI grade after one SIRT. The baseline ALBI grade was significantly associated with OS (p = 0.001), also in the multivariable analysis. The ALBI grade after the first SIRT was significantly associated with OS (p ≤ 0.001), with median OS of 26.4 months (CI 95% 18.2–34.7) for ALBI grade 1 patients (n = 48) versus 17.3 months (CI 95% 12.9–21.8) for ALBI grade 2 patients (n = 123) and 8.1 months (CI 95% 4.1–12.1) for ALBI grade 3 patients (n = 36). Conclusions: The baseline ALBI grade is a strong predictor of REILD. The baseline ALBI score and variations of ALBI are prognostic after SIRT.
Subarachnoid hemorrhage (SAH) results in significant long-lasting cognitive dysfunction. Therefore, evaluating acute and long-term outcomes after therapeutic intervention is important for clinical translation. The aim of this study was to use minocycline, a known neuroprotectant agent, to evaluate the long-term benefits in terms of neurobehavior and neuropathology after experimental SAH in rats, and to determine which neurobehavioral test would be effective for long-term evaluation. SAH wasdoi:10.1089/neu.2011.1864 pmid:22013966 pmcid:PMC3235340 fatcat:mbqw7a3cpnerfjgovxemm4uvya
more »... ced by endovascular perforation in adult male Sprague-Dawley rats (n = 118). The animals were treated with intraperitoneal injection of minocycline (45 mg/kg or 135 mg/kg) or vehicle 1 h after SAH induction. In the short-term, animals were euthanized at 24 and 72 h for evaluation of neurobehavior, brain water content, and matrix metalloproteinase (MMP) activity. In the longterm, neurobehavior was evaluated at days 21-28 post-SAH, and histopathological analysis was done at day 28. High-dose but not low-dose minocycline reduced brain water content at 24 h, and therefore only the high-dose regimen was used for further evaluation, which reduced MMP-9 activity at 24 h. Further, high-dose minocycline improved spatial memory and attenuated neuronal loss in the hippocampus and cortex. The rotarod, T-maze, and water maze tests, but not the inclined plane test, detected neurobehavioral deficits in SAH rats at days 21-28. This study demonstrates that minocycline attenuates long-term functional and morphological outcomes after endovascular perforation-induced SAH. Long-term neurobehavioral assessments using the rotarod, T-maze, and water maze tests could be useful to evaluate the efficacy of therapeutic intervention after experimental SAH.
Journal of Virology
The extensive diversity of human immunodeficiency virus type 1 (HIV-1) and its capacity to mutate and escape host immune responses are major challenges for AIDS vaccine development. Ancestral sequences, which minimize the genetic distance to circulating strains, provide an opportunity to design immunogens with the potential to elicit broad recognition of HIV epitopes. We developed a phylogenetics-informed algorithm to reconstruct ancestral HIV sequences, called Center of Tree (COT). COTdoi:10.1128/jvi.02683-06 pmid:17537854 pmcid:PMC1951385 fatcat:hb3ghqg5crhylceq53j6c4oa5y
more »... s have potentially significant benefits over isolate-based strategies, as they minimize the evolutionary distances to circulating strains. COT sequences are designed to surmount the potential pitfalls stemming from sampling bias with the consensus method and outlier bias with the most-recent-common-ancestor approach. We computationally derived COT sequences from circulating HIV-1 subtype B sequences for the genes encoding the major viral structural protein (Gag) and two regulatory proteins, Tat and Nef. COT genes were synthesized de novo and expressed in mammalian cells, and the proteins were characterized. COT Gag was shown to generate virus-like particles, while COT Tat transactivated gene expression from the HIV-1 long terminal repeat and COT Nef mediated downregulation of cell surface major histocompatibility complex class I. Thus, retrodicted ancestral COT proteins can retain the biological functions of extant HIV-1 proteins. Additionally, COT proteins were immunogenic, as they elicited antigen-specific cytotoxic T-lymphocyte responses in mice. These data support the utility of the COT approach to create novel and biologically active ancestral proteins as a starting point for studies of the structure, function, and biological fitness of highly variable genes, as well as for the rational design of globally relevant vaccine candidates.
Although bone marrow aspiration (BMA) is still considered a painful procedure, pain level remains poorly documented. We therefore conducted a prospective study intended to evaluate pain level in adult patients undergoing BMA at the sternal or iliac crest site to identify factors associated with pain. We enrolled a total of 448 patients who underwent 461 BMA and asked those patients to score their pain intensity after BMA using numerical pain rating scale (NPRS). The following factors: level ofdoi:10.1371/journal.pone.0221534 pmid:31465426 pmcid:PMC6715342 fatcat:oeo6qqvcu5h6fgrsuknlzhvcee
more »... nxiety, quality of the information given to the patient, operator's experience, and bone texture were recorded using a standardized questionnaire. The median NPRS score was 3.5 (IQR [2.0; 5.0]) the sternal site (n = 405) was associated with an increased median NPRS score (3.5 [2.0; 5.0]) compared to the iliac crest (n = 56, 2.5 [1.0; 4.0]; p<0.0001). For those patients who underwent sternal BMA, the median NPRS score was significantly lower when using lidocaine infiltration (p = 0.0159) as compared with no anesthetic use. Additionally there was no significant effect of anesthetic cream found. After multivariate analysis, the model of NPRS score at the sternal site included patient anxiety (p<0.0001) and the use of lidocaine infiltration (0.0378). This study underlines the usefulness of a comprehensive management including pain relief and efforts to reduce anxiety including appropriate information given to the patient during BMA.
Radioembolization with 90 Y-loaded microspheres is increasingly used in the treatment of primary and secondary liver cancer. Technetium-99 m macroaggregated albumin (MAA) scintigraphy is used as a surrogate of microsphere distribution to assess lung or digestive shunting prior to therapy, based on tumoral targeting and dosimetry. To date, this has been the sole pre-therapeutic tool available for such evaluation. Several dosimetric approaches have been described using both glass and resindoi:10.1007/s00259-015-3157-8 pmid:26338177 pmcid:PMC4731431 fatcat:pof4z33w7rejhpqjulkqpt7ff4
more »... heres in hepatocellular carcinoma (HCC) and liver metastasis. Given that each product offers different specific activities and numbers of spheres injected, their radiobiological properties are believed to lightly differ. This paper summarizes and discusses the available studies focused on MAA-based dosimetry, particularly concentrating on potential confounding factors like clinical context, tumor size, cirrhosis, previous or concomitant therapy, and product used. In terms of the impact of tumoral dose in HCC, the results were concordant and a response relationship and tumoral threshold dose was clearly identified, especially in studies using glass microspheres. Tumoral dose has also been found to influence survival. The concept of treatment intensification has recently been introduced, yet despite several studies publishing interesting findings on the tumor dosemetastasis relationship, no consensus has been reached, and further clarification is thus required. Nor has the maximal tolerated dose to the liver been well documented, requiring more accurate evaluation. Lung dose was well described, despite recently identified factors influencing its evaluation, requiring further assessment. Conclusion: MAA SPECT/CT dosimetry is accurate in HCC and can now be used in order to achieve a fully customized approach, including treatment intensification. Yet further studies are warranted for the metastasis setting and evaluating the maximal tolerated liver dose.
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