A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is
Bloch oscillations (BOs) refer to a periodically oscillatory motion of particle in lattice systems driven by a constant force. By temporally modulating acoustic waveguides, BOs can be generalized from spatial to frequency domain, opening new possibilities for spectrum manipulations. The modulation can induce mode transitions in the waveguide band and form an artificial frequency lattice, with the mismatched wave vector during transitions acting as a constant force that drives frequency BlocharXiv:1811.07121v1 fatcat:skfgk4oixbadzagjszus3sttnq
more »... illations (FBOs). Furthermore, the modulation phase accompanying transitions serves as a gauge potential that controls the initial oscillation phase, providing an additional degree of freedom to tailor FBOs. We report that multiple FBOs with judiciously designed oscillation phases can be further cascaded to realize acoustic spectrum self-imaging, unidirectional transduction and bandwidth engineering. The study proposes the concept of FBOs in acoustic systems and functionalizes its cascade configurations for advanced control of sound spectrum. This paradigm may find versatile applications in underwater secure communication, voice encryption and signal processing.
Conflict of Interest Authors Dekker, Bai, Oldenburg, Qiu, and Zhong declare that they have no conflict of interest. ...doi:10.1007/s12529-014-9419-1 pmid:24898631 fatcat:zu4b7daykrhh3dbuen6pepfidi
Semen-derived amyloid fibrils, composing SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, could remarkably enhance HIV-1 sexual transmission and thus, are potential targets for the development of an effective microbicide. Previously, we found that ADS-J1, apart from being an HIV-1 entry inhibitor, could also potently inhibit seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. However, the remodeling effects of ADS-J1 on maturedoi:10.1101/292342 fatcat:x7f3lspimjdjljzhepf3dwpc4m
more »... l fibrils were unexplored. Herein, we investigated the capacity of ADS-J1 to disassemble seminal fibrils and the potential mode of action by applying several biophysical and biochemical measurements, combined with molecular dynamic (MD) simulations. We found that ADS-J1 effectively remodeled SEVI, SEM186-107 fibrils and endogenous seminal fibrils. Unlike epi-gallocatechin gallate (EGCG), a universal amyloid fibril breaker, ADS-J1 disaggregated SEVI fibrils into monomeric peptides, which was independent of oxidation reaction. MD simulations revealed that ADS-J1 displayed strong binding potency to the full-length PAP248-286 via electrostatic interactions, hydrophobic interactions and hydrogen bonds. ADS-J1 might initially bind to the fibrillar surface and then occupy the amyloid core, which eventually lead to fibril disassembly. Furthermore, the binding of ADS-J1 with PAP248-286 might induce conformational changes of PAP248-286. Disassembled PAP248-286 might not be favor to re-aggregate into fibrils. ADS-J1 also exerts abilities to remodel a panel of amyloid fibrils, including Aβ1-42, hIAPP1-37 and EP2 fibrils. ADS-J1 displays promising potential to be a combination microbicide and an effective lead-product to treat amyloidogenic diseases.
Acknowledgments: We thank the members of the Qiu lab for technical support and valuable discussions. ...doi:10.3390/genes11040439 pmid:32316599 pmcid:PMC7231168 fatcat:tds7h3v33jf43bvpld7lbyz4aq
current Yeh et al.  InGaN/GaN QW 465 Au A dip in transmission in 511 nm 180% with a 20-mA current Sung et al.  Organic poly 575 Ag Large absorption from 330 to 500 nm Sixfold Qiu ...doi:10.1186/1556-276x-6-199 pmid:21711711 pmcid:PMC3211255 fatcat:eggvhodiyvegxajzzcxntmegmm
In this paper, the anisotropic mechanical properties of rolled AZ31 magnesium alloys are investigated using nanoindentation tests at room temperature. Nanoindentation was carried out at four angles, including the rolling direction (0°), diagonal direction (45°), transverse direction (90°), and vertical direction (ND). Experimental results show that hardness increases as the rolling angle increases from 0° to 90° and is lowest in the ND direction. The hardness independent of the effect ofdoi:10.3390/app10248997 fatcat:yxcxw5hljva47j5f2n6a53nmfe
more »... tion depth is obtained by analyzing the indentation size effect and then converting hardness values into yield strengths. A new criterion is proposed on the basis of the Hill48 yield criterion. The data obtained through the above experiments are used to determine the parameters in the new criterion. Finally, a solution to the challenge of modeling a function that accurately describes the anisotropic yielding behavior of AZ31 magnesium alloys is proposed using the nanoindentation technique to solve the requirements of specimen size and experimental methods of the macro test.
In view of the limitation of the traditional installation method of the shaker placed on the floor structure, a method of foundation isolation based on the AIR spring is proposed. According to the dynamic characteristics of the AIR spring, the relationship between the natural frequency and the parameters, such as the air pressure and the weight of the load, are analyzed. In order to evaluate the coupling properties between the vibration isolation system and the vibration test system, thedoi:10.21595/vp.2017.19278 fatcat:dmgjh72aijdypmivytfwgqe34q
more »... affecting the vibration isolation transfer function of the system and the response of the foundation under vibration excitation were analyzed. Test results revealed that: it is feasible to adjust the natural frequency of system, to obtain the good isolation performance and stationary dynamic response, by reasonably choosing the structural parameters of the AIR spring and adjusting the internal inflation pressure of spring.
Little is known about the biological behavior of Xp11.2 translocation renal cell carcinomas (RCCs) as few clinical studies have been performed using a large sample size. Methods: This study included 103 consecutive young adult patients (age ≤ 45 years) with RCC who underwent partial or radical nephrectomy at our institution from 2008 to 2013. Five patients without complete clinical data were excluded. Of the 98 remaining patients, 16 and 82 patients were included in the Xp11.2 translocation anddoi:10.1186/s12894-015-0055-0 pmid:26126525 pmcid:PMC4487560 fatcat:2kv5a3kcivderdz2ni5wpjhw5e
more »... non-Xp11.2 translocation groups, respectively. Clinicopathologic data were collected, including age, gender, tumor size, laterality, symptoms at diagnosis, surgical procedure, pathologic stage, tumor grade, time of recurrence and death. Results: Xp11.2 translocation RCCs were associated with higher tumor grade and pathologic stage (P < 0.05, Fisher's exact test). During the median follow-up of 36 months (range: 3-71 months), the number of cancer-related deaths was 4 (4.9 %) and 3 (18.7 %) in the non-Xp11.2 translocation and Xp11.2 translocation groups, respectively. The Kaplan-Meier cancer specific survival curves revealed a significant difference between non-Xp11.2 translocation RCCs and Xp11.2 translocation RCCs in young adults (P = 0.042). Conclusions: Compared with non-Xp11.2 translocation RCCs, the Xp11.2 translocation RCCs seemingly showed a higher tumor grade and pathologic stage and have similar recurrence-free survival rates but poorer cancer-specific survival rates in young adults.
We thank members in the Qiu lab for valuable discussions, and are indebted to Fang Cheng for excellent technical support. ... ., 1987; Qiu et al., 2007a; Sun et al., 2009) . ... Whole-cell lysate was prepared as previously described (Qiu et al., 2006a) . ...doi:10.1016/j.virol.2012.01.031 pmid:22361476 pmcid:PMC3294060 fatcat:rv3srcq77nbjleatd62vp4auy4
Sarah Tague for help in taking confocal microscopy images and members of the Qiu lab for valuable discussion. ...doi:10.1016/j.jviromet.2013.10.012 pmid:24134939 pmcid:PMC3855471 fatcat:tehenrize5ctfidlt4sotmqzfy
A 1.55 μm AlGaInAs multi-quantum-well (MQW) ridge waveguide polarization mode controller (PMC) is proposed. The design is based on an asymmetric half-ridge waveguide structure in which the ridge is shallow etched on one side and has a deeply etched mesa structure on the other side. The Finite-Element Method (FEM) was used to simulate the PMC and optimize its structural parameters comprehensively. Furthermore, the fabrication tolerances were also investigated in detail. The optimized PMC has adoi:10.3390/photonics8100422 fatcat:i55vi4yz5ncn7hywesdmlebeyq
more »... larization conversion efficiency (PCE) of around 92.5% with a half-beat length of 1250 μm. When the PMC length was fixed at 1250 μm, to achieve a PCE derivation less than 8%, the tolerances for the ridge waveguide width and shallow etch height were 1.60 μm to 1.65 μm and 2.13 μm to 2.18 μm, respectively. In order to reduce interband gap absorption loss, the quantum well intermixing (QWI) technique was used in the model to realize a blueshift (200 nm) in the PMC. QWI is a simple, flexible, and low-cost technique for fabricating a PMC integrated with a laser diode and reduces parasitic reflections, which would otherwise degrade the overall performance. QWI also eliminates MQW material anisotropy and alleviates the birefringence effect without the need for regrowth, achieving nearly uniform properties as a bulk material.
In humans, arsenic is primarily metabolized by arsenic (þ3 oxidation state) methyltransferase (As3MT) to yield both trivalent and pentavalent methylated metabolites. We recently reported that the putative N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) can biotransform monomethylarsonous acid (MMA III ) to dimethylarsinic acid, conferring resistance of human cells to arsenic exposure. To further decipher the role of N6AMT1 and its interaction with As3MT in arsenic biomethylation, wedoi:10.1093/toxsci/kfv101 pmid:25997655 pmcid:PMC4542820 fatcat:444ccwdgx5a3rcj5f3zfmllfry
more »... ed the relative contribution of N6AMT1 and As3MT in metabolizing arsenic using several newly modified UROtsa human urothelial cells, ie, UROtsa cells with either a constant level of N6AMT1 or As3MT in combination with an inducible level of As3MT or N6AMT1, respectively. Our analysis confirmed the involvement of N6AMT1 in MMA III biomethylation but not for inorganic arsenic. In a comparable level of N6AMT1 and As3MT, the effect of N6AMT1 mediated MMA III biomethylation was obscured by the action of As3MT. Furthermore, we showed that the levels of N6AMT1 and As3MT proteins varied among and within human normal and cancerous tissues. Overall, the data showed that N6AMT1 has a role in MMA III biomethylation, but its effect is relatively minor and limited compared with As3MT. In addition, the varied levels and distributions of N6AMT1 and As3MT among human tissues may potentially contribute to the tissue specificity and susceptibility to arsenic toxicity and carcinogenicity.
The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye.doi:10.1039/c4cc09689d pmid:25619336 fatcat:iwkr7mpcmza2nmflfvo7zmb5by
Implanted biomaterials and biomedical devices generally induce foreign body reaction and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix. Fibroblasts/ myofibroblasts are thought to be the major cell type involved in encapsulation, but it is unclear whether and how stem cells contribute to this process. Here we show, for the first time, that Sox10 + adult stem cells contribute to both encapsulation and microvessel formation. Sox10 + adult stem cellsdoi:10.1038/srep40295 pmid:28071739 pmcid:PMC5223127 fatcat:xd6futovzzfonpahijvgstip7q
more »... ere found sparsely in the stroma of subcutaneous loose connective tissues. Upon subcutaneous biomaterial implantation, Sox10 + stem cells were activated and recruited to the biomaterial scaffold, and differentiated into fibroblasts and then myofibroblasts. This differentiation process from Sox10 + stem cells to myofibroblasts could be recapitulated in vitro. On the other hand, Sox10 + stem cells could differentiate into perivascular cells to stabilize newly formed microvessels. Sox10 + stem cells and endothelial cells in three-dimensional co-culture self-assembled into microvessels, and plateletderived growth factor had chemotactic effect on Sox10 + stem cells. Transplanted Sox10 + stem cells differentiated into smooth muscle cells to stabilize functional microvessels. These findings demonstrate the critical role of adult stem cells in tissue remodeling and unravel the complexity of stem cell fate determination.
« Previous Showing results 1 — 15 out of 396 results