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Research on the Technology Affordance of Online Education Platform—A Case of Hu-jiang Zhong-xue

QIANG YAN, CHU-FEI JING
2020 DEStech Transactions on Social Science Education and Human Science  
With the development of the online education market, some problems have gradually emerged: lack of development and use of emerging technology tools, insufficient construction of platform interaction, high turnover rate and low willingness to continuance learning. In response to these problems, the existing research mainly focuses on the technology use, teaching interaction and learning effects, but does not deeply explore the possibilities for action of the platform's emerging technology tools
more » ... nd the learner's teaching interaction process on the platform. This paper introduces the technology affordance perspective and conducts in-depth research on the actualization process of technology affordance on online education platform through SPS method. The conclusions of this paper are as follows: The technical affordances of the online education platform include teaching presence, learning presence and social presence. These affordances are actualized through three kinds of instructional interactions (student-teacher (ST) interaction, student-student (SS) interaction and student-content (SC) interaction), which ultimately forms the learner's cognitive construction and willingness to continuance learning. This paper expands the theory of technology affordance, forms the interpretation theory of technology affordance and instructional interaction, proposes the technical affordance model of online education platform, and provides suggestion for developers and learners of online education platform.
doi:10.12783/dtssehs/aems2019/33571 fatcat:t3ghyon56nfg7ky23v7iwcv7h4

Chinfloxacin hydrochloride inhibits HERG potassium channel at open state

Xiang-mei Zhang, Zhong-hua Zhu, Xiao-li Sun, Jia Guo, Zhong-zhong Zhao, Zhao Zhang
2010 Yao xue xue bao = Acta pharmaceutica Sinica  
This study is designed to investigate the effects of chinfloxacin hydrochloride (CFX) on the kinetics of HERG K+ channel. Whole cell patch clamp technique was used to record HERG K+ currents from HEK293 cells transiently transfected with cgi-HERG-GFP plasmids and channel kinetics were assessed in the absence and presence of CFX and moxifloxacin hydrochloride (MOX). Results demonstrated that the open state of HERG K+ channel was inhibited by CFX in a concentration- and time-dependent manner,
more » ... an IC50 of 162.1 +/- 14.2 micromol x L(-1), two folds higher than its positive control MOX. But there were no significant effects on channel kinetics. In addition, the inhibitory effect of CFX on HERG was enhanced when cells were subjected to altered extracellular K+ concentration.
pmid:21351488 fatcat:xnlr3y65dndv5kpgrydrcbhjn4

Autoimmune factors and epilepsy

Yating Wu, Aihua Liu
2017 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Epilepsy is a common chronic brain disorder with multiple causes, and now autoimmune factors are believed to be an independent cause for epilepsy. Accumulating data support an autoimmune basis in patients with antiepileptic drug-resistant seizures. Moreover, systemic autoimmune diseases and epilepsy co-occur frequently. Neural specific autoantibodies can also mediate the process of seizures through different pathways. The diagnosis of autoimmune epilepsy is based on frequency of antiepileptic
more » ... ug-resistant seizures, the presence of neural specific autoantibodies, inflammatory changes in serum or spinal fluid or on magneticresonanceimaging, the change in electroencephalogram, a personal or family history of autoimmunity. Once autoimmune epilepsy is diagnosed, the immunotherapy is required. Early immunotherapy is crucial for improving the prognosis of the patients.
doi:10.11817/j.issn.1672-7347.2017.12.015 pmid:29317588 fatcat:vrov35st2bdcjjzk44yovr64ye

Triterpenoid from Lycopodium obscurum L

Tie-Zhong Deng, Yong Ai, Yu Chen, Guang-Zhong Yang
2009 Yao xue xue bao = Acta pharmaceutica Sinica  
C (21), C (22), C (30) 30 1.24 (3H, s) 28.4 C (17), C (21), C (22), C (29) 31 171.4 32 1.93 (3H, s) 21.3 C (31) OH 6.70 (1H, d, J = 4.2 Hz) OH 6.30 (1H, d, J = 4.8 Hz) OH 5.80 (1H, d, br s) DENG Tie-zhong  ... 
pmid:20055158 fatcat:2jepo3tzvnaszbrsryids3hnfm

Gene therapy and Alzheimer's disease

Jian Li, Wenwen Li, Jun Zhou
2015 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the presence of extracellular β-amyloid in the senile plaques, intracellular aggregates of abnormal phosphorylation of tau protein in the neurofibrillary tangles, neuronal loss and cerebrovascular amyloidosis. The manifestations of clinical symptoms include memory impairment, cognitive decline, altered behavior and language deficit. Currently available drugs in AD therapy consist of acetylcholinesterase
more » ... rs, NMDA receptor antagonists, non-steroidal anti-inflammatory drugs, etc. These drugs can only alleviate the symptoms of AD. Gene therapy is achieved by vector-mediated gene transfer technology, which can delivery DNA or RNA into target cells to promote the expression of a protective or therapeutic protein and silence certain virulence genes.
doi:10.11817/j.issn.1672-7347.2015.04.015 pmid:25931222 fatcat:fkt5lpyzofckhghylsinu227be

Perioperative management for patients with coronavirus disease 2019
2019冠状病毒病患者的围手术期管理

Tao Zhong, Gang Qin, Qulian Guo, E Wang
2020 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
The coronavirus disease 2019 (COVID-19) is a new infectious disease, which has a strong virus transmission power and complex transmission routes. This disease is prone to outbreak of cluster infection. It is difficult for medical workers to provide a better perioperative treatment for surgery patient with COVID-19 while avoiding hospital spread effectively. The perioperative management for such patients needs to fully consider the possible lung injury factors caused by anesthesia and surgery.
more » ... also needs to choose the suitable timing of the operation, carry out preoperative infection screening and evaluation, and implement lung protection strategies during and after the operation to avoid aggravating the lung injury. Meanwhile, it is necessary to pay more attention to infection prevention and control in order to avoid nosocomial infection.
doi:10.11817/j.issn.1672-7347.2020.200082 pmid:32879115 fatcat:ss4yyvu5gnf5deqrvecbfvsacm

Genome instability and lymphoma
基因组不稳定性与淋巴瘤

Pengfei Cao, Guiyuan Li, Juanjuan Xiang
2021 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Lymphoma is one of the most common malignant tumor of the hematologic system. The genome instability is not only an important molecular basis for the development of lymphoma, but also has important value in the diagnosis and prognosis of lymphoma. There are 2 types of genome instability: Microsatellite instability (MSI/MIN) at gene level and chromosomal instability at chromosome level. Through the study on genes associated with lymphoma, the unstable genes associated with lymphoma could be
more » ... , meanwhile the mechanism of its occurrence and development of lymphoma could be explored, and the important basis of molecular biology could also be provided in the field of current hot lymphoma precision medical research.
doi:10.11817/j.issn.1672-7347.2021.190427 pmid:34148893 fatcat:iuzfs2l2b5b5lddfje2jcnxjtm

Multistage CT features of coronavirus disease 2019
2019冠状病毒病多阶段CT影像学特征

Zheng Zhong, Ying Hu, Qizhi Yu, Yuxin Li, Peng Li, Wei Huang, Jingui Liu, Jun Liu, Xingzhi Xie, Wei Zhao
2020 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
To determine imaging features of coronavirus disease 2019 (COVID-19) in different stages, and to provide foundations for early diagnosis and treatment. CT image data of 187 COVID-19 patients were analyzed in the period of hospitalization. CT scanning was performed on admission and repeated every 3 days. The improvement time of clinical symptoms and the image changes of follow-up CT were statistically analyzed. All 187 patients' nucleic acid test were positive to severe acute respiratory
more » ... coronavirus 2 (SARS-CoV-2). The early CT images of lung in 187 cases (100%) showed multiple patchy and ground-glass opacities with fine mesh and consolidation shade, which mainly distributed in pulmonary band or under the pleura. In the progressive stage, the pulmonary lesions in 146 cases (78.1%) were mainly consolidation, accompanied by air bronchogram, thickening of blood vessels, and interstitial changes. Severe pulmonary CT images in 15 cases (8%) showed diffuse lesions in both lungs, displaying consolidation, or "white lung". The CT imaging features in 185 cases (98.9%) at the absorptive period showed that the lesions diminished and fibrogenesis. The imaging features of 6 times of lung CT examination in one case showed continuous progress. The original lesion in one case was obviously absorbed, but new lesions appeared under the pleura of both lungs at the third review of CT scanning. The changes of CT imaging lesions during follow-up were significantly different in different clinical symptoms improvement time (P< 0.01). Images of COVID-19 in various stages have special characteristics. The change of clinical symptoms is synchronous with the change of reexamination CT. Follow-up CT can reflect the trend of clinical changes. Repeat CT examination plays an important role in the early clinical diagnosis and the evaluation for the therapeutic effect on COVID-19 patient.
doi:10.11817/j.issn.1672-7347.2020.200144 pmid:32386015 fatcat:bywma7o44najdcvdzjlripj7ce

Research progress in the pathogenesis of preeclampsia
子痫前期发病机制研究进展

Bei Zhou, Kaili Xie
2020 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Preeclampsia is a multisystem disorder clinical syndrome, coexisting hypertension and proteinuria. It is a result of the shallow remodeling of the spiral arteries after 20 weeks of gestation, which changes the placental microenvironment and releases a series of maternal circulation factors. Currently, there are no effective tools for the treatment of preeclampsia unless terminating pregnancy. The unclear pathogenesis, the high rate of fetal growth restriction, fetal disability and maternal
more » ... lity make it important for researchers to explore the pathogenesis of preeclampsia. MicroRNAs (miRNAs) play an important role in regulating the expression of almost 30% of all genes by binding to the 3' untranslated region of a target mRNA, which affects various cell processes, including differentiation, proliferation, apoptosis, and development. A large number of miRNAs can be expressed in human placental tissues, while some are only specifically expressed and can also be released into the maternal blood in the form of exosome during pregnancy. Thus, it makes miRNA hopefully as a novel molecular marker for monitoring pregnancy, prediction and diagnosis of gestational diseases.
doi:10.11817/j.issn.1672-7347.2020.190451 pmid:33051430 fatcat:443blxsmyrcqvpgar4uaxc6qre

Research progress in prediction of postpartum depression
产后抑郁预测研究进展

Meili Xiao, Jingqiang Zhang
2020 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Postpartum depression is a kind of mental disorder caused by the comprehensive effects of economics, psychosociology, biology, obstetrics and other characteristic factors in the process of female pregnancy. The pathogenesis of postpartum depression is complicated and has not been clarified. With the process pregnancy, the influence of psychosocial and biology factors are also in dynamic change. The postpartum depression predictor among psychosocial factors are antenatal depression, life events
more » ... nd social supports. Among biological factors, the predictors are hypothalamic-pituitary-thyroid axis and serum lipids. Timely and effective prediction can identify the high-risk population and risk factors for postpartum depression.
doi:10.11817/j.issn.1672-7347.2020.190731 pmid:32879072 fatcat:vmqj2236svhrthdmidp4y5qmjy

Agmatine and glycolipid metabolism
胍丁胺与糖脂代谢

Yanpei Zhang, Shuqiao Yuan, Tuanjie Che, Jinchun He
2021 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
The prevalence of abnormal glucose and lipid metabolism and its relevant diseases has increased year by year, and it has become a problem that threatens human health. Therefore, finding a more effective way to prevent and treat diseases related to abnormal glucose and lipid metabolism has become an urgent public problem. Agmatine is a polyamine substance which widely presents in mammals.It is a metabolite produced by decarboxylation of L-arginine under the action of arginine decarboxylase,
more » ... also known as decarboxylated arginine. Its biological effects have been confirmed. Previous studies have shown that agmatine possesses anti-diabetic effects in diabetic animals. Agmatine not only increases the insulin secretion form β-pancreatic cells to inhibit the hyperglycemia, but also attenuates insulin resistance in rats. Agmatine also plays a positive role in lipid metabolism disorders and related diseases by modulating lipid metabolism and fatty acid oxidation.
doi:10.11817/j.issn.1672-7347.2021.200351 pmid:34565735 fatcat:cayr3mgztbbnlpji2brqbct7wi

Mental health of front-line staff in prevention of coronavirus disease 2019
2019冠状病毒病防控一线人员的心理状况

Ziwei Teng, Jing Huang, Yan Qiu, Yuxi Tan, Qiuping Zhong, Hui Tang, Haishan Wu, Ying Wu, Jindong Chen
2020 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
The coronavirus disease 2019 (COVID-19) pandemic is a global public health crisis, which elicits psychological problems in different population. This study is to investigate the impact of COVID-19 on mental health in the front-line staff. Patient Health Questionnare-9 (PHQ-9), Self-Rating Anxiety Scale (SAS), and Fatigue Self-assessment Scale (FSAS) were used to assess the depression, anxiety, and fatigue in front-line staff. The detection rates of depression, anxiety, and fatigue were 49.1%,
more » ... .8%, and 76.0% among the front-line staff. The rates of depression, anxiety, and fatigue in community workers were higher than those in medical workers and other occupational staff (P<0.01). The PHQ-9 of front-line staffs was negatively correlated with age, family income, family members' support, satisfaction of service objects, and sleep quality (all P<0.01), while positively correlated with education level, fatigue, fear of pneumonia, and the duration of daily attention to the COVID-19 (all P<0.01). SAS was negatively correlated with age, family income, family support, satisfaction of objects service, and sleep quality (all P<0.01), while positively correlated with gender, fatigue, fear of pneumonia, and duration of daily attention to the COVID-19 (all P<0.01). The front-line workers should manage work and rest time reasonably to adjust their negative mood and fatigue. The government and the society should pay more attention to the psychological state of the front-line staff, particularly for the staff working in the community or villages and towns in preventing the COVID-19 pandemic. Thus, front-line staff can be obtained mental intervention or be taken a rest from the high-intensive work.
doi:10.11817/j.issn.1672-7347.2020.200241 pmid:32879116 fatcat:giz22cqhyfaiblf5hljarr3jze

Chest CT findings and clinical features of coronavirus disease 2019 in children
儿童2019冠状病毒病患者的胸部CT表现和临床特征

Zheng Zhong, Xingzhi Xie, Wei Huang, Wei Zhao, Qizhi Yu, Jun Liu
2020 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
To describe the CT features and clinical characteristics of pediatric patients with coronavirus disease 2019 (COVID-19). A total of 9 COVID-19 infected pediatric patients were included in this study. Clinical history, laboratory examination, and detailed CT imaging features were analyzed. All patients underwent the first CT scanning on the same day of being diagnosed by real-time reverse-transcription polymerase chain reaction (rRT-PCR). A low-dose CT scan was performed during follow-up. All
more » ... child patients had positive results. Four patients had cough and one patient had fever. One patient presented both cough and fever. Two children presented other symptoms like sore throat and stuffy nose. One child showed no clinical symptom. Five patients had positive initial CT findings with subtle lesions like ground-glass opacity (GGO) or spot-like mixed consolidation. Three patients were reported with negative results in the initial and follow-up CT examination. One patient was reported with initial negative CT findings but turning positive during the first follow-up. All patients had absorbed lesions on follow-up CT images after treatment. Pediatric COVID-19 patients have certain imaging and clinical features as well as disease prognosis. Children with COVID-19 tend to have normal or subtle CT findings and relatively better outcome.
doi:10.11817/j.issn.1672-7347.2020.200206 pmid:32386013 fatcat:bzbvptepznbyzpvesh5hbmjswi

Neuroprotective action of lithium in disorders of the central nervous system

Chi-Tso Chiu, De-Maw Chuang
2011 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Zhong Nan Da Xue Xue Bao Yi Xue Ban. Author manuscript; available in PMC 2012 June 1.  ... 
doi:10.3969/j.issn.1672-7347.2011.06.001 pmid:21743136 pmcid:PMC3172812 fatcat:lf5s2qwdvzd7bgch4znxtsfgdi

Long noncoding RNA and atrial fibrillation
长链非编码RNA与心房纤颤

Boyao Yu, Chunfan Xie, Siyang Yu, Yongbin Hu
2021 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences  
Atrial fibrillation (AF), a common arrhythmia that usually occurs in patients with heart disease, is one of the leading causes for mortality and disability worldwide. Current drug therapy for AF patients lacks sufficient efficacy and has side effects. Radiofrequency ablation is more effective than traditional drug therapy, but this invasive procedure is associated with potential risks and postoperative recurrence, limiting the clinical benefits for AF patients. Therefore, it is necessary to
more » ... nd our understanding about the underlying molecular mechanism of AF and to explore the new therapeutic strategies. Long noncoding RNA (lncRNA) is a set of noncoding RNA longer than 200 nucleotides. Growing evidence indicates that lncRNA is involved in numerous pathophysiological processes of AF, such as structural remodeling, electrical remodeling, renin-angiotensin system, abnormal calcium regulation, etc. In addition, lncRNA involved in structural remodeling and electrical remodeling has the potential to be a novel target for the diagnosis and treatment of AF, and lncRNA involved in autonomic nerve remodeling may bring new enlightenment for the prognosis and recurrence of AF.
doi:10.11817/j.issn.1672-7347.2021.200531 pmid:34565733 fatcat:w4v7aye33rb63hjtsp2m3nyqfm
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