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A Class Of Delay Differential Inverse Variational Inequalities

HAN GAO, CHANGCHUN GAO, XINLEI HUANG
2018 Zenodo  
This paper is focused on a class of delay differential inverse variational inequality composed of a system of delay differential equations and inverse variational inequalities. Also, the existence theorem of Carathéodory weak solution for delay differential inverse variational inequalities is established under suitable conditions. Furthermore, an algorithm for solving delay differential inverse variational inequalities is shown, and the convergence of the algorithm is given. Finally, a
more » ... example is given to simulate the effectiveness of the algorithm.
doi:10.5281/zenodo.1482974 fatcat:szkvrfeymng35j65laiqmcxzkm

Future changes of global potential evapotranspiration simulated from CMIP5 to CMIP6 models

Xinlei LIU, Chunxiang LI, Tianbao ZHAO, Lin HAN
2020 figshare.com  
This research evaluated the ability of different coupled climate models to simulate the historical variability of potential evapotranspiration (PET) for the time period 1979–2017 in phases 5 and 6 of the Coupled Model Intercomparison Project (CMIP5 and CMIP6, respectively). Their projected future changes of PET under two emission scenarios for the 21st century were also compared. Results show that PET has an increasing trend of 0.2–0.6 mm d−1/50 yr over most land surfaces and that there are
more » ... r regional differences. The future value of PET is higher in the CMIP6 multi-model simulations than in the CMIP5 ones under the same emissions scenario, possibly because CMIP6 models simulate stronger warming for a given forcing or scenario. The contributions of each individual climate driver to future changes in PET were examined and revealed that the surface vapor pressure deficit makes a major contribution to changes in PET. Shortwave radiation increases PET in most terrestrial regions, except for northern Africa, East Asia, South Asia, and Australia; the effect of longwave radiation is the opposite to that of shortwave radiation. The contribution of surface wind speed to PET is small, but results in a slight reduction.
doi:10.6084/m9.figshare.13078728.v1 fatcat:wu2ms5vr3zgfto32haheds7tzy

Insight into Rapid DNA-Specific Identification of Animal Origin Based on FTIR Analysis: A Case Study

Yahong Han, Lin Jian, Yumei Yao, Xinlei Wang, Lujia Han, Xian Liu
2018 Molecules  
In this study, a methodology has been proposed to identify the origin of animal DNA, employing high throughput extension accessory Fourier transform infrared (HT-FTIR) spectroscopy coupled with chemometrics. Important discriminatory characteristics were identified in the FTIR spectral peaks of 51 standard DNA samples (25 from bovine and 26 from fish origins), including 1710, 1659, 1608, 1531, 1404, 1375, 1248, 1091, 1060, and 966 cm−1. In particular, the bands at 1708 and 1668 cm−1 were higher
more » ... n fish DNA than in bovine DNA, while the reverse was true for the band at 1530 cm−1 was shown the opposite result. It was also found that the PO2− Vas/Vs ratio (1238/1094 cm−1) was significantly higher (p < 0.05) in bovine DNA than in fish DNA. These discriminatory characteristics were further revealed to be closely related to the base content and base sequences of different samples. Multivariate analyses, such as principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were conducted, and both the sensitivity and specificity values of PLS-DA model were one. This methodology has been further validated by 20 meat tissue samples (4 from bovine, 5 from ovine, 5 from porcine, and 6 from fish origins), and these were successfully differentiated. This case study demonstrated that FTIR spectroscopy coupled with PLS-DA discriminant model could provide a rapid, sensitive, and reliable approach for the identification of DNA of animal origin. This methodology could be widely applied in food, feed, forensic science, and archaeology studies.
doi:10.3390/molecules23112842 fatcat:gwrysmd6vzebzmxyt7q3hprxla

The Porosity Dynamic Model of the Compacted Broken Coal

Xuefeng Han, Tingxiang Chu, Minggao Yu, Jiangkun Chao, Zhihui Ma, Xinlei Yang
2020 Advances in Civil Engineering  
In order to study the dynamic change law of the porosity of the compacted broken coal under different axial stress loading, based on the environment of the broken and compacted coal in the gob, aiming at the influence of the porosity on the spontaneous combustion of the coal, combined with the fractal theory, the fractal model of the porosity of the broken coal is established. A self-designed "testing device for permeability evolution and spontaneous combustion characteristics of crushed coal
more » ... der pressure" is used to carry out axial loading test on selected coal samples in the gob. By comparing and analyzing the calculated results of void dynamic evolution model and experimental data, it is found that the relative error of void dynamic evolution model is between 2.8% and 6.2%, which meets the engineering needs. According to the stress-strain curve, initial accumulation state parameters, fractal dimension of initial crushing, and particle size distribution, the change of porosity under different compacted conditions can be predicted by the model, which has certain significance for identifying the change of compacted broken coal porosity and analyzing the process of coal spontaneous combustion and oxidation.
doi:10.1155/2020/8884075 fatcat:zl25pjj55bgd3ekjsb7uw7brtq

Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy

Xinlei Yu, Yun Chau Long, Han-Ming Shen
2015 Autophagy  
Abbreviations: 3-MA, 3-methyladenine; AMBRA1, autophagy/Beclin 1 regulator 1; ATG, autophagy related; ATM, ATM serine/threonine kinase; ATR, ATR serine/threonine kinase; BH3, Bcl-2 homology 3; CCD, coiled-coil domain; CDK, cyclin-dependent kinase; CISD2, CDGSH iron sulfur domain 2; class I/II PI3K, class I/II phosphoinositide 3-kinase; class III PtdIns3K, class III phosphatidylinositol 3-kinase; DAPK1, death-associated protein kinase 1; DDR, DNA damage response; EIF4EBP1, eukaryotic translation
more » ... initiation factor 4E binding protein 1; ER, endoplasmic reticulum; FOXO, forkhead box O; FYCO1, FYVE and coiledcoil domain containing 1; GAP, GTPase-activating protein; HMGB1, high mobility group box 1; HSPA1A, heat shock 70kDa protein 1A; IR, ionizing radiation; MAPK8, mitogen-activated protein kinase 8; MEFs, mouse embryonic fibroblasts; MTMR, myotubularin-related protein; MTOR, mechanistic target of rapamycin (serine/threonine kinase); MTORC1, mechanistic target of rapamycin complex 1; MVBs, spherical multivesicular bodies; NRBF2, nuclear receptor binding factor 2; PAS, phagophore assembly site; PDPK1, 3-phosphoinositide dependent protein kinase 1; PE, phosphatidylethanolamine; PIKFYVE, phosphoinositide kinase, FYVE finger containing; PINK1, PTEN-induced putative kinase 1; PtdIns3K-C1, class III phosphatidylinositol 3-kinase complex I; PtdIns3K-C2, class III phosphatidylinositol 3-kinase complex II; PKB, protein kinase B; PRKA, protein kinase, AMP-activated; PRKD1, protein kinase D1; PRKDC, protein kinase, DNA-activated, catalytic polypeptide; PtdIns5P, phosphatidylinositol 5-phosphate; PtdIns4P, phosphatidylinositol 4-phosphate; PtdIns(4,5)P 2 , phosphatidylinositol 4,5-bisphosphate; PtdIns3P, phosphatidylinositol 3-phosphate; PtdIns(3,5)P 2 , phosphatidylinositol 3,5-bisphosphate; PtdIns(3,4,5)P 3 , phosphatidylinositol 3,4,5-trisphosphate; RHEB, Ras homolog enriched in brain; RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1; SQSTM1, sequestosome 1; TECPR1, tectonin b-propeller repeat containing 1; TFEB, transcription factor EB; TRIM28, tripartite motif containing 28; TSC, tuberous sclerosis; UV, ultraviolet; UVRAG, UV radiation resistance associated; WDFY3, WD repeat and FYVE domain containing 3; WIPI, WD repeat domain, phosphoinositide interacting; ZFYVE1, zinc finger, FYVE domain containing 1. that the PIK3CB catalytic subunit of class I PI3K acts as a positive regulator of autophagy, and PIK3C3 was thought to be an amino acid sensor for MTOR, which curbs autophagy. At present, a number of PtdIns3K and PI3K inhibitors, including specific PIK3C3 inhibitors, have been developed for suppression of autophagy and for clinical applications in autophagy-related human diseases.
doi:10.1080/15548627.2015.1043076 pmid:26018563 pmcid:PMC4824607 fatcat:ort3fbze7vhpvbcrv5zaz2xoa4

Mobility-Aware Fog Computing in Dynamic Environments: Understandings and Implementation

Muhammad Waqas, Yong Niu, Jiayou He, Manzoor Ahmed, Xinlei Chen, Yong Li, Depeng Jin, Zhu Han
2018 IEEE Access  
ZHU HAN (S'01-M'04-SM'09-F'14) received the B.S. degree in electronic engineering from Tsinghua University, in 1997, and the M.S. and Ph.D. degrees in electrical and computer engineering from the University  ... 
doi:10.1109/access.2018.2883662 fatcat:c6z3lqqu4baevfn5r4ecqrgpsa

Dilution and Enhancement of Celebrity Brands Through Sequential Movie Releases

Lan Luo, Xinlei (Jack) Chen, Jeanie Han, C Whan Park
2010 Journal of Marketing Research  
This paper examines the effects of sequential movie releases on the dilution and the enhancement of celebrity brands. The authors use favorability ratings collected over a 12-year period (1993 to 2005) to capture movement in the brand equity of a panel of actors/actresses. A dynamic panel data model is used to investigate how the changes of brand equity are associated with the sequence of movies featuring these actors/actresses, after controlling for the possible influence from these stars'
more » ... camera activities. The authors also examine the underlying factors that influence the magnitude and the longevity of such effects. In contrast to the findings from existing research in product branding, the authors find evidence supporting the general existence of dilution and enhancement effects on the equity of a celebrity brand through his/her movie appearances. They also find that star favorability erodes substantially over time. Finally, this research offers insights for actors/actresses regarding how to strategically make movie selections for maximizing their brand equity.
doi:10.1509/jmkr.47.6.1114 fatcat:5ozb4miw4bblnd3marfu5or6su

Accelerating Content Delivery via Efficient Resource Allocation for Network Coding Aided D2D Communications

Xuefeng Xiao, Manzoor Ahmed, Xinlei Chen, Yulei Zhao, Yong Li, Zhu Han
2019 IEEE Access  
XINLEI CHEN received the B.E. and M.S. degrees in electrical engineering from Tsinghua University, China, in 2009 and 2012, respectively.  ...  ZHU HAN (S'01-M'04-SM'09-F'14) received the B.S. degree in electronic engineering from Tsinghua University, in 1997, and the M.S. and Ph.D. degrees in electrical and computer engineering from the University  ... 
doi:10.1109/access.2019.2930728 fatcat:ojaf3cqbjfgwxnyumvtpqmrawq

Reversible Conversion of Dominant Polarity in Ambipolar Polymer/Graphene Oxide Hybrids

Ye Zhou, Su-Ting Han, Prashant Sonar, Xinlei Ma, Jihua Chen, Zijian Zheng, V. A. L. Roy
2015 Scientific Reports  
The possibility to selectively modulate the charge carrier transport in semiconducting materials is extremely challenging for the development of high performance and low-power consuming logic circuits. Systematical control over the polarity (electrons and holes) in transistor based on solution processed layer by layer polymer/graphene oxide hybrid system has been demonstrated. The conversion degree of the polarity is well controlled and reversible by trapping the opposite carriers. Basically,
more » ... electron device is switched to be a hole only device or vice versa. Finally, a hybrid layer ambipolar inverter is demonstrated in which almost no leakage of opposite carrier is found. This hybrid material has wide range of applications in planar p-n junctions and logic circuits for high-throughput manufacturing of printed electronic circuits. O ver the past few years materials with balanced charge carrier transport have received special interest owing to their potential applications in light emitting transistors 1-3 , complementary metal oxide semiconductor (CMOS)-like logic circuits 4-6 , sensors 7-9 , spintronics 10 and memories 11,12 . On this aspect, the possibility to selectively modulate the charge carrier transport in semiconducting materials is extremely attractive for the development of high performance and low-power consuming ambipolar logic circuits with low leakage currents 13-15 . Independent control over charge transport is also quite important for light-emitting transistors 16 . Several approaches have been developed to control the charge injection and transport such as interface modification 17-19 , split-gate 20 , dielectric selection 21 , exposition to oxygen 22 , introduction of buffer layers 23,24 , doping of other materials 25 or thermal treatment 26-28 . However, most of the methods always require a systematical selection of materials and conditions to obtain a reliable result, and cannot be a collective approach for various structures. On the other hand, these approaches cannot switch the charge transport reversibly and dynamically in a controlled manner. Therefore, exploring a simple and universal technique to achieve reversible charge transport (from holes to electrons vice versa) is attractive for wide variety of applications. A balanced charge transport can be achieved by bilayer heterostructures, blended material systems or single component materials 29-34 . Among these strategies, polymeric semiconductors are highly promising and attractive due to their large scale solution processability 35,36 and the cost-effective device fabrication procedure by using one single type of electrode 37,38 . To achieve ultimate success of practical polymer devices, a large number of efforts have been devoted to the synthesis of novel polymers, the development of new processing methods and the interface engineering in device architecture 39 . To achieve controlled charge transport in semiconducting polymers, introducing charge trapping sites with the following properties can be an effective approach: i) flattened surface with good interface quality with polymer; ii) large area with plenty of trapping sites; iii) easy processability with polymer to form hybrids. Graphene oxide (GO), the insulating analog of graphene, is a nonstoichiometrically oxidized sheet derived from the acid exfoliation of graphite 40 . The high density of oxygen-containing groups, planar structure with atomthickness and excellent solution processabbility make chemically synthesized GO extremely promising as functional trapping layer in polymer bilayer hybrids. Here we report a novel approach on systematic control over polarity (from holes to electron or vice versa) in transistors based on solution processed semiconducting polymer/GO hybrid system. Recently, diketopyrrolopyrrole (DPP) based polymers with planar conjugated bicyclic structure have shown some of the highest OPEN SUBJECT AREAS: ELECTRONIC DEVICES ELECTRONIC PROPERTIES AND MATERIALS
doi:10.1038/srep09446 pmid:25801827 pmcid:PMC4371103 fatcat:4tra2gnwarcyfibukt6oogvn3q

MicroRNAs: potential biomarkers for disease diagnosis

Li Xu, Xiuli Qi, Shengliang Duan, Yumei Xie, Xinlei Ren, Gaoyun Chen, Xiaocong Yang, Lili Han, Qirui Dong
2014 Bio-medical materials and engineering  
MicroRNAs (miRNAs) are a group of endogenous noncoding small RNAs characterized by high conservation; furthermore, various studies have shown the capability of miRNAs to impact diseases. For example, a study shows that cell-free miRNAs are stable in bodily fluids, which gives circulating miRNAs the ability to be potential biomarkers for noninvasive diagnosis. Additionally, accumulating studies have supported that miRNAs can function as suppressor genes, again demonstrating their effect on
more » ... e. This review introduces this particular role of miRNAs as well as analyzes the prospect of miRNAs as biomarkers and the capacity for using miRNA-based resources to benefit mankind.
doi:10.3233/bme-141223 pmid:25227110 fatcat:rkdmdg6ljvgpvm24ubdpzqfkpa

An Investigation of the Relationship between Cyniclomyces guttulatus and Rabbit Diarrhoea

Tuanyuan Shi, Xinlei Yan, Hongchao Sun, Yuan Fu, Lili Hao, Yongxue Zhou, Yan Liu, Wenying Han, Guolian Bao, Xun Suo
2021 Pathogens  
Cyniclomyces guttulatus is usually recognised as an inhabitant of the gastrointestinal (GI) tract in rabbits. However, large numbers of C. guttulatus are often detected in the faeces of diarrhoeic rabbits. The relationship of C. guttulatus with rabbit diarrhoea needs to be clearly identified. In this study, a C. guttulatus Zhejiang strain was isolated from a New Zealand White rabbit with severe diarrhoea and then inoculated into SPF New Zealand white rabbits alone or co-inoculated with
more » ... testinalis, another kind of pathogen in rabbits. Our results showed that the optimal culture medium pH and temperature for this yeast were pH 4.5 and 40–42 °C, respectively. The sequence lengths of the 18S and 26S ribosomal DNA fragments were 1559 bp and 632 bp, respectively, and showed 99.8% homology with the 18S ribosomal sequence of the NRRL Y-17561 isolate from dogs and 100% homology with the 26S ribosomal sequence of DPA-CGR1 and CGDPA-GP1 isolates from rabbits and guinea pigs, respectively. In animal experiments, the C. guttulatus Zhejiang strain was not pathogenic to healthy rabbits, even when 1 × 108 vegetative cells were used per rabbit. Surprisingly, rabbits inoculated with yeast showed a slightly better body weight gain and higher food intake. However, SPF rabbits co-inoculated with C. guttulatus and E. intestinalis developed more severe coccidiosis than rabbits inoculated with C. guttulatus or E. intestinalis alone. In addition, we surveyed the prevalence of C. guttulatus in rabbits and found that the positive rate was 83% in Zhejiang Province. In summary, the results indicated that C. guttulatus alone is not pathogenic to healthy rabbits, although might be an opportunistic pathogen when the digestive tract is damaged by other pathogens, such as coccidia.
doi:10.3390/pathogens10070880 fatcat:7ddkslkyqzh57einfqqgzwi43y

Experimental Study on the Compression Behavior of Grouted Rock with Bi-Directional Penetrating Crack

Han Feng, Xuemin Zhang, Xianshun Zhou, Xuefeng Ou, Cong Zhang, Xinlei Chen
2021 Applied Sciences  
[12] and Han et al. [13] , based on the results of theoretical analyses and direct shear tests, developed a peak shear strength model.  ... 
doi:10.3390/app11020537 fatcat:qskvqdohlnacdfkyvpcn7dynzy

Prior-aware Neural Network for Partially-Supervised Multi-Organ Segmentation [article]

Yuyin Zhou, Zhe Li, Song Bai, Chong Wang, Xinlei Chen, Mei Han, Elliot Fishman, Alan Yuille
2019 arXiv   pre-print
Accurate multi-organ abdominal CT segmentation is essential to many clinical applications such as computer-aided intervention. As data annotation requires massive human labor from experienced radiologists, it is common that training data are partially labeled, e.g., pancreas datasets only have the pancreas labeled while leaving the rest marked as background. However, these background labels can be misleading in multi-organ segmentation since the "background" usually contains some other organs
more » ... interest. To address the background ambiguity in these partially-labeled datasets, we propose Prior-aware Neural Network (PaNN) via explicitly incorporating anatomical priors on abdominal organ sizes, guiding the training process with domain-specific knowledge. More specifically, PaNN assumes that the average organ size distributions in the abdomen should approximate their empirical distributions, a prior statistics obtained from the fully-labeled dataset. As our training objective is difficult to be directly optimized using stochastic gradient descent [20], we propose to reformulate it in a min-max form and optimize it via the stochastic primal-dual gradient algorithm. PaNN achieves state-of-the-art performance on the MICCAI2015 challenge "Multi-Atlas Labeling Beyond the Cranial Vault", a competition on organ segmentation in the abdomen. We report an average Dice score of 84.97%, surpassing the prior art by a large margin of 3.27%.
arXiv:1904.06346v2 fatcat:iknxol6yafbvjaqtgt72ixpfme

Structure of the human metapneumovirus polymerase phosphoprotein complex

Junhua Pan, Xinlei Qian, Simon Lattmann, Abbas El Sahili, Tiong Han Yeo, Huan Jia, Tessa Cressey, Barbara Ludeke, Sarah Noton, Marian Kalocsay, Rachel Fearns, Julien Lescar
2019 Nature  
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause severe respiratory diseases in infants and elderly adults1. No vaccine or effective antiviral therapy currently exists to control RSV or HMPV infections. During viral genome replication and transcription, the tetrameric phosphoprotein P serves as a crucial adaptor between the ribonucleoprotein template and the L protein, which has RNA-dependent RNA polymerase (RdRp), GDP polyribonucleotidyltransferase and cap-specific
more » ... ltransferase activities2,3. How P interacts with L and mediates the association with the free form of N and with the ribonucleoprotein is not clear for HMPV or other major human pathogens, including the viruses that cause measles, Ebola and rabies. Here we report a cryo-electron microscopy reconstruction that shows the ring-shaped structure of the polymerase and capping domains of HMPV-L bound to a tetramer of P. The connector and methyltransferase domains of L are mobile with respect to the core. The putative priming loop that is important for the initiation of RNA synthesis is fully retracted, which leaves space in the active-site cavity for RNA elongation. P interacts extensively with the N-terminal region of L, burying more than 4,016 Å2 of the molecular surface area in the interface. Two of the four helices that form the coiled-coil tetramerization domain of P, and long C-terminal extensions projecting from these two helices, wrap around the L protein in a manner similar to tentacles. The structural versatility of the four P protomers-which are largely disordered in their free state-demonstrates an example of a 'folding-upon-partner-binding' mechanism for carrying out P adaptor functions. The structure shows that P has the potential to modulate multiple functions of L and these results should accelerate the design of specific antiviral drugs.
doi:10.1038/s41586-019-1759-1 pmid:31698413 pmcid:PMC6949429 fatcat:yv756xuhdrb5nddlkgcladkv7q

The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity

Chuangang You, Chunmao Han, Xingang Wang, Yurong Zheng, Qiyin Li, Xinlei Hu, Huafeng Sun
2012 Molecular Biology Reports  
Nanotechnology is a highly promising field, with nanoparticles produced and utilized in a wide range of commercial products. Silver nanoparticles (AgNPs) has been widely used in clothing, electronics, bio-sensing, the food industry, paints, sunscreens, cosmetics and medical devices, all of which increase human exposure and thus the potential risk related to their short-and long-term toxicity. Many studies indicate that AgNPs are toxic to human health. Interestingly, the majority of these
more » ... focus on the interaction of the nano-silver particle with single cells, indicating that AgNPs have the potential to induce the genes associated with cell cycle progression, DNA damage and mitochondrial associated apoptosis. AgNPs administered through any method were subsequently detected in blood and were found to cause deposition in several organs. There are very few studies in rats and mice involving the in vivo bio-distribution and toxicity, organ accumulation and degradation, and the possible adverse effects and toxicity in vivo are only slowly being recognized. In the present review, we summarize the current data associated with the increased medical usage of nano-silver and its related nano-materials, compare the mechanism of antibiosis and discuss the proper application of nano-silver particles.
doi:10.1007/s11033-012-1792-8 pmid:22722996 fatcat:26og6udnvrfa3pz2i3lyrbhtpu
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