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Li X, Chen ZH, Ma XK, Chen J, Wu DH, Lin Q, et al. Neutrophil- to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma. ...doi:10.1002/hep.27633 pmid:25477185 fatcat:iu2qd2mofvg3xibz2vbw3ohoni
Three new diarylpropanes (1–3), including two diarylpropane glycosides, and three known ones, were isolated from 70% aqueous acetone extract of the twigs and leaves of Horsfieldia kingii. Their structures were elucidated by spectroscopic analysis. Bioactive evaluation of inhibition on DDC enzyme assay showed that the new compounds were inactive.doi:10.6084/m9.figshare.8966051.v1 fatcat:przqcxavq5bpnabymnuz25dley
We present an interactive approach to synthesizing realistic variations in facial hair in images, ranging from subtle edits to existing hair to the addition of complex and challenging hair in images of clean-shaven subjects. To circumvent the tedious and computationally expensive tasks of modeling, rendering and compositing the 3D geometry of the target hairstyle using the traditional graphics pipeline, we employ a neural network pipeline that synthesizes realistic and detailed images of facialarXiv:2004.06848v1 fatcat:ldp4ujm2rbejnlxlt2ox6b2uha
more »... hair directly in the target image in under one second. The synthesis is controlled by simple and sparse guide strokes from the user defining the general structural and color properties of the target hairstyle. We qualitatively and quantitatively evaluate our chosen method compared to several alternative approaches. We show compelling interactive editing results with a prototype user interface that allows novice users to progressively refine the generated image to match their desired hairstyle, and demonstrate that our approach also allows for flexible and high-fidelity scalp hair synthesis.
In order to improve the accuracy of intelligent detection of rural buildings, this paper uses massive remote sensing data of UAV to train convolutional neural network and improves CaffeNet model. Experimental results are as the followings: With reference to the traditional CaffeNet, the improved a-CaffeNet has an accuracy rate of 97.30%. The test time and the training time are shortened by 30.4% and 11.84% respectively. According to the experiments, this method is more suitable for remote sensing image of rural buildings detection.doi:10.12783/dtetr/aemce2019/29502 fatcat:bk2ms7oewrerbpsr2vjbtcbtgu
Dwell time estimation plays an important role in the operation of urban rail system. On this specific problem, a range of models based on either polynomial regression or microsimulation have been proposed. However, the generalization performance of polynomial regression models is limited and the accuracy of existing microsimulation models is unstable. In this paper, a new dwell time estimation model based on extreme learning machine (ELM) is proposed. The underlying factors that may affectdoi:10.1155/2015/473432 fatcat:p7yfhbj5tbf2doj67f47ujiaru
more »... rail dwell time are analyzed first. Then, the relationships among different factors are extracted and modeled by ELM neural networks, on basis of which an overall estimation model is proposed. At last, a set of observed data from Beijing subway is used to illustrate the proposed method and verify its overall performance.
ChenYu Zhao and SiYao Chen analysed the data and interpreted the results. XingJun Ge and ChenYu Zhao wrote the manuscript. ... Author Contributions XingJun Ge and Jun Zhang conceived and designed the device. XingJun Ge, ZhiCheng Luo and Peng Zhang performed the experiments and PIC simulations. ...doi:10.1038/s41598-019-47496-8 pmid:31439902 pmcid:PMC6706425 fatcat:xdfz5aql5nhqjfus3s74dqcxjy
This paper proposes an improved coupled modeling method for coalbed methane extraction after hydraulic fracturing. Based on the damage mechanics theory, we introduce a state damage variable to record the damage changes at different times and construct the coupling governing equations of the seepage field and solid mechanics field in the hydraulic fracturing process. Then, the results of hydraulic fracturing simulation are used as initial values to perform coupling modeling for coalbed methanedoi:10.1155/2022/8995347 fatcat:2r24hun6tvedlf7utpjisldb6y
more »... traction. The method is implemented by the combination of different modules in COMSOL to solve the state damage variable, displacement, and pressure. Additionally, two 2D numerical examples are used to verify the precision of this method, and a 3D coalbed methane extraction simulation is performed to analyze the extraction effects and the evolution characteristics of the permeability before and after hydraulic fracturing. Numerical examples show that the proposed coupling modeling method can not only simplify the calculation steps of the CwM method and reduce the numerical errors caused, but also characterize the damage, porosity, permeability, and extraction effect caused by hydraulic fracturing in coal seams with permeability anisotropy.
Chinese Physics B
Chen Yi-Feng et alVol. 18 ...doi:10.1088/1674-1056/18/7/019 fatcat:qdyayz542baopljufykruupciy
Workflows have been found useful for a variety of applications [Grossman et al. 2010; Denning et al. 2011; Chen et al. 2011; Zitnick 2013] . ... et al. 2014] , tutorial [Kong et al. 2012; Lafreniere et al. 2013] , revision [Chen et al. 2011] , stylization [Fernquist et al. 2011] , and beautification [Zitnick 2013 ]. ...doi:10.1145/2661229.2661247 fatcat:a3oiv5szlfgijbykfodqvekm6m
The newly developed 2D SWI has been successfully used to visualize the hemorrhage of hepatocellular carcinoma in a previous study. 11 Xing et al 9 first used this technique to study renal cancer and ...doi:10.1097/md.0000000000002960 pmid:26962796 pmcid:PMC4998877 fatcat:sjicku6rvvhlvbg5krqpvfxfdy
http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Amphioxus microRNAs An analysis of amphioxus miRNAs suggests an expansion of miRNAs played a key role in the evolution of chordates to vertebrates Abstract Background: microRNAs (miRNAs) are endogenous small non-coding RNAs that regulate gene expression at the post-transcriptional level. While the number of known human anddoi:10.1186/gb-2009-10-7-r78 pmid:19615057 pmcid:PMC2728532 fatcat:e2u5sj3trba3tkr3lizsixzzeq
more »... miRNAs is continuously increasing, information regarding miRNAs from other species such as amphioxus remains limited. Results: We combined Solexa sequencing with computational techniques to identify novel miRNAs in the amphioxus species B. belcheri (Gray). This approach allowed us to identify 113 amphioxus miRNA genes. Among them, 55 were conserved across species and encoded 45 nonredundant mature miRNAs, whereas 58 were amphioxus-specific and encoded 53 mature miRNAs. Validation of our results with microarray and stem-loop quantitative RT-PCR revealed that Solexa sequencing is a powerful tool for miRNA discovery. Analyzing the evolutionary history of amphioxus miRNAs, we found that amphioxus possesses many miRNAs unique to chordates and vertebrates, and these may thus represent key steps in the evolutionary progression from cephalochordates to vertebrates. We also found that amphioxus is more similar to vertebrates than are tunicates with respect to their miRNA phylogenetic histories. Conclusions: Taken together, our results indicate that Solexa sequencing allows the successful discovery of novel miRNAs from amphioxus with high accuracy and efficiency. More importantly, our study provides an opportunity to decipher how the elaboration of the miRNA repertoire that occurred during chordate evolution contributed to the evolution of the vertebrate body plan.
Mitochondrial tumor suppressor 1 (MTUS1) is a newly identified candidate tumor suppressor gene. Previous studies have demonstrated that the expression status of MTUS1 is altered in several types of tumors. However, its clinical significance for bladder cancer patients remains undetermined. In this study, we detected the expression of MTUS1 mRNA in bladder tumors and paired normal samples obtained from 5 patients using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Adoi:10.3892/ol.2012.673 pmid:22807972 pmcid:PMC3398346 fatcat:a6i4nq5zlfgcrp6jkn76ibl7z4
more »... significant downregulation of MTUS1 mRNA expression was observed in the tumor tissues compared with the corresponding normal bladder tissue (P<0.001). We further tested the expression of MTUS1 mRNA in 55 bladder cancer tissues and 10 adjacent normal bladder tissues by quantitative real-time RT-PCR. Correlations between MTUS1 and clinicopathological features and prognosis were investigated by statistical analyses. The results showed that MTUS1 expression was correlated with tumor grade, stage, size and number (P<0.001, P<0.001, P=0.034 and P=0.029, respectively). Patients with low levels of MTUS1 mRNA expression had a poor prognosis compared with those with a high expression (P<0.001). Univariate and multivariate logistic regression prognostic analyses revealed that MTUS1 mRNA was an independent prognostic factor for disease-free survival in bladder cancer (P<0.05). In conclusion, these data suggest that MTUS1 is significant in the progression of bladder cancer and that the status of MTUS1 mRNA expression is a novel prognostic marker for predicting bladder tumor disease-free survival.
Sixteen tropinone derivatives were prepared, and their antitumor activities against five human cancer cells (HL-60, A-549, SMMC-7721, MCF-7 and SW480) were evaluated with MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium] assay. Most of the derivatives exhibited better activities compared with tropinone at the concentration of 40 lM. Particularly, derivative 6 showed significant activities with IC 50 values of 3.39, 13.59, 6.65, 13.09 and 12.38 lMdoi:10.1007/s13659-017-0124-z pmid:28321792 pmcid:PMC5397392 fatcat:yzj75r2fb5eupgdmvou5klgjna
more »... ectively against HL-60, A-549, SMMC-7721, MCF-7 and SW480 cells, which suggested more potent activities than that of cis-dichlorodiamineplatinum (DDP).
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