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SGEQ: A New Social Group Enlarging Query with Size Constraints

Xiaoxu Song, Bin Wang, Xiaochun Yang, Jing Qin, Liang Zhao, Lianqiang Niu
2020 IEEE Access  
LIANQIANG NIU received the master degree in Computational Mathematics from Jilin University, China, in 1986.  ...  7.35 TABLE 3 . 3 Parameters of the Datasets Parameter Range Default k 3, 4, 5 3 m 5, 7, 9 5 k + ∆ 4, 5, 6, 7, 8, 9 6 m + n 10, 11, 12, 13, 14, 15 11 VOLUME 4, 2016 Xiaoxu  ... 
doi:10.1109/access.2020.3032987 fatcat:giuur6gbubdbdk5horcgqon4oq

Power Output of Two Semiconductor Lasers: An Observational Study

Vicky Wenqing Xue, Iris Xiaoxue Yin, John Yun Niu, Kenneth Luk, Edward Chin Man Lo, Chun Hung Chu
2022 Photonics  
The objective of this study was to evaluate the power output of two dental devices. The study examined two semiconductor lasers, namely, SIROLaser Blue (445 nm, 970 nm) and Picasso (810 nm). The power output performance was studied at the maximum output power of the devices. The study compared the preset power output measured by a power meter in a continuous-wave mode and in pulsed mode at 50% duty cycles. Ten 60 s measurements were performed for each setting. The largest difference between the
more » ... stipulated and the actual output power at continuous-wave (D-cw) and pulsed (D-p) modes was calculated. Moreover, the percentage variations in the mean output power at continuous-wave (%D-cw) and pulsed (%D-p) modes were calculated. The D-cw values for 445 nm, 970 nm, and 810 nm lasers were 0.7 W, 0.5 W, and −0.3 W, respectively, and %D-cw values were 21%, 23%, and −8%, respectively. The D-p values for 445 nm, 970 nm, and 810 nm lasers were 1.1 W, 0.5 W, and −0.1 W, respectively, whereas the %D-p values were 37%, 26%, and −3%, respectively. This study found that the actual power is not necessarily lower but can be higher than the displayed power output. Clinicians are recommended to calibrate the laser output by using a power meter before use.
doi:10.3390/photonics9040219 fatcat:rq3ilfgc7fbizdthdbb4mupta4

Factors Associated with Nurses' Willingness to Participate in Care of Patients with COVID‐19: a Survey in China

Wu Bainv, Zhao Yun, Xu Dejing, Zhi Xiaoxu, Wang Yan, Niu Niu, Zhang Maomao, Zhu Ping, Meng Aifeng
2020 Journal of Nursing Management  
The research aims to assess nurses' willingness to participate in care of patients with coronavirus disease 2019 (COVID-19) in China, and to identify its associated factors. Along with the increasing number of infections, the world has paid widespread attention to COVID-19. This cross-sectional study used a convenience sampling method that included a demographics questionnaire and the Nurses' Perceived Professional Benefits Questionnaire. The survey was distributed to 1,787 nurses from 36
more » ... als in China. In total, 1176 questionnaires were usable for this research. 92.79% of nurses were willing to participate in care of patients with COVID-19. Intensive Care Unit (ICU) nurses were less willing to participate, while surgical nurses were more willing to participate. In addition, nurses with high positive professional perception scores were more willing to participate than those with low scores. The vast majority of nurses were willing to participate in care of patients with COVID-19 in China. Surgical nurses and nurses with positive professional perceptions are more likely to be willing to participate in treatment. To increase nurses' willingness to participate in care of patients with COVID-19, improving the sense of perceived professional benefits, offering salary and offering paid sick leave for nursing staff are effective ways. In addition, raise the awareness of infectious diseases and increase pre-disaster training during infectious diseases is critical.
doi:10.1111/jonm.13126 pmid:32767852 pmcid:PMC7436655 fatcat:mm4xkhevhbarvgowrpnym2s4ki

Genomic analysis of Helicobacter himalayensis sp. nov. isolated from Marmota himalayana

Shoukui Hu, Lina Niu, Lei Wu, Xiaoxue Zhu, Yu Cai, Dong Jin, Linlin Yan, Fan Zhao
2020 BMC Genomics  
Background Helicobacter himalayensis was isolated from Marmota himalayana in the Qinghai-Tibet Plateau, China, and is a new non-H. pylori species, with unclear taxonomy, phylogeny, and pathogenicity. Results A comparative genomic analysis was performed between the H. himalayensis type strain 80(YS1)T and other the genomes of Helicobacter species present in the National Center for Biotechnology Information (NCBI) database to explore the molecular evolution and potential pathogenicity of H.
more » ... yensis. H. himalayensis 80(YS1)T formed a clade with H. cinaedi and H. hepaticus that was phylogenetically distant from H. pylori. The H. himalayensis genome showed extensive collinearity with H. hepaticus and H. cinaedi. However, it also revealed a low degree of genome collinearity with H. pylori. The genome of 80(YS1)T comprised 1,829,936 bp, with a 39.89% GC content, a predicted genomic island, and 1769 genes. Comparatively, H. himalayensis has more genes for functions in "cell wall/membrane/envelope biogenesis" and "coenzyme transport and metabolism" sub-branches than the other compared helicobacters, and its genome contained 42 virulence factors genes, including that encoding cytolethal distending toxin (CDT). Conclusions We characterized the H. himalayensis 80(YS1)T genome, its phylogenetic position, and its potential pathogenicity. However, further understanding of the pathogenesis of this potentially pathogenic bacterium is required, which might help to manage H. himalayensis-induced diseases.
doi:10.1186/s12864-020-07245-y pmid:33228534 fatcat:z2ou3fnhkna5nksrkiwdtyoxke

Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

Yiyangzi Ma, Xiaoxue Xu, Mengtao Li, Jun Cai, Qiang Wei, Haitao Niu
2019 Molecular Medicine  
et al. 2008; Niu et al. 2013) .  ...  Enzyme-linked immunosorbent assay (ELISA) for serum IgG anti-dsDNA antibodies Serum IgG anti-dsDNA antibodies were measured using ELISA as previously described (Niu et al. 2008; Niu et al. 2013) .  ... 
doi:10.1186/s10020-019-0102-5 pmid:31370803 pmcid:PMC6676588 fatcat:xd4gsy52hbca3o7dmv2pxfcizy

Comparative transcriptome analysis of Gentiana macrophylla seeds after ferrous-priming and hydro-priming

Xiaoxue Niu, He Su, Baohua Li, Meng Mu, Xuehui Dong
2019 Seed science and technology  
The root of Gentiana macrophylla is a traditional Chinese medicine that has been used for over 2000 years. We introduced seed priming to improve germination performance for this species and found that after ferrous sulphate priming (FeP), seeds presented higher germination under both optimal and adverse environments than non-primed (NP) seeds. Transcriptome analysis conducted on FeP, hydro-primed (HP) and NP seeds was used to identify the key genes involved in metabolism and contribute to
more » ... tanding of the molecular mechanisms of seed priming. After calculating the gene expression and analysing the differentially-expressed genes (DEGs), a total of 2050 and 914 unigenes were identified as differentially expressed in FeP and HP seeds, respectively, relative to NP seeds. On the basis of the KEGG pathway enrichment analysis results, by analysing and summarising those DEGs related to enzymes during metabolism, enzymes involved in carbohydrate, nucleic acid metabolism, hormone biosynthesis and signal transduction, respiration and energy metabolism, and stress-related metabolism were all regulated after FeP treatment. Their regulated trends exhibited almost similar patterns with the initial germination process, whereas those from HP treatment were weaker than the effect of FeP, where only a small number of enzymes were regulated. Primed seeds are developmentally more advanced towards the completion of germination than NP seeds.
doi:10.15258/sst.2019.47.3.03 fatcat:3d3ynnvsz5aoxk2ayknnjj4cyu

Gene or environment? Species-specific control of stomatal density and length

Lirong Zhang, Haishan Niu, Shiping Wang, Xiaoxue Zhu, Caiyun Luo, Yingnian Li, Xinquan Zhao
2012 Ecology and Evolution  
Stomatal characteristics are used as proxies of paleo-environment. Only a few model species have been used to study the mechanisms of genetic and environmental effects on stomatal initiation. Variation among species has not been quantified. In this paper, results from an in situ reciprocal transplant experiment along an elevation gradient in the northeast Tibetan Plateau are reported, in which the relative effects of genetics (original altitude) and environment (transplant altitude) on stomatal
more » ... density (SD) and length (SL) were quantified. In Thalictrum alpinum, only the environment significantly influenced SD, with the variance component (s 2 T ) of the environment found to be much greater than that of genetics (s 2 O ) (s 2 T /s 2 O = 10.9). In Kobresia humillis, only genetics significantly influenced SD and SL, with the genetics variance component found to be greater than that of the environment (s 2 T /s 2 O = 0.17, for SD). These results suggest that the extent to which genetics and the environment determine stomatal initiation and development is species-specific. This needs to be considered when studying genetic or environmental controls of stomatal initiation, as well as when SD and SL are used as proxies for ancient climate factors (e.g., CO 2 concentration).
doi:10.1002/ece3.233 pmid:22837850 pmcid:PMC3399171 fatcat:vwrx4elblzcojo7euucszjgrua

Mesoporous silica nanoparticles for drug and gene delivery

Yixian Zhou, Guilan Quan, Qiaoli Wu, Xiaoxu Zhang, Boyi Niu, Biyuan Wu, Ying Huang, Xin Pan, Chuanbin Wu
2018 Acta Pharmaceutica Sinica B  
Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume, selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug
more » ... ity, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,
doi:10.1016/j.apsb.2018.01.007 pmid:29719777 pmcid:PMC5926503 fatcat:p2qpxl4c2rbafezy7av6ysakpm

CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection [article]

Zhiwei Zhu, Jie Wang, Xiaoxue Fan, Qi Long, Huazhi Chen, Yaping Ye, Kaiyao Zhang, Zhongmin Ren, Yang Zhang, Qingsheng Niu, Dafu Chen, Rui Guo
2022 bioRxiv   pre-print
Nosema ceranae is a widespread fungal parasite for honey bees, causing bee nosemosis. Based on deep sequencing and bioinformatics, identification of circular RNAs (circRNAs) in Apis cerana cerana workers midguts and circRNA-regulated immune response of host to N. ceranae invasion were conducted in this current work, followed by molecular verification of back-splicing sites and expression trends of circRNAs. Here, 10185 and 7405 circRNAs were identified in the midguts of workers at 7 d (AcT1)
more » ... 10 d (AcT2) post inoculation (dpi) with N. ceranae. PCR amplification result verified the back-splicing sites in three specific circRNAs (novel_circ_005123, novel_circ_007177, and novel_circ_015140) expressed in N. ceranae-inoculated midgut. In combination with transcriptome data from corresponding un-inoculated midguts (AcCK1 and AcCK2), 2266 circRNAs were found to be shared by the aforementioned four groups, whereas the numbers of specific ones were 2618, 1917, 5691 and 3723 respectively. Further, 83 (52) differentially expressed circRNAs (DEcircRNAs) were identified in AcCK1 vs AcT1 (AcCK2 vs AcT2) comparison group. Source genes of DEcircRNAs in workers midgut at 7 dpi were involved in two cellular immune-related pathways such as endocytosis and ubiquitin mediated proteolysis. Additionally, competing endogenous RNA network analysis showed that 23 (13) DEcircRNAs in AcCK1 vs AcT1 (AcCK2 vs AcT2) can target 18 (14) miRNAs and further link to 1111 (1093) mRNAs. These target mRNAs were annotated to six cellular immunity pathways including endocytosis, lysosome, phagosome, ubiquitin mediated proteolysis, metabolism of xenobiotics by cytochrome P450, and insect hormone biosynthesis. Moreover, 284 (164) IRES and 54 (26) ORF were identified from DEcircRNAs in AcCK1 vs AcT1 (AcCK2 vs AcT2) comparison group; additionally, ORFs in DEcircRNAs in midgut at 7 dpi with N. ceranae were associated with several crucial pathways including endocytosis and ubiquitin-mediated proteolysis. Finally, RT-qPCR results showed that the expression trends of six DEcircRNAs were consistent with those in transcriptome data. These results demonstrated that N. ceranae altered the expression pattern of circRNAs in A. c. cerana workers midguts, and DEcircRNAs were likely to regulate host cellular and humoral immune response to microsporidian infection. Our findings lay a foundation for clarifying the mechanism underlying host immune response to N. ceranae infection and provide a new insight into interaction between Asian honey bee and microsporidian.
doi:10.1101/2022.06.30.498258 fatcat:rm3sjrmh4zatpnuobz5rkclhtu

Heterocornols from the Sponge-Derived Fungus Pestalotiopsis heterocornis with Anti-Inflammatory Activity

Hui Lei, Xiaoxu Bi, Xiuping Lin, Jianglian She, Xiaowei Luo, Hong Niu, Dan Zhang, Bin Yang
2021 Marine Drugs  
One strain-many compounds (OSMAC) manipulation of the sponge-derived fungus Pestalotiopsis heterocornis XWS03F09 resulted in the production of new secondary metabolites. The chemical study of the fermentation, cultivated on 3% artificial sea salt in the rice media, led to the isolation of twelve compounds, including eight new polyketide derivatives, heterocornols Q–X (1–8), one new ceramide (9), and three known analogues (10–12). The structures and absolute configurations of the new compounds
more » ... re elucidated by spectroscopic data and calculated ECD analysis. Heterocornols Q (1) and R (2) are novel 6/5/7/5 tetracyclic polyketide derivatives featuring dihydroisobenzofuran and benzo-fused dioxabicyclo [4.2.1] nonane system, which might be derived from the acetyl-CoA by epoxidation, polyene cyclization, and rearrangement to form the core skeleton. Compound 12 showed moderate or weak antimicrobial activities against with MIC values ranging from 25 to 100 μg/mL. Heterocornols T and X (7 and 8) could inhibit the production of LPS-induced NO significantly, comparable to dexamethasone. Further Western blotting analysis showed 7 and 8 markedly suppressed the iNOS protein expression in LPS-induced RAW 264.7 cells in a dose-dependent manner. The result showed that 7 and 8 might serve as potential leads for development of anti-inflammatory activity.
doi:10.3390/md19110585 pmid:34822456 pmcid:PMC8620458 fatcat:aif3debv6nd4jnunnrdkdltjca

Vapor Phase Sensing Using Metal Nanorod Thin Films Grown by Cryogenic Oblique Angle Deposition

Piyush Shah, Dongquan Ju, Xiaoxu Niu, Andrew M. Sarangan
2013 Journal of Sensors  
We demonstrate the chemical sensing capability of silver nanostructured films grown by cryogenic oblique angle deposition (OAD). For comparison, the films are grown side by side at cryogenic (~100 K) and at room temperature (~300 K) by e-beam evaporation. Based on the observed structural differences, it was hypothesized that the cryogenic OAD silver films should show an increased surface enhanced Raman scattering (SERS) sensitivity. COMSOL simulation results are presented to validate this
more » ... esis. Experimental SERS results of 4-aminobenzenethiol (4-ABT) Raman test probe molecules in vapor phase show good agreement with the simulation and indicate promising SERS applications for these nanostructured thin films.
doi:10.1155/2013/823041 fatcat:vk4fpk24hre3dm3gdxgbjjyf2e

Non-existence for a semi-linear fractional system with Sobolev exponents via direct method of moving spheres

Xiaoxue Ji, Pengcheng Niu
2020 Boundary Value Problems  
The aim of this article is to consider the semi-linear fractional system with Sobolev exponents q = n+α n-β and p = n+β n-α (α = β):
doi:10.1186/s13661-020-01360-1 fatcat:uysr56lfqrbw3ftiewglmqqnwi

Label-free electrochemical impedance sensing of DNA hybridization based on functionalized graphene sheets

Yuwei Hu, Fenghua Li, Xiaoxue Bai, Dan Li, Shucheng Hua, Kaikai Wang, Li Niu
2011 Chemical Communications  
Label-free electrochemical impedance sensing of DNA hybridization based on functionalized graphene sheets Experimental Section Chemicals. Graphite powders (320 mesh) were of spectroscopically pure reagent and obtained from Shanghai Chemicals, China. 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA, 97%), tris(hydroxymethyl)amminomethane (Tris), N-hydroxysulfosuccinimide (NHS) and N-(3-dimethylamino) propyl-N'-ethyl carbodiimidehydrochloride (EDC) were obtained from Sigma-Aldrich, USA.
more » ... ne solution (50% in water) was purchased from Beijing Yili Chemicals, China. Ammonia solution (25% in water) was purchased from Beijing Chemicals, China. Sodium dodecylsulfate (SDS) was purchased from Shanghai Reagent Company, China. Other reagents were of analytical grade and were used as received. All aqueous solutions were prepared with ultrapure water (>18 MΩ) from a Milli-Q Plus system (Millipore). The 20-base synthetic oligonucleotides probe (ssDNA), its cDNA (target DNA, conserved sequence of the pol gene of human immunodeficiency virus 1 (HIV-1)), single-base mismatched, double-base mismatched, four-base mismatched and non-complementary DNA were all synthesized in Sangon Biotechnology Inc. (Shanghai, China). All oligonucleotide stock solutions (1.0×10 -4 M) were prepared by using Tris-HCl solution (pH 7.0), which were stored at 4 °C. More diluted solutions were obtained by diluting an aliquot of the stock solution with ultrapure water prior to use. The hybridization solution was diluted with 2×SSC (pH 7.0), which consisted of NaCl (0.30 M) and sodium citrate tribasic dihydrate (C 6 H 5 Na 3 O 7 ·2H 2 O; 0.030 M). Instruments. UV-vis absorption spectra were recorded using a Cary 500 UV/vis/near-IR
doi:10.1039/c0cc04514d pmid:21125081 fatcat:zktvyez6wvbd5cmrq7b5obikqm

Sensitive miRNA markers for the detection and management of NSTEMI acute myocardial infarction patients

Guoyong Liu, Xiaowei Niu, Xiaoxue Meng, Zheng Zhang
2018 Journal of Thoracic Disease  
NSTEMI patients will benefit greatly with better biomarker screening to detect and prognose the disease. Using miRNAs, we evaluated the clinical utility in acute myocardial infarction (AMI) patients during disease onset and therapy. Methods: A total of 145 NSTEMI patients and 30 healthy volunteers with no history of cardiovascular disease (CVD) were recruited. miRNA levels in plasma were measured during disease manifestation and serially during treatment phase. Levels of multiple candidates
more » ... -1, miR-133, miR-208, miR-499) were analysed. The miRNA levels were directly compared between NSTEMI and healthy volunteers. Results: Cardiac related miRNAs levels demonstrated significant increase compared with healthy controls. miR-499 exhibited the highest elevation with more than 6.03-fold change compared with healthy participants. Conventional cTnT measurements were in good agreement to miRNA relative expressions. In serial measurements, miR-499 demonstrated large fluctuations and could be linked to the secondary complications. In contrast, miR-133 showed insignificant variations in mean levels during serial sampling. Conclusions: miRNA is a potentially sensitive biomarker for NSTEMI AMI patients for disease detection and treatment monitoring. The sensitivities were comparable to cTnT for diagnostic accuracy and patients with sustained or higher levels were correlated to secondary complications.
doi:10.21037/jtd.2018.05.141 pmid:30069316 pmcid:PMC6051819 fatcat:5cuqcwhjujafromvb4cd3rdihe

Development and implementation of an "Internet+" management plan for cancer patients with wounds/stomas during the coronavirus disease 2019 pandemic

Niu Niu, Xiaoxu Zhi, Liuliu Zhang, Meixiang Wang, Yun Zhao, Lifang Yang, Bing Wu, Ping Zhu, Na Wang, Maomao Zhang, Bainv Wu, Yinan Zhang (+1 others)
2021 Precision Medical Sciences  
., Niu N., Zhi X.X., Zhang L.L., Yang L.F., Wu B., Zhu P., Wang N.: Made substantial contributions to data collection and analysis.  ...  Niu N., Meng A.F., Zhi X.X., Zhang L.L., Zhang Y.N., Wang M.X., Zhao Y., Yang L.F.: Made substantial contributions to design the study.  ... 
doi:10.1002/prm2.12055 fatcat:p2hzgso3bbccnmwlygjvyqybne
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