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Optimal Design Aircraft Engine Mount Systems

Jiang Xianghua, Du Ran
2015 Procedia Engineering  
The main component of APU (Auxiliary Power Unit) mount systems is a frame structure. A spare beam is a smart structure to ensure the frame structure's reliability. However, light-weighted design and spare beam structure are difficultly considered simultaneously in the traditional design. This paper addresses two techniques to solve this problem, using topology optimization method and the FEM (Finite Element Method). The two methods are put into practice on an example model to prove their
more » ... y and compared to attach a report of their characteristic. The two methods this paper addressed also can be references to other frame structures' design optimization.
doi:10.1016/j.proeng.2014.12.662 fatcat:jkcp7wrtybhjtjizhmgemc4ogq

NANOG regulates epithelial–mesenchymal transition and chemoresistance in ovarian cancer

Shan Qin, Yanfang Li, Xuexia Cao, Jiexian Du, Xianghua Huang
2016 Bioscience Reports  
Xianghua Huang edited and reviewed the manuscript. Yanfang Li, Xuexia Cao and Jiexian Du acquired the data.  ... 
doi:10.1042/bsr20160247 pmid:27884977 pmcid:PMC5223747 fatcat:wgzgkmmxrrc4zmlrlzwvm5i67i

Co-management Model for Dealing with Intellectual Property Rights in Standards

Xiaoyan Du, Xianghua Zhu
2009 International Journal of Business and Management  
As the technical barriers characterized by standards including intellectual property right (IPR) have restricted industrial development in China, to improve industry core competence through self-innovation and standardization and industrialization of independent intellectual property has come to our primary task. On base of the situation in China, the problems arisen from IPRs in standards relate to the government, standardization organizations, enterprises, colleges and universities,
more » ... research institutions and so on, then how to make the stakeholders cooperate with each other becomes the key point. This paper analyzed current situation of each stakeholder, constructed co-management model including instructing of the government and governmental standardization organizations, folk industrial associations as bridge, industry and research integration with enterprises as the mainstay and with colleges and universities, scientific research institutions as pioneers.
doi:10.5539/ijbm.v4n6p97 fatcat:7v52xffi4zbarhytjgiqhkiy6i

Determination of Upper Limit Temperature of Strain-induced Transformation of Low Carbon Steels

Linxiu Du, Caibei Zhang, Hua Ding, Xianghua Liu, Guodong Wang
2002 ISIJ International  
doi:10.2355/isijinternational.42.1119 fatcat:gx2sgrwifrgnnkpmhnzgbn7vfe

Dynamic Robustness Analysis for Subway Network with Spatiotemporal Characteristic of Passenger Flow

Yi Fan, Fan Zhang, Shihong Jiang, Chao Gao, Zhanwei Du, Zhen Wang, Xianghua Li
2020 IEEE Access  
XIANGHUA LI received the Ph.D. degree from Jilin University, China, in 2009.  ...  ZHANWEI DU received the Ph.D. degree from the Department of Computer Science and Technology, Jilin University, in 2015.  ... 
doi:10.1109/access.2020.2978279 fatcat:4knosjb3dnb4tawaswa5etfapu

Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol

Xianghua Yuan, Jing Liu, Ruilian Li, Junlin Zhou, Jinhua Wei, Siming Jiao, Zhuo A. Wang, Yuguang Du
2020 Molecules  
The formation of bacterial biofilms has increased the resistance of bacteria to various environmental factors and is tightly associated with many persistent and chronic bacterial infections. Herein we design a strategy conjugating florfenicol, an antibiotic commonly used in the treatment of streptococcus, with the antimicrobial biomaterial, chitosan oligosaccharides. The results demonstrated that the florfenicol-COS conjugate (F-COS) efficiently eradicated the mature Streptococcus hyovaginalis
more » ... iofilm, apparently inhibiting drug resistance to florfenicol. A quantity of 250 μg/mL F-COS showed effective inhibitory activity against planktonic cells and biofilm of the bacteria, and a 4-fold improvement of the F-COS compared to unmodified florfenicol was observed. Furthermore, the conjugate showed a broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It suggested that F-COS might have a potential for application in the treatment of biofilm-related infections.
doi:10.3390/molecules25246043 pmid:33371321 fatcat:gm7dlw7rnnfo3clgu2eakwimm4

High Accuracy and Miniature 2-D Wind Sensor for Boundary Layer Meteorological Observation

Yichen Pan, Zhan Zhao, Rongjian Zhao, Zhen Fang, Hong Wu, Xianghua Niu, Lidong Du
2019 Sensors  
Wind speed and direction are important parameters in meteorological observation. A solid wind sensor is needed with a small quadcopter for boundary layer meteorological observation. In this paper, the principle of a cylindrical two-dimensional wind sensor is reported and the data from wind tunnel experiments are analyzed. A model is proposed to describe the distribution of the pressure difference across a diameter of a cylinder, and the wind sensor is fabricated with MEMS
more » ... al System) differential pressure sensors. The wind sensor cylinder has a small size with a diameter of 30 mm and a height of 80 mm. In wind tunnel tests in the range of 1 to 40 m/s, the relative speed measuring errors and the direction measuring errors of the prototype are no more than ± (0.2 + 0.03 V) m/s (V is standard wind speed) and 5°, respectively. An inclination angle model is proposed to correct the influence of tilt angle on the quadcopter platform, the wind sensor can maintain the original wind speed and direction measurement accuracy within the 30° inclination range after compensation.
doi:10.3390/s19051194 fatcat:genpquirlrasddaxnlpcioatym

Synthesis and Evaluation of a Chitosan Oligosaccharide-Streptomycin Conjugate against Pseudomonas aeruginosa Biofilms

Ruilian Li, Xianghua Yuan, Jinhua Wei, Xiafei Zhang, Gong Cheng, Zhuo Wang, Yuguang Du
2019 Marine Drugs  
Microbial biofilms are considerably more resistant to antibiotics than planktonic cells. It has been reported that chitosan coupling with the aminoglycoside antibiotic streptomycin dramatically disrupted biofilms of several Gram-positive bacteria. This finding suggested the application of the covalent conjugate of antimicrobial natural polysaccharides and antibiotics on anti-infection therapy. However, the underlying molecular mechanism of the chitosan-streptomycin conjugate (CS-Strep) remains
more » ... nclear and the poor water-solubility of the conjugate might restrict its applications for anti-infection therapy. In this study, we conjugated streptomycin with water-soluble chitosan oligosaccharides (COS). Unlike CS-Strep, the COS-streptomycin conjugate (COS-Strep) barely affected biofilms of tested Gram-positive bacteria. However, COS-Strep efficiently eradicated established biofilms of the Gram-negative pathogen Pseudomonas aeruginosa. This activity of COS-Strep was influenced by the degree of polymerization of chitosan oligosaccharide. The increased susceptibility of P. aeruginosa biofilms to antibiotics after conjugating might be related to the following: Suppression of the activation of MexX-MexY drug efflux pump system induced by streptomycin treatment; and down-regulation of the biosynthesis of biofilm exopolysaccharides. Thus, this work indicated that covalently linking antibiotics to chitosan oligosaccharides was a possible approach for the development of antimicrobial drugs against biofilm-related infections.
doi:10.3390/md17010043 fatcat:amd3xjkc4fe5lmsu42alop676m

Heterologous expression and biochemical characterization of a GHF9 endoglucanase from the termite Reticulitermes speratus in Pichia pastoris

Pengfei Zhang, Xianghua Yuan, Yuguang Du, Jian-Jun Li
2018 BMC Biotechnology  
Cellulases are of great significance for full utilization of lignocellulosic biomass. Termites have an efficient ability to degrade cellulose. Heterologous production of the termite-origin cellulases is the first step to realize their industrial applications. The use of P. pastoris for the expression of recombinant proteins has become popular. The endoglucanase from Reticulitermes speratus (RsEG), belonging to glycoside hydrolase family 9 (GHF9), has not been produced in P. pastoris yet.
more » ... : A mutant RsEG m (G91A/Y97W/K429A) was successfully overexpressed in P. pastoris. RsEG m , with optimum pH 5.0, was active over the pH range of 4.0 to 9.0, and exhibited superior pH stability over between pH 4.0 and pH 11.0. It displayed the highest activity and good stability at 40°C, but lost activity quickly at 50°C. The apparent kinetic parameters of RsEG m against Carboxymethyl Cellulose (CMC) were determined, with K m and V max of 7.6 mg/ ml and 5.4 μmol/min•mg respectively. Co 2+ , Mn 2+ and Fe 2+ enhanced the activity of RsEG m by 32.0, 19.5 and 11.2% respectively, while Pb 2+ and Cu 2+ decreased its activity by 19.6 and 12.7% separately. Conclusions: RsEG m could be overexpressed in P. pastoris. It was stable between pH 4.0 and pH 11.0, and exhibited higher stability at temperatures ≤ 40°C. This endoglucanase may have potential to be used in the field of laundry, textile and lignocellulose-based biofuels and chemicals.
doi:10.1186/s12896-018-0432-3 pmid:29859082 pmcid:PMC5984754 fatcat:n3dslczrojhyln5xjiqrhip7fe

Genome-wide association study of seed coat color in sesame (Sesamum indicum L.)

Chengqi Cui, Yanyang Liu, Yan Liu, Xianghua Cui, Zhiyu Sun, Zhenwei Du, Ke Wu, Xiaolin Jiang, Hongxian Mei, Yongzhan Zheng
2021 PLoS ONE  
Investigation: Yanyang Liu, Yan Liu, Xianghua Cui, Zhiyu Sun, Zhenwei Du, Ke Wu, Xiaolin Jiang, Hongxian Mei. Methodology: Hongxian Mei. Project administration: Hongxian Mei.  ...  Writing -review & editing: Yanyang Liu, Zhenwei Du, Ke Wu, Hongxian Mei.  ... 
doi:10.1371/journal.pone.0251526 pmid:34019554 pmcid:PMC8139513 fatcat:ravdgcfomzd53njgdayrxox2ti

A homolog of ETHYLENE OVERPRODUCER, OsETOL1, differentially modulates drought and submergence tolerance in rice

Hao Du, Nai Wu, Fei Cui, Lei You, Xianghua Li, Lizhong Xiong
2014 The Plant Journal  
under various stresses, seedlings at the four-leaf stage were subjected to cold (4°C); heat shock (42°C); salt (200 mM NaCl); and ultraviolet (UV) light treatment as described in our previous study (Du  ...  Wiley & Sons Ltd, The Plant Journal, (2014), 78, 834-849 © 2014 The Authors © 2014 The Authors The Plant Journal © 2014 John Wiley & Sons Ltd, The Plant Journal, (2014), 78, 834-849 846 Hao Du  ... 
doi:10.1111/tpj.12508 pmid:24641694 fatcat:6vbmvrvlrjejjd22fwuzcwqzy4

Design of a Wind Sensor Based on Cylinder Diametrical Pressure Differences for Boundary Layer Meteorological Observation

Zhan Zhao, Yichen Pan, Rongjian Zhao, Lidong Du, Zhen Fang, Hong Wu, Xianghua Niu
2018 Proceedings (MDPI)  
Wind speed and direction are important parameters in meteorological observation. Solid wind sensor has needed with small Quadcopter for boundary layer meteorological observation. In this paper the principle of a cylindrical two-dimensional wind sensor is reported by analyzing the data from wind tunnel experiments. A model is proposed to describe the distribution of the pressure difference across a diameter of a cylinder and the wind sensor is fabricated with MEMS differential pressure sensors.
more » ... n wind tunnel tests in range of 1~40 m/s, the relative speed measuring errors and the direction measuring errors of the prototype are no more than ±(0.2 + 0.03 V) m/s and 5° respectively.
doi:10.3390/proceedings2131511 fatcat:6d7d23plunc4dgambpuguqcua4

Some pharmacokinetic parameters of salvianolic acid A following single-dose oral administration to rats

Jialin Sun, Junke Song, Wen Zhang, Fanbo Jing, Wen Xu, Ping Leng, Xianghua Quan, Guanhua Du, Zhongguo Sui
2018 Pharmaceutical Biology  
Context: Salvianolic acid A (Sal A) is a hydrophilic bioactive compound isolated from Salvia miltiorrhiza Bunge (Lamiaceae). It exerts beneficial effects after oral administration on diabetic complications. Objective: To systematically study the absorption, distribution and excretion of Sal A after single-dose oral administration. Materials and methods: Animal experiments were conducted in Sprague-Dawley rats. Plasma was sampled at designated times after oral doses of 5, 10 and 20 mg/kg, and an
more » ... intravenous dose of 50 lg/ kg. Tissues were harvested at 10, 60 and 120 min postdosing. Bile, urine and feces were collected at specified intervals before and after dosing. Absorption and distribution characteristics were analyzed by LC-MS, and excretion characteristics were analyzed by UPLC-MS/MS. The Caco-2 cell model was applied to investigate potential mechanisms. Results: The C max (5 mg/kg: 31.53 lg/L; 10 mg/kg: 57.39 lg/L; 20 mg/kg: 111.91 lg/L) of Sal A increased linearly with doses (r> 0.99). The calculated absolute bioavailability was 0.39-0.52%. Transport experiment showed poor permeability and the ratio of P B-A to P A-B was 3.13-3.97. The highest concentration of Sal A was achieved in stomach followed by small intestine and liver, and it could also be detected in brain homogenate. Approximately 0.775% of its administered dose was excreted via feces, followed by bile (0.00373%) and urine (0.00252%). Discussion and conclusions: These results support the future development of Sal A as an oral drug for the treatment of diabetic complications. Future research should be conducted to investigate the reason for its poor bioavailability and improve this situation. ARTICLE HISTORY
doi:10.1080/13880209.2018.1491998 pmid:30122142 fatcat:u2x4iaz75jdixkk6icot5fdppm

Identification and expression profiling analysis of TIFY family genes involved in stress and phytohormone responses in rice

Haiyan Ye, Hao Du, Ning Tang, Xianghua Li, Lizhong Xiong
2009 Plant Molecular Biology  
The TIFY family is a novel plant-specific gene family involved in the regulation of diverse plant-specific biologic processes, such as development and responses to phytohormones, in Arabidopsis. However, there is limited information about this family in monocot species. This report identifies 20 TIFY genes in rice, the model monocot species. Sequence analysis indicated that rice TIFY proteins have conserved motifs beyond the TIFY domain as was previously shown in Arabidopsis. On the basis of
more » ... ir protein structures, members of the TIFY family can be divided into two groups. Transcript level analysis of OsTIFY genes in tissues and organs revealed different tempospatial expression patterns, suggesting that expression and function vary by stage of plant growth and development. Most of the OsTIFY genes were predominantly expressed in leaf. Nine OsTIFY genes were responsive to jasmonic acid and wounding treatments. Interestingly, almost all the OsTIFY genes were responsive to one or more abiotic stresses including drought, salinity, and low temperature. Over-expression of OsTIFY11a, one of the stress-inducible genes, resulted in significantly increased tolerance to salt and dehydration stresses. These results suggest that the OsTIFY family may have important roles in response to abiotic stresses. The data presented in this report provide important clues for further elucidating the functions of the genes in the OsTIFY family.
doi:10.1007/s11103-009-9524-8 pmid:19618278 fatcat:6pxr4plexbdjvkngjrfufk2x5q

A stress-responsive NAC transcription factor SNAC3 confers heat and drought tolerance through modulation of reactive oxygen species in rice

Yujie Fang, Kaifeng Liao, Hao Du, Yan Xu, Huazhi Song, Xianghua Li, Lizhong Xiong
2015 Journal of Experimental Botany  
For estimation of the degree of membrane lipid peroxidation in cells, the MDA (malondialdehyde) content was determined as described previously (Du et al., 2010) .  ... 
doi:10.1093/jxb/erv386 pmid:26261267 pmcid:PMC4623689 fatcat:ag4qkcyuqzfgxanzqyvkagngca
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