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Chinese Physics B
The nitrogen doping of ZnO film deposited by the magnetron sputtering method is subsequently realized by the hydrothermal synthesis method. The nitrogen-doped ZnO film is preferably (002) oriented. With the increase of hexamethylenetetramine (HMT) solution concentration, the average grain size of the film along the 002 direction almost immediately decreases and then monotonously increases, conversely, the lattice strain first increases and then decreases. The structural evolution of the filmdoi:10.1088/1674-1056/22/2/024202 fatcat:jvqnnqvu7zcj7fb6vxlborv7ry
more »... face from compact and even to sparse and rough is attributed to the enhanced nitrogen doping content in the hydrothermal process. The transmission and photoluminescence properties of the film are closely related to grain size, lattice strain, and nitrogen-related defect arising from the enhanced nitrogen doping content with HMT concentration increasing.
As an endoplasmic reticulum (ER) stress-inducible protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) has been proven to protect dopaminergic neurons and nondopaminergic cells. Our previous studies had shown that MANF protected against ischemia/reperfusion injury. Here, we developed a magnetic resonance imaging (MRI) technology to dynamically evaluate the therapeutic effects of MANF on ischemia/reperfusion injury. We established a rat focal ischemic model by using middledoi:10.3390/ijms17091476 pmid:27608005 pmcid:PMC5037754 fatcat:fzy7c6dfgbbrjfjdw64yl5jjfy
more »... artery occlusion (MCAO). MRI was performed to investigate the dynamics of lesion formation. MANF protein was injected into the right lateral ventricle at 3 h after reperfusion following MCAO for 90 min, when the obvious lesion firstly appeared according to MRI investigation. T2-weighted imaging for evaluating the therapeutic effects of MANF protein was performed in ischemia/reperfusion injury rats on Days 1, 2, 3, 5, and 7 post-reperfusion combined with histology methods. The results indicated that the administration of MANF protein at the early stage after ischemia/reperfusion injury decreased the mortality, improved the neurological function, reduced the cerebral infarct volume, and alleviated the brain tissue injury. The findings collected from MRI are consistent with the morphological and pathological changes, which suggest that MRI is a useful technology for evaluating the therapeutic effects of drugs.
This paper focuses on the risks of fraud, credit risk, market risk and central institutions in traditional financial markets, as well as the main problems faced by blockchain technology in financial services such as supply chain finance, trade finance, credit reporting, transaction clearing, insurance, and securities. The problem, through the research and analysis of the basic model and composition technology of the block chain, proposes that the future blockchain technology in the financialdoi:10.12783/dtem/icem2019/31178 fatcat:vvblkfyolvhubcb3ys4k4xi5dm
more »... ld innovation and development direction is the block chain technology and distributed security authentication technology, artificial intelligence technology, security cloud storage technology and big data processing technology are effectively combined to design a financial service and management platform based on block chain.
The a/b-mixed dimeric protein Ssh10b from the hyperthermophile Sulfolobus shibatae is a member of the Sac10b family that is thought to be involved in chromosomal organization or DNA repair/recombination. The equilibrium unfolding/refolding of Ssh10b induced by denaturants and heat was fully reversible, suggesting that Ssh10b could serve as a good model for folding/unfolding studies of protein dimers. Here, we investigate the folding/ unfolding kinetics of Ssh10b in detail by stopped-flowdoi:10.1007/s00792-008-0204-4 pmid:19002648 fatcat:beqar6jhyzhmtplsoh3kmzobtm
more »... r dichroism (SF-CD) and using GdnHCl as denaturant. In unfolding reactions, the native Ssh10b turned rapidly into fully unfolded monomers within the stoppedflow dead time with no detectable kinetic intermediate, agreeing well with the results of equilibrium unfolding experiments. In refolding reactions, two unfolded monomers associate in the burst phase to form a dimeric intermediate that undergoes a further, slower, first-order folding process to form the native dimer. Our results demonstrate that the dimerization is essential for maintaining the native tertiary interactions of the protein Ssh10b. In addition, folding mechanisms of Ssh10b and several other a/b-mixed or pure b-sheet proteins are compared.
According to the literature reports and clinical studies on alopecia areata (AA) from 2008 to 2018, most clinical treatments have been oral drugs and external ointments. At present, systemic immunosuppressive therapy has been widely used in AA, but there are various side effects such as elevated liver enzymes, gastrointestinal discomfort, poor drug compliance, and repeated illness. We present a case report describing a traditional medicine treatment for AA that uses an ethnic therapy of Zhuangdoi:10.1097/md.0000000000017793 pmid:31689855 pmcid:PMC6946491 fatcat:54r3snjoubbejd5br5n4f4znle
more »... edicine, a kind of Traditional Chinese Medicine, namely, medicated thread moxibustion. A 36-year-old man endured AA after going through a family misfortune. Half a year ago, his father passed away suddenly. Since then, he suffered continuous anguish, alcoholism and hair loss, especially in the past 2 months. A coin-shaped area of hair loss began to appear at the top of his head and gradually expanded to the surrounding region. A diagnosis of AA was made in the dermatology department of a local hospital. The patient was treated with the medicated thread moxibustion method of Traditional Zhuang Medicine at the Kuihua (special points of Zhuang medicine), Zusanli (ST 36), Xuehai (SP 10), Baihui (DU 20), and Taichong (LR 3) points every other day for 4 weeks. The area of hair loss showed slight improvement after 1 week of treatment. Only just a sprinkling of wooly hairs, whose color and thickness were similar to those of fine facial hairs, began to emerge sporadically from the follicles; they could be seen only in a bright light. When the patient saw the obvious curative effect, we continued the treatment for 2 weeks with the patient's consent. Three weeks later, the patchy AA area was covered with small cotton-like hairs of different lengths and uneven colors. The medicated thread moxibustion method of Zhuang medicine can be an effective alternative treatment in patients with AA.
The space fractional Cahn-Hilliard phase-field model is more adequate and accurate in the description of the formation and phase change mechanism than the classical Cahn-Hilliard model. In this article, we propose a temporal second-order energy stable scheme for the space fractional Cahn-Hilliard model. The scheme is based on the second-order backward differentiation formula in time and a finite difference method in space. Energy stability and convergence of the scheme are analyzed, and thearXiv:2011.02106v1 fatcat:2svtsy4qenfhda2dsmyd2eijoe
more »... mal convergence orders in time and space are illustrated numerically. Note that the coefficient matrix of the scheme is a 2 × 2 block matrix with a Toeplitz-like structure in each block. Combining the advantages of this special structure with a Krylov subspace method, a preconditioning technique is designed to solve the system efficiently. Numerical examples are reported to illustrate the performance of the preconditioned iteration.
The purpose of this study was to propose and test a conceptual model that links online vendors' attributes, relationship quality, and customer citizenship behavior. The empirical results showed that relational selling behavior was the most important attribute to enhancing both trust, commitment and satisfaction, followed by security and order fulfillment.doi:10.12783/dtem/emem2017/17109 fatcat:2shvpskvrbexdchw7s47i4ryoa
Di Chen for the rrf-1(pk1417) strain as well as Mei-Qing Zuo and Yong Cao, members of M.-Q.D.'s laboratory, for coding support. ...doi:10.1038/s41467-021-24816-z fatcat:tfeic7dkhvhxvjqus6dws65w2i
E64, o853 [doi:10.1107/S1600536808009884] 3-Phenyl-1,5-di-2-thienylpentane-1,5-dione Tuan-Jie Meng, Xian-Qiang Huang, Qing-Peng He and Jian-Yong Wang S1. ...doi:10.1107/s1600536808009884 pmid:21202340 pmcid:PMC2961221 fatcat:krsfmhe64ba5nkyejvg7uouthq
Unregulated expression of wild-type BRCA1 (wtBRCA1) confers an altered phenotype in cultured human prostate cancer cells, characterized by chemosensitivity, susceptibility to apoptosis, decreased DNA repair activity, and alterations of key cell regulatory proteins. We now report that the expression of truncated or mutant full-length BRCA1 genes can abrogate certain phenotypic characteristics and/or confer the opposite phenotype to the wild-type BRCA1 gene. In particular, severaldoi:10.1038/sj.onc.1205033 pmid:11781837 fatcat:faztoahepncahczwfqlauifkza
more »... l truncated BRCA1 proteins conferred chemoresistance, decreased susceptibility to apoptosis, and decreased ability to suppress in vivo tumor growth. These truncated BRCA1 proteins also blocked the ability of ectopically expressed wtBRCA1 to induce chemosensitivity and to inhibit estrogen receptor transcriptional activity. Studies using epitope-tagged truncated proteins con®rmed their expression, nuclear localization, and functionality. On the other hand, in cells with no endogenous wild-type BRCA1 (HCC1937 human breast cancer cells), the wtBRCA1 gene enhanced cellular DNA repair activity and rendered the cells resistant to DNA damage; while truncated BRCA1 proteins blocked the wtBRCA1induced chemoresistance. Our ®ndings suggest that truncated BRCA1 proteins can inhibit the function of wild-type BRCA1. They raise the possibility that some inherited BRCA1 mutations may actively promote oncogenesis by blocking the function of the remaining wild-type BRCA1 allele, although this hypothesis remains to be proved. Oncogene (2001) 20, 8215 ± 8235.
E67, o810 [doi:10.1107/S1600536811007653] 2-Chloro-N′-(2-hydroxy-3,5-diiodobenzylidene)benzohydrazide Fei Wang, Da-Yong Liu, Hai-Bo Wang, Xian-Sheng Meng and Ting-Guo Kang were placed in calculated positions ...doi:10.1107/s1600536811007653 pmid:21754096 pmcid:PMC3099825 fatcat:icevag2crrcltjj5r6ero7adnu
Water-soluble Fe3O4@F127@FA nanoclusters were prepared by a facile ultrasonic-treated method for MR imaging and targeted drug delivery.doi:10.1039/c9ra09670a pmid:35498332 pmcid:PMC9049288 fatcat:4xt3r67spva7rfowor2alggowa
h i g h l i g h t s • Diffused attachment of pure nitrogen arc on water-cooled anode surface. • Arc channel design with a flow-restrictor and downstream expansion. • Suitable combination of working parameters and the structural features of the plasma generator. • Mechanism of arc dispersion through thermal blocking and downstream expansion.doi:10.1016/j.taml.2016.09.001 fatcat:i5ywbypo7nc3lln7ppcetieoei
Aims: This study evaluated the safety and efficacy of stereotactic radiation therapy (SRT) for the treatment of patients with oligometastases or oligorecurrence within mediastinal lymph nodes (MLNs) originating from different tumors. Methods: Between October 2006 and May 2015, patients with MLN oligometastases or oligorecurrence were enrolled and treated with SRT at our hospital. The primary endpoint was MLN local control (LC). Secondary endpoints were time to symptom alleviation, overalldoi:10.18632/oncotarget.7636 pmid:26919113 pmcid:PMC4951277 fatcat:n2b6hwbi4zgsdkvtr22sjdo6x4
more »... al (OS) after SRT, and toxicity using the Common Terminology Criteria for Adverse Events (CTCAE v4.0). Results: Eighty-five patients with 98 MLN oligometastases or oligorecurrences were treated with SRT. For the entire cohort, the 1-year and 5-year actuarial LC rates were 97% and 77%, respectively. Of 53 symptomatic patients, symptom alleviation was observed in 47 (89%) after a median of 5 days (range, 3-30 days). The median OS was 27.2 months for all patients. For patients with non-small cell lung cancer, univariate and multivariate analyses revealed that a shorter interval between diagnosis of primary tumors and SRT and larger MLN SRT volume were associated with worse OS. CTCAE v4.0 ≥ Grade 3 toxicities occurred in six patients (7%), with Grade 5 in three patients (all with RT history to MLN station 7). Conclusions: SRT is a safe and efficacious treatment modality for patients with oligometastases or oligorecurrence to MLNs originating from different tumors, except for patients who received radiotherapy to MLN station 7. Further investigation is warranted to identify the patients who benefit most from this treatment modality.
Rhein, the active ingredient of rhubarb, a medicinal and edible plant, is widely used in clinical practice. In this work, we investigated the alterations of 14 bile acids and hepatic transporters after rats were administered rhein for 5 consecutive weeks. There was no obvious injury to the liver and kidney, and there were no significant changes in biochemical indicators. However, 1,000 mg/kg rhein increased the liver total bile acid (TBA) levels, especially taurine-conjugated bile acidsdoi:10.1101/2020.01.29.925297 fatcat:hexafacccnfkhokgmzfmpw3u7a
more »... , inhibited the expression of Farnesoid X receptor (FXR) and (bile salt export pump) BSEP mRNA, and upregulated the expression of (cholesterol 7-hydroxylase) CYP7A1 mRNA. Rhein close to the clinical dose reduced the amounts of TBAs, especially unconjugated bile acids (UCBAs), and elevated the expression of FXR and multidrug resistance-associated protein 3 (Mrp3) mRNA. These results denote that rhein is not toxic and is safe to use at a reasonable dose and timing.
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