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A Human Case of Lumbosacral Canal Sparganosis in China

Jian-Feng Fan, Sheng Huang, Jing Li, Ren-Jun Peng, He Huang, Xi-Ping Ding, Li-Ping Jiang, Jian Xi
2021 Korean Journal of Parasitology  
In this study, we intended to describe a human case of lumbosacral canal sparganosis in People's Republic of China (China). A 56-year-old man was admitted to Xiangya Hospital Central South University in Changsha, Hunan province, China after having an experience of perianal pain for a week. An enhancing mass, a tumor clinically suggested, was showed at the S1-S2 level of the lumbosacral spine by the examination of magnetic resonance imaging (MRI) with gadolinium contrast. The patient was
more » ... the laminectomy from S1 to S2, and an ivory-white living worm was detected in inferior margin of L5. In ELISA-test with cerebrospinal fluid (CSF) and serum samples, anti-sparganum antibodies were detected. He had a ingesting history of undercooked frog meat in his youth. By the present study, a human case of spinal sparganosis invaded in lumbosacral canal at the S1-S2 level was diagnosed in China. Although the surgical removal of larvae is known to be the best way of treatment for sparganosis, we administered the high-dosage of praziquantel, albendazole and dexamethasone to prevent the occurrence of another remain worms in this study.
doi:10.3347/kjp.2021.59.6.635 pmid:34974670 pmcid:PMC8721303 fatcat:5l4eb6lgcfd7pdjls47uaa4mm4

A Data Readout Approach for Physics Experiment [article]

Huang Xi-Ru, Cao Ping, Gao Li-Wei, Zheng Jia-Jun
2014 arXiv   pre-print
With the increasing physical event rate and number of electronic channels, traditional readout scheme meets the challenge of improving readout speed caused by the limited bandwidth of crate backplane. In this paper, a high-speed data readout method based on Ethernet is designed for each module to have capability of transmitting data to DAQ. Features of explicitly parallel data transmitting and distributed network architecture make the readout system has advantage of adapting varying
more » ... of particle physics experiments. Furthermore, to guarantee the readout performance and flexibility, a standalone embedded CPU system is utilized for network protocol stack processing. To receive customized data format and protocol from front-end electronics, a field programmable gate array (FPGA) is used for logic reconfiguration. To optimize the interface and improve the data swap speed between CPU and FPGA, a sophisticated method based on SRAM is presented in this paper. For the purpose of evaluating this high-speed readout method, a simplified readout module is designed and implemented. Test results show that this module can support up to 70Mbps data throughput from the readout module to DAQ smoothly.
arXiv:1410.5811v1 fatcat:h6qtkgpm55az5bkdhr2w52sesu

Dezocine Alleviates Morphine-Induced Dependence in Rats

Fei-xiang Wu, Hasan Babazada, Hao Gao, Xi-Ping Huang, Chun-hua Xi, Chun-hua Chen, Jin Xi, Wei-feng Yu, Renyu Liu
2018 Anesthesia and Analgesia  
BACKGROUND-Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models. METHODS-Dezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA)
more » ... llowed by Tukey's post hoc test. Buprenorphine and vehicle solution containing 20% (v/v) dimethyl sulfoxide were used for positive and negative control, respectively. The astrocytes activation in nucleus accumbens was assessed by immunofluorescence assay of glial fibrillary acidic protein. Effect of dezocine and buprenorphine on the internalization of κ opioid receptor (KOR) was investigated using Neuro2A expressing KOR fused to red fluorescent protein tdTomato (KOR-tdT). Buprenorphine and dezocine were screened against 44 G-protein-coupled receptors, ion channels, and transporter proteins using radioligand-binding assay to compare the molecular targets. RESULTS- The mean withdrawal score was reduced in rats treated with 1.25 mg·kg −1 dezocine compared to vehicle-treated control animals starting from the day 1 (mean difference: 7.8; 95% confidence interval [CI], 6.35-9.25; P < .0001 by 2-way ANOVA). Significance was observed at all treatment days, including day 7 (mean difference: 2.13; 95% CI, 0.68-3.58; P < .001 by 2-way ANOVA). Furthermore, dezocine inhibited the reinstatement of morphine-induced CPP (mean difference: 314; 95% CI, 197.9-430.1; P < .0001 by 2-way ANOVA) compared to the control group. Chronic morphine administration induced astrocytes activation in nucleus accumbens, which was attenuated by dezocine. Dezocine blocked the agonist-induced KOR internalization in vitro, 1 of the mechanisms involved in the downstream signaling and development of opioid dependence. Dezocine had affinity to norepinephrine and serotonin transporters and sigma-1 receptor, whereas buprenorphine showed no activity against these targets. CONCLUSIONS-Dezocine could potentially be used to alleviate opioid dependence. Due to the unique molecular target profile different from buprenorphine, it might have important value in studying the mechanisms of morphine dependence and developing novel therapeutic approaches. Opioid dependence, a growing clinical and social problem, is characterized by tolerance, withdrawal, and relapse, yet its precise management remains challenging. Increasing evidence indicates that κ opioid receptor (KOR) plays an important role in the development of μ opioid receptor (MOR)-mediated opioid dependence, tolerance, and withdrawal. 1-3 Activation of KOR relates to the opioid withdrawal, as morphine-dependent KOR knockout mice displayed fewer withdrawal symptoms than wild-type mice. 4 Importantly, KOR undergoes qualitative and quantitative changes including elevated levels of mRNA in nucleus accumbens (NAcc), ventral tegmental area, and locus coeruleus-the brain regions associated with drug dependence, 5-8 as well as agonist-induced activation and internalization of the receptor for signal transduction cascades. 9,10 Although accumulating evidence suggests that KOR agonists attenuate drug reward and demonstrate potent analgesic effects, these agonists have also been shown to accelerate drug relapse, 11 establish conditioned place aversions, 12,13 and generate aversive mood, such as dysphoria 14,15 and Wu et al.
doi:10.1213/ane.0000000000003365 pmid:29624527 pmcid:PMC6173660 fatcat:edw5od3xcrbsxatjodia47nlz4

Novel Molecular Targets of Dezocine and Their Clinical Implications

Renyu Liu, Xi-Ping Huang, Alexei Yeliseev, Jin Xi, Bryan L. Roth
2014 Anesthesiology  
Although dezocine is a partial μ-opioid receptor agonist, it is not a controlled substance. Thus, the characterization of the molecular targets of dezocine is critical for scientific and clinical implications. The goal of this study is to characterize molecular targets for dezocine and determine their implications. A binding screen for dezocine was performed on 44 available receptors and transporter proteins. Functional assays for the novel targets were performed along with computation
more » ... ons to locate the binding site. A G protein activation study was performed for the human κ opioid receptor to determine whether dezocine is a κ-antagonist. Data are presented as mean ± standard error. The affinities for dezocine were 3.7 ± 0.7 nM for the μ receptor, 527 ± 70 nM for the δ-receptor, and 31.9 ± 1.9 nM for the κ-receptor. Dezocine failed to induce G protein activation with κ-opioid receptor and concentration dependently inhibited κ-agonist (salvinorin A and nalbuphine)-induced receptor activation, indicating that dezocine is a κ-antagonist. Two novel molecular targets (norepinephrine transporter and serotonin transporter) were identified. Dezocine concentration-dependently inhibited norepinephrine and serotonin reuptake in vitro. The half maximal inhibitory concentrations (expressed as pIC50) were 5.68 ± 0.11 for norepinephrine transporter and 5.86 ± 0.17 for serotonin transporter. Dezocine occupied the binding site for known norepinephrine transporter and serotonin transporter inhibitors. The unique molecular pharmacological profile of dezocine as a partial μ-receptor agonist, a κ-receptor antagonist, and a norepinephrine and serotonin reuptake inhibitor (via norepinephrine transporter and serotonin transporter) was revealed. These discoveries reveal potentially important novel clinical implications and drug interactions of dezocine.
doi:10.1097/aln.0000000000000076 pmid:24263237 pmcid:PMC3944410 fatcat:dt6gbno5ejdqpiirblu2m73hp4

Bondi accretion of dark matter by neutron stars [article]

Xi Huang, Jian-Feng Liu, Wei-Hua Wang, Quan Cheng, Xiao-Ping Zheng
2017 arXiv   pre-print
In this paper, we have compared two different accretion mechanisms of dark matter particles by a canonical neutron star with M=1.4 M_ and R=10 km, and shown the effects of dark matter heating on the surface temperature of star. We should take into account the Bondi accretion of dark matter by neutron stars rather than the accretion mechanism of Kouvaris (2008) Kouvaris08, once the dark matter density is higher than ∼3.81 GeV/cm^3. Based on the Bondi accretion mechanism and heating of dark
more » ... annihilation, the surface temperature platform of star can appear at ∼ 10^6.5 year and arrive ∼ 1.12×10^5 K for the dark matter density of 3.81 GeV/cm^3, which is one order of magnitude higher than the case of Kouvaris (2008) with dark matter density of 30 GeV/cm^3.
arXiv:1705.08864v1 fatcat:cjc7qczujvhlhgsae5o5de46ly

Brand Alliance: Consumer Characteristics and the Interactive Effects

Pu LIU, Ping ZHOU, Chun-Ping HUANG, Fang YANG, Xi MA
2016 DEStech Transactions on Engineering and Technology Research  
This article explores how product involvement and brand knowledge, which can be expressed by consumer characteristics, moderate the influence of brand equity and joint fit on brand alliance evaluation. Results indicate that the four variables have interactions in the brand alliance evaluation and suggest that brand equity and joint fit should be considered when enterprises choose their partners and the target promotion strategy should be taken according to consumer characteristics.
doi:10.12783/dtetr/ssme-ist2016/3922 fatcat:vw7nnwvqtfbyjess7jxmwyqemy

Development of a Genomic DNA Reference Material Panel for Thalassemia Genetic Testing [article]

Zhen-Zhen Yin, Shou-Fang Qu, Chuan-Feng Huang, Fang Chen, Jian-Biao Li, Shi-Ping Chen, Yu Zheng, Xi Zhang, Xue-Xi Yang, Long-Xu Xie, Ji-Tao Wei, Feng-Xiang Wei (+2 others)
2019 bioRxiv   pre-print
Thalassemia is one of the most common autosomal recessive inherited diseases worldwide, and it is also highly prevalent and variable in Southern China. Various types of genetic testing technologies have been developed for diagnosis and screening of thalassemia. Characterized genomic DNA reference materials are necessary for assay development, validation, proficiency testing and quality assurance. However, there is no publicly available reference materials for thalassemia genetic testing as yet.
more » ... To address the need for these materials, the National Institutes for Food and Drug Control and the China National Gene Bank established 31 new cell lines with 2 wild genotypes and 29 distinct genotypes of thalassemia which account for approximately 90% thalassemia carriers in China. The genomic DNA of 31 cell lines were characterized by four clinical genetic testing laboratories using different genetic testing methods and technology platforms. The genotyping results were concordant among four laboratories. In addition, the results of stability test demonstrated that the genotypes of these DNA samples were not influenced by preanalytical conditions such as long-term exposure to high temperature(37oC) environment and repeated freeze-thawing. In conclusion, we developed the first national panel of 31 genomic DNA reference materials which are renewable and publicly available for the quality assurance of various genetic testing methods and will facilitate research and development in thalassemia genetic testing.
doi:10.1101/676015 fatcat:xqhcw2ifonhmtneg34g4fk6r44

The role of NMDA receptors in rat propofol self-administration

Bei-ping Chen, Xi-xi Huang, Dong-mei Dong, Hui Wu, Tian-qi Zhu, Ben-fu Wang
2020 BMC Anesthesiology  
Propofol is among the most frequently used anesthetic agents, and it has the potential for abuse. The N-methyl-D-aspartate (NMDA) receptors are key mediators neural plasticity, neuronal development, addiction, and neurodegeneration. In the present study, we explored the role of these receptors in the context of rat propofol self-administration. Sprague-Dawley Rats were trained to self-administer propofol (1.7 mg/kg/infusion) using a fixed-ratio (FR) schedule over the course of 14 sessions (3
more » ... ay). After training, rats were intraperitoneally administered the non-competitive NDMA receptor antagonist MK-801, followed 10 min later by a propofol self-administration session. After training, rats successfully underwent acquisition of propofol self-administration, as evidenced by a significant and stable rise in the number of active nose-pokes resulting in propofol administration relative to the number of control inactive nose-pokes (P < 0.01). As compared to control rats, rats that had been injected with 0.2 mg/kg MK-801 exhibited a significantly greater number of propofol infusions (F (3, 28) = 4.372, P < 0.01), whereas infusions were comparable in the groups administered 0.1 mg/kg and 0.4 mg/kg of this compound. In addition, MK-801 failed to alter the numbers of active (F (3, 28) = 1.353, P > 0.05) or inactive (F (3, 28) = 0.047, P > 0.05) responses in these study groups. Animals administered 0.4 mg/kg MK-801 exhibited significantly fewer infusions than animals administered 0.2 mg/kg MK-801 (P = 0.006, P < 0.01). In contrast, however, animals in the 0.4 mg/kg MK-801 group displayed a significant reduction in the number of active nose-poke responses (F (3, 20) = 20.8673, P < 0.01) and the number of sucrose pellets (F (3, 20) = 23.77, P < 0.01), while their locomotor activity was increased (F (3, 20) = 22.812, P < 0.01). These findings indicate that NMDA receptors may play a role in regulating rat self-administration of propofol.
doi:10.1186/s12871-020-01056-0 pmid:32539742 pmcid:PMC7294660 fatcat:ijyzqporkjbt7gdgrqzmxes3ge

Blood coagulation system in patients with chronic kidney disease: a prospective observational study

Meng-Jie Huang, Ri-bao Wei, Yang Wang, Ting-yu Su, Ping Di, Qing-ping Li, Xi Yang, Ping Li, Xiang-mei Chen
2017 BMJ Open  
doi:10.1136/bmjopen-2016-014294 pmid:28576889 pmcid:PMC5541338 fatcat:3mg5bjqdnnef7bjk72gawfwkam

Bilateral Lower Limb and Abdominal Elephantiasis Due to Erysipelas

Qi-Ming Feng, Yan-Ping Yang, Wan-Xue Huang, Wei-Xi Zhong, Yi-Mu Fu, Ping-An He, Gang Zhao
2018 Chinese Medical Journal  
doi:10.4103/0366-6999.228244 pmid:29578137 pmcid:PMC5887752 fatcat:vreyy4k72fbofb6vbb2kj5sqvu

Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients

Xiao-chun Xie, Jun Li, Hong-yang Wang, Hong-liang Li, Jing Liu, Qian Fu, Jia-wen Huang, Chen Zhu, Guo-ping Zhong, Xue-ding Wang, Ping-ping Sun, Min Huang (+2 others)
2015 Acta Pharmacologica Sinica  
Aim: To evaluate the effects of UDP-glucuronosyltransferases (UGTs) polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil (MMF) in Chinese renal transplant recipients. Methods: A total of 127 renal transplant patients receiving MMF were genotyped for polymorphisms in UGT1A9 -1818T>C, I399C>T, -118T9/10, -440C>T, -331T>C, UGT2B7 IVS1+985A>G, 211G>T, -900A>G, UGT1A8 518C>G and UGT1A7 622T>C. The plasma concentrations of the MMF active moiety mycophenolic acid (MPA)
more » ... nd main metabolite 7-O-MPA-glucuronide (MPAG) were analyzed using HPLC. Univariate and multivariate analyses were used to assess the effects of UGT-related gene polymorphisms on MPA pharmacokinetics. Results: The dose-adjusted MPA AUC 0-12 h of the patients with the UGT2B7 IVS1+985AG genotype was 48% higher than that of the patients with the IVS1+985AA genotype, which could explain 11.2% of the inter-individual variation in MPA pharmacokinetics. The dose-adjusted MPAG AUC 0-12 h of the patients with the UGT1A7 622CC and UGT1A9 -440CT/-331TC genotypes, respectively, was significantly higher than that of the patients with 622T homozygotes and -440C/-331T homozygotes. Furthermore, the genotypes UGT1A9 -1818T>C and UGT1A8 518C>G were associated with a low dose-adjusted MPAG AUC 0-12 h . Conclusion: The UGT2B7 11+985A>G genotype is associated with the pharmacokinetics of MPA in Chinese renal transplant patients, which demonstrates the usefulness of this SNP for individualizing MMF dosing.
doi:10.1038/aps.2015.7 pmid:25864649 pmcid:PMC4422949 fatcat:4vl3sa3yvzdg5d3r3d3jugwh6y

A Simple Representation Of Three-Dimensional Molecular Structure [article]

Seth D. Axen, Xi-Ping Huang, Elena L. Caceres, Leo Gendelev, Bryan L. Roth, Michael J. Keiser
2017 bioRxiv   pre-print
Statistical and machine learning approaches predict drug-to-target relationships from 2D small-molecule topology patterns. One might expect 3D information to improve these calculations. Here we apply the logic of the Extended Connectivity FingerPrint (ECFP) to develop a rapid, alignment-invariant 3D representation of molecular conformers, the Extended Three-Dimensional FingerPrint (E3FP). By integrating E3FP with the Similarity Ensemble Approach (SEA), we achieve higher precision-recall
more » ... nce relative to SEA with ECFP on ChEMBL20, and equivalent receiver operating characteristic performance. We identify classes of molecules for which E3FP is a better predictor of similarity in bioactivity than is ECFP. Finally, we report novel drug-to-target binding predictions inaccessible by 2D fingerprints and confirm three of them experimentally with ligand efficiencies from 0.442 - 0.637 kcal/mol/heavy atom.
doi:10.1101/136705 fatcat:spjnyzatzvcfri5insngzrysvm

A Data Transmission Method Based on Ethernet Physical Layer for Particle Physics Experiment [article]

Huang Xi-Ru, Cao Ping, Zheng Jia-Jun
2015 arXiv   pre-print
Due to the advantages of universality, flexibility and high performance, fast Ethernet is widely used in readout system design of modern particle physics experiments. However, Ethernet is usually used together with TCP/IP protocol stack, which makes it difficult to be implemented because designers have to use operating system to process this protocol. Furthermore, TCP/IP protocol degrades the transmission efficiency and real-time performance. To maximize the performance of Ethernet in physics
more » ... periment applications, a data readout method based on physical layer (PHY) is proposed in this paper. In this method, TCP/IP protocol is forsaken and replaced with a customized and simple protocol, which make it easier to be implemented. On each readout module, data from front-end electronics is first fed into an FPGA for protocol processing and then sent out to a PHY chip controlled by this FPGA for transmission. This kind of data path is fully implemented by hardware. While from the side of data acquisition system (DAQ), absence of standard protocol makes the network related applications panic. To solve this problem, in the operating system kernel space, data received by network interface card is drawn away from the traditional flow and redirected to a specified memory space by a customized program. This memory space can be easily accessed by applications in user space. For the purpose of verification, a prototype system is designed and implemented. Preliminary test result shows that this method can meet the requirement of data transmission from readout module to DAQ with good efficiency and simplicity.
arXiv:1503.00474v1 fatcat:7p4yalwusjbgpclsyjzpxvvyfi

Generalized Chaplygin cosmology with changeable-signs interactions

XI Ping, HUANG Zhenzi
2013 Journal of Shanghai Normal University (Natural Sciences)  
Using phase space analysis methods,we discuss two kinds of Generalized Chaplygin cosmology with changeable-signs interactions dynamically.Some new stable attractor solutions and heteroclinic trajectory solutions are found in these two types of models.
doaj:8a172e27fba74bed9435ede9171eedd6 fatcat:itiecen7hnci3e63zpimbazghe

Role of confinement in water solidification under electric fields

Guo-Xi Nie, Yu Wang, Ji-Ping Huang
2015 Frontiers of Physics  
In contrast to the common belief that confinement promotes water solidification, here we show by molecular dynamics simulations that confinement can impede water solidification under electric fields. The behavior is evidenced by the increase in critical electric field strength for water solidification as the confinement progresses. We also show that the solidification occurs more easily with a parallel field than a perpendicular one. We understand and generalize these results by developing an
more » ... ergy theory incorporated with the anisotropic Clausius-Mossotti equation. It is revealed that the underlying mechanism lies in the confinement effect on molecules' electro-orientations. Thus, it becomes possible to achieve electro-freezing (i.e., room-temperature ice) by choosing both confinement and electric fields appropriately.
doi:10.1007/s11467-015-0504-y fatcat:dfzekoj3jnafregwwytrg4n7wq
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