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XAVIER MORLANS I MOLINA, La experiencia de Dios en la acción social. Hipótesis para una interpretación teológica inspirada en los prime- ros escritos de Maurice Blondel, Ed. ... El libro se lee con gusto y resulta instructivo; la vuelta a Blondel siempre es estimulante e invita a mejorar nuestro compromiso humano y cristiano. ...doaj:d6fb26f1f80f4ef5889b61639d5a298e fatcat:23wgz73smnhupkucbakmf7rwsu
1,2,3 , Claire Navarro 4 , Nicolas Lévy 4,5 , Marc Peschanski 1,2,3 , Xavier Nissan 1,2,3 1 CECS, I-STEM (Institute for stem cell therapy and exploration of monogenic diseases), AFM, 5, rue Henri Desbruères ... structuration de la matrice nucléaire, de prolifération et de réparation de l'ADN comparables à ceux qui sont observés dans des cultures de cellules miR-9 : la sentinelle des neurones dans la progéria Sophie Blondel ...doi:10.1051/medsci/2012286022 pmid:22805145 fatcat:wjl6lnmvgvb6hhjgglidgfenfy
Journal of Virology
BLONDEL ET AL. J. VIROL. on May 1, 2019 by guest http://jvi.asm.org/ Downloaded from BLONDEL ET AL. J. VIROL. on May 1, 2019 by guest http://jvi.asm.org/ Downloaded from ...doi:10.1128/jvi.01286-10 pmid:20702643 pmcid:PMC2950589 fatcat:tovt4vodsbc7zlxybo7syfj4dy
We present a case of acute schistosomiasis acquired in Corsica after bathing in the Cavu River during the summer of 2015. The diagnosis was made following epidemiological, laboratory and serological assessments. After a previous outbreak of urogenital schistosomiasis during the summer of 2013, when more than 120 infections were diagnosed, this further case indicates transmission was still effective in 2015, thus suggesting a permanent presence of schistosomiasis in Corsica. We report a case ofdoi:10.2807/1560-7917.es.2016.21.1.30100 pmid:26767427 fatcat:3ylqdek5mzeujbtgl7p6l2nl24
more »... chistosomiasis acquired in 2015 in Corsica, indicating that permanent transmission of this helminthiasis has been established on the island. Case description On 11 September 2015, a person in their 40s presented to the Consultation Board at the Infectious and Tropical Disease Department of Toulouse University Hospitals in France with a 15-day history of diffuse abdominal pain, headache and asthenia. The patient had no fever, and physical examination was unremarkable. In particular, the patient neither displayed any skin rash nor complained of pruritus. The white blood cell count was 6.0 × 10 9 /L, within the normal range (4.0-10.0 × 10 9 cells/L), but a blood eosinophilia (3.2 × 10 9 cells/L, normal range: < 0.5 × 10 9 cells/L) was observed by differential count. Biochemical tests of liver function found several abnormalities, namely a serum alanine aminotransferase level at 140 UI/L (normal range: 0-40 UI/L) and a gamma-glutamyl transferase level at 323 IU/L (normal range: 0-60 IU/L). Aspartate aminotransferase and total bilirubin levels were within the normal range. C-reactive protein was 11.7 mg/L (normal value: < 5 mg/L). By serology, the patient tested negative for cytomegalovirus, Epstein-Barr virus, hepatitis A, B and C, and Leptospira infections. Serodiagnostics of ascariasis, alveolar and cystic echinococcoses, fascioliasis, filariases, strongyloidiasis, trichinellosis and schistosomiasis were negative. The ELISA result for schistosomiasis (expressed as a ratio), although negative with a ratio of 0.770, was close to the cut-off value of 1.0. Schistosomiasis serology relied upon commercial ELISA kits (Bordier Affinity Products, Crissier, Switzerland) and indirect haemagglutination assay (IHA) (Fumouze Diagnostics, Levallois-Perret, France), which are both screening tests using Schistosoma mansoni extracts as antigen. Because an aetiological diagnosis was not reached, the patient attended a further consultation on 24 September. The clinical picture remained unchanged, but blood eosinophilia decreased to 2 × 10 9 cells/L. By that time, specific laboratory examinations for urogenital schistosomiasis had been carried out because of the previous ELISA result and also because the patient informed us of their vacation in Corsica in summer 2015. Urinalysis was normal, and microscopic search for Schistosoma haematobium eggs remained negative. Serology was positive, with an ELISA ratio of 2.65 (cutoff: 1.0). The IHA result (expressed as a titre of dilution) was 160 (cut-off: 160). These results were checked by a commercial Western blot using a mixture of adult S. haematobium and S. mansoni antigens (SCHISTO II Western blot IgG, LDBIO Diagnostics, Lyon, France). Faintly positive bands were observed at 30 kDa and 34 kDa, a result which was specific for the Schistosoma genus. On 15 October, the patient was asymptomatic, the eosinophil count had decreased to 0.5 × 10 9 cells/L and hepatic tests were back to normal values. The level of Schistosoma-specific antibodies, as measured by ELISA (ratio: 4.67) or IHA (titre: 320) had increased.
Caval vein thrombosis after hepatectomy is rare, although it increases mortality and morbidity. The evolution of this thrombosis into a septic thrombophlebitis responsible for persistent septicaemia after a hepatectomy has not been reported to date in the literature. We here report the management of a 54-year-old woman operated for a peripheral cholangiocarcinoma who developed a suppurated thrombophlebitis of the vena cava following a hepatectomy. This patient was operated by left lobectomydoi:10.4254/wjh.v11.i1.133 pmid:30705726 pmcid:PMC6354118 fatcat:65exbv3hgvgjfivcql4udpilka
more »... nded to segment V with bile duct resection and Roux-en-Y hepaticojejunostomy. After the surgery, she developed Streptococcus anginosus, Escherichia coli, and Enterococcus faecium bacteraemias, as well as Candida albicans fungemia. A computed tomography scan revealed a bilioma which was percutaneously drained. Despite adequate antibiotic therapy, the patient's condition remained septic. A diagnosis of septic thrombophlebitis of the vena cava was made on post-operative day 25. The patient was then operated again for a surgical thrombectomy and complete caval reconstruction with a parietal peritoneum tube graft. Use of the peritoneum as a vascular graft is an inexpensive technique, it is readily and rapidly available, and it allows caval replacement in a septic area. Septic thrombophlebitis of the vena cava after hepatectomy has not been described previously and it warrants being added to the spectrum of potential complications of this procedure. Septic thrombophlebitis of the vena cava was successfully treated with antibiotic and anticoagulation treatments, prompt surgical thrombectomy and caval reconstruction.
Lecture Notes in Computer Science
Martin-Blondel, X. Iriart, T. Le Taillandier, B. Marchou, A. Berry); INSERM UMR1043, Toulouse, France (G. Martin-Blondel, X. Iriart, A. ...doi:10.3201/eid2105.141181 pmid:25897573 pmcid:PMC4412217 fatcat:xz4iie5y6vaavldoxjl5y6boi4
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that causes systemic accelerated aging in children. This syndrome is due to a mutation in the LMNA gene that leads to the production of a truncated and toxic form of lamin A called progerin. Because the balance between the A-type lamins is controlled by the RNA-binding protein SRSF1, we have hypothesized that its inhibition may have therapeutic effects for HGPS. For this purpose, we evaluated the antidiabetic drug metformindoi:10.1038/npjamd.2016.26 pmid:28721276 pmcid:PMC5515002 fatcat:blsupynd2zgy7kuwtk6hv4jap4
more »... nd demonstrated that 48 h treatment with 5 mmol/l metformin decreases SRSF1 and progerin expression in mesenchymal stem cells derived from HGPS induced pluripotent stem cells (HGPS MSCs). The effect of metformin on progerin was then confirmed in several in vitro models of HGPS, i.e., human primary HGPS fibroblasts, Lmna G609G/G609G mouse fibroblasts and healthy MSCs previously treated with a PMO (phosphorodiamidate morpholino oligonucleotide) that induces progerin. This was accompanied by an improvement in two in vitro phenotypes associated with the disease: nuclear shape abnormalities and premature osteoblastic differentiation of HGPS MSCs. Overall, these results suggest a novel approach towards therapeutics for HGPS that can be added to the currently assayed treatments that target other molecular defects associated with the disease.
Both dust and silica phytoliths have been shown to contribute to reducing tooth volume during chewing. However, the way and the extent to which they individually contribute to tooth wear in natural conditions is unknown. There is still debate as to whether dental microwear represents a dietary or an environmental signal, with far-reaching implications on evolutionary mechanisms that promote dental phenotypes, such as molar hypsodonty in ruminants, molar lengthening in suids or enamel thickeningdoi:10.1098/rspb.2016.1032 pmid:27629027 pmcid:PMC5031653 fatcat:f6gabzzforcibmzdnjzmtxufta
more »... in human ancestors. By combining controlled-food trials simulating natural conditions and dental microwear textural analysis on sheep, we show that the presence of dust on food items does not overwhelm the dietary signal. Our dataset explores variations in dental microwear textures between ewes fed on dust-free and dust-laden grass or browse fodders. Browsing diets with a dust supplement simulating Harmattan windswept environments contain more silica than dust-free grazing diets. Yet browsers given a dust supplement differ from dust-free grazers. Regardless of the presence or the absence of dust, sheep with different diets yield significantly different dental microwear textures. Dust appears a less significant determinant of dental microwear signatures than the intrinsic properties of ingested foods, implying that diet plays a critical role in driving the natural selection of dental innovations.
Citation: Grohé C, Morlo M, Chaimanee Y, Blondel C, Coster P, et al. (2012) New Apterodontinae (Hyaenodontida) from the Eocene Locality of Dur At-Talah (Libya): Systematic, Paleoecological and Phylogenetical ...doi:10.1371/journal.pone.0049054 pmid:23185292 pmcid:PMC3504055 fatcat:5m3eu2kspray5dpaas56o73ggy
and ObjectivesProgressive multifocal leukoencephalopathy (PML) is a disabling neurologic disorder resulting from the infection of the CNS by JC polyomavirus in immunocompromised individuals. For the last 2 decades, increasing use of immunotherapies leads to iatrogenic PML. Iatrogenic PML is often associated with signs of inflammation at onset (inflammatory PML) and/or after treatment withdrawal immune reconstitution inflammatory syndrome (PML-IRIS). Although immune reconstitution is a keydoi:10.1212/nxi.0000000000001097 pmid:34728496 pmcid:PMC8564863 fatcat:4i76od7ynjey3jczjqz57sydcy
more »... t for viral clearance, it may also be harmful and induce clinical worsening. A C-C chemokine receptor type 5 (CCR5) antagonist (maraviroc) has been proposed to prevent and/or limit the deleterious immune responses underlying PML-IRIS. However, the data to support its use remain scarce and disputed.MethodsWe conducted a multicenter retrospective cohort study at 8 university hospitals in France and Switzerland by collecting clinical, biological, and radiologic data of patients who developed inflammatory PML (iPML) or PML-IRIS related to immunosuppressive therapies used for chronic inflammatory diseases between 2010 and 2020. We added to this cohort, a meta-analysis of individual case reports of patients with iPML/PML-IRIS treated with maraviroc published up to 2021.ResultsOverall, 27 cases were identified in the cohort and 9 from the literature. Among them, 27 met the inclusion criteria: 16 treated with maraviroc and 11 with standard of care (including corticosteroids use). Most cases were related to MS (92.6%) and natalizumab (88%). Inflammatory features (iPML) were present at onset in 12 patients (44.4%), and most patients (92.6%) received corticosteroids within the course of PML. Aggravation due to PML-IRIS was not prevented by maraviroc compared with patients who received only corticosteroids (adjusted odds ratio: 0.408, 95% CI: 0.06–2.63). Similarly, maraviroc did not influence time to clinical worsening due to PML-IRIS (adjusted hazard ratio = 0.529, 95% CI: 0.14–2.0) or disability at the last follow-up (adjusted odds ratio: 2, 95% CI: 0.23–17.3).DiscussionThe use of CCR5 blockade did not help to keep deleterious immune reconstitution in check even when associated with corticosteroids. Despite maraviroc's reassuring safety profile, this study does not support its use in iPML/PML-IRIS.Classification of EvidenceThis study provides Class IV evidence showing that adding maraviroc to the management of iatrogenic iPML/PML-IRIS does not improve the outcome.
Both dust and silica phytoliths have been shown to contribute to reducing tooth volume during chewing. However, the way and the extent to which they individually contribute to tooth wear in natural conditions is unknown. There is still debate as to whether dental microwear represents a dietary or an environmental signal, with far reaching implications on evolutionary mechanisms which promote dental phenotypes such as molar hypsodonty in ruminants, molar lengthening in suids or enamel thickeningdoi:10.6084/m9.figshare.3811155.v1 fatcat:ec24nci7b5dndkkn22qfe2muru
more »... in human ancestors.By combining controlled-food trials simulating natural conditions and dental microwear textural analysis on sheep, we show that the presence of dust on food items does not overwhelm the dietary signal. Our dataset explores variations in dental microwear textures between ewes fed on dust-free and dust-laden grass or browse fodders. Browsing diets with a dust supplement simulating Harmattan windswept environments contain more silica than dust-free grazing diets. Yet, browsers given a dust supplement differ from dust-free grazers. Regardless of the presence or the absence of dust, sheep with different diets yield significantly different dental microwear textures. Dust appears a less significant determinant of dental microwear signatures than the intrinsic properties of ingested foods, implying that diet plays a critical role in driving the natural selection of dental innovations.
To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection. In this retrospective, multicentric study, we analyzed brain MRI exams from 72 patients diagnosed with definite PML: 32 after natalizumab treatment, 20 after rituximab treatment, and 20 HIV patients. We compared T2- or FLAIR-weighted images, diffusion-weighted images, T2*-weighted images, and contrast enhancement features, as well as lesiondoi:10.1007/s00330-020-07362-y pmid:33155106 pmcid:PMC7644389 fatcat:x6n3a54vo5habgk7hmg5exwjwy
more »... ibution, especially gray matter involvement. The three PML entities affect U-fibers associated with low signal intensities on T2*-weighted sequences. Natalizumab-associated PML showed a punctuate microcystic appearance in or in the vicinity of the main PML lesions, a potential involvement of the cortex, and contrast enhancement. HIV and rituximab-associated PML showed only mild contrast enhancement, punctuate appearance, and cortical involvement. The CD4/CD8 ratio showed a trend to be higher in the natalizumab group, possibly mirroring a more efficient immune response. Imaging features of rituximab-associated PML are different from those of natalizumab-associated PML and are closer to those observed in HIV-associated PML. • Nowadays, PML is emerging as a complication of new effective therapies based on monoclonal antibodies. • Natalizumab-associated PML shows more inflammatory signs, a perivascular distribution "the milky way," and more cortex involvement than rituximab- and HIV-associated PML. • MRI differences are probably related to higher levels of immunosuppression in HIV patients and those under rituximab therapy.
One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack of expression in neural derivatives of lamin A, a major isoform of LMNA that is initially produced as a precursor called prelamin A. In HGPS, defective maturation of a mutateddoi:10.1016/j.celrep.2012.05.015 pmid:22840390 fatcat:kq4n4tqg3fgnlmnv73xx7bkr7e
more »... min A induces the accumulation of toxic progerin in patient cells. Here, we show that a microRNA, miR-9, negatively controls lamin A and progerin expression in neural cells. This may bear major functional correlates, as alleviation of nuclear blebbing is observed in nonneural cells after miR-9 overexpression. Our results support the hypothesis, recently proposed from analyses in mice, that protection of neural cells from progerin accumulation in HGPS is due to the physiologically restricted expression of miR-9 to that cell lineage.
Blondel, Jaskowiak, Egesipe et al. ... Information was collected with vHCS View Blondel, Jaskowiak, Egesipe et al. software (Cellomics). ...doi:10.5966/sctm.2013-0168 pmid:24598781 pmcid:PMC3973719 fatcat:46ttn2g2rfa3fp47wmzt5zxu3m
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