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Working Memory Maintenance Contributes to Long-term Memory Formation: Neural and Behavioral Evidence

Charan Ranganath, Michael X. Cohen, Craig J. Brozinsky
2005 Journal of Cognitive Neuroscience  
& Theories of human memory have led to conflicting views regarding the relationship between working memory (WM) maintenance and episodic long-term memory (LTM) formation.  ...  These results demonstrate that processing during the initial stage of WM maintenance directly contributes to successful LTM formation, and that this effect is mediated by a network that includes the dorsolateral  ...  Senate and Alzheimer's Disease Center.  ... 
doi:10.1162/0898929054475118 pmid:16102232 fatcat:xqtwdlxekjcdhilqw3kkxdtpka

Working memory maintenance contributes to long-term memory formation: Evidence from slow event-related brain potentials

Patrick Khader, Charan Ranganath, Anna Seemüller, Frank Rösler
2007 Cognitive, Affective, & Behavioral Neuroscience  
ehavioral research has led to conflicting views regarding the relationship between working memory (WM) maintenance and long-term memory (LTM) formation.  ...  Together, these results are strongly consistent with the ideas that WM maintenance contributes to LTM formation and that this may occur through strengthening of stimulus-specific cortical memory traces  ...  AUTHOR NOTE This work was supported by Grant FOR254/2-1 of the German Research Foundation (DFG) assigned to F.R. and by Public Health Service Grant 1R01MH068721 from the National Institute of Mental Health  ... 
doi:10.3758/cabn.7.3.212 pmid:17993207 fatcat:7fz2hlqemvgblldd52zunw4y2u

RNA localization in neurite morphogenesis and synaptic regulation: current evidence and novel approaches

Martin Mikl, Georgia Vendra, Michael Doyle, Michael A. Kiebler
2010 Journal of Comparative Physiology A. Sensory, neural, and behavioral physiology  
Second, we will brieXy present recent work on the role of microRNAs in translational control in dendrites and its implications for learning and memory.  ...  Finally, we discuss recent approaches to visualize RNAs in living cells and their employment for studying RNA traYcking in neurons.  ...  The authors would like to thank Jacki Heraud, Alexandre Raposo and Lucia Schoderböck for critical comments and Sebastian Butter for assistance in preparing the Wgures.  ... 
doi:10.1007/s00359-010-0520-x pmid:20237785 pmcid:PMC2858279 fatcat:wibiukolzfcn3l3ypvvw47x6si

DNA methylation and memory formation

Jeremy J Day, J David Sweatt
2010 Nature Neuroscience  
Recent evidence indicates that DNA methylation may serve as a contributing mechanism in memory formation and storage.  ...  Here we evaluate the existing evidence supporting a role for DNA methylation in memory, discuss how DNA methylation may affect genetic and neuronal function to contribute to behavior, propose several future  ...  Recent evidence indicates that DNA methylation may serve as a contributing mechanism in memory formation and storage.  ... 
doi:10.1038/nn.2666 pmid:20975755 pmcid:PMC3130618 fatcat:w67i42l6vjc2reuipsvrnbm7u4

Circuit Mechanisms of Memory Formation

Björn M. Kampa, Anja Gundlfinger, Johannes J. Letzkus, Christian Leibold
2011 Neural Plasticity  
In addition, the authors present data on the inhibition of protein kinase Mζ, which is necessary for the maintenance of long-term potentiation.  ...  The many forms and functions of long-term plasticity at GABAergic synapses are reviewed by A. Maffei.  ... 
doi:10.1155/2011/494675 pmid:22203914 pmcid:PMC3238405 fatcat:fihhtt2gpfe3dmsgdyz6zdpabu

Regulation of chromatin structure in memory formation

Tania L Roth, J David Sweatt
2009 Current Opinion in Neurobiology  
This brief review focuses on the role of epigenetic mechanisms in plasticity and memory formation, and their identification as targets of activity-dependent regulation in neurons.  ...  In this review, we focus on this theme, describing some basic background concerning epigenetic molecular mechanisms, and describing recent results concerning plasticity and memory formation.  ...  We would also like to apologize to the colleagues whose work we could not cite because of space limitations.  ... 
doi:10.1016/j.conb.2009.05.011 pmid:19539459 pmcid:PMC2744442 fatcat:6adfwot5abdwzemmzxdlklon7m

Epigenetic regulation of memory formation and maintenance

I. B. Zovkic, M. C. Guzman-Karlsson, J. D. Sweatt
2013 Learning & memory (Cold Spring Harbor, N.Y.)  
Their ability to regulate gene transcription dynamically in response to neuronal activation supports the consolidation of long-term memory.  ...  Understanding the cellular and molecular mechanisms underlying the formation and maintenance of memories is a central goal of the neuroscience community.  ...  Acknowledgments The authors' work is supported by NIH grants MH091122, MH57014, NS 057098, and AG031722, as well as NR012686 (J.D.S.) and NSERC-PDF (I.B.Z.).  ... 
doi:10.1101/lm.026575.112 pmid:23322554 pmcid:PMC3549063 fatcat:wbbdynrvnbcm7f4hakaumcus2i

Switching Gears: Translational Mastery of Transcription during Memory Formation

Charles A. Hoeffer, Eric Klann
2007 Neuron  
long-term memory?  ...  The degree to which reward/goalselection processes and interoceptive awareness of craving differentially contribute to drug-seeking behavior is not known.  ... 
doi:10.1016/j.neuron.2007.04.003 pmid:17442240 fatcat:5ulf7dxnrzb7vidol5ncv4shku

Alzheimer's Disease and the Neurobiology of Long-Term Memory Formation

Varun Upadhyay
2022 Berkeley scientific journal  
ACKNOWLEDGEMENTS I would like to thank and acknowledge Dr.  ...  I' d also like to thank my editors Jonny Hale and Marley Ottman, of the Berkeley Scientific Journal Features Department, for their thorough edits and guidance throughout the writing process.  ...  The complex process of long-term memory formation relies on an incredible array of intricate interactions between neurobiological processes that work in tandem to strengthen connections across the neural  ... 
doi:10.5070/bs326258273 fatcat:p2jzbj6jevgv5antmpzn5fwv3e

Synaptic Clustering and Memory Formation

George Kastellakis, Panayiota Poirazi
2019 Frontiers in Molecular Neuroscience  
Their main contribution is to facilitate the induction of dendritic spikes and dendritic plateau potentials, which provide advanced computational and memory-related capabilities to dendrites and single  ...  This grouping of synapses has been termed "synapse clustering" and has been shown to emerge in many different memory-related paradigms, as well as in in vitro studies.  ...  that early-life environment may lead to long-term changes in adulthood behavior via its effect in the clustering of GABAa receptors.  ... 
doi:10.3389/fnmol.2019.00300 pmid:31866824 pmcid:PMC6908852 fatcat:4oahyyli55ef7o6ooiijt4afxm

Neocortical Connectivity during Episodic Memory Formation

Christopher Summerfield, Matthew Greene, Tor Wager, Tobias Egner, Joy Hirsch, Jennifer Mangels, Mick Rugg
2006 PLoS Biology  
During the formation of new episodic memories, a rich array of perceptual information is bound together for long-term storage.  ...  Citation: Summerfield C, Greene M, Wager T, Egner T, Hirsch J, et al. (2006) Neocortical connectivity during episodic memory formation. PLoS Biol 4(5): e128.  ...  CS, MG, TW, TE, JH, and JM contributed reagents/materials/analysis tools. CS wrote the paper. Funding. This work was carried out with support from the William J.  ... 
doi:10.1371/journal.pbio.0040128 pmid:16605307 pmcid:PMC1436028 fatcat:x63sn3enxzfcldpgixyzr42agq

Memory formation by neuronal synchronization

Nikolai Axmacher, Florian Mormann, Guillen Fernández, Christian E. Elger, Juergen Fell
2006 Brain Research Reviews  
Recent EEG studies suggest that synchronized neural activity in the gamma frequency range (around 30-100 Hz) plays a functional role for the formation of declarative long-term memories in humans.  ...  In order to encode spatial locations or sequences of multiple items and to guarantee a defined temporal order of memory processing, synchronization in the gamma frequency range has to be accompanied by  ...  Acknowledgment This work was supported by the Volkswagen Foundation (grant I/79 878). We thank Nikolaus Maier and the three anonymous referees for helpful comments and suggestions.  ... 
doi:10.1016/j.brainresrev.2006.01.007 pmid:16545463 fatcat:7etxxnzvqnge7leqe2vsky2tby

The development of neural correlates for memory formation

Noa Ofen
2012 Neuroscience and Biobehavioral Reviews  
This review considers evidence from behavioral studies of memory development, neural correlates of memory formation in adults, and structural brain development, all of which form the foundation of a developmental  ...  I then aim to integrate the current evidence from developmental functional neuroimaging studies of memory formation with respect to three hypotheses.  ...  Acknowledgements The author wishes to thank X.J. Chai, R.E. Martin, E.C. Gutierrez Ramon, K.M. Morin, R. Serota and J.D.E.  ... 
doi:10.1016/j.neubiorev.2012.02.016 pmid:22414608 pmcid:PMC3437984 fatcat:j5t2hy64gjeanfdga4wtvzy3oq

Frontal cortex contributes to human memory formation

Randy L. Buckner, William M. Kelley, Steven E. Petersen
1999 Nature Neuroscience  
Frontal activity during encoding As might be expected, intentional memorization is a highly effective means of encoding words into long-term memory.  ...  311 Primate models of memory and multiple lines of evidence from neuropsychology suggest that medial temporal lobe brain structures are essential for memory formation.  ...  Areas within the medial temporal lobes receive inputs from many cortical regions and may contribute to memory formation by associating or 'binding' these inputs with already-present contents of long-term  ... 
doi:10.1038/7221 pmid:10204536 fatcat:iov6thx2bzc3vhpwkzcu6xasdu

Epigenetic mechanisms in experience-driven memory formation and behavior

Rosemary E Puckett, Farah D Lubin
2011 Epigenomics  
Behavioral neuroscientists have now begun to investigate these epigenetic mechanisms as potential regulators of genetranscription changes in the CNS subserving synaptic plasticity and long-term memory  ...  The present article examines how such learning-induced epigenetic changes contribute to LTM formation and influence behavior.  ...  Acknowledgments The authors wish to thank the Federation of American Societies for Experimental Biology, the National Institute of Mental Health (MH082106), and the Evelyn F McKnight Brain Institute at  ... 
doi:10.2217/epi.11.86 pmid:22126252 pmcid:PMC3235677 fatcat:o5htcp2osney5ngeehx4thfvdu
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