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Extremely low-frame-rate digital fluoroscopy in catheter ablation of atrial fibrillation

Ji Hyun Lee, Jun Kim, Minsu Kim, Jongmin Hwang, You Mi Hwang, Joon-Won Kang, Gi-Byoung Nam, Kee-Joon Choi, You-Ho Kim
2017 Medicine  
Despite the technological advance in 3-dimensional (3D) mapping, radiation exposure during catheter ablation of atrial fibrillation (AF) continues to be a major concern in both patients and physicians. Previous studies reported substantial radiation exposure (7369-8690 cGy cm 2 ) during AF catheter ablation with fluoroscopic settings of 7.5 frames per second (FPS) under 3D mapping system guidance. We evaluated the efficacy and safety of a low-frame-rate fluoroscopy protocol for catheter
more » ... for AF. Retrospective analysis of data on 133 patients who underwent AF catheter ablation with 3-D electro-anatomic mapping at our institute from , fluoroscopy frame rate of 4-FPS was implemented at our institute, which was further decreased to 2-FPS in September 2014. We compared the radiation exposure quantified as dose area product (DAP) and effective dose (ED) between the 4-FPS (n = 57) and 2-FPS (n = 76) groups. The 4 -FPS group showed higher median DAP (599.9 cGy cm 2 ; interquartile range [IR], 371.4-1337.5 cGy cm 2 vs. 392.0 cGy cm 2 ; IR, 289.7-591.4 cGy cm 2 ; P < .01), longer median fluoroscopic time (24.4 min; IR, 17.5-34.9 min vs. 15.1 min; IR, 10.7-20.1 min; P < .01), and higher median ED (1.1 mSv; IR, 0.7-2.5 mSv vs. 0.7 mSv; IR, 0.6-1.1 mSv; P < .01) compared with the 2-FPS group. No major procedure-related complications such as cardiac tamponade were observed in either group. Over follow-up durations of 331 ± 197 days, atrial tachyarrhythmia recurred in 20 patients (35.1%) in the 4-FPS group and in 27 patients (35.5%) in the 2-FPS group (P = .96). Kaplan-Meier survival analysis revealed no significant different between the 2 groups (log rank, P = .25). In conclusion, both the 4-FPS and 2-FPS settings were feasible and emitted a relatively low level of radiation compared with that historically reported for DAP in a conventional fluoroscopy setting. Abbreviations: 3D = 3-dimensional, AF = atrial fibrillation, AT = atrial tachyarrhythmia, BMI = body mass index, CT = computed tomography, CTI = cavotricuspid isthmus, DAP = dose area product, DLP = dose length product, ECG = electrocardiography, ED = effective dose, FPS = frames per second, IR = interquartile range, PVI = pulmonary vein (electrical) isolation, PV = pulmonary vein, RF = radiofrequency.
doi:10.1097/md.0000000000007200 pmid:28614264 pmcid:PMC5478349 fatcat:vlvfb6jwrzhm3hae2caplqe7t4

Surgical Treatment for Pectus Excavatum

Won Min Jo, Young Ho Choi, Young-Sang Sohn, Hark Jei Kim, Jae Joon Hwang, Sung Joon Cho
2003 Journal of Korean medical science  
doi:10.3346/jkms.2003.18.3.360 pmid:12808322 pmcid:PMC3055048 fatcat:4d5tylvtxvg3djktdsqwth5wla

Factors associated with liver stiffness in chronic liver disease

Da Mi Lee, Eun Joon Moon, Joo An Hwang, Min Suk Lee, Jae Youn Cheong, Sung Won Cho, Yeong Bae Kim, Dong Joon Kim, Seong Gyu Hwang, Jin Mo Yang
2009 Korean Journal of Hepatology  
Factors associated with liver stiffness in chronic liver disease
doi:10.3350/kjhep.2009.15.4.464 pmid:20037265 fatcat:apl2rlnpmrcajmogcdqmcobzdi

Absorption of soil residual azoxystrobin to lettuce

Min-Gi Kim, Kyu-Won Hwang, Eun-Jung Hwang, Soo-Cheol Yoo, Joon-Kwan Moon
2017 Journal of Applied Biological Chemistry  
This study was conducted to investigate the residual level and the amount of transfer to lettuce grown in field condition treated with the 5-methyl-1,2,4-triazolo[3,4-b][1,3]benzothiazole (Azoxystrobin). The field trials on lettuce were carried out at two different green houses located in Gwangju (Field 1) and Yongin (Field 2). Soil and lettuce samples were collected at different days after soil treatment of azoxystrobin with two different concentrations, respectively. Average recoveries for
more » ... xystrobin ranged from 86.9 to 113.6% from soil and lettuce with the variation coefficient of 0.1-4.6%. The initial concentrations of azoxystrobin in Gwangju soil were 9.20, 11.00 mg/kg and decreased to 1.36, 2.70 mg/kg at 43 DAT (days after treatment) in field 1, while 1.06, 2.23 mg/kg decreased to 0.20 and 0.67 mg/kg at 36 DAT in field 2, respectively. The half-lives of azoxystrobin were about 19.4 and 23.3 days for the low and high concentration of azoxystrobin treated soils in field 1 and 11.5 and 17.8 days in field 2 soils, respectively. Residue levels of azoxystrobin in lettuce were not detected in filed 1 and field 2 soils, respectively.
doi:10.3839/jabc.2017.054 fatcat:slosjvrf3zch5c2c7tsdabpq2e

Phosphokinase Antibody Arrays on Dendron-Coated Surface

Ju-Won Kwak, Hyobin Jeong, Sun-Ho Han, Youngkyu Kim, Sung Min Son, Inhee Mook-Jung, Daehee Hwang, Joon Won Park, Stefan Wölfl
2014 PLoS ONE  
Monitoring protein phosphorylation at the cellular level is important to understand the intracellular signaling. Among the phosphoproteomics methods, phosphokinase antibody arrays have emerged as preferred tools to measure wellcharacterized phosphorylation in the intracellular signaling. Here, we present a dendron-coated phosphokinase antibody array (DPA) in which the antibodies are immobilized on a dendron-coated glass slide. Self-assembly of conically shaped dendrons well-controlled in size
more » ... d structure resulted in precisely controlled lateral spacing between the immobilized phosphosite-specific antibodies, leading to minimized steric hindrance and improved antigen-antibody binding kinetics. These features increased sensitivity, selectivity, and reproducibility in measured amounts of protein phosphorylation. To demonstrate the utility of the DPA, we generated the phosphorylation profiles of brain tissue samples obtained from Alzheimer's disease (AD) model mice. The analysis of the profiles revealed signaling pathways deregulated during the course of AD progression.
doi:10.1371/journal.pone.0096456 pmid:24802362 pmcid:PMC4011796 fatcat:7mg2fkdw3fbndkx37z66dqnroe

Translocation of residual tricyclazole from soil to Korean cabbage

Eun-Jung Hwang, Kyu-won Hwang, Min-Gi Kim, Chae-Ho Jeon, Joon-Kwan Moon
2017 Journal of Applied Biological Chemistry  
흡수성은 log P값이 낮고 물에 대한 용해도가 높을 수록 강하게 나타난다고 알려져 있다(Juraske 등, 2011; Hwang 등, 2014; Lu 등, 2014; Jeon 등, 2014). 중 농약의 반감기는 토양의 종류, 유기물 함량등에 크 게 영향을 받는것으로 알려져 있다.  ... 
doi:10.3839/jabc.2017.047 fatcat:6sl523rg7rd2nb2ze7kzopd22e

Clinical Characteristics of Leber's Congenital Amaurosis in Korea

Joon Seo Hwang, Jeong Hun Kim, Ho Kyung Choung, Jang Won Heo, Seong-Joon Kim, Young Suk Yu
2007 Journal of the Korean Ophthalmological Society  
Purpose: To study the clinical characteristics and visual prognosis of Leber's congenital amaurosis in Korea. Methods: Children who were diagnosed with Leber's congenital amaurosis at Seoul Natioanl University Children's Hospital between 1992 and 2004, were included in this study. The medical records pertaining to the clinical characteristics and visual outcomes of the patients were retrospectively reviewed. Results: The mean age of the patients at presentation and during the subsequent
more » ... p period was 15.5 and 62.7 months, respectively. The principal symptoms included lack of fixation (69.0%) and nystagmus (23.8%). At first observation, nystagmus was found in 40 patients, and the appearance of the fundi were variable, including 'normal' (23.8%), pigmentary degeneration (54.8%), vascular attenuation (35.7%) and macular coloboma (19.0%). At the age of three to five years, 44.4% of patients had hyperopia greater than +5D. At the time of last follow-up, the visual acuities of the patients who were examined after the age of four were 'hand motion' in 68.7%, 20/400 in 9.4%. No patient had visual acuity better than 20/200. Eight (25%) patients could read with glasses or low-vision aids. Conclusions: The visual prognosis of patients with Leber's congenital amaurosis was poor in most cases, but a majority of our patients displayed a stable clinical course. Progression was rare, and one fourth of the patients were able to read with appropriate aides. In conclusion, regular follow-up care to assess visual function is necessary for optimal outcomes.
doi:10.3341/jkos.2007.48.9.1257 fatcat:m5zf3xrc4za7rnhghyjxzscgn4

Photocatalytic bacterial inactivation by polyoxometalates

Eunyoung Bae, Jae Won Lee, Byeong Hee Hwang, Jiman Yeo, Jeyong Yoon, Hyung Joon Cha, Wonyong Choi
2008 Chemosphere  
The photocatalytic inactivation (PCI) of Escherichia coli (Gram-negative) and Bacillus subtilis (Gram-positive) was performed using polyoxometalate (POM) as a homogeneous photocatalyst and compared with that of heterogeneous TiO 2 photocatalyst. Aqueous suspensions of the microorganisms (10 7 -10 8 cfu ml À1 ) and POM (or TiO 2 ) were irradiated with black light lamps. The POM-PCI was faster than (or comparable to) TiO 2 -PCI under the experimental conditions employed in this study. The
more » ... efficiency of POM-PCI was species-dependent. Among three POMs (H 3 PW 12 O 40 , H 3 PMo 12 O 40 , and H 4 SiW 12 O 40 ) tested in this study, the inactivation of E. coli was fastest with H 4 SiW 12 O 40 while that of B. subtilis was the most efficient with H 3 PW 12 O 40 . Although the biocidal action of TiO 2 photocatalyst has been commonly ascribed to the role of photogenerated reactive oxygen species such as hydroxyl radicals and superoxides, the cell death mechanism with POM seems to be different from TiO 2 -PCI. While TiO 2 caused the cell membrane disruption, POM did not induce the cell lysis. When methanol was added to the POM solution, not only the PCI of E. coli was enhanced (contrary to the case of TiO 2 -PCI) but also the dark inactivation was observed. This was ascribed to the in situ production of formaldehyde from the oxidation of methanol. The interesting biocidal property of POM photocatalyst might be utilized as a potential disinfectant technology.
doi:10.1016/j.chemosphere.2008.01.071 pmid:18343481 fatcat:xkl2glvcyvdahj3lwxx6hzipna

Translocation of chlorpyrifos residue from soil to Korean cabbage

Kyu-Won Hwang, Joon-Kwan Moon
2018 Applied Biological Chemistry  
The loss of residual chlorpyrifos in soil and the amount translocated to Korean cabbage were investigated in this study. Field trials with Korean cabbage were carried out in two greenhouses located in Yongin (Field 1) and Gwangju (Field 2). Soil and Korean cabbage samples were collected on different days following the treatment of soil with chlorpyrifos at two different rates. The initial amounts of residue in soil were 1.15 and 3.58 mg/kg, and these decreased to 0.22 and 0.49 mg/kg at 36 days
more » ... fter treatment (DAT) in Field 1. These values were 20.9 and 59.3 mg/kg, decreasing to 3.03 and 5.24 mg/kg at 43 DAT in Field 2, respectively. In Field 1, the half-life of chlorpyrifos was approximately 15.0 and 10.2 days in soil treated with 0.12 and 0.24 g a.i./m 2 , respectively. In Field 2, the half-life of chlorpyrifos was approximately 27.7 and 9.6 days following application of 0.36 and 0.72 g a.i./m 2 , respectively. When compared with the initial concentration in soil, the absorption ratio of chlorpyrifos residue to Korean cabbage was 0.93-6.01 and 0.57-2.61%, respectively. Therefore, safe management guidelines for chlorpyrifos in soil used to cultivate Korean cabbage may be suggested as 3.3 mg/kg regarding the maximum residue limit of chlorpyrifos on Korean cabbage (0.2 mg/kg).
doi:10.1007/s13765-017-0341-5 fatcat:5jgophxsszg4lfjxaskeprbvbm

Transdermal iontophoresis patch with reverse electrodialysis

Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S. Hwang, Won-serk Kim
2017 Drug Delivery  
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy. The current density, which can be controlled easily without special circuit, is enough to iontophoretic drug delivery. In vitro study, this iontophoretic system enhanced the transdermal delivery of peptide, which is difficult to penetrate the skin barrier by simple diffusion. We design the
more » ... isposable iontophoretic skin patch using RED system and suggest this patch can be apply on new cosmetic patch or disposable drug patch.
doi:10.1080/10717544.2017.1282555 pmid:28426265 fatcat:hwp3jxvy2rgfrgrripf5kg2fzq

Paleopathological Study of Dwarfism-Related Skeletal Dysplasia in a Late Joseon Dynasty (South Korean) Population

Eun Jin Woo, Won-Joon Lee, Kyung-Seok Hu, Jae Joon Hwang, Clark Spencer Larsen
2015 PLoS ONE  
Skeletal dysplasias related to genetic etiologies have rarely been reported for past populations. This report presents the skeletal characteristics of an individual with dwarfism-related skeletal dysplasia from South Korea. To assess abnormal deformities, morphological features, metric data, and computed tomography scans are analyzed. Differential diagnoses include achondroplasia or hypochondroplasia, chondrodysplasia, multiple epiphyseal dysplasia, thalassemia-related hemolytic anemia, and
more » ... somal storage disease. The diffused deformities in the upper-limb bones and several coarsened features of the craniofacial bones indicate the most likely diagnosis to have been a certain type of lysosomal storage disease. The skeletal remains of EP-III-4-No.107 from the Eunpyeong site, although incomplete and fragmented, provide important clues to the paleopathological diagnosis of skeletal dysplasias.
doi:10.1371/journal.pone.0140901 pmid:26488291 pmcid:PMC4619213 fatcat:yxe5oetqpfadvl4qgmwg5eskzq

Long-term immunogenicity of influenza vaccine among the elderly: Risk factors for poor immune response and persistence

Joon Young Song, Hee Jin Cheong, In Sook Hwang, Won Suk Choi, Yu Mi Jo, Dae Won Park, Geum Joo Cho, Taik Gun Hwang, Woo Joo Kim
2010 Vaccine  
The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre-and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period.
more » ... ection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.
doi:10.1016/j.vaccine.2010.03.067 pmid:20394719 fatcat:wsayadlopjahzf4dduz3gi4tjy

A Study on the Application of ISO Standard Sampling in Grading of Chicken Meats
닭고기 등급판정 시 ISO 기준 샘플링의 적용 연구

Yong Joon Hwang, Ha Sik Son, Jong Won Seung, Jong Woon Park, Won Uk Hwang, Soo-Ki Kim
2018 Korean Journal of Poultry Science  
If the KS A ISO 2859-1 conversion principle is applied, 40,530 won per day is saved for a 50-lot inspection.  ...  won to inspect; inspection cost is 20,253,420 won (17,490 × 1,158 won).  ...  : 54 won each. 2 Putting in ice (3 kg): 15 won. 3 Container clip 273,000 unit, 2,730,000 won: 10 won each. 4 Labor charge per hour, 15,000 won.  ... 
doi:10.5536/kjps.2018.45.4.285 fatcat:pgdcabfhofat7pwcuu5v3ciryu

Dermatological conditions in patients with brain damage

Joon Lee, Sang-Hyeon Hwang, Ji-Hye Park, Won-Serk Kim
2014 Zhōnghuá Pífūkē Yīxué Zázhì  
Background: As a result of the focus on vital functions in patients with brain damage, dermatological symptoms are often overlooked during their period of admission to hospital. However, patients with brain damage are more likely to have dermatological diseases than the general population and other inpatients for various reasons, including immobilization, treatment with multiple drugs, long-term hospitalization, and their immunocompromised status. Objectives: The purposes of this study were:
more » ... to analyze the frequency and characteristics of dermatological consultations among patients who were admitted to hospital as a result of brain damage; and (2) to compare these findings with other reports about inpatient dermatological consultations. Methods: We analyzed data for 240 patients with brain damage who attended our department of dermatology between January 1, 2007 and December 31, 2011. The total numbers of male and female patients were 132 (55%) and 108 (45%), respectively (male to female ratio 1.22:1). We retrospectively reviewed medical records, demographic information, reason for dermatological consultation, and the diagnosis of the dermatoses. Results: The age group most frequently seen was patients in the 7 th decade of life and the most common underlying brain injury was traumatic intracranial hemorrhage. The mean AE standard deviation score on the Glasgow Coma Scale (GCS) was 6.8 AE 3.0. When the levels of brain damage of the patients were classified using the GCS, 68.3% of the patients were in the severe (GCS 8) category. The most common skin disorders were seborrheic dermatitis (17.9%), followed by mycoses (15.5%), and drug-induced skin eruption (13.2%). Conclusion: The characteristics of dermatological consultations in patients with brain damage may be different from those of other inpatients attending dermatological clinics. The analysis of dermatological disorders in patients with brain damage can assist in understanding the "braineskin connection".
doi:10.1016/j.dsi.2013.11.003 fatcat:e3yslu22trgg5lwsx3duyzc6ou

The Biochemical Prognostic Factors of Subclinical Hypothyroidism

Myung Won Lee, Dong Yeob Shin, Kwang Joon Kim, Sena Hwang, Eun Jig Lee
2014 Endocrinology and Metabolism  
Patients with subclinical hypothyroidism (SHT) are common in clinical practice. However, the clinical significance of SHT, including prognosis, has not been established. Further clarifying SHT will be critical in devising a management plan and treatment guidelines for SHT patients. Thus, the aim of this study was to investigate the prognostic factors of SHT. We reviewed the medical records of Korean patients who visited the endocrinology outpatient clinic of Severance Hospital from January 2008
more » ... to September 2012. Newly-diagnosed patients with SHT were selected and reviewed retrospectively. We compared two groups: the SHT maintenance group and the spontaneous improvement group. The SHT maintenance group and the spontaneous improvement group had initial thyroid-stimulating hormone (TSH) levels that were significantly different (P=0.035). In subanalysis for subjects with TSH levels between 5 to 10 µIU/mL, the spontaneous improvement group showed significantly lower antithyroid peroxidase antibody (anti-TPO-Ab) titer than the SHT maintenance group (P=0.039). Regarding lipid profiles, only triglyceride level, unlike total cholesterol and low density lipoprotein cholesterol, was related to TSH level, which is correlated with the severity of SHT. Diffuse thyroiditis on ultrasonography only contributed to the severity of SHT, not to the prognosis. High sensitivity C-reactive protein and urine iodine excretion, generally regarded as possible prognostic factors, did not show any significant relation with the prognosis and severity of SHT. Only initial TSH level was a definite prognostic factor of SHT. TPO-Ab titer was also a helpful prognostic factor for SHT in cases with mildly elevated TSH. Other than TSH and TPO-Ab, we were unable to validate biochemical prognostic factors in this retrospective study for Korean SHT patients.
doi:10.3803/enm.2014.29.2.154 pmid:25031888 pmcid:PMC4091497 fatcat:s4paijou5jgzlfn6k5mfte2o7q
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