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Stabilization of Coiled-Coil Peptide Domains by Introduction of Trifluoroleucine†

Yi Tang, Giovanna Ghirlanda, Nagarajan Vaidehi, Jeremy Kua, Daniel T. Mainz, William A. Goddard, William F. DeGrado, David A. Tirrell
2001 Biochemistry  
Substitution of leucine residues by 5,5,5-trifluoroleucine at the d-positions of the leucine zipper peptide GCN4-p1d increases the thermal stability of the coiled-coil structure. The midpoint thermal unfolding temperature of the fluorinated peptide is elevated by 13°C at 30 µM peptide concentration. The modified peptide is more resistant to chaotropic denaturants, and the free energy of folding of the fluorinated peptide is 0.5-1.2 kcal/mol larger than that of the hydrogenated form. A similarly
more » ... fluorinated form of the DNA-binding peptide GCN4-bZip binds to target DNA sequences with affinity and specificity identical to those of the hydrogenated form, while demonstrating enhanced thermal stability. Molecular dynamics simulation on the fluorinated GCN4-p1d peptide using the Surface Generalized Born implicit solvation model revealed that the coiled-coil binding energy is 55% more favorable upon fluorination. These results suggest that fluorination of hydrophobic substructures in peptides and proteins may provide new means of increasing protein stability, enhancing protein assembly, and strengthening receptor-ligand interactions.
doi:10.1021/bi0022588 pmid:11258889 fatcat:72u56uhhsvgqjavtmx2i755hsq

Microdebrider Tonsillotomy vs Electrosurgical Tonsillectomy

Matthew T. Lister, Michael J. Cunningham, Barry Benjamin, Michael Williams, Ann Tirrell, Debra A. Schaumberg, Christopher J. Hartnick
2006 Archives of Otolaryngology - Head and Neck Surgery  
Objective: To examine whether microdebrider intracapsular tonsillotomy (MT) results in less postoperative pain compared with electrosurgical extracapsular tonsillectomy (ET). Design: Prospective, randomized, double-blind, matched pair, clinical trial. Setting: Specialty care hospital. Patients: Twelve male (48%) and 13 female (52%) children aged 5 to 15 years, with obstructive tonsillar hyperplasia were randomized to have one tonsil removed by MT and the other by ET. Interventions: An angled
more » ... oscopic microdebrider was used to perform MT, and ET was performed by standard monopolar cautery technique. Parents and children were blinded to the side of MT and ET. Children rated the pain 0 to 5 by side using the Faces Pain Scale-Revised. Blinded data collection was via telephone daily for 2 weeks by a study nurse. Main Outcome Measures: Primary: postoperative pain as recorded by Faces Pain Scale-Revised; secondary, presence or absence of otalgia and postoperative bleeding. Results: Twenty-two children (88%) had tonsillectomy and adenoidectomy, while 3 children (12%) had tonsillectomy alone. On postoperative days 1 to 9, children reported significantly less pain on the MT side compared with the ET side (paired t test; PϽ.01). By postoperative days 10 to 14, the difference between sides disappeared. Twenty children (80%) reported otalgia, and it was always unilateral. For those children reporting otalgia, there was a 100% correlation between the side of otalgia and the side of ET. There was no posttonsillectomy bleeding among the 25 children. Conclusion: Microdebrider intracapsular tonsillotomy is significantly less painful compared with electrosurgical ET in children undergoing surgical intervention for obstructive tonsillar hypertrophy.
doi:10.1001/archotol.132.6.599 pmid:16785404 fatcat:2urhy6hsbfbkjbokj2ndlieula

Gel phase formation in dilute triblock copolyelectrolyte complexes

Samanvaya Srivastava, Marat Andreev, Adam E. Levi, David J. Goldfeld, Jun Mao, William T. Heller, Vivek M. Prabhu, Juan J. de Pablo, Matthew V. Tirrell
2017 Nature Communications  
doi:10.1038/ncomms14131 pmid:28230046 pmcid:PMC5331217 fatcat:5bffxdttwfdjvhlj5itgx5ml6i

2010 Panel on the Biomaterials Grand Challenges

William "Monty" Reichert, Buddy D. Ratner, James Anderson, Art Coury, Allan S. Hoffman, Cato T. Laurencin, David Tirrell
2010 Journal of Biomedical Materials Research. Part A  
William Nelson Joy, Cofounder Sun Microsystems I really believe in implants. I have had an intraocular lens for almost 20 years and a hip implant for almost 10 years.  ...  Left to right: Art Coury, Allan Hoffman, Jim Anderson, Buddy Ratner (panel moderator), Cato Laurencin, David Tirrell, and panel organizer Monty Reichert.  ... 
doi:10.1002/jbm.a.32969 pmid:21171147 pmcid:PMC4076103 fatcat:apkmw7jbtzcobig24wn3ou27w4

Exploring Religiousness and Hope: Examining the Roles of Spirituality and Social Connections among Salvadoran Youth

Pamela Ebstyne King, Jennifer Medina Vaughn, Yeonsoo Yoo, Jonathan M. Tirrell, Elizabeth M. Dowling, Richard M. Lerner, G. John Geldhof, Jacqueline V. Lerner, Guillermo Iraheta, Kate Williams, Alistair T. R. Sim
2020 Religions  
The current study is part of the larger Compassion International Study of Positive Youth Development (Tirrell et al. 2019b (Tirrell et al. , 2019c .  ...  These eight total items were selected based on findings from Tirrell et al. (2019c) .  ... 
doi:10.3390/rel11020075 fatcat:zuwkeunusfdevmgjoi47uoom7e

Supplemental Material, sj-pdf-1-jbd-10.1177_01650254211022858 - Exploring the role of the "Big Three" features of effective youth development programs in El Salvador: The sample case of programs of Compassion International

Jonathan M. Tirrell, Samuel W. Hay, Patricia K. Gansert, Trang U. Le, Bridget C. O'Neil, Jennifer M. Vaughn, Leanne Bishara, Esther Tan, Jacqueline V. Lerner, Pamela Ebstyne King, Elizabeth M. Dowling, Kate Williams (+3 others)
2021 Figshare  
Dowling, Kate Williams, Guillermo Iraheta, Alistair T. R. Sim and Richard M. Lerner in International Journal of Behavioral Development  ...  Tirrell, Samuel W. Hay, Patricia K. Gansert, Trang U. Le, Bridget C. O'Neil, Jennifer M. Vaughn, Leanne Bishara, Esther Tan, Jacqueline V. Lerner, Pamela Ebstyne King, Elizabeth M.  ... 
doi:10.25384/sage.14912928.v1 fatcat:jngprwqaffdofp5sgpdrhu3hhy

Therapy of Small Cell Lung Cancer (SCLC) with a Topoisomerase-I–inhibiting Antibody–Drug Conjugate (ADC) Targeting Trop-2, Sacituzumab Govitecan

Jhanelle E. Gray, Rebecca S. Heist, Alexander N. Starodub, D. Ross Camidge, Ebenezer A. Kio, Gregory A. Masters, W. Thomas Purcell, Michael J. Guarino, Jamal Misleh, Charles J. Schneider, Bryan J. Schneider, Allyson Ocean (+11 others)
2017 Clinical Cancer Research  
Purpose: We evaluated a Trop-2-targeting antibody conjugated with SN-38 in metastatic small cell lung cancer (mSCLC) patients. Experimental Design: Sacituzumab govitecan was studied in patients with pretreated (median, 2; range, 1-7) mSCLC who received either 8 or 10 mg/kg i.v. on days 1 and 8 of 21-day cycles. The primary endpoints were safety and objective response rate (ORR); duration of response, progression-free survival (PFS), and overall survival (OS) were secondary endpoints.
doi:10.1158/1078-0432.ccr-17-0933 pmid:28679770 fatcat:4axgvpyuv5fx5op2ez5kwntdpy

Page 214 of The New England Historical and Genealogical Register Vol. 12, Issue 3 [page]

1858 The New England Historical and Genealogical Register  
William & Mrs. Martha Swain, died March 25, 1810, aged 9 months. 96. In Memory of Mr. William Swain died me 23. 1813, Aged 33 Years. THOMPSON. 97. Mrs.  ...  TIRRELL. 98. In Memory of Jane Dau’tr of Mr. Gideon Tirrell, & Mary his Wife She died May [11th ?] 1802, in her [7th ?] year. 99. In Memory of Nancy Dau’tr of Mr. Gideon Tirrell, & Mary his Wife.  ... 

Page 60 of The New England Historical and Genealogical Register Vol. 4, Issue 1 [page]

1850 The New England Historical and Genealogical Register  
Nicholas son of Nicholas & Deborah Shaw born Gedion son of Gedion & Hannah Tirrell Mary of Remember & Mary Briggs Mary of John & Abigail Blancher Abigail of William & Abigail Tirrell Ebenezer of Joseph  ...  & Mary Slack Stephen son of Philip & Abigail Reed Mary of Samuel & Ann White David son of Ichabod & Sarah Holbrook Mary of Gedion & Hannah Tirrell Joshua son of Jonathan & Ruth Torrey Mary of Nicholas  ... 

Page 67 of Notes and Queries Vol. 25, Issue 1 [page]

1978 Notes and Queries  
HENRY BROOKE, WILLIAM GODWIN, AND “ BARNABAS TIRRELL/TYRREL ” (COMMENTATORS on Caleb Williams do not seem to have hit upon Godwin’s source for the name of Falkland’s antagon- ist in the first volume, Barnabas  ...  Here one “ Barnabas Tirrell”, a London shopkeeper, has a wife whose beloved brother is a sailor.  ... 

Page 786 of Great Britain. Public Record Office. Calendar of State Papers. Domestic, Edward VI, Mary, Elizabeth I, and James I Vol. , Issue [page]

1547 Great Britain. Public Record Office. Calendar of State Papers. Domestic, Edward VI, Mary, Elizabeth I, and James I  
Tin, Coinage of, 511. _ Tin, Pre-emption of, 639. | Tintern and Tintern Abbey, 278, 322. ee William, 522, 551, 621, Tirrell, Edmund, 104. ' Tirrell, William, 26, 90. , Tirrell, see Tyrell. | Tirwhitt,  ...  Thurston, William, 150. Thwayts, Edward, 634. Thymblebie, Anne, 610. Thymblebie, Dionysius, 105. Tiger, The, 238. Tikinhill, House of, 163. Tilbury, West, 45, 691. Tildesley, William, 201.  ... 

Introduction to Editorial Board Members: Professor David A. Tirrell

Julie Champion
2016 Bioengineering & Translational Medicine  
Tirrell is the Ross McCollum-William H. Corcoran Professor of Chemistry and Chemical Engineering and Director of the Beckman Institute at California Institute of Technology.  ...  Tirrell In this second issue of Bioengineering and Translational Medicine, we are pleased to introduce our Editorial Board Member, Prof. David A. Tirrell. Prof.  ... 
doi:10.1002/btm2.10040 fatcat:xhogkt6glngcfiiooomzzvurva

Page 171 of The New England Historical and Genealogical Register Vol. 4, Issue 2 [page]

1850 The New England Historical and Genealogical Register  
son of William & Joanna Dyar Mar 22 1693 Jacob son of Jacob & Jane Turner April 4 1693 Gedion son of Gedion & Hannah Tirrell April 10 1693 Judith Daughter of Joseph & Judith Shaw May 4 1693 William of  ...  & Abigail Tirrell June 14 1694 John son of John & Sarah Drake Sept 20 1694 Mercy of John & Mercy Porter Sept 28 1694 Sarah of Ezra & Bathsheba Whitmarsh Oct 19 1694 Elizabeth of Thomas & Sarah Reed Nov  ... 

Page 22 of The New England Journal of History Vol. 21, Issue 1 [page]

1963 The New England Journal of History  
William G. Saltonstall, Phillips Exeter Academy. Pres. Mildred E. Bassett, Rhode Island School of Educa- tion; Vice-Pres. William G. Saltonstall. Pres. William G. Saltonstall; Vice-Pres. Harold U.  ...  Winthrop Tirrell, Bos- ton High School of Commerce. Pres. Winthrop Tirrell; Vice-Pres. Frank M. Anderson, Dartmouth. Pres. Frank M. Anderson: Vice-Pres. Lawrence V. Roth, Phillips Academy, Andover.  ... 

Page 621 of Great Britain. Public Record Office. Calendar of State Papers, of the Reign of Charles I, 1625-[1649]. Domestic Series, Vol. , Issue [page]

1628 Great Britain. Public Record Office. Calendar of State Papers, of the Reign of Charles I, 1625-[1649]. Domestic Series,  
Timothy Tirrell, 344. Sir Timothy Tirrell, 196, 344. William Tirrey, 572, 583. Thomas Tirwhitt, 215 (2). William Todderick, 381. Thomas Tomkins, 19. Richard Tomlins, 161, 163. Adam Torless, 399.  ...  Sir Abraham Williams, 345 (2). Griffin Williams, D.D., 192. John Williams, 577. Richard Williams, 106, 216 (2), Thomas Willys, 572 (2). George Wilmer, 16, 597. Thomas Wilson, 406.  ... 
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