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TXNIP Regulates Peripheral Glucose Metabolism in Humans

Hemang Parikh, Emma Carlsson, William A Chutkow, Lovisa E Johansson, Heidi Storgaard, Pernille Poulsen, Richa Saxena, Christine Ladd, P. Christian Schulze, Michael J Mazzini, Christine Bjørn Jensen, Anna Krook (+10 others)
2007 PLoS Medicine  
A B S T R A C T Background Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure. Methods and Findings We combined human insulin/glucose clamp physiological studies with genome-wide expression profiling to identify thioredoxin interacting protein (TXNIP) as a gene whose expression is
more » ... ly suppressed by insulin yet stimulated by glucose. In healthy individuals, its expression was inversely correlated to total body measures of glucose uptake. Forced expression of TXNIP in cultured adipocytes significantly reduced glucose uptake, while silencing with RNA interference in adipocytes and in skeletal muscle enhanced glucose uptake, confirming that the gene product is also a regulator of glucose uptake. TXNIP expression is consistently elevated in the muscle of prediabetics and diabetics, although in a panel of 4,450 Scandinavian individuals, we found no evidence for association between common genetic variation in the TXNIP gene and T2DM. Conclusions TXNIP regulates both insulin-dependent and insulin-independent pathways of glucose uptake in human skeletal muscle. Combined with recent studies that have implicated TXNIP in pancreatic b-cell glucose toxicity, our data suggest that TXNIP might play a key role in defective glucose homeostasis preceding overt T2DM.
doi:10.1371/journal.pmed.0040158 pmid:17472435 pmcid:PMC1858708 fatcat:we7jzdphl5bofakjv5jjzozcc4

Page 117 of Physical Review Vol. 27, Issue 2 [page]

1908 Physical Review  
William Thomson, Philosophical Magazine, ser. 4, vol. 5, p. 393- nM eas ea a, SE DOE AP LO ES Tt, LTE LEE: late ae  ...  Poulsen, British Patent Specification 15599 of 1903. See also Science Abstracts, vol. 8A, p. 521. ‘V. Poulsen, Elektrotechnische Zeitschrift, vol. 27, p. 1040, 1906. ‘ Prof.  ... 

Officers and Board of Direction, 1916

1916 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAm DUDDELL LEONARD FULLER ALFRED N. GOLDSMITH GUY HILL LESTER ISRAEL FREDERICK A. KOLSTER GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W. PIERCE JOHN STONE STONE. CHARLES H.  ...  JOHN STONE STONE, 1907 -8 LEE DE FOREST, 1909 -10 FRITZ LOWENSTEIN, 1911 12 THE WIRELESS INSTITUTE ROBERT H.MARRIOTT, 1909-10-11-12 New York, N. Y. THE INSTITUTE OF RADIO ENGINEERS ROBERT H.  ... 
doi:10.1109/jrproc.1916.217223 fatcat:rvix3qrdhzfqxnwun3dpfk5p2u

Officers and Board of Direction, 1916

1916 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAM DUDDELL LEONARD FULLER ALFRED N. GOLDSMITH GuY HILL LESTER ISRAEL FREDERICK A. KOLSTER GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W. PIERCE JOHN STONE STONE. CHARLES H.  ...  WILLIAM H. G. BULLARD . . . . Radio, Va. LEE DE FOREST . . . . . New York, N. Y. MELVILLE EASTHAM . . . . Cambridge, Mass. LLOYD ESPENSCHIED . . . . . New York, N.  ... 
doi:10.1109/jrproc.1916.217234 fatcat:dkabqi6uyfdbnloovijt7j2qfa

Officers and Board of Direction, 1919

1919 Proceedings of the Institute of Radio Engineers  
WILLIAM DUDDELL. LEONARD FULLER ALFRED N. GOLDSMITH CAPTAIN GuY HILL LESTER ISRAEL FREDERICK A. KOLSTER LIEUTENANT GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W.  ...  PAST-PRESI DENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOhIN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 THE WIRELESS INSTITUTE ROBERT H.  ... 
doi:10.1109/jrproc.1919.217447 fatcat:owcbwmsas5e6rdtltqb2xjapuy

Officers and Board of Direction, 1916

1916 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAM DUDDELL LEONARD FULLER ALFRED N. GOLDSMITH GUY HILL LESTER ISRAEL FREDERICK A. KOLSTER GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W. PIERCE JOHN STONE STONE. CHARLES H.  ...  PAST-PRESIDENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHN STONE STONE, 1907 -8 LEE DE FOREST, 1909 -10 FRITZ LOWENSTEIN, 1911 THE WIRELESS INSTITUTE WIRELESS ROBERT H.MARRIOTT, 1909-10-11-12  ... 
doi:10.1109/jrproc.1916.217251 fatcat:nc67mnbjencjlerzfeihzvxinm

Officers and Board of Direction, 1919

1919 Proceedings of the Institute of Radio Engineers  
WILLIAM DUDDELL. LEONARD FULLER ALFRED N. GOLDSMITH GuY HILL LESTER TSRAEL FREDERICK A. KOLSTER LIEUTENANT G-EORGE H. LEWIS VALDEMAR POULSEN GEORGE W. PIERCE JOHN STONE STONE Brooklyn, N.  ...  PAST-PRESI DENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOIIN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 STANDING COMMITTEES 1919 COMMITTEE ON STANDARDIZATION JOHN  ... 
doi:10.1109/jrproc.1919.217410 fatcat:2cbhvq4apbcehgvbpqiay4keu4

Officers and Board of Direction, 1917

1917 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAM DUDDELL . LEONARD FULLER ALFRED N. GOLDSMITH Guy HILL LESTER ISRAEL FREDERICK A. KOLSTER GEORGE H. LEWIS VALDEMAR POULSEN . Co] GEORGE W. PIERCE Brooklyn, N. Y.  ...  PAST-PRESIDENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 THE WIRELESS INSTITUTE ARTHUR E.  ... 
doi:10.1109/jrproc.1917.217339 fatcat:kmz5nu2gjzavzdlqt2wfl5qwje

Officers and Board of Direction, 1918

1918 Proceedings of the Institute of Radio Engineers  
VALDEMAR POULSEN .Copenhagen, Denmark GEORGE W. PIERCE .Cambridge, Mass.  ...  WILLIAM DUDDELL .London, England LEONARD FULLER .San Francisco, Cal. ALFRED N. GOLDSMITH .New York, N. Y. GUy HILL Washington, D. C. LESTER TSRAEL .Washington, D. C. FREDERICK A.  ... 
doi:10.1109/jrproc.1918.217400 fatcat:ugnrl4tjf5frdozjuqdtgeflyu

Officers and Board of Direction, 1918

1918 Proceedings of the Institute of Radio Engineers  
WILLIAM DUDDELL . LEONARD FULLER ALFRED N. GOLDSMITH GuY HILL LESTER ISRAEL FREDERICK A. KOLSTER LIEUTENANT GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W. PIERCE JOHN STONE STONE Brooklyn, N.  ...  PAST-PRESI DENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHiN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 STANDING COMMITTEES 1917 COMMITTEE ON STANDARDIZATION  ... 
doi:10.1109/jrproc.1918.217390 fatcat:gcxi5rsqtzgqpj5k6jjaczzv6e

Page 545 of American Mathematical Society. Bulletin of the American Mathematical Society Vol. 67, Issue 6 [page]

1961 American Mathematical Society. Bulletin of the American Mathematical Society  
Lee, Autometric Corp., New York, N. Y.; Mr. William H. K. Lee, University of Alberta; Professor Wuhan Lee, Tong Kook University, Seoul, Korea; Mr. Michael Maschler, Princeton University; Mr.  ...  Poulsen, The Martin Co., Baltimore, Maryland; Professor James Radlow, Adelphi College; Mr. Vincent Ribas, Stromberg Carlsen, Rochester, New York; Mr. Michael Rossin, Hunter College; Mr. W.  ... 

Officers and Board of Direction, 1916

1916 Proceedings of the Institute of Radio Engineers  
PAST-PRESIDENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 THE WIRELESS INSTITUTE ROBERT H.  ...  VALDEMAR POULSEN . Copenhagen, Denmark GEORGE W. PIERCE Cambridge, Mass. JOHN STONE STONE. New York, N. Y. CHARLES H. TAYLOR Kahuku, Hawaii RoY A. WEAGANT . . Aldene, N. J.  ... 
doi:10.1109/jrproc.1916.217275 fatcat:ueb6zjwzrrfbhcosvhpaebifdy

Officers and Board of Direction, 1918

1918 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAM DUDDELL LEONARD FULLER ALFRED N. GOLDSMITH GuY HILL LESTER ISRAEL FREDERICK A. KOLSTER LIEUTENANT GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W.  ...  PAST-PRESI DENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 THE WIRELESS INSTITUTE ROBERT H.  ... 
doi:10.1109/jrproc.1918.217379 fatcat:mnjqyxyhwvdr7luackjmycvfbi

Officers and Board of Direction, 1919

1919 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAM DUDDELL. LEONARD FULLER ALFRED N. GOLDSMITH. CAPTAIN GUY HILL LESTER TSRAEL FREDERICK A. KOLSTER LIEUTENANT GCEORGE H. LEWIS VALDEMAR POULSEN GEORGE W.  ...  PAST-PRESI DENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOhiN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 THE WIRELESS INSTITUTE ROBERT H.  ... 
doi:10.1109/jrproc.1919.217423 fatcat:bsfh2z2mgfdrzmad3icc2xn6ie

Officers and Board of Direction, 1917

1917 Proceedings of the Institute of Radio Engineers  
CLARK WILLIAM DUDDELL LEONARD FULLER ALFRED N. GOLDSMITH GuY HILL LESTER ISRAEL FREDERICK A. KOLSTEIZ GEORGE H. LEWIS VALDEMAR POULSEN GEORGE W. PIERCE Brooklyn, N. Y. Schenectady, N. Y.  ...  PAST-PRESIDENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHN STONE STONE, 1907-8 LEE DE FOREST, 1909-10 FRITZ LOWENSTEIN, 1911-12 THE WIRELESS INSTITUTE ROBERT H.  ... 
doi:10.1109/jrproc.1917.217318 fatcat:hli7byyrcnfy3d4b3d26djyyae
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