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TXNIP Regulates Peripheral Glucose Metabolism in Humans
2007
PLoS Medicine
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A B S T R A C T Background Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure. Methods and Findings We combined human insulin/glucose clamp physiological studies with genome-wide expression profiling to identify thioredoxin interacting protein (TXNIP) as a gene whose expression is
doi:10.1371/journal.pmed.0040158
pmid:17472435
pmcid:PMC1858708
fatcat:we7jzdphl5bofakjv5jjzozcc4
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... ly suppressed by insulin yet stimulated by glucose. In healthy individuals, its expression was inversely correlated to total body measures of glucose uptake. Forced expression of TXNIP in cultured adipocytes significantly reduced glucose uptake, while silencing with RNA interference in adipocytes and in skeletal muscle enhanced glucose uptake, confirming that the gene product is also a regulator of glucose uptake. TXNIP expression is consistently elevated in the muscle of prediabetics and diabetics, although in a panel of 4,450 Scandinavian individuals, we found no evidence for association between common genetic variation in the TXNIP gene and T2DM. Conclusions TXNIP regulates both insulin-dependent and insulin-independent pathways of glucose uptake in human skeletal muscle. Combined with recent studies that have implicated TXNIP in pancreatic b-cell glucose toxicity, our data suggest that TXNIP might play a key role in defective glucose homeostasis preceding overt T2DM.
Page 117 of Physical Review Vol. 27, Issue 2
[page]
1908
Physical Review
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William Thomson, Philosophical Magazine, ser. 4, vol. 5, p. 393-
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AP LO ES Tt, LTE LEE: late ae ...
Poulsen, British Patent Specification 15599 of 1903. See also Science Abstracts, vol. 8A, p. 521.
‘V. Poulsen, Elektrotechnische Zeitschrift, vol. 27, p. 1040, 1906.
‘ Prof. ...
Officers and Board of Direction, 1916
1916
Proceedings of the Institute of Radio Engineers
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CLARK
WILLIAm DUDDELL
LEONARD FULLER
ALFRED N. GOLDSMITH
GUY HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. PIERCE
JOHN STONE STONE.
CHARLES H. ...
JOHN STONE STONE, 1907 -8 LEE DE FOREST, 1909 -10 FRITZ LOWENSTEIN, 1911 12 THE WIRELESS INSTITUTE ROBERT H.MARRIOTT, 1909-10-11-12 New York, N. Y. THE INSTITUTE OF RADIO ENGINEERS
ROBERT H. ...
doi:10.1109/jrproc.1916.217223
fatcat:rvix3qrdhzfqxnwun3dpfk5p2u
Officers and Board of Direction, 1916
1916
Proceedings of the Institute of Radio Engineers
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CLARK
WILLIAM DUDDELL
LEONARD FULLER
ALFRED N. GOLDSMITH
GuY HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. PIERCE
JOHN STONE STONE.
CHARLES H. ...
WILLIAM H. G. BULLARD
.
.
.
.
Radio, Va.
LEE DE FOREST
.
.
.
.
.
New York, N. Y.
MELVILLE EASTHAM
.
.
.
.
Cambridge, Mass.
LLOYD ESPENSCHIED
.
.
.
.
.
New York, N. ...
doi:10.1109/jrproc.1916.217234
fatcat:dkabqi6uyfdbnloovijt7j2qfa
Officers and Board of Direction, 1919
1919
Proceedings of the Institute of Radio Engineers
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WILLIAM DUDDELL.
LEONARD FULLER
ALFRED N. GOLDSMITH
CAPTAIN GuY HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
LIEUTENANT GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. ...
PAST-PRESI DENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOhIN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
THE WIRELESS INSTITUTE
ROBERT H. ...
doi:10.1109/jrproc.1919.217447
fatcat:owcbwmsas5e6rdtltqb2xjapuy
Officers and Board of Direction, 1916
1916
Proceedings of the Institute of Radio Engineers
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CLARK
WILLIAM DUDDELL
LEONARD FULLER
ALFRED N. GOLDSMITH
GUY HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. PIERCE
JOHN STONE STONE.
CHARLES H. ...
PAST-PRESIDENTS SOCIETY OF WIRELESS TELEGRAPH ENGINEERS JOHN STONE STONE, 1907 -8 LEE DE FOREST, 1909 -10 FRITZ LOWENSTEIN, 1911 THE WIRELESS INSTITUTE WIRELESS ROBERT H.MARRIOTT, 1909-10-11-12 ...
doi:10.1109/jrproc.1916.217251
fatcat:nc67mnbjencjlerzfeihzvxinm
Officers and Board of Direction, 1919
1919
Proceedings of the Institute of Radio Engineers
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WILLIAM DUDDELL.
LEONARD FULLER
ALFRED N. GOLDSMITH
GuY HILL
LESTER TSRAEL
FREDERICK A. KOLSTER
LIEUTENANT G-EORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. PIERCE
JOHN STONE STONE
Brooklyn, N. ...
PAST-PRESI DENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOIIN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
STANDING COMMITTEES
1919
COMMITTEE ON STANDARDIZATION
JOHN ...
doi:10.1109/jrproc.1919.217410
fatcat:2cbhvq4apbcehgvbpqiay4keu4
Officers and Board of Direction, 1917
1917
Proceedings of the Institute of Radio Engineers
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CLARK
WILLIAM DUDDELL .
LEONARD FULLER
ALFRED N. GOLDSMITH
Guy HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
GEORGE H. LEWIS
VALDEMAR POULSEN
.
Co]
GEORGE W. PIERCE
Brooklyn, N. Y. ...
PAST-PRESIDENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOHN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
THE WIRELESS INSTITUTE
ARTHUR E. ...
doi:10.1109/jrproc.1917.217339
fatcat:kmz5nu2gjzavzdlqt2wfl5qwje
Officers and Board of Direction, 1918
1918
Proceedings of the Institute of Radio Engineers
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VALDEMAR POULSEN
.Copenhagen, Denmark
GEORGE W. PIERCE
.Cambridge, Mass. ...
WILLIAM DUDDELL
.London, England
LEONARD FULLER
.San Francisco, Cal.
ALFRED N. GOLDSMITH
.New
York, N. Y.
GUy HILL
Washington, D. C.
LESTER TSRAEL
.Washington, D. C.
FREDERICK A. ...
doi:10.1109/jrproc.1918.217400
fatcat:ugnrl4tjf5frdozjuqdtgeflyu
Officers and Board of Direction, 1918
1918
Proceedings of the Institute of Radio Engineers
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WILLIAM DUDDELL .
LEONARD FULLER
ALFRED N. GOLDSMITH
GuY HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
LIEUTENANT GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. PIERCE
JOHN STONE STONE
Brooklyn, N. ...
PAST-PRESI DENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOHiN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
STANDING COMMITTEES
1917
COMMITTEE ON STANDARDIZATION ...
doi:10.1109/jrproc.1918.217390
fatcat:gcxi5rsqtzgqpj5k6jjaczzv6e
Page 545 of American Mathematical Society. Bulletin of the American Mathematical Society Vol. 67, Issue 6
[page]
1961
American Mathematical Society. Bulletin of the American Mathematical Society
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Lee, Autometric Corp., New York, N. Y.;
Mr. William H. K. Lee, University of Alberta;
Professor Wuhan Lee, Tong Kook University, Seoul, Korea;
Mr. Michael Maschler, Princeton University;
Mr. ...
Poulsen, The Martin Co., Baltimore, Maryland;
Professor James Radlow, Adelphi College;
Mr. Vincent Ribas, Stromberg Carlsen, Rochester, New York;
Mr. Michael Rossin, Hunter College;
Mr. W. ...
Officers and Board of Direction, 1916
1916
Proceedings of the Institute of Radio Engineers
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The Internet Archive has a preservation copy of this work in our general collections.
PAST-PRESIDENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOHN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
THE WIRELESS INSTITUTE
ROBERT H. ...
VALDEMAR POULSEN
.
Copenhagen, Denmark
GEORGE W. PIERCE
Cambridge, Mass.
JOHN STONE STONE.
New York, N. Y.
CHARLES H. TAYLOR
Kahuku, Hawaii
RoY A. WEAGANT
.
. Aldene, N. J. ...
doi:10.1109/jrproc.1916.217275
fatcat:ueb6zjwzrrfbhcosvhpaebifdy
Officers and Board of Direction, 1918
1918
Proceedings of the Institute of Radio Engineers
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The Internet Archive has a preservation copy of this work in our general collections.
CLARK
WILLIAM DUDDELL
LEONARD FULLER
ALFRED N. GOLDSMITH
GuY HILL
LESTER ISRAEL
FREDERICK A. KOLSTER
LIEUTENANT GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. ...
PAST-PRESI DENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOHN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
THE WIRELESS INSTITUTE
ROBERT H. ...
doi:10.1109/jrproc.1918.217379
fatcat:mnjqyxyhwvdr7luackjmycvfbi
Officers and Board of Direction, 1919
1919
Proceedings of the Institute of Radio Engineers
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CLARK
WILLIAM DUDDELL.
LEONARD FULLER
ALFRED N. GOLDSMITH.
CAPTAIN GUY HILL
LESTER TSRAEL
FREDERICK A. KOLSTER
LIEUTENANT GCEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. ...
PAST-PRESI DENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOhiN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
THE WIRELESS INSTITUTE
ROBERT H. ...
doi:10.1109/jrproc.1919.217423
fatcat:bsfh2z2mgfdrzmad3icc2xn6ie
Officers and Board of Direction, 1917
1917
Proceedings of the Institute of Radio Engineers
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CLARK
WILLIAM DUDDELL
LEONARD FULLER
ALFRED N. GOLDSMITH
GuY HILL
LESTER ISRAEL
FREDERICK A. KOLSTEIZ
GEORGE H. LEWIS
VALDEMAR POULSEN
GEORGE W. PIERCE
Brooklyn, N. Y.
Schenectady, N. Y. ...
PAST-PRESIDENTS
SOCIETY OF WIRELESS TELEGRAPH ENGINEERS
JOHN STONE STONE, 1907-8
LEE DE FOREST, 1909-10
FRITZ LOWENSTEIN, 1911-12
THE WIRELESS INSTITUTE
ROBERT H. ...
doi:10.1109/jrproc.1917.217318
fatcat:hli7byyrcnfy3d4b3d26djyyae
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